| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Cai, Ming-Ming Zhang, Ming Wang, Zhuo-Hang Jiang, Zhi-Gang Ta. Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 2022-05-24. PMID:35609560. |
bone marrow-derived mesenchymal stem cell-derived exosomes containing gli1 alleviate microglial activation and neuronal apoptosis in vitro and in a mouse parkinson disease model by direct inhibition of sp1 signaling. |
2022-05-24 |
2023-08-13 |
mouse |
| Yang Cai, Ming-Ming Zhang, Ming Wang, Zhuo-Hang Jiang, Zhi-Gang Ta. Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 2022-05-24. PMID:35609560. |
thus, bmsc-derived exosomal gli1 alleviates inflammatory damage and neuronal apoptosis by inhibiting sp1 in vitro and in vivo. |
2022-05-24 |
2023-08-13 |
mouse |
| Mei Wu, Zehong Huang, Wenfang Huang, Mengyu Lin, Weifeng Liu, Kexuan Liu, Cai L. microRNA-124-3p attenuates myocardial injury in sepsis via modulating SP1/HDAC4/HIF-1α axis. Cell death discovery. vol 8. issue 1. 2022-01-29. PMID:35091534. |
mir-124-3p overexpression and sp1 silencing assays were implemented on lps-treated h9c2 cells to explore theirs actions in inflammation, oxidative stress and cell apoptosis. |
2022-01-29 |
2023-08-13 |
rat |
| Zhao Zhu, Guoxiu Zhang, Dahuan Li, Xiaojun Yin, Tianzhong Wan. Silencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-κB signaling. Bioengineered. vol 13. issue 2. 2022-01-20. PMID:35048778. |
moreover, silencing of sp1 or cxcr4 suppressed lps-induced inflammation and cell apoptosis in h9c2 cells, as evidenced by the increase in cell viability and decrease in lactate dehydrogenase release, interleukin (il)-6, il-8, and tumor necrosis factor (tnf)-α levels, and caspase-3 activity. |
2022-01-20 |
2023-08-13 |
Not clear |
| Boshen Wang, Liu Wan, Peng Sun, Ludi Zhang, Lei Han, Hengdong Zhang, Juan Zhang, Yuepu Pu, Baoli Zh. Associations of genetic variation in E3 SUMO-protein ligase CBX4 with noise-induced hearing loss. Human molecular genetics. 2022-01-17. PMID:35038734. |
knockdown of transcription factor sp1 reduced the expression of cbx4 expression and simultaneously reduced apoptosis in hei-oc1 cells. |
2022-01-17 |
2023-08-13 |
mouse |
| Yanqun Cao, Xiangxiang Tan, Quzhe Lu, Kai Huang, Xiaoer Tang, Zhiming H. miR-590-3 and SP1 Promote Neuronal Apoptosis in Patients with Alzheimer's Disease via AMPK Signaling Pathway. Contrast media & molecular imaging. vol 2021. 2022-01-07. PMID:34992508. |
mir-590-3 and sp1 promote neuronal apoptosis in patients with alzheimer's disease via ampk signaling pathway. |
2022-01-07 |
2023-08-13 |
Not clear |
| Ra Ham Lee, Jae-Don Oh, Jae Sam Hwang, Hak-Kyo Lee, Donghyun Shi. Antitumorigenic effect of insect-derived peptide poecilocorisin-1 in human skin cancer cells through regulation of Sp1 transcription factor. Scientific reports. vol 11. issue 1. 2021-11-29. PMID:34531430. |
additionally, we discovered a novel anticancer mechanism of insect-derived peptides in melanoma through the regulation of transcription factor sp1 protein, which is overexpressed in cancer, apoptosis, and cell cycle-related proteins. |
2021-11-29 |
2023-08-13 |
human |
| Kyung-Eun Lee, Ji-Ae Shin, In-Sun Hong, Nam-Pyo Cho, Sung-Dae Ch. Effect of methanol extracts of Cnidium officinale Makino and Capsella bursa-pastoris on the apoptosis of HSC-2 human oral cancer cells. Experimental and therapeutic medicine. vol 5. issue 3. 2021-10-21. PMID:23403540. |
these results suggest that meco and mecb inhibit cell growth and induce apoptosis via the sp1 protein, indicating that meco and mecb are useful bioactive materials and attractive drug candidates for oral cancer. |
2021-10-21 |
2023-08-12 |
human |
| Haihua Geng, Yamin Su, Rong Huang, Mengkang Fan, Xiaofei Li, Xiaochen Lu, Hongzhuan Shen. Specific protein 1 inhibitor mithramycin A protects cardiomyocytes from myocardial infarction via interacting with PARP. In vitro cellular & developmental biology. Animal. vol 57. issue 3. 2021-10-07. PMID:33580416. |
specific protein 1 (sp1) might act as a critical transcription regulator in myocardial infarction (mi), but little evidence about its function in regulating cardiac apoptosis, a major cause of mi development, has been revealed. |
2021-10-07 |
2023-08-13 |
mouse |
| Haihua Geng, Yamin Su, Rong Huang, Mengkang Fan, Xiaofei Li, Xiaochen Lu, Hongzhuan Shen. Specific protein 1 inhibitor mithramycin A protects cardiomyocytes from myocardial infarction via interacting with PARP. In vitro cellular & developmental biology. Animal. vol 57. issue 3. 2021-10-07. PMID:33580416. |
the cardioprotective role of sp1 inhibitor mitha was demonstrated here expanding the role of sp1 in mi development involving hypoxia-induced cardiac apoptosis. |
2021-10-07 |
2023-08-13 |
mouse |
| Zihao Zhang, Xinyu Zhang, Chengwei Wang, Peng Zhou, Jie Xiao, Hui Zheng, Lei Wang, Senbo Yan, Yue Zhang, Xiaoping J. Deacetylated Sp1 improves β-glycerophosphate-induced calcification in vascular smooth muscle cells. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504597. |
in conclusion, a deacetylated mutant of sp1 decreased sp1 binding to the bmp2 promoter, thus decreasing apoptosis, phenotypic switching and calcium deposition in calcified vsmcs. |
2021-09-11 |
2023-08-13 |
Not clear |
| Min Xiang, He-Guo Jiang, Yang Shu, Yu-Jiao Chen, Jun Jin, Yu-Min Zhu, Mei-Yu Li, Jian-Nong Wu, Jian L. Bisdemethoxycurcumin Enhances the Sensitivity of Non-small Cell Lung Cancer Cells to Icotinib via Dual Induction of Autophagy and Apoptosis. International journal of biological sciences. vol 16. issue 9. 2021-08-23. PMID:32226300. |
compared with bdmc or icotinib alone, the two drug combination induced more significant apoptosis and autophagy via suppressing egfr activity and interaction of sp1 and hdca1/hdca2, which was accompanied by accumulation of reactive oxygen species (ros), induction of dna damage, and inhibition of cell migration and invasion. |
2021-08-23 |
2023-08-13 |
Not clear |
| Xiao Dong, Zixin Liu, Encheng Zhang, Pingzhao Zhang, Yuqi Wang, Junjie Hang, Qi L. USP39 promotes tumorigenesis by stabilizing and deubiquitinating SP1 protein in hepatocellular carcinoma. Cellular signalling. vol 85. 2021-08-10. PMID:34197957. |
knocking-down of usp39 promotes the cell apoptosis and arrest of the cell cycle, whereas sp1 forcefully reversed these effects. |
2021-08-10 |
2023-08-13 |
Not clear |
| Jinhe Yang, Junli Wang, Hongmei Zhang, Changlong Li, Changyan Chen, Tongbo Zh. Transcription factor Sp1 is upregulated by PKCι to drive the expression of YAP1 during pancreatic carcinogenesis. Carcinogenesis. vol 42. issue 3. 2021-06-24. PMID:33146712. |
