| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Lu, Li Zhou, Lijun Wang, Shan He, Honglei Ren, Nian Zhou, Zhenming H. The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress. Aging. vol 12. issue 10. 2021-08-02. PMID:32445555. |
the results showed that sirt1 could promote bmp2-induced chondrogenic differentiation of mscs, and reduce the apoptosis and decomposition of extracellular matrix under oxidative stress. |
2021-08-02 |
2023-08-13 |
Not clear |
| Zhihong Wang, Min Zhang, Zhong Wang, Zongjun Guo, Zongqiu Wang, Qun Che. Cyanidin-3-O-glucoside attenuates endothelial cell dysfunction by modulating miR-204-5p/SIRT1-mediated inflammation and apoptosis. BioFactors (Oxford, England). vol 46. issue 5. 2021-07-29. PMID:32593198. |
in in vitro assays, the treatments of c3g suppressed apoptosis, inhibited inflammation, down-regulated mir-204-5p level, and induced sirt1 level in huvecs. |
2021-07-29 |
2023-08-13 |
human |
| Panpan Liu, Jinghan Li, Miaomiao Liu, Muqing Zhang, Yucong Xue, Yuanyuan Zhang, Xue Han, Xuan Jing, Li Ch. Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-26. PMID:33839495. |
furthermore, l-hsp and h-hsp also reversed the iso-induced apoptosis and the changes in the sirt1/nrf2 signaling pathway, as evident from the levels of proteins bax, bcl-2, caspase-3, sirt1, nrf2, nqo-1, and ho-1. |
2021-07-26 |
2023-08-13 |
mouse |
| Yan Xue, Xiaofeng Yu, Xiuhang Zhang, Ping Yu, Yuangeng Li, Wenwen Fu, Jiaao Yu, Dayun Su. Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats. Journal of food science. vol 86. issue 7. 2021-07-19. PMID:34146399. |
the results of the current study suggested that ginsenoside rc could alleviate acute cold exposure-induced myocardial injury in rats by inhibiting cardiomyocyte apoptosis via regulating sirt1 expression and attenuating the inflammatory responses. |
2021-07-19 |
2023-08-13 |
rat |
| Pei-Ying Pai, Wan-Ching Chou, Shih-Hung Chan, Shu-Yih Wu, Hsiu-I Chen, Chi-Wen Li, Pei-Ling Hsieh, Pei-Ming Chu, Yu-An Chen, Hsiu-Chung Ou, Kun-Ling Tsa. Epigallocatechin Gallate Reduces Homocysteine-Caused Oxidative Damages through Modulation SIRT1/AMPK Pathway in Endothelial Cells. The American journal of Chinese medicine. vol 49. issue 1. 2021-07-16. PMID:33371812. |
this study aimed to explore that egcg ameliorates homocysteine-induced endothelial cell apoptosis through enhancing the sirtuin 1 (sirt1)/amp-activated protein kinase (ampk) survival signaling pathway. |
2021-07-16 |
2023-08-13 |
human |
| Haoren Qin, Heng Zhang, Xipeng Zhang, Shiwu Zhang, Siwei Zhu, Hui Wan. Resveratrol protects intestinal epithelial cells against radiation-induced damage by promoting autophagy and inhibiting apoptosis through SIRT1 activation. Journal of radiation research. vol 62. issue 4. 2021-07-14. PMID:33912959. |
resveratrol protects intestinal epithelial cells against radiation-induced damage by promoting autophagy and inhibiting apoptosis through sirt1 activation. |
2021-07-14 |
2023-08-13 |
Not clear |
| Haoren Qin, Heng Zhang, Xipeng Zhang, Shiwu Zhang, Siwei Zhu, Hui Wan. Resveratrol protects intestinal epithelial cells against radiation-induced damage by promoting autophagy and inhibiting apoptosis through SIRT1 activation. Journal of radiation research. vol 62. issue 4. 2021-07-14. PMID:33912959. |
these results suggest that resveratrol reduces radiation-induced iec-6 cell damage by inhibiting apoptosis and promoting autophagy via the activation of sirt1, and that the pi3k/akt/mtor signaling pathway is involved in the induction of autophagy. |
2021-07-14 |
2023-08-13 |
Not clear |
| Hui Zhang, Xue-Mei Zhang, Dan-Dan Zong, Xiao-Ying Ji, Hua Jiang, Feng-Zheng Zhang, Sheng-Dong H. miR-34a-5p up-regulates the IL-1β/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons. FEBS open bio. vol 11. issue 1. 2021-07-13. PMID:33155431. |
in summary, these findings suggest that mir-34a-5p up-regulates the il-1β/cox2/pge2 inflammation pathway, induces apoptosis and enhances release of cgrp via inhibition of sirt1 expression in trigeminal ganglion neurons; thus, mir-34a-5p may have potential as a therapeutic target for the treatment of migraine. |
2021-07-13 |
2023-08-13 |
rat |
| Hongyan Li, Zhenzi Bai, Chenghua Li, Chuanlun Sheng, Xiaonan Zha. EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31898369. |
ev71 infection induces cell apoptosis through ros generation and sirt1 activation. |
2021-07-12 |
2023-08-13 |
mouse |
| Hongyan Li, Zhenzi Bai, Chenghua Li, Chuanlun Sheng, Xiaonan Zha. EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31898369. |
