| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Ho Han, Dae-Sung Lee, Jin-Woo Jeong, Su-Hyun Hong, Il-Whan Choi, Hee-Jae Cha, Suhkmann Kim, Heui-Soo Kim, Cheol Park, Gi-Young Kim, Sung-Kwon Moon, Wun-Jae Kim, Yung Hyun Cho. Fucoidan Induces ROS-Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway. Drug development research. vol 78. issue 1. 2017-11-06. PMID:27654302. |
meanwhile, fucoidan treatment increased the generation of intracellular ros, whereas the over-elimination of ros by n-acetylcysteine, an anti-oxidant, attenuated fucoidan-induced apoptosis, inhibition of htert, c-myc, and sp1 expression, and reversed fucoidan-induced inactivation of the pi3k/akt signaling pathway. |
2017-11-06 |
2023-08-13 |
human |
| Xiaopeng An, Yuxuan Song, Jinxing Hou, Yue Zhang, Kaiwen Chen, Haidong Ma, Xinyan Zhao, Guang Li, Kexin Gao, Shan Wang, Binyun Cao, Yueyu Ba. Chi-miR-4110 promotes granulosa cell apoptosis by targeting Sma- and Mad-related protein 2 (Smad2) in the caprine ovary. PloS one. vol 12. issue 7. 2017-09-25. PMID:28704526. |
the increase in sp1 induces p53-upregulated modulator of apoptosis, which increases the relative abundance of bax and causes caprine gc apoptosis. |
2017-09-25 |
2023-08-13 |
Not clear |
| Shazia Nafis, Kalaiarasan Ponnusamy, Mohammad Husain, R K Brojen Singh, Rameshwar N K Bameza. Identification of key regulators and their controlling mechanism in a combinatorial apoptosis network: a systems biology approach. Molecular bioSystems. vol 12. issue 11. 2017-07-24. PMID:27754508. |
finally, sp1, nfkb1 and hsa-let-7a were observed to regulate apoptosis by influencing motifs, signal transduction, and module regulation, which was validated through the removal of hubs, signifying their biological importance in association with cancers. |
2017-07-24 |
2023-08-13 |
Not clear |
| Jun Wang, Min Kang, Qin Wen, Yu-Tao Qin, Zhu-Xin Wei, Jing-Jian Xiao, Ren-Sheng Wan. Berberine sensitizes nasopharyngeal carcinoma cells to radiation through inhibition of Sp1 and EMT. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350122. |
this study aimed to investigate the effect of berberine on the proliferation, cell cycle regulation, apoptosis, radioresistance of npc cells and whether specificity protein 1 (sp1) is a functional target of berberine. |
2017-06-29 |
2023-08-13 |
Not clear |
| Jun Wang, Min Kang, Qin Wen, Yu-Tao Qin, Zhu-Xin Wei, Jing-Jian Xiao, Ren-Sheng Wan. Berberine sensitizes nasopharyngeal carcinoma cells to radiation through inhibition of Sp1 and EMT. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350122. |
mithramycin a, a selective sp1 inhibitor, enhanced the radiosensitivity and the rate of apoptosis in the cne-2 cells. |
2017-06-29 |
2023-08-13 |
Not clear |
| Nicola Amodio, Maria Angelica Stamato, Anna Maria Gullà, Eugenio Morelli, Enrica Romeo, Lavinia Raimondi, Maria Rita Pitari, Ida Ferrandino, Gabriella Misso, Michele Caraglia, Ida Perrotta, Antonino Neri, Mariateresa Fulciniti, Christian Rolfo, Kenneth C Anderson, Nikhil C Munshi, Pierosandro Tagliaferri, Pierfrancesco Tasson. Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma. Molecular cancer therapeutics. vol 15. issue 6. 2017-06-27. PMID:27196750. |
