| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiqiang Sun, Xia Wang, Guoyong Fu, Xiaopeng Gen. MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21. Molecular therapy. Nucleic acids. vol 24. 2021-05-14. PMID:33981481. |
also, mir-199a-5p inhibited sirt1, promoted p21 acetylation, and upregulated p21 expression, thus accelerating nucleus pulposus cell apoptosis and ivdd. |
2021-05-14 |
2023-08-13 |
rat |
| Shuwei Ning, Zhiying Li, Zhenyu Ji, Dandan Fan, Keke Wang, Qian Wang, Lei Hua, Junyue Zhang, Xiangguang Meng, Yiqiang Yua. MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174056. |
microrna‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the pi3k/akt/mtor signaling pathway by targeting sirt1. |
2021-05-13 |
2023-08-13 |
rat |
| Shuwei Ning, Zhiying Li, Zhenyu Ji, Dandan Fan, Keke Wang, Qian Wang, Lei Hua, Junyue Zhang, Xiangguang Meng, Yiqiang Yua. MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174056. |
furthermore, mir‑494 inhibitor‑mediated effects on h/r‑induced cardiomyocyte apoptosis and autophagy were partially reversed by sirt1 knockdown. |
2021-05-13 |
2023-08-13 |
rat |
| Shuwei Ning, Zhiying Li, Zhenyu Ji, Dandan Fan, Keke Wang, Qian Wang, Lei Hua, Junyue Zhang, Xiangguang Meng, Yiqiang Yua. MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174056. |
collectively, the results indicated that mir‑494 served a protective role against h/r‑induced cardiomyocyte apoptosis and autophagy by directly targeting sirt1, suggesting that mir‑494 may serve as a novel therapeutic target for myocardial i/r injury. |
2021-05-13 |
2023-08-13 |
rat |
| Fangzhou Jiao, Zuojiong Gon. The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases. Oxidative medicine and cellular longevity. vol 2020. 2021-05-12. PMID:33014276. |
among seven sirtuins, sirt1 plays a critical role in modulating a wide range of physiological processes, including apoptosis, dna repair, inflammatory response, metabolism, cancer, and stress. |
2021-05-12 |
2023-08-13 |
Not clear |
| Liwei Liu, Chao Liu, Lin Fan. AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane. Molecular medicine reports. vol 23. issue 1. 2021-05-11. PMID:33200801. |
aicar, an activator of ampk, was able to suppress sev‑induced neuronal apoptosis and sirt1 activity reduction in vitro. |
2021-05-11 |
2023-08-13 |
rat |
| Shimaa M Elshazly, Ahmed E M Elhassanny, Nevertyty M Mahmou. Cilostazol protects against acetic acid-induced colitis in rats: Possible role for cAMP/SIRT1 pathway. European journal of pharmacology. vol 881. 2021-05-10. PMID:32497625. |
sirt1 is suggested to contribute to cilostazol-induced suppression of nf-κb, akt and mapk inflammatory pathways, oxidative stress and apoptosis. |
2021-05-10 |
2023-08-13 |
rat |
| Jiong Zhang, Yang Zou, Yan Cheng-Jing, Lu Xiang-Heng, Xue-Peng Wang, Xiao-Jia Yu, Gui-Sen Li, Jia Wan. Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria-mediated apoptosis via SIRT1/p53 signalling. Journal of cellular and molecular medicine. vol 24. issue 20. 2021-05-06. PMID:32881246. |
apoptosis is associated with mitochondrial dysfunction and sirt1 activation can decrease cell apoptosis in cisplatin nephrotoxicity. |
2021-05-06 |
2023-08-13 |
Not clear |
| Shi-Bin Jiang, Yan-Song Lu, Tao Liu, Liang-Man Li, He-Xiao Wang, Yan Wu, Xing-Hua Gao, Hong-Duo Che. UVA influenced the SIRT1-miR-27a-5p-SMAD2-MMP1/COL1/BCL2 axis in human skin primary fibroblasts. Journal of cellular and molecular medicine. vol 24. issue 17. 2021-05-04. PMID:32790210. |
both sirt1 and uva radiation are involved in cellular damage processes such as apoptosis, senescence and ageing. |
2021-05-04 |
2023-08-13 |
human |
| Zhaoyan Nie, Lei Zhang, Wei Chen, Yanan Zhang, Rui Hua, Wei Wang, Tiantian Zhang, Haifeng W. The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study. Reproductive toxicology (Elmsford, N.Y.). vol 95. 2021-04-28. PMID:32446930. |
