| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Behzad Torabi, Samuel Flashner, Kate Beishline, Aislinn Sowash, Kelly Donovan, Garrett Bassett, Jane Azizkhan-Cliffor. Caspase cleavage of transcription factor Sp1 enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 23. issue 1. 2019-08-28. PMID:29236199. |
sp1 is a ubiquitous transcription factor that regulates many genes involved in apoptosis and senescence. |
2019-08-28 |
2023-08-13 |
Not clear |
| Behzad Torabi, Samuel Flashner, Kate Beishline, Aislinn Sowash, Kelly Donovan, Garrett Bassett, Jane Azizkhan-Cliffor. Caspase cleavage of transcription factor Sp1 enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 23. issue 1. 2019-08-28. PMID:29236199. |
depletion of sp1 increases the sensitivity of cells to dna damage, whereas overexpression of sp1 can drive cells into apoptosis. |
2019-08-28 |
2023-08-13 |
Not clear |
| Behzad Torabi, Samuel Flashner, Kate Beishline, Aislinn Sowash, Kelly Donovan, Garrett Bassett, Jane Azizkhan-Cliffor. Caspase cleavage of transcription factor Sp1 enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 23. issue 1. 2019-08-28. PMID:29236199. |
here, we show that activation of apoptosis through dna damage or trail-mediated activation of the extrinsic apoptotic pathway induces caspase-mediated cleavage of sp1. |
2019-08-28 |
2023-08-13 |
Not clear |
| Behzad Torabi, Samuel Flashner, Kate Beishline, Aislinn Sowash, Kelly Donovan, Garrett Bassett, Jane Azizkhan-Cliffor. Caspase cleavage of transcription factor Sp1 enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 23. issue 1. 2019-08-28. PMID:29236199. |
mutation of aspartic acid 183 to alanine conferred resistance to cleavage, and ectopic expression of the sp1 d183a rendered cells resistant to apoptotic stimuli, indicating that sp1 cleavage is involved in the induction of apoptosis. |
2019-08-28 |
2023-08-13 |
Not clear |
| Behzad Torabi, Samuel Flashner, Kate Beishline, Aislinn Sowash, Kelly Donovan, Garrett Bassett, Jane Azizkhan-Cliffor. Caspase cleavage of transcription factor Sp1 enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 23. issue 1. 2019-08-28. PMID:29236199. |
together, these data reveal a new caspase cleavage site in sp1 and demonstrate for the first time that caspase cleavage of sp1 promotes apoptosis. |
2019-08-28 |
2023-08-13 |
Not clear |
| Bei Jin, Chengyan Wang, Yingying Shen, Jingxuan Pa. Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant. Cell death & disease. vol 9. issue 2. 2019-06-17. PMID:29358661. |
anthelmintic niclosamide suppresses transcription of bcr-abl fusion oncogene via disabling sp1 and induces apoptosis in imatinib-resistant cml cells harboring t315i mutant. |
2019-06-17 |
2023-08-13 |
mouse |
| Su Jin Kang, Won Jong Rhe. Silkworm Storage Protein 1 Inhibits Autophagy-Mediated Apoptosis. International journal of molecular sciences. vol 20. issue 2. 2019-04-24. PMID:30646576. |
therefore, we investigated the effect of silkworm storage protein 1 (sp1), an antiapoptotic protein, on autophagy-mediated apoptosis. |
2019-04-24 |
2023-08-13 |
Not clear |
| Su Jin Kang, Won Jong Rhe. Silkworm Storage Protein 1 Inhibits Autophagy-Mediated Apoptosis. International journal of molecular sciences. vol 20. issue 2. 2019-04-24. PMID:30646576. |
we observed that sp1 significantly inhibited autophagy-mediated apoptosis by suppressing caspase-3 activation and reactive oxygen species generation. |
2019-04-24 |
2023-08-13 |
Not clear |
| Su Jin Kang, Won Jong Rhe. Silkworm Storage Protein 1 Inhibits Autophagy-Mediated Apoptosis. International journal of molecular sciences. vol 20. issue 2. 2019-04-24. PMID:30646576. |
together, these findings suggest that sp1 offers a new strategy for overcoming severe autophagy-mediated apoptosis in mammalian cells, and it can be used widely in biopharmaceutical production. |
2019-04-24 |
2023-08-13 |
Not clear |
| Keshav Karki, Sneha Harishchandra, Stephen Saf. Bortezomib Targets Sp Transcription Factors in Cancer Cells. Molecular pharmacology. vol 94. issue 4. 2019-04-16. PMID:30115673. |
the functional importance of this pathway was confirmed by showing that individual knockdown of sp1, sp3, and sp4 in mm cells inhibited cell growth and induced apoptosis, and that this correlates with the results of previous studies in pancreatic, colon, and other cancer cell lines. |
2019-04-16 |
2023-08-13 |
Not clear |
| Fatma Guesmi, Marwa Ben Hmed, Sahdeo Prasad, Amit K Tyagi, Ahmed Landouls. In vivo pathogenesis of colon carcinoma and its suppression by hydrophilic fractions of Clematis flammula via activation of TRAIL death machinery (DRs) expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551475. |
our findings showed that cfl sensitizes apoptosis in trail-resistant cells by activating mapks, sp1, and chop, that induced dr5 expression. |
2019-04-01 |
2023-08-13 |
Not clear |
| Eric Alejandro Rhon-Calderón, Carlos Alejandro Toro, Alejandro Lomniczi, Rocío Alejandra Galarza, Alicia Graciela Falett. Changes in the expression of genes involved in the ovarian function of rats caused by daily exposure to 3-methylcholanthrene and their prevention by α-naphthoflavone. Archives of toxicology. vol 92. issue 2. 2019-01-17. PMID:29094188. |
3mc increased ahr binding to promoter regions of genes involved in notch signaling (hes1, jag1), activation of primordial follicles (cdk2), cell adhesion (icam1), stress and tumor progression (dnajb6), apoptosis (bax, caspase-9) and expression of growth and transcription factors (igf2, sp1). |
2019-01-17 |
2023-08-13 |
rat |
| Duksun Han, Jin Hyoung Cho, Ra Ham Lee, Woong Bang, Kyungho Park, Minseok S Kim, Jung-Hyun Shim, Jung-Il Chae, Se Youn Moo. Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor. Scientific reports. vol 7. 2018-10-29. PMID:28225083. |
thus, plasma treatment inhibited cell viability and colony formation by suppressing sp1, which induced apoptosis and cell-cycle arrest in these two human colorectal cancer cell lines. |
2018-10-29 |
2023-08-13 |
human |
| Felipe Teixeira Lima, Viviane Seba, Gabriel Silva, Guilherme Silva Torrezan, Carlos Roberto Polaquini, Vitor Caressato Pinhanelli, Seung J Baek, Ana Lúcia Fachin, Luis Octavio Regasini, Mozart Marin. The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. International journal of molecular sciences. vol 19. issue 7. 2018-10-16. PMID:29966255. |
the cellular levels of the transcription factors p53 and sp1 affect the expression of cellular pathways that lead to apoptosis. |
2018-10-16 |
2023-08-13 |
human |
| Nianxin Jiang, Jingwen Xia, Bing Jiang, Yinghui Xu, Yansong L. TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-11. PMID:29864957. |
over-expression of hic-5 could increase the expression of sp1 and survivin, which inhibited the cell apoptosis, thereby reducing the cell damage induced by hypoxia. |
2018-10-11 |
2023-08-13 |
Not clear |
| Rui Li, Hai-Hua Geng, Jie Xiao, Xiao-Teng Qin, Fu Wang, Jun-Hui Xing, Yan-Fei Xia, Yang Mao, Jing-Wen Liang, Xiao-Ping J. miR-7a/b attenuates post-myocardial infarction remodeling and protects H9c2 cardiomyoblast against hypoxia-induced apoptosis involving Sp1 and PARP-1. Scientific reports. vol 6. 2018-05-29. PMID:27384152. |
mir-7a/b attenuates post-myocardial infarction remodeling and protects h9c2 cardiomyoblast against hypoxia-induced apoptosis involving sp1 and parp-1. |
2018-05-29 |
2023-08-13 |
mouse |
| Shou-Chieh Wang, Shou-Tsung Wang, Hung-Te Liu, Xiang-Yu Wang, She-Ching Wu, Lei-Chin Chen, Yi-Wen Li. Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28713892. |
taken together, the present study delineated that tsa-induced growth inhibition and apoptosis in 5,637 cells was associated with pakt inhibition and mmp loss at the early phase, followed by downregulation of sp1 and survivin at the late phase of treatment. |
2018-04-25 |
2023-08-13 |
Not clear |
| Eunji Im, Changhwan Yeo, Hyo-Jeong Lee, Eun-Ok Le. Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells. Life sciences. vol 192. 2018-01-08. PMID:29128513. |
this study investigated whether and how dha induces apoptosis focusing on the specificity protein 1 (sp1) pathway in hepatocellular carcinoma (hcc) sk-hep-1 cells. |
2018-01-08 |
2023-08-13 |
Not clear |
| Yutaka Furutani, Mariko Toguchi, Rajan Shrestha, Soichi Kojim. Phenosafranin inhibits nuclear localization of transglutaminase 2 without affecting its transamidase activity. Amino acids. vol 49. issue 3. 2017-12-29. PMID:27665106. |
transglutaminase 2 (tg2) localizes to the nucleus and induces apoptosis through a crosslinking inactivation of sp1 in jhh-7 cells treated with acyclic retinoid. |
2017-12-29 |
2023-08-13 |
Not clear |
| Soumyananda Chakraborti, Samik Chakraborty, Shilpi Saha, Argha Manna, Shruti Banerjee, Arghya Adhikary, Shamila Sarwar, Tapas K Hazra, Tanya Das, Pinak Chakrabart. PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2. Free radical biology & medicine. vol 103. 2017-12-20. PMID:27940348. |
mechanistically at low ros conditions, transcription factor sp1 binds to the neil2 promoter and facilitates its transcription for triggering a 'fight-back mechanism' thereby resisting cancer cell apoptosis. |
2017-12-20 |
2023-08-13 |
Not clear |