| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sagar Shelake, Don Eslin, Robert M Sutphin, Umesh T Sankpal, Anmol Wadwani, Laura E Kenyon, Leslie Tabor-Simecka, W Paul Bowman, Jamboor K Vishwanatha, Riyaz Bash. Combination of 13 cis-retinoic acid and tolfenamic acid induces apoptosis and effectively inhibits high-risk neuroblastoma cell proliferation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 46. 2016-06-20. PMID:26287661. |
la1-55n and sh-sy5y cells were treated with ta (30μm) or ra (20μm) or both (optimized doses, derived from dose curves) for 48h and tested the effect on cell viability, apoptosis and selected molecular markers (sp1, survivin, akt and erk1/2). |
2016-06-20 |
2023-08-13 |
Not clear |
| Huiqing Li, Chunying We. Mechanism studies on anti-HepG2 cell proliferation of phenanthroline derivatives as G-quadruplex DNA stabilizers. Bioorganic & medicinal chemistry letters. vol 25. issue 18. 2016-05-31. PMID:26253636. |
the current results suggested that the decreases of c-myc, sp1, and htert expressions and the increase of p53 expression, together with the reduction of cyclins/cdks proteins in the regulation of the cell cycle, and/or the telomeric chromatin alteration led to cell cycle arrest, apoptosis, and growth inhibition induced by both ligands. |
2016-05-31 |
2023-08-13 |
human |
| Guangde Zhang, Hongbo Shi, Lin Wang, Meng Zhou, Zhenzhen Wang, Xiaoxia Liu, Liang Cheng, Weimin Li, Xueqi L. MicroRNA and transcription factor mediated regulatory network analysis reveals critical regulators and regulatory modules in myocardial infarction. PloS one. vol 10. issue 8. 2016-05-10. PMID:26258537. |
furthermore, based on the mirna and tf mediated regulatory network and literature survey, we proposed a pathway model for mir-21-5p, the mir-29 family and sp1 to demonstrate their potential co-regulatory mechanisms in cardiac fibrosis, apoptosis and angiogenesis. |
2016-05-10 |
2023-08-13 |
human |
| Cong Long, Jingchao Wang, Wei Guo, Huan Wang, Chao Wang, Yu Liu, Xiaoping Su. Triptolide inhibits transcription of hTERT through down-regulation of transcription factor specificity protein 1 in primary effusion lymphoma cells. Biochemical and biophysical research communications. vol 469. issue 1. 2016-04-28. PMID:26631963. |
inhibition of sp1 by specific shrnas enhanced triptolide-induced cell growth inhibition and apoptosis. |
2016-04-28 |
2023-08-13 |
human |
| YaSai Yao, Jian Hu, Zan Shen, RuYong Yao, ShiHai Liu, Yong Li, Hui Cong, XinGang Wang, WenSheng Qiu, Lu Yu. MiR-200b expression in breast cancer: a prognostic marker and act on cell proliferation and apoptosis by targeting Sp1. Journal of cellular and molecular medicine. vol 19. issue 4. 2016-04-01. PMID:25639535. |
mir-200b expression in breast cancer: a prognostic marker and act on cell proliferation and apoptosis by targeting sp1. |
2016-04-01 |
2023-08-13 |
human |
| YaSai Yao, Jian Hu, Zan Shen, RuYong Yao, ShiHai Liu, Yong Li, Hui Cong, XinGang Wang, WenSheng Qiu, Lu Yu. MiR-200b expression in breast cancer: a prognostic marker and act on cell proliferation and apoptosis by targeting Sp1. Journal of cellular and molecular medicine. vol 19. issue 4. 2016-04-01. PMID:25639535. |
knockdown of sp1 inhibited cell proliferation, induce apoptosis and act on cell cycle resembling that of mir-200b high expression. |
2016-04-01 |
2023-08-13 |
human |
| Carolina Vizcaíno, Sylvia Mansilla, José Portuga. Sp1 transcription factor: A long-standing target in cancer chemotherapy. Pharmacology & therapeutics. vol 152. 2016-04-01. PMID:25960131. |
sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes sp2, sp3 and sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis. |
2016-04-01 |
2023-08-13 |
Not clear |
| Jin Hyoung Cho, Ra Ham Lee, Young-Joo Jeon, Jae-Cheon Shin, Seon-Min Park, Nag-Jin Choi, Kang Seok Seo, Goo Yoon, Seung-Sik Cho, Ka Hwi Kim, Jung Jae Cho, Young Sik Cho, Dae Hwan Kim, Jin Tae Hong, Tae-Hoon Lee, Hong Ju Park, Seunggon Jung, Jae-Min Seo, Hanyong Chen, Zigang Dong, Jung-Il Chae, Jung-Hyun Shi. Role of transcription factor Sp1 in the 4-O-methylhonokiol-mediated apoptotic effect on oral squamous cancer cells and xenograft. The international journal of biochemistry & cell biology. vol 64. 2016-03-11. PMID:25982202. |
here, we demonstrated that mh decreased cell growth and induced apoptosis in hn22 and hsc4 cells through the regulation of specificity protein 1 (sp1). |
2016-03-11 |
2023-08-13 |
mouse |
| Jin Hyoung Cho, Ra Ham Lee, Young-Joo Jeon, Jae-Cheon Shin, Seon-Min Park, Nag-Jin Choi, Kang Seok Seo, Goo Yoon, Seung-Sik Cho, Ka Hwi Kim, Jung Jae Cho, Young Sik Cho, Dae Hwan Kim, Jin Tae Hong, Tae-Hoon Lee, Hong Ju Park, Seunggon Jung, Jae-Min Seo, Hanyong Chen, Zigang Dong, Jung-Il Chae, Jung-Hyun Shi. Role of transcription factor Sp1 in the 4-O-methylhonokiol-mediated apoptotic effect on oral squamous cancer cells and xenograft. The international journal of biochemistry & cell biology. vol 64. 2016-03-11. PMID:25982202. |
these results indicated that mh inhibited cell growth, colony formation and also induced apoptosis via sp1 suppression in oscc cells and xenograft tumors. |
2016-03-11 |
2023-08-13 |
mouse |
| Young-Joo Jeon, Woong Bang, Jae-Cheon Shin, Seon-Min Park, Jung-Jae Cho, Yung Hyun Choi, Kang Seok Seo, Nag-Jin Choi, Jung-Hyun Shim, Jung-Il Cha. Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma. International journal of oncology. vol 46. issue 6. 2016-02-02. PMID:25891355. |
downregulation of sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma. |
2016-02-02 |
2023-08-13 |
Not clear |
| Young-Joo Jeon, Woong Bang, Jae-Cheon Shin, Seon-Min Park, Jung-Jae Cho, Yung Hyun Choi, Kang Seok Seo, Nag-Jin Choi, Jung-Hyun Shim, Jung-Il Cha. Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma. International journal of oncology. vol 46. issue 6. 2016-02-02. PMID:25891355. |
particularly, β-lap suppresses activation of transcription factor specificity protein 1 (sp1) followed by apoptosis in a concentration-dependent manner in osccs. |
2016-02-02 |
2023-08-13 |
Not clear |
| Young-Joo Jeon, Woong Bang, Jae-Cheon Shin, Seon-Min Park, Jung-Jae Cho, Yung Hyun Choi, Kang Seok Seo, Nag-Jin Choi, Jung-Hyun Shim, Jung-Il Cha. Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma. International journal of oncology. vol 46. issue 6. 2016-02-02. PMID:25891355. |
furthermore, β-lap modulated protein expression levels of cell cycle regulatory proteins and apoptosis-related proteins that are known as sp1 target genes, resulting in apoptosis. |
2016-02-02 |
2023-08-13 |
Not clear |
| Young-Joo Jeon, Woong Bang, Jae-Cheon Shin, Seon-Min Park, Jung-Jae Cho, Yung Hyun Choi, Kang Seok Seo, Nag-Jin Choi, Jung-Hyun Shim, Jung-Il Cha. Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma. International journal of oncology. vol 46. issue 6. 2016-02-02. PMID:25891355. |
our results collectively indicated that β-lap was able to modulate sp1 transactivation and induce apoptosis through the regulation of cell cycle and apoptosis-related proteins. |
