| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eman Taha Mohammed, Khalid S Hashem, Ahmed Z Abdelazem, Fatma A M A Fod. Prospective Protective Effect of Ellagic Acid as a SIRT1 Activator in Iron Oxide Nanoparticle-Induced Renal Damage in Rats. Biological trace element research. vol 198. issue 1. 2021-06-18. PMID:31933277. |
in the present study, the potent antioxidant and antiapoptotic effects of ea were indicated by the significant overexpression of sirt1 in renal tissues that leads to significant decreases in renal mda content, p53 protein level and forkhead-box transcription factor1 (foxo1) expression, and significant increases in renal gsh level, catalase activity, growth arrest and dna damage-inducible protein 45 alpha (gaddα45), and renal inhibition of apoptosis protein (kiap) gene expression levels in the ea + ionp-treated group. |
2021-06-18 |
2023-08-13 |
rat |
| Suma Elumalai, Udayakumar Karunakaran, Jun Sung Moon, Kyu Chang Wo. High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic β-cells: Prevention by Teneligliptin. Free radical biology & medicine. vol 160. 2021-06-18. PMID:32763411. |
sirt1 deficiency induces beta cell apoptosis via nox-jnk-p66shc signalosome activation. |
2021-06-18 |
2023-08-13 |
human |
| Suma Elumalai, Udayakumar Karunakaran, Jun Sung Moon, Kyu Chang Wo. High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic β-cells: Prevention by Teneligliptin. Free radical biology & medicine. vol 160. 2021-06-18. PMID:32763411. |
intriguingly, inhibition of sirt1 activity by ex-527 or sirt1 sirna knockdown exacerbated the sirt3 mediated prdx3 deacetylation which leads to peroxiredoxin-3 hyper-oxidation and beta-cell apoptosis by the activation of nox-jnk-p66shc signalosome. |
2021-06-18 |
2023-08-13 |
human |
| Can Hu, Xin Zhang, Peng Song, Yu-Pei Yuan, Chun-Yan Kong, Hai-Ming Wu, Si-Chi Xu, Zhen-Guo Ma, Qi-Zhu Tan. Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway. Redox biology. vol 37. 2021-06-18. PMID:33045622. |
collectively, cardiac-derived metrnl activates sirt1 via camp/pka signaling axis in an autocrine manner, which ultimately improves dox-elicited oxidative stress, apoptosis and cardiac dysfunction. |
2021-06-18 |
2023-08-13 |
mouse |
| Wei Song, Mei-Li Liu, Zhi-Jun Zhao, Chong-Quan Huang, Jun-Wei Xu, An-Qing Wang, Ping Li, Yu-Bo Fa. SIRT1 Inhibits High Shear Stress-Induced Apoptosis in Rat Cortical Neurons. Cellular and molecular bioengineering. vol 13. issue 6. 2021-06-18. PMID:33281991. |
sirt1 inhibits high shear stress-induced apoptosis in rat cortical neurons. |
2021-06-18 |
2023-08-13 |
rat |
| Keyu Huang, Chunqing Yang, Jian Zheng, Xiaobai Liu, Jie Liu, Dongfang Che, Yixue Xue, Ping An, Di Wang, Xuelei Ruan, Bo Y. Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis. Cell death discovery. vol 7. issue 1. 2021-06-16. PMID:34052838. |
overexpression of circ_0000296, runx3, sirt1, and silenced mir-194-5p significantly inhibited neuronal apoptosis induced by cci. |
2021-06-16 |
2023-08-13 |
Not clear |
| Keyu Huang, Chunqing Yang, Jian Zheng, Xiaobai Liu, Jie Liu, Dongfang Che, Yixue Xue, Ping An, Di Wang, Xuelei Ruan, Bo Y. Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis. Cell death discovery. vol 7. issue 1. 2021-06-16. PMID:34052838. |
overexpression of circ_0000296 by mir-194-5p reduced the negative regulatory effect of mir-194-5p on runx3, promoted the transcriptional effect of runx3 on sirt1, and inhibited neuronal apoptosis induced by cci. |
2021-06-16 |
2023-08-13 |
Not clear |
| Tayier Gulifeire, Chunbo Yang, Xiang Li, Yi Wang, Xiangyou Y. [Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis]. Zhonghua wei zhong bing ji jiu yi xue. vol 33. issue 5. 2021-06-14. PMID:34112288. |
to explore whether resveratrol (rsv) could activate silent information regulator 1 (sirt1) to regulate the activation of nod-like receptor protein 3 (nlrp3) inflammasome in sepsis induced intestinal injury model, and then reduce intestinal inflammation and cell apoptosis, so as to play a protective role in intestinal barrier function. |
2021-06-14 |
2023-08-13 |
Not clear |
| Xuancheng Ou, Jinwei Ying, Xuedong Bai, Chaofeng Wang, Dike Rua. Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration. International journal of molecular medicine. vol 46. issue 3. 2021-06-01. PMID:32705163. |