during ev71-induced apoptosis in the different cell lines, ros generation and sirt1 downregulation were observed. |
2021-07-12 |
2023-08-13 |
mouse |
| Hongyan Li, Zhenzi Bai, Chenghua Li, Chuanlun Sheng, Xiaonan Zha. EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31898369. |
further investigations showed that the administration of ros inhibitor, n-acetyl- l-cysteine (nac), reduced the level of apoptosis and inflammation, reduced ev71 propagation, and increased sirt1 expression in ev71-infected cells. |
2021-07-12 |
2023-08-13 |
mouse |
| Hongyan Li, Zhenzi Bai, Chenghua Li, Chuanlun Sheng, Xiaonan Zha. EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31898369. |
in addition, combined administration of nac and ex527 (sirt1 inhibitor) restored apoptosis in the ev71-infected cells, which was reduced due to nac. |
2021-07-12 |
2023-08-13 |
mouse |
| Hongyan Li, Zhenzi Bai, Chenghua Li, Chuanlun Sheng, Xiaonan Zha. EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31898369. |
this data demonstrated that ros generation is positively associated with ev71-induced apoptosis and inflammation, while this effect could be reversed by sirt1 inhibition. |
2021-07-12 |
2023-08-13 |
mouse |
| Hongyan Li, Zhenzi Bai, Chenghua Li, Chuanlun Sheng, Xiaonan Zha. EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31898369. |
collectively, we have shown that ev71 induces apoptosis and inflammation by promoting ros generation and reducing sirt1 expression. |
2021-07-12 |
2023-08-13 |
mouse |
| Xiao-Jun Chen, Wen-Jun Wu, Qi Zhou, Jin-Ping Jie, Xiong Chen, Fang Wang, Xiao-Hua Gon. Advanced glycation end-products induce oxidative stress through the Sirt1/Nrf2 axis by interacting with the receptor of AGEs under diabetic conditions. Journal of cellular biochemistry. 2021-06-30. PMID:30324763. |
however, the increase in age-bsa concentration led to an increase in cell apoptosis, rage, and nuclear factor-κb expressions but produced the opposite effect on sirt1, nrf2, and heme oxygenase-1 expressions, as well as a decrease in antioxidant response element protein levels. |
2021-06-30 |
2023-08-13 |
human |
| Jung-Hwan Park, Sang-Ah Park, Young-Ju Lee, Na-Rae Joo, Jongdae Shin, Sang-Muk O. TOPK inhibition accelerates oxidative stress‑induced granulosa cell apoptosis via the p53/SIRT1 axis. International journal of molecular medicine. vol 46. issue 5. 2021-06-30. PMID:32901866. |
co‑treatment with the topk inhibitor, ots514, in combination with h2o2 increased p53 acetylation and its expression, whereas it decreased sirtuin 1 (sirt1) expression, contributing to the promotion of apoptosis. |
2021-06-30 |
2023-08-13 |
human |
| Jung-Hwan Park, Sang-Ah Park, Young-Ju Lee, Na-Rae Joo, Jongdae Shin, Sang-Muk O. TOPK inhibition accelerates oxidative stress‑induced granulosa cell apoptosis via the p53/SIRT1 axis. International journal of molecular medicine. vol 46. issue 5. 2021-06-30. PMID:32901866. |
in addition, the sirt1 activator, resveratrol, or the sirt1 inhibitor, ex527, reduced or elevated h2o2‑induced cov434 cell apoptosis, respectively. |
2021-06-30 |
2023-08-13 |
human |
| Jung-Hwan Park, Sang-Ah Park, Young-Ju Lee, Na-Rae Joo, Jongdae Shin, Sang-Muk O. TOPK inhibition accelerates oxidative stress‑induced granulosa cell apoptosis via the p53/SIRT1 axis. International journal of molecular medicine. vol 46. issue 5. 2021-06-30. PMID:32901866. |
taken together, the findings of the present study demonstrate that topk inhibition promotes p53‑mediated granulosa cell apoptosis through sirt1 downregulation in response to h2o2. |
2021-06-30 |
2023-08-13 |
human |
| Hong-Ji Deng, Chen-Hui Zhou, Li-Tian Huang, Liang-Bao Wen, Meng-Liang Zhou, Chun-Xi Wan. Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF-κB/p65. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33289070. |
activation of sirt1 by resveratrol had a neuroprotective effect, along with decreased levels of ac-p65, il-1β, tnf-α, and apoptosis after ich. |
2021-06-21 |
2023-08-13 |
Not clear |
| Zhiru Zeng, Kaixiang Yu, Wangxing Hu, Si Cheng, Chenyang Gao, Feng Liu, Jinyong Chen, Minjian Kong, Fengjiang Zhang, Xianbao Liu, Jian'an Wan. SRT1720 Pretreatment Promotes Mitochondrial Biogenesis of Aged Human Mesenchymal Stem Cells and Improves Their Engraftment in Postinfarct Nonhuman Primate Hearts. Stem cells and development. vol 30. issue 7. 2021-06-21. PMID:33567991. |
our previous study has demonstrated that srt1720, a specific sirt1 activator, could protect aged human mscs (hmscs) against apoptosis. |
2021-06-21 |
2023-08-13 |
human |