| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Liu, Yufang Leng, Xinghua Lv, Jipeng Lv, Mengjie Zhang, Yajing Sh. Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression. Journal of bioenergetics and biomembranes. vol 53. issue 6. 2021-11-17. PMID:34586578. |
in conclusion, dex could inhibit h/r-induced intestinal epithelial cells ers, apoptosis and pyroptosis via activating sirt1 expression. |
2021-11-17 |
2023-08-13 |
Not clear |
| Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Gu. Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts. Aging. vol 13. issue 20. 2021-11-17. PMID:34711685. |
up-regulation of sirt1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts. |
2021-11-17 |
2023-08-13 |
Not clear |
| Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Gu. Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts. Aging. vol 13. issue 20. 2021-11-17. PMID:34711685. |
silent information regulator factor 2 homolog 1 (sirt1) is crucial in the regulation of several biological processes, including bone metabolism, autophagy, apoptosis, and aging. |
2021-11-17 |
2023-08-13 |
Not clear |
| Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Gu. Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts. Aging. vol 13. issue 20. 2021-11-17. PMID:34711685. |
this study aimed to assess whether the up-regulation of sirt1 induced by 17beta-estradiol (17β-e2) could promote autophagy and inhibit apoptosis in osteoblasts via the ampk-mtor and foxo3a pathways, respectively. |
2021-11-17 |
2023-08-13 |
Not clear |
| Ruixiang Li, Jiahua Hu, Sue Ca. The Clinical Significance of miR-135b-5p and Its Role in the Proliferation and Apoptosis of Hippocampus Neurons in Children with Temporal Lobe Epilepsy. Developmental neuroscience. vol 42. issue 5-6. 2021-11-16. PMID:33596573. |
overexpression of mir-135b-5p alleviates the postepileptic influence on cell viability and apoptosis by targeting sirt1. |
2021-11-16 |
2023-08-13 |
rat |
| Faiza Alam, Hareem Syed, Sofia Amjad, Mukhtiar Baig, Taseer Ahmed Khan, Rehana Rehma. Interplay between oxidative stress, SIRT1, reproductive and metabolic functions. Current research in physiology. vol 4. 2021-11-10. PMID:34746831. |
in the female reproductive system, sirt1 regulates proliferation and apoptosis in granulosa cells (gcs), and its down-regulation is associated with a reduced ovarian reserve. |
2021-11-10 |
2023-08-13 |
Not clear |
| Chao Gu, Qi Zhang, Dan Ni, Qin-Feng Xiao, Lin-Feng Cao, Chun-Yuan Fei, Ying Ying, Na Li, Feng Ta. Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD. vol 17. issue 4. 2021-11-08. PMID:32722945. |
sirtuin 1 (sirt1), an antiaging molecule involved in the response to chronic inflammation and oxidative stress, regulates many pathophysiological changes including stress resistance, apoptosis, inflammation, and cellular senescence. |
2021-11-08 |
2023-08-13 |
rat |
| Kenneth Maies. Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders. Current neurovascular research. vol 18. issue 1. 2021-11-08. PMID:33397266. |
the underlying biological pathways of nicotinamide that involve the silent mating type information regulation 2 homolog 1 (saccharomyces cerevisiae) (sirt1), the mechanistic target of rapamycin (mtor), amp activated protein kinase (ampk), and mammalian forkhead transcription factors (foxos) may offer insight for the clinical translation of nicotinamide into a safe and efficacious therapy through the modulation of oxidative stress, apoptosis, and autophagy. |
2021-11-08 |
2023-08-13 |
Not clear |
| Sedat Kacar, Ceyhan Hacioglu, Fatih Kar, Varol Sahinturk, Gungor Kanba. Cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of SIRT1 in C6 glioblastoma cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 73. 2021-11-08. PMID:33675893. |
cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of sirt1 in c6 glioblastoma cells. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xiulian Miao, Yan Guo, Sheng Zeng, Xingyu Liu, Xiao Teng, Luyang Li, Wenxuan Hon. HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes. Cell death discovery. vol 7. issue 1. 2021-11-05. PMID:34689159. |
sirt1 knockdown or inhibition offset the effect of hes5 over-expression on light transcription and hepatocyte apoptosis. |
2021-11-05 |