activation of sirt1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the mcp1/ccr2 axis in subjects with intervertebral disc degeneration. |
2021-06-01 |
2023-08-13 |
human |
| Xuancheng Ou, Jinwei Ying, Xuedong Bai, Chaofeng Wang, Dike Rua. Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration. International journal of molecular medicine. vol 46. issue 3. 2021-06-01. PMID:32705163. |
furthermore, mcp1 reversed the progression of the cartilage differentiation of npmscs and the inhibition of npmsc apoptosis induced by sirt1 overexpression. |
2021-06-01 |
2023-08-13 |
human |
| Xuancheng Ou, Jinwei Ying, Xuedong Bai, Chaofeng Wang, Dike Rua. Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration. International journal of molecular medicine. vol 46. issue 3. 2021-06-01. PMID:32705163. |
therefore, sirt1 overexpression improved cartilage differentiation and reduced the apoptosis of npmscs by inactivating the mcp1/ccr2 axis, thus attenuating idd in rats. |
2021-06-01 |
2023-08-13 |
human |
| Chaoting Ma, Dandan Zhang, Qiuyan Ma, Yu Liu, Yingxin Yan. Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 30. issue 5. 2021-06-01. PMID:33974755. |
arbutin inhibits inflammation and apoptosis by enhancing autophagy via sirt1. |
2021-06-01 |
2023-08-13 |
Not clear |
| Chaoting Ma, Dandan Zhang, Qiuyan Ma, Yu Liu, Yingxin Yan. Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 30. issue 5. 2021-06-01. PMID:33974755. |
sirt1 plays a protective role against diabetic retinopathy as it regulates inflammation, apoptosis and autophagy of cells. |
2021-06-01 |
2023-08-13 |
Not clear |
| Man Li, Shi-Chun Li, Bao-Kai Dou, Ying-Xiang Zou, Hao-Zhen Han, Dong-Xiang Liu, Zun-Ji Ke, Zhi-Fei Wan. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta pharmacologica Sinica. vol 41. issue 8. 2021-05-28. PMID:32203080. |
cycloastragenol upregulates sirt1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. |
2021-05-28 |
2023-08-13 |
mouse |
| Man Li, Shi-Chun Li, Bao-Kai Dou, Ying-Xiang Zou, Hao-Zhen Han, Dong-Xiang Liu, Zun-Ji Ke, Zhi-Fei Wan. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta pharmacologica Sinica. vol 41. issue 8. 2021-05-28. PMID:32203080. |
our findings suggest that cag is neuroprotective against ischemic brain injury in mice and that its beneficial effect may involve sirt1 upregulation and the inhibition of apoptosis and neuroinflammation in the ischemic brain. |
2021-05-28 |
2023-08-13 |
mouse |
| Wei Qi, Dong Ren, Pengcheng Wang, Zhaohui Song, Haotian Wu, Shuangquan Yao, Lindan Geng, Yunshan Su, Xiaoliang Ba. Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway. International immunopharmacology. vol 88. 2021-05-27. PMID:32866785. |
upregulation of sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of pi3k/akt pathway. |
2021-05-27 |
2023-08-13 |
human |
| Wei Qi, Dong Ren, Pengcheng Wang, Zhaohui Song, Haotian Wu, Shuangquan Yao, Lindan Geng, Yunshan Su, Xiaoliang Ba. Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway. International immunopharmacology. vol 88. 2021-05-27. PMID:32866785. |
sirt1 knockdown attenuated the effects of tyrosol on il-1β-induced apoptosis, inflammation, and ecm remodeling in hnpcs. |
2021-05-27 |
2023-08-13 |
human |
| Wei Qi, Dong Ren, Pengcheng Wang, Zhaohui Song, Haotian Wu, Shuangquan Yao, Lindan Geng, Yunshan Su, Xiaoliang Ba. Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway. International immunopharmacology. vol 88. 2021-05-27. PMID:32866785. |
in summary, upregulation of sirt1 by tyrosol suppressed apoptosis and inflammation and regulated ecm remodeling in il-1β-stimulated hnpcs through activation of pi3k/akt pathway. |
2021-05-27 |
2023-08-13 |
human |
| Hong Yang, Jianxia Chen, Yanghaoyu Chen, Yan Jiang, Baoxue Ge, Ling Hon. Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax. International immunopharmacology. vol 91. 2021-05-26. PMID:33373810. |
sirt1 activation negatively regulates overt apoptosis in mtb-infected macrophage through bax. |
2021-05-26 |
2023-08-13 |
mouse |
| Hong Yang, Jianxia Chen, Yanghaoyu Chen, Yan Jiang, Baoxue Ge, Ling Hon. Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax. International immunopharmacology. vol 91. 2021-05-26. PMID:33373810. |
sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. |
2021-05-26 |
2023-08-13 |
mouse |