| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiwei Li, Sheng Jin, Jie Hao, Yun Shi, Wenjie Li, Lingling Jian. Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1. Canadian journal of physiology and pharmacology. vol 99. issue 9. 2021-08-27. PMID:33517853. |
metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microrna-34a via activation of sirt1. |
2021-08-27 |
2023-08-13 |
rat |
| Yao Wang, Wei He, Wei Wei, Xiaoxue Mei, Ming Yang, Ying Wan. Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells. Frontiers in endocrinology. vol 12. 2021-08-27. PMID:34434166. |
here, we show that exenatide treatment reversed hfd induced tecs injuries, including tecs apoptosis and sirt1 downregulation. |
2021-08-27 |
2023-08-13 |
Not clear |
| Yao Wang, Wei He, Wei Wei, Xiaoxue Mei, Ming Yang, Ying Wan. Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells. Frontiers in endocrinology. vol 12. 2021-08-27. PMID:34434166. |
in palmitate (pa)-stimulated hk2 cells, exenatide treatment reversed the downregulation of sirt1 and prevented an increase in reactive oxygen species (ros) production, a decrease in mitochondrial membrane potential, and mitochondrial apoptosis. |
2021-08-27 |
2023-08-13 |
Not clear |
| Yao Wang, Wei He, Wei Wei, Xiaoxue Mei, Ming Yang, Ying Wan. Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells. Frontiers in endocrinology. vol 12. 2021-08-27. PMID:34434166. |
the renal-protective effects of exenatide on the generation of mitochondrial ros and mitochondrial apoptosis were blocked by inhibiting sirt1 activation. |
2021-08-27 |
2023-08-13 |
Not clear |
| Yao Wang, Wei He, Wei Wei, Xiaoxue Mei, Ming Yang, Ying Wan. Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells. Frontiers in endocrinology. vol 12. 2021-08-27. PMID:34434166. |
collectively, these findings show that exenatide was superior to simvastatin in the treatment of obesity-tecs injuries, the mechanism is partially through sirt1 restoration, which directly reverses mitochondrial dysfunction and apoptosis. |
2021-08-27 |
2023-08-13 |
Not clear |
| Yiran Liang, Hong Liu, Jiaming Zhu, Nana Song, Zhihui Lu, Yi Fang, Jie Teng, Yan Dai, Xiaoqiang Din. Inhibition of p53/miR-34a/SIRT1 axis ameliorates podocyte injury in diabetic nephropathy. Biochemical and biophysical research communications. vol 559. 2021-08-26. PMID:33932899. |
sirt1 overexpression also impacts age induced apoptosis through deacetylating p53, whereas silencing of sirt1 by ex527 attenuated the cytoprotective functions of mir-34a knockdown. |
2021-08-26 |
2023-08-13 |
mouse |
| Yiran Liang, Hong Liu, Jiaming Zhu, Nana Song, Zhihui Lu, Yi Fang, Jie Teng, Yan Dai, Xiaoqiang Din. Inhibition of p53/miR-34a/SIRT1 axis ameliorates podocyte injury in diabetic nephropathy. Biochemical and biophysical research communications. vol 559. 2021-08-26. PMID:33932899. |
moreover, blockade of p53 acetylation significantly rescued mir-34a-induced apoptosis through sirt1 restoration. |
2021-08-26 |
2023-08-13 |
mouse |
| Xianglun Zhang, Fachun Wan, Wei You, Xiuwen Tan, Guifen Liu, Qing Jin, Chen Wei, Xiaomu Liu, Hongbo Zhao, Yifan Liu, Chen Zhan. Comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via SIRT1. Animal biotechnology. vol 31. issue 6. 2021-08-25. PMID:31287374. |
comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via sirt1. |
2021-08-25 |
2023-08-13 |
cattle |
| Xianglun Zhang, Fachun Wan, Wei You, Xiuwen Tan, Guifen Liu, Qing Jin, Chen Wei, Xiaomu Liu, Hongbo Zhao, Yifan Liu, Chen Zhan. Comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via SIRT1. Animal biotechnology. vol 31. issue 6. 2021-08-25. PMID:31287374. |
resveratrol is a natural activator of sirtuin type 1 (sirt1), a nad-dependent deacetylase involved in regulating the cell cycle, energy homeostasis and apoptosis in adipose tissue. |
2021-08-25 |
2023-08-13 |
cattle |
| Xianglun Zhang, Fachun Wan, Wei You, Xiuwen Tan, Guifen Liu, Qing Jin, Chen Wei, Xiaomu Liu, Hongbo Zhao, Yifan Liu, Chen Zhan. Comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via SIRT1. Animal biotechnology. vol 31. issue 6. 2021-08-25. PMID:31287374. |
we found that resveratrol-induced apoptosis in bovine adipocytes by regulating sirt1 activity. |