rat gcs were treated with 4-hc alone, res + 4-hc or res + 4-hc + ex527, and gcs survival rates, oxidative stress levels, apoptosis rates and related sirt1 pathway proteins were evaluated. |
2021-04-28 |
2023-08-13 |
rat |
| Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhan. Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. International immunopharmacology. vol 85. 2021-04-28. PMID:32492628. |
quercetin attenuates nlrp3 inflammasome activation and apoptosis to protect inh-induced liver injury via regulating sirt1 pathway. |
2021-04-28 |
2023-08-13 |
rat |
| Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhan. Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. International immunopharmacology. vol 85. 2021-04-28. PMID:32492628. |
however, sirt1 inhibitor ex527 reversed the suppression of que on nlrp3 inflammasome activation and the protection of que on rat liver injury and cell apoptosis. |
2021-04-28 |
2023-08-13 |
rat |
| Yingjie Ding, Jing Wang, Hongliang Zhang, Huanting L. Long noncoding RNA-GAS5 attenuates progression of glioma by eliminating microRNA-10b and Sirtuin 1 in U251 and A172 cells. BioFactors (Oxford, England). vol 46. issue 3. 2021-04-22. PMID:31889362. |
after co-transfection, we analyzed the viability, migration, invasion, apoptosis, and sirt1 expression. |
2021-04-22 |
2023-08-13 |
Not clear |
| Jeong Woo Kim, Ji Hye Yang, Eun-Joo Ki. SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells. Animal cells and systems. vol 24. issue 1. 2021-04-22. PMID:32158616. |
sirt1 and aros suppress doxorubicin-induced apoptosis via inhibition of gsk3β activity in neuroblastoma cells. |
2021-04-22 |
2023-08-13 |
human |
| Jeong Woo Kim, Ji Hye Yang, Eun-Joo Ki. SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells. Animal cells and systems. vol 24. issue 1. 2021-04-22. PMID:32158616. |
sirt1, the best-characterized member of the sirtuin family of deacetylases, is involved in cancer, apoptosis, inflammation, and metabolism. |
2021-04-22 |
2023-08-13 |
human |
| Jeong Woo Kim, Ji Hye Yang, Eun-Joo Ki. SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells. Animal cells and systems. vol 24. issue 1. 2021-04-22. PMID:32158616. |
here, we demonstrated that depletion of sirt1 and aros increases doxorubicin-mediated apoptosis in human neuroblastoma sh-sy5y cells. |
2021-04-22 |
2023-08-13 |
human |
| Jeong Woo Kim, Ji Hye Yang, Eun-Joo Ki. SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells. Animal cells and systems. vol 24. issue 1. 2021-04-22. PMID:32158616. |
glycogen synthase kinase 3β (gsk3β) promoted doxorubicin-mediated apoptosis, but this effect was abolished by overexpression of sirt1 and aros. |
2021-04-22 |
2023-08-13 |
human |
| J Xie, Q-G Yu, L-L Yang, Y-Y Su. Kallistatin alleviates heart failure in rats by inhibiting myocardial inflammation and apoptosis via regulating sirt1. European review for medical and pharmacological sciences. vol 24. issue 11. 2021-04-21. PMID:32572936. |
kallistatin alleviates heart failure in rats by inhibiting myocardial inflammation and apoptosis via regulating sirt1. |
2021-04-21 |
2023-08-13 |
rat |
| Raanan Bulvik, Raphael Breuer, Mona Dvir-Ginzberg, Eli Reich, Neville Berkman, Shulamit B Wallach-Daya. SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis. Biomolecules. vol 10. issue 7. 2021-04-19. PMID:32630813. |
sirt1 deficiency, specifically in fibroblasts, decreases apoptosis resistance and is associated with resolution of lung-fibrosis. |
2021-04-19 |
2023-08-13 |
mouse |
| Dawei Wang, Hongyan Cao, Xu Wang, Jinchun Wang, Manli Wang, Jian Zhang, Lin Wan. SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury. Journal of inflammation research. vol 14. 2021-04-16. PMID:33854356. |
while sirt1 has been proved to protects the heart from myocardial ischemia/reperfusion (mi/r) injury and apoptosis, less is known about the association between exercise-induced cardioprotection and sirt1. |
2021-04-16 |
2023-08-13 |
Not clear |