2023-08-13 |
Not clear |
| Zhu Wu, Jie Chen, Wei Zhao, Chun-Hua Zhuo, Qiong Che. Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1. The Kaohsiung journal of medical sciences. vol 37. issue 3. 2021-11-04. PMID:33058411. |
inhibition of mir-181a attenuates sepsis-induced inflammation and apoptosis by activating nrf2 and inhibiting nf-κb pathways via targeting sirt1. |
2021-11-04 |
2023-08-13 |
mouse |
| Zhu Wu, Jie Chen, Wei Zhao, Chun-Hua Zhuo, Qiong Che. Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1. The Kaohsiung journal of medical sciences. vol 37. issue 3. 2021-11-04. PMID:33058411. |
the expressions of mir-181a and sirt1 were identified by qrt-pcr, the levels of sirt1, nrf2, p-p65, bcl-2 and bax were detected by western blotting, the inflammatory cytokines tnf-α, il-6 and il-1β were detected by elisa, and the apoptosis was measured by flow cytometry. |
2021-11-04 |
2023-08-13 |
mouse |
| Zhu Wu, Jie Chen, Wei Zhao, Chun-Hua Zhuo, Qiong Che. Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1. The Kaohsiung journal of medical sciences. vol 37. issue 3. 2021-11-04. PMID:33058411. |
moreover, the inhibition of mir-181a attenuated inflammatory response and apoptosis during lps stimulation, which was implemented by up-regulating the expression of its target sirt1. |
2021-11-04 |
2023-08-13 |
mouse |
| Zhu Wu, Jie Chen, Wei Zhao, Chun-Hua Zhuo, Qiong Che. Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1. The Kaohsiung journal of medical sciences. vol 37. issue 3. 2021-11-04. PMID:33058411. |
more fully, downregulation of sirt1 by short hairpin interference resulted in a decreased expression of nrf2, increased expression of p-p65 and proinflammatory cytokines, and intensive apoptosis. |
2021-11-04 |
2023-08-13 |
mouse |
| Zhu Wu, Jie Chen, Wei Zhao, Chun-Hua Zhuo, Qiong Che. Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1. The Kaohsiung journal of medical sciences. vol 37. issue 3. 2021-11-04. PMID:33058411. |
downregulation of mir-181a could promote the expression of its target sirt1, and then, attenuate inflammatory response and apoptosis via nrf2 and nf-κb signaling pathways during lps treatment. |
2021-11-04 |
2023-08-13 |
mouse |
| Mangmang Chen, Lipeng Huang, Yangxun Lv, Liubing Li, Qirong Don. Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis. Molecular medicine reports. vol 24. issue 2. 2021-10-27. PMID:34184072. |
sulforaphane protects against oxidative stress‑induced apoptosis via activating sirt1 in mouse osteoarthritis. |
2021-10-27 |
2023-08-13 |
mouse |
| Mangmang Chen, Lipeng Huang, Yangxun Lv, Liubing Li, Qirong Don. Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis. Molecular medicine reports. vol 24. issue 2. 2021-10-27. PMID:34184072. |
in the present study, sfn was shown to significantly inhibit chondrocyte apoptosis while enhancing expression levels of sirt1 in a h |
2021-10-27 |
2023-08-13 |
mouse |
| Qiang Tu, Jun-Feng Wang, Hua-Qiang Xie, Qi Zhao, Jie Fu, Hua-Lin Xu, Zheng Ca. Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression. Molecular and cellular endocrinology. vol 538. 2021-10-27. PMID:34509564. |
after glp-1r or sirt1 knockdown, or the treatment by glp-1r agonist and/or sirt1 agonist/inhibitor, the effects of sirt1 and glp-1r and their relationship in regulating the function of late epcs under hyperglycemia stimulation was studied by detecting the apoptosis, migration, adhesion and angiogenicity abilities of epcs. |
2021-10-27 |
2023-08-13 |
human |
| Qiang Tu, Jun-Feng Wang, Hua-Qiang Xie, Qi Zhao, Jie Fu, Hua-Lin Xu, Zheng Ca. Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression. Molecular and cellular endocrinology. vol 538. 2021-10-27. PMID:34509564. |
the knockdown of either glp-1r or sirt1 could increase epcs apoptosis and weaken the migration, adhesion and angiogenicity abilities of epcs. |
2021-10-27 |
2023-08-13 |
human |
| Qingshan Ji, Jing Han, Lisong Wang, Jiajia Liu, Yiran Dong, Kai Zhu, Lei Sh. MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy. Cell cycle (Georgetown, Tex.). vol 19. issue 21. 2021-10-22. PMID:33064974. |
microrna-34a promotes apoptosis of retinal vascular endothelial cells by targeting sirt1 in rats with diabetic retinopathy. |
2021-10-22 |
2023-08-13 |
rat |