| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
in conclusion, sirt1 plays a role in the occurrence and development of ch by regulating nerve cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |
| Saba Ubaid, Shivani Pandey, Mohd Sohail Akhtar, Mohammad Rumman, Babita Singh, Abbas Ali Mahd. SIRT1 Mediates Neuroprotective and Neurorescue Effects of Camel α-Lactalbumin and Oleic Acid Complