| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Han Cai, Bingying Liu, Huarong Wang, Guanghong Sun, Lizhao Feng, Ziqi Chen, Jiaqi Zhou, Jiawei Zhang, Tuo Zhang, Meina He, Tingting Yang, Qirui Guo, Zhen Teng, Qiliang Xin, Bo Zhou, Hua Zhang, Guoliang Xia, Chao Wan. SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice. Journal of molecular cell biology. vol 12. issue 3. 2021-03-29. PMID:31282930. |
knockdown of sp1 expression, especially in pregranulosa cells, significantly suppressed nest breakdown, oocyte apoptosis, and pf formation, suggesting that sp1 expressed by somatic cells functions in the process of primordial folliculogenesis. |
2021-03-29 |
2023-08-13 |
mouse |
| Yung-Che Chen, Chiu Ping Lee, Chang-Chun Hsiao, Po-Yuan Hsu, Ting-Ya Wang, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu-Ping Chang, Meng-Chih Li. MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1. International journal of molecular sciences. vol 21. issue 22. 2021-03-04. PMID:33202583. |
mir-23a-3p mimic transfection reversed esat6-induced reduction of reactive oxygen species generation, and augmented esat6-induced late apoptosis and phagocytosis, in association with down-regulations of the predicted target genes, including tumor necrosis factor (tnf)-α, tlr4, tlr2, il6, il10, notch1, il6r, bcl2, tgf-β1, sp1, and irf1. |
2021-03-04 |
2023-08-13 |
human |
| Dan Wang, Fengshou Chen, Bo Fang, Zaili Zhang, Yan Dong, Xiangyi Tong, Hong M. MiR-128-3p Alleviates Spinal Cord Ischemia/Reperfusion Injury Associated Neuroinflammation and Cellular Apoptosis via SP1 Suppression in Rat. Frontiers in neuroscience. vol 14. 2021-01-12. PMID:33424542. |
mir-128-3p alleviates spinal cord ischemia/reperfusion injury associated neuroinflammation and cellular apoptosis via sp1 suppression in rat. |
2021-01-12 |
2023-08-13 |
rat |
| Jie Qi, Qichao Wu, Qian Cheng, Xiangyuan Chen, Minmin Zhu, Changhong Mia. High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression. Journal of diabetes research. vol 2020. 2020-12-08. PMID:32185234. |
in general, our data indicate that setd8 interacts with sp1 to coregulate ese-1 expression, which is involved in hyperglycaemia-mediated endothelial apoptosis in huvecs. |
2020-12-08 |
2023-08-13 |
human |
| Balachandar Vellingiri, Mahalaxmi Iyer, Mohana Devi Subramaniam, Kaavya Jayaramayya, Zothan Siama, Bupesh Giridharan, Arul Narayanasamy, Ahmed Abdal Dayem, Ssang-Goo Ch. Understanding the Role of the Transcription Factor Sp1 in Ovarian Cancer: from Theory to Practice. International journal of molecular sciences. vol 21. issue 3. 2020-11-20. PMID:32050495. |
the ubiquitous transcription of sp1 apparently mediates the maintenance of normal and cancerous biological processes such as cell growth, differentiation, angiogenesis, apoptosis, cellular reprogramming and tumorigenesis. |
2020-11-20 |
2023-08-13 |
Not clear |
| Polina S Loshchenova, Svetlana V Sergeeva, Dmitry V Limonov, Zhigang Guo, Grigory L Diano. Sp1-independent downregulation of NHEJ in response to BER deficiency. DNA repair. vol 86. 2020-11-04. PMID:31812125. |
on the other hand, in response to persistent dna strand breaks, atm-dependent degradation of transcription factor sp1 leads to downregulation of ber genes expression, further accumulation of ssbs and renders cells susceptible to elimination via apoptosis. |
2020-11-04 |
2023-08-13 |
Not clear |
| EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-β-glucopyranoside-induced apoptosis in osteosarcoma cells [Retraction]. American journal of cancer research. vol 10. issue 7. 2020-10-23. PMID:32775013. |