2016-02-02 |
2023-08-13 |
Not clear |
| Xiao Li, Li Chen, Wei Wang, Fan-Bin Meng, Ren-Tao Zhao, Yang Che. MicroRNA-150 Inhibits Cell Invasion and Migration and Is Downregulated in Human Osteosarcoma. Cytogenetic and genome research. vol 146. issue 2. 2016-01-04. PMID:26361218. |
the mrna and protein levels of sp1 were upregulated after transfection with a sp1-expression plasmid and partially reversed the inhibitory effects of mir-150 on cell proliferation, invasion, and metastasis in mg63 and sosp-9607 cells, as well as promoted cell apoptosis. |
2016-01-04 |
2023-08-13 |
human |
| Xiao Li, Li Chen, Wei Wang, Fan-Bin Meng, Ren-Tao Zhao, Yang Che. MicroRNA-150 Inhibits Cell Invasion and Migration and Is Downregulated in Human Osteosarcoma. Cytogenetic and genome research. vol 146. issue 2. 2016-01-04. PMID:26361218. |
in conclusion, mir-150 inhibits cell proliferation, invasion, and metastasis and stimulates cell apoptosis by regulating the expression of sp1. |
2016-01-04 |
2023-08-13 |
human |
| Valéryane Dupuis-Maurin, Lilia Brinza, Joël Baguet, Emilie Plantamura, Stéphane Schicklin, Solène Chambion, Claire Macari, Martine Tomkowiak, Emmanuelle Deniaud, Yann Leverrier, Jacqueline Marvel, Marie-Cécile Michalle. Overexpression of the transcription factor Sp1 activates the OAS-RNAse L-RIG-I pathway. PloS one. vol 10. issue 3. 2015-12-03. PMID:25738304. |
paradoxically in untransformed cells, sp1 overexpression induces late apoptosis but the early intrinsic response is poorly characterized. |
2015-12-03 |
2023-08-13 |
human |
| Sung-Won Shin, Seong-Hoon Yun, Eun-Seon Park, Jin-Sook Jeong, Jong-Young Kwak, Joo-In Par. Overexpression of PGC‑1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein. International journal of oncology. vol 46. issue 3. 2015-10-05. PMID:25585584. |
in pgc‑1α, acbp, and specificity protein 1 (sp1) sirna knockdown experiments in pgc‑1α-hek293 and snu-c4 cells, we also observed inhibition of cell proliferation, reduced expression of antioxidant enzymes, and increased h2o2-induced reactive oxygen species production and apoptosis. |
2015-10-05 |
2023-08-13 |
mouse |
| Ka Hwi Kim, Goo Yoon, Jung Jae Cho, Jin Hyoung Cho, Young Sik Cho, Jung-Il Chae, Jung-Hyun Shi. Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway. International journal of oncology. vol 46. issue 3. 2015-10-05. PMID:25586190. |
licochalcone a induces apoptosis in malignant pleural mesothelioma through downregulation of sp1 and subsequent activation of mitochondria-related apoptotic pathway. |
2015-10-05 |
2023-08-13 |
human |
| Ka Hwi Kim, Goo Yoon, Jung Jae Cho, Jin Hyoung Cho, Young Sik Cho, Jung-Il Chae, Jung-Hyun Shi. Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway. International journal of oncology. vol 46. issue 3. 2015-10-05. PMID:25586190. |
in conclusion, these results present that lca may be a potential bioactive material to control human mpm cells by apoptosis via the downregulation of sp1. |
2015-10-05 |
2023-08-13 |
human |
| Jung-Il Chae, Young-Joo Jeon, Jung-Hyun Shi. Anti-proliferative properties of kahweol in oral squamous cancer through the regulation specificity protein 1. Phytotherapy research : PTR. vol 28. issue 12. 2015-08-21. PMID:25196544. |
interestingly, suppression of the transcription factor specificity protein 1 (sp1) was followed by induced apoptosis by kahweol in a dose-dependent manner. |
2015-08-21 |
2023-08-13 |
Not clear |