in fact, silencing of hdac4 by shrnas inhibited multiple myeloma cell survival and migration and triggered apoptosis and autophagy, along with the induction of mir-29b expression by promoter hyperacetylation, leading to the downregulation of prosurvival mir-29b targets (sp1, mcl-1). |
2017-06-27 |
2023-08-13 |
human |
| Ra H Lee, Young-Joo Jeon, Jin H Cho, Jeong-Yun Jang, Il-Keun Kong, Seok-Ho Kim, MinSeok S Kim, Hak-Jae Chung, Keon B Oh, Seon-Min Park, Jae-Cheon Shin, Jae-Min Seo, Sungho Ko, Jung-Hyun Shim, Jung-Il Cha. Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro. General physiology and biophysics. vol 36. issue 1. 2017-06-16. PMID:27901471. |
furthermore, the levels of p27 and p21, two key regulators of the cell cycle, were up-regulated by the esculetin-mediated down-regulation of sp1; the level of a third cell-cycle regulator, survivin, was decreased, resulting in caspase-dependent apoptosis. |
2017-06-16 |
2023-08-13 |
human |
| Gabriel Silva, Mozart Marins, Ana Lúcia Fachin, Seong-Ho Lee, Seung Joon Bae. Anti-cancer activity of trans-chalcone in osteosarcoma: Involvement of Sp1 and p53. Molecular carcinogenesis. vol 55. issue 10. 2017-05-26. PMID:26294168. |
building on this knowledge, we evaluated the ability of trans-chalcone to reduce viability, to induce apoptosis, and to alter gene expression of p53 and sp1 in human osteosarcoma cell lines. |
2017-05-26 |
2023-08-13 |
human |
| Ka Hwi Kim, Jung-Il Chae, Hana Oh, Jin Hyoung Cho, Ra-Ham Lee, Goo Yoon, Seung-Sik Cho, Young-Sik Cho, Mee-Hyun Lee, Kangdong Liu, Hyun-Jeong Lee, Jung-Hyun Shi. Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27176604. |
manumycin a induces apoptosis in malignant pleural mesothelioma through regulation of sp1 and activation of the mitochondria-related apoptotic pathway. |
2017-03-13 |
2023-08-13 |
human |
| Ka Hwi Kim, Jung-Il Chae, Hana Oh, Jin Hyoung Cho, Ra-Ham Lee, Goo Yoon, Seung-Sik Cho, Young-Sik Cho, Mee-Hyun Lee, Kangdong Liu, Hyun-Jeong Lee, Jung-Hyun Shi. Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27176604. |
the downregulation of sp1 mrna and protein expression by manu a led to apoptosis by suppressing sp1-regulated proteins (cyclin d1, mcl-1 and survivin). |
2017-03-13 |
2023-08-13 |
human |
| Ye Wang, Zhao-Xiong Zhang, Sheng Chen, Guang-Bin Qiu, Zhen-Ming Xu, Wei-Neng F. Methylation Status of SP1 Sites within miR-23a-27a-24-2 Promoter Region Influences Laryngeal Cancer Cell Proliferation and Apoptosis. BioMed research international. vol 2016. 2016-12-22. PMID:27099864. |
methylation status of sp1 sites within mir-23a-27a-24-2 promoter region influences laryngeal cancer cell proliferation and apoptosis. |
2016-12-22 |
2023-08-13 |
Not clear |
| Ye Wang, Zhao-Xiong Zhang, Sheng Chen, Guang-Bin Qiu, Zhen-Ming Xu, Wei-Neng F. Methylation Status of SP1 Sites within miR-23a-27a-24-2 Promoter Region Influences Laryngeal Cancer Cell Proliferation and Apoptosis. BioMed research international. vol 2016. 2016-12-22. PMID:27099864. |
we conclude that demethylated sp1 sites in mir-23a-27a-24-2 cluster upregulate the cluster expression, leading to proliferation promotion and early apoptosis inhibition in laryngeal cancer cells. |
2016-12-22 |
2023-08-13 |
Not clear |
| H J Lee, J M Ryu, Y H Jung, K H Lee, D I Kim, H J Ha. Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation. Cell death & disease. vol 7. 2016-12-21. PMID:27010859. |