moreover, our apoptotic detection data demonstrate that combination of pkcι and sp1 inhibitors at subtoxic doses displays synergistic effects on inducing apoptosis and reversing the immunosuppression of pancreatic cancer cells, establishing the combination of pkcι and sp1 inhibitors as a promising novel therapeutic approach, or an adjuvant strategy to potentiate the antitumor effects of other immunotherapeutic agents in pancreatic cancer treatment. |
2021-06-24 |
2023-08-13 |
Not clear |
| Guoying Lv, Chuangang Li, Weiwei Wang, Ning Li, Kai Wan. Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32594292. |
loss-of-function assay indicated that sp1 knockdown rescued the deactivation of cap and alleviated the sevoflurane-induced neuro-inflammation and apoptosis in rat hippocampus. |
2021-06-08 |
2023-08-13 |
rat |
| Guoying Lv, Chuangang Li, Weiwei Wang, Ning Li, Kai Wan. Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32594292. |
generally, our study documented that the sevoflurane-induced sp1 up-regulation affected the activation of cap, leading to the aggravated neuro-inflammation and apoptosis. |
2021-06-08 |
2023-08-13 |
rat |
| Ruili Wang, Ying Yang, Hui Wang, Ya He, Chen L. MiR-29c protects against inflammation and apoptosis in Parkinson's disease model in vivo and in vitro by targeting SP1. Clinical and experimental pharmacology & physiology. vol 47. issue 3. 2021-05-07. PMID:31732967. |
mir-29c protects against inflammation and apoptosis in parkinson's disease model in vivo and in vitro by targeting sp1. |
2021-05-07 |
2023-08-13 |
mouse |
| Han Cai, Bingying Liu, Huarong Wang, Guanghong Sun, Lizhao Feng, Ziqi Chen, Jiaqi Zhou, Jiawei Zhang, Tuo Zhang, Meina He, Tingting Yang, Qirui Guo, Zhen Teng, Qiliang Xin, Bo Zhou, Hua Zhang, Guoliang Xia, Chao Wan. SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice. Journal of molecular cell biology. vol 12. issue 3. 2021-03-29. PMID:31282930. |
knockdown of sp1 expression, especially in pregranulosa cells, significantly suppressed nest breakdown, oocyte apoptosis, and pf formation, suggesting that sp1 expressed by somatic cells functions in the process of primordial folliculogenesis. |
2021-03-29 |
2023-08-13 |
mouse |
| Yung-Che Chen, Chiu Ping Lee, Chang-Chun Hsiao, Po-Yuan Hsu, Ting-Ya Wang, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu-Ping Chang, Meng-Chih Li. MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1. International journal of molecular sciences. vol 21. issue 22. 2021-03-04. PMID:33202583. |
mir-23a-3p mimic transfection reversed esat6-induced reduction of reactive oxygen species generation, and augmented esat6-induced late apoptosis and phagocytosis, in association with down-regulations of the predicted target genes, including tumor necrosis factor (tnf)-α, tlr4, tlr2, il6, il10, notch1, il6r, bcl2, tgf-β1, sp1, and irf1. |
2021-03-04 |
2023-08-13 |
human |
| Dan Wang, Fengshou Chen, Bo Fang, Zaili Zhang, Yan Dong, Xiangyi Tong, Hong M. MiR-128-3p Alleviates Spinal Cord Ischemia/Reperfusion Injury Associated Neuroinflammation and Cellular Apoptosis via SP1 Suppression in Rat. Frontiers in neuroscience. vol 14. 2021-01-12. PMID:33424542. |
mir-128-3p alleviates spinal cord ischemia/reperfusion injury associated neuroinflammation and cellular apoptosis via sp1 suppression in rat. |
2021-01-12 |
2023-08-13 |
rat |