emmprin, sp1 and microrna-27a mediate physcion 8-o-β-glucopyranoside-induced apoptosis in osteosarcoma cells [retraction]. |
2020-10-23 |
2023-08-13 |
Not clear |
| Xiaolei Liu, Ruwei Chen, Lijun Li. SP1-DLEU1-miR-4429 feedback loop promotes cell proliferative and anti-apoptotic abilities in human glioblastoma. Bioscience reports. vol 39. issue 12. 2020-10-16. PMID:31713587. |
overexpression of sp1 or mir-4429 inhibitor could partly abolish the effect of dleu1 knockdown on cell viability and apoptosis in gbm. |
2020-10-16 |
2023-08-13 |
human |
| Wenkang Ma, Xueyuan Liu, Wei D. Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor. Anti-cancer drugs. vol 30. issue 2. 2020-09-14. PMID:30362980. |
baicalin induces apoptosis in sw480 cells through downregulation of the sp1 transcription factor. |
2020-09-14 |
2023-08-13 |
human |
| Wenkang Ma, Xueyuan Liu, Wei D. Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor. Anti-cancer drugs. vol 30. issue 2. 2020-09-14. PMID:30362980. |
both baicalin and mithramycin-a downregulated sp1 expression, attenuated sw480 cell proliferation, and increased cell apoptosis. |
2020-09-14 |
2023-08-13 |
human |
| Wenkang Ma, Xueyuan Liu, Wei D. Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor. Anti-cancer drugs. vol 30. issue 2. 2020-09-14. PMID:30362980. |
baicalin inhibited sp1 expression and led to sw480 apoptosis, thus clarifying the effect of this traditional chinese medicine compound in the treatment of colon cancer. |
2020-09-14 |
2023-08-13 |
human |
| Xinxing Wang, Shang Wang, Weili Liu, Tianhui Wang, Jing Wang, Xiujie Gao, Ruifeng Duan, Yingying Li, Lingling Pu, Bingnan Deng, Zhaoli Che. Epigenetic upregulation of miR-126 induced by heat stress contributes to apoptosis of rat cardiomyocytes by promoting Tomm40 transcription. Journal of molecular and cellular cardiology. vol 129. 2020-06-22. PMID:30296408. |
in the present study, we showed that environmental thermal exposure upregulated microrna mir-126, consequently reducing au-rich element rna-binding protein 1 (auf1)-mediated sp1 mrna degradation and increasing tomm40 transcription, which in turn decreased the mitochondria membrane potential and apoptosis of cardiomyocytes. |
2020-06-22 |
2023-08-13 |
rat |
| Lu Ding, Chengxin Gong, Jiani Zhao, Xingzi Liu, Tao Li, Shenqiang Rao, Shuo Wang, Yuanyuan Liu, Shanping Peng, Wen Xiao, Chaopeng Xiong, Rumeng Wang, Shangdong Liang, Hong X. Noncoding transcribed ultraconserved region (T-UCR) UC.48+ is a novel regulator of high-fat diet induced myocardial ischemia/reperfusion injury. Journal of cellular physiology. vol 234. issue 6. 2020-04-13. PMID:30417395. |
the functional relevance of uc.48+ regulated p2x7r expression and the subsequent nf-κb signaling to promote cardiomyocyte apoptosis was supported by inhibition of p2x7r with its specific antagonist (a438079) as well as the inhibitor of nf-κb signaling (pyrrolidine dithiocarbamate, pdtc) in h9c2 hypoxia/reoxygenation (h/r) cells transfected with pcdna3.0-uc.48 + plasmid, and rna immunoprecipitation (rip) suggested uc.48+ could interact with transcription factor sp1. |
2020-04-13 |
2023-08-13 |
mouse |
| Lu Ding, Chengxin Gong, Jiani Zhao, Xingzi Liu, Tao Li, Shenqiang Rao, Shuo Wang, Yuanyuan Liu, Shanping Peng, Wen Xiao, Chaopeng Xiong, Rumeng Wang, Shangdong Liang, Hong X. Noncoding transcribed ultraconserved region (T-UCR) UC.48+ is a novel regulator of high-fat diet induced myocardial ischemia/reperfusion injury. Journal of cellular physiology. vol 234. issue 6. 2020-04-13. PMID:30417395. |