2021-08-25 |
2023-08-13 |
cattle |
| Xianglun Zhang, Fachun Wan, Wei You, Xiuwen Tan, Guifen Liu, Qing Jin, Chen Wei, Xiaomu Liu, Hongbo Zhao, Yifan Liu, Chen Zhan. Comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via SIRT1. Animal biotechnology. vol 31. issue 6. 2021-08-25. PMID:31287374. |
these data indicate that bovine subcutaneous adipocytes are more sensitive to apoptosis than intramuscular adipocytes following treatment with resveratrol by regulating sirt1 activity. |
2021-08-25 |
2023-08-13 |
cattle |
| Rania M Salama, Abdelkader M Mohamed, Nada S Hamed, Raneem M Ata, Amira S NourelDeen, Mohamed A Hassa. Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway. Toxicology research. vol 9. issue 4. 2021-08-19. PMID:32905193. |
this could offer protection to multiple organs against reactive oxygen species (ros) through modulating sirtuin 1 (sirt1) expression and, in turn, inactivation of forkhead box transcription factor of the o class 1 (foxo1), thus inhibiting apoptosis. |
2021-08-19 |
2023-08-13 |
rat |
| Yanchao Xu, Yusong Zhang, Hongwei Liang, Xiaomeng Li. Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1. Aging. vol 13. issue 4. 2021-08-13. PMID:33536350. |
coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of sirt1. |
2021-08-13 |
2023-08-13 |
human |
| Liao Zhiyin, Chen Jinliang, Chen Qiunan, Yang Yunfei, Xiao Qia. Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-08-11. PMID:33865017. |
through activating sirt1, fucoxanthin inhibits forkhead box o (foxo) transcriptional activity to reduce protein degradation, induces autophagy to enhance degraded protein clearance, promotes mitochondrial function and diminishes apoptosis. |
2021-08-11 |
2023-08-13 |
Not clear |
| Xintong Sui, Wei Liu, Zhi Li. Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181. Acta biochimica et biophysica Sinica. vol 53. issue 6. 2021-08-10. PMID:33891698. |
furthermore, we demonstrated that treatment with exosomal lncrna-p21 could increase the expression of sirtuin 1 (sirt1) to protect mle-12 cells from apoptosis during sepsis. |
2021-08-10 |
2023-08-13 |
Not clear |
| Xintong Sui, Wei Liu, Zhi Li. Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181. Acta biochimica et biophysica Sinica. vol 53. issue 6. 2021-08-10. PMID:33891698. |
our results showed that the lncrna-p21-induced downregulation of mir-181 might suppress epithelial cell apoptosis and alleviate lung tissue injury by upregulating sirt1 expression, suggesting the potential therapeutic effects of lncrna-p21 on sali. |
2021-08-10 |
2023-08-13 |
Not clear |
| Qingxia Huang, Hang Su, Bin Qi, Ying Wang, Kaili Yan, Xinglin Wang, Xiangyan Li, Daqing Zha. A SIRT1 Activator, Ginsenoside Rc, Promotes Energy Metabolism in Cardiomyocytes and Neurons. Journal of the American Chemical Society. vol 143. issue 3. 2021-08-09. PMID:33439015. |
more importantly, ginsenoside rc reduces mitochondrial damage and apoptosis through sirt1 restoration-mediated reduction of pgc1α acetylation in the i/r-induced cardiac and neuronal models. |
2021-08-09 |
2023-08-13 |
Not clear |
| Shaohong Zhang, Mengxiao Zhang, Shuoshuo Sun, Xiao Wei, Yu Chen, Peng Zhou, Rendong Zheng, Guofang Chen, Chao Li. Moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through SIRT1 signaling in obese mice. Annals of translational medicine. vol 9. issue 11. 2021-08-06. PMID:34350248. |
moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through sirt1 signaling in obese mice. |
2021-08-06 |
2023-08-13 |
mouse |
| Yaoyao Hou, Yingjun Fan, Xian Xia, Jicheng Pan, Jianjun Hou, Xixia Liu, Xinpeng Che. USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth. Acta biochimica et biophysica Sinica. vol 53. issue 8. 2021-08-04. PMID:34184746. |
finally, inhibition or knockdown of sirt1 suppressed usp31 activity in hela cell line, leading to cisplatin-induced apoptosis resistance. |
2021-08-04 |
2023-08-13 |
Not clear |
| Nasser Al Sabaan. Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 36. issue 7. 2021-08-02. PMID:32412821. |
kaempferol protects against hydrogen peroxide-induced retinal pigment epithelium cell inflammation and apoptosis by activation of sirt1 and inhibition of parp1. |
2021-08-02 |
2023-08-13 |
Not clear |