glycerol-3-phosphate acyltransferase-1 upregulation by o-glcnacylation of sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mtor activation. |
2016-12-21 |
2023-08-13 |
mouse |
| H J Lee, J M Ryu, Y H Jung, K H Lee, D I Kim, H J Ha. Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation. Cell death & disease. vol 7. 2016-12-21. PMID:27010859. |
in conclusion, enhancing o-glcnacylation of sp1 by glucosamine stimulates gpat1 expression, which leads to inhibition of hypoxia-induced mesc apoptosis via mtor activation. |
2016-12-21 |
2023-08-13 |
mouse |
| Faisal Aziz, Xiaoqi Wang, Jiwei Liu, Qiu Ya. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicology in vitro : an international journal published in association with BIBRA. vol 31. 2016-10-11. PMID:26427350. |
ginsenoside rg3 induces fut4-mediated apoptosis in h. pylori caga-treated gastric cancer cells by regulating sp1 and hsf1 expressions. |
2016-10-11 |
2023-08-13 |
Not clear |
| Faisal Aziz, Xiaoqi Wang, Jiwei Liu, Qiu Ya. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicology in vitro : an international journal published in association with BIBRA. vol 31. 2016-10-11. PMID:26427350. |
we treated the gastric cancer cells with caga followed by rg3, and analyzed their ability to induce apoptosis by evaluating the role of fut4 as well as sp1 and hsf1 expressions by western blot, flow cytometry and elisa. |
2016-10-11 |
2023-08-13 |
Not clear |
| William O Ward, Allen D Ledbetter, Mette C Schladweiler, Urmila P Kodavant. Lung transcriptional profiling: insights into the mechanisms of ozone-induced pulmonary injury in Wistar Kyoto rats. Inhalation toxicology. vol 27 Suppl 1. 2016-09-21. PMID:26667333. |
in conclusion, ozone-induced injury and inflammation are preceded by changes in gene targets for cell adhesion/migration, apoptosis, cell cycle control and growth regulated by rela, sp1 and tp53, likely mediated by the process of endocytosis and altered steroid receptor signaling. |
2016-09-21 |
2023-08-13 |
rat |
| Jung Jae Cho, Jung-Il Chae, Ka Hwi Kim, Jin Hyoung Cho, Young-Joo Jeon, Ha Na Oh, Goo Yoon, Do Young Yoon, Young Sik Cho, Seung-Sik Cho, Jung-Hyun Shi. Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma. International journal of oncology. vol 47. issue 5. 2016-08-05. PMID:26352011. |
in conclusion, these results indicate that manu a is a potential to treat human oscc via cell apoptosis through the downregulation of sp1. |
2016-08-05 |
2023-08-13 |
human |
| Zhaohong Wang, Huilin Yan. EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-β-glucopyranoside-induced apoptosis in osteosarcoma cells. American journal of cancer research. vol 6. issue 6. 2016-07-19. PMID:27429847. |
emmprin, sp1 and microrna-27a mediate physcion 8-o-β-glucopyranoside-induced apoptosis in osteosarcoma cells. |
2016-07-19 |
2023-08-13 |
human |
| Young-Joo Jeon, Woong Bang, Yung Hyun Choi, Jung-Hyun Shim, Jung-Il Cha. Beta-Lapachone Suppresses Non-small Cell Lung Cancer Proliferation through the Regulation of Specificity Protein 1. Biological & pharmaceutical bulletin. vol 38. issue 9. 2016-06-22. PMID:26328485. |
furthermore, β-lap modulated the protein expression levels of the sp1 regulatory genes, including cell-cycle regulatory proteins and antiapoptotic proteins, resulting in apoptosis. |
2016-06-22 |
2023-08-13 |
human |