importantly, sp1 inhibitor (mithramycin, mit) was found to suppress uc.48+ -induced p2x7r expression and the nf-κb signaling and cardiomyocyte apoptosis. |
2020-04-13 |
2023-08-13 |
mouse |
| Xinyu Zhang, Rui Li, Xiaoteng Qin, Lei Wang, Jie Xiao, Yu Song, Xi Sheng, Mengqi Guo, Xiaoping J. Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro. Journal of the American Heart Association. vol 7. issue 6. 2019-12-09. PMID:29572322. |
specific protein 1 (sp1) is a transactivation molecule that plays a crucial role in the regulation of apoptosis, fibrosis, angiogenesis, and other pathological disorders. |
2019-12-09 |
2023-08-13 |
Not clear |
| Yoon Jin Lee, Woo Il Kim, Soo Young Kim, Sung Woo Cho, Hae Seon Nam, Sang Han Lee, Moon Kyun Ch. Flavonoid morin inhibits proliferation and induces apoptosis of melanoma cells by regulating reactive oxygen species, Sp1 and Mcl-1. Archives of pharmacal research. vol 42. issue 6. 2019-12-09. PMID:31049822. |
flavonoid morin inhibits proliferation and induces apoptosis of melanoma cells by regulating reactive oxygen species, sp1 and mcl-1. |
2019-12-09 |
2023-08-13 |
Not clear |
| Ra Ham Lee, Jin Hyoung Cho, Young-Joo Jeon, Woong Bang, Jung-Jae Cho, Nag-Jin Choi, Kang Seok Seo, Jung-Hyun Shim, Jung-Il Cha. Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1). Drug development research. vol 76. issue 1. 2019-11-20. PMID:25619802. |
here, we demonstrated that quercetin decreased cell growth and induce apoptosis in hepg2 cells via suppression of sp1 using 3-(4,5-dimethyl-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2h-tetrazolium, inner salt (mts) assay, 4',6-diamidino-2-phenylindole (dapi) staining, annexin v, and western blot analysis, an effect that was dose- and time-dependent manner. |
2019-11-20 |
2023-08-13 |
human |
| Ra Ham Lee, Jin Hyoung Cho, Young-Joo Jeon, Woong Bang, Jung-Jae Cho, Nag-Jin Choi, Kang Seok Seo, Jung-Hyun Shim, Jung-Il Cha. Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1). Drug development research. vol 76. issue 1. 2019-11-20. PMID:25619802. |
treatment of hepg2 cells with quercetin reduced cell growth and induced apoptosis, followed by regulation of sp1 and sp1 regulatory protein. |
2019-11-20 |
2023-08-13 |
human |
| Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Ryota Amachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Keiichiro Watanabe, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kimiko Sogabe, Shingen Nakamura, Hirokazu Miki, Kiyoe Kurahashi, Sumiko Yoshida, Kenichi Aihara, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Ab. TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects. Blood advances. vol 1. issue 24. 2019-11-20. PMID:29296860. |
interestingly, the trail-induced caspase-8 activation caused enzymatic degradation of the transcription factor sp1 to noticeably reduce c-flip expression, which further sensitized ocs to trail-induced apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| X-H Liu, J Wang, Y-H Don. The inhibitory effect of miR-375 targeting sp1 in colorectal cancer cell proliferation. European review for medical and pharmacological sciences. vol 22. issue 2. 2019-10-09. PMID:29424897. |
sp1 is a member of super zinc finger structure family that participates in cancer cells' apoptosis, proliferation, survival, and differentiation. |
2019-10-09 |
2023-08-13 |
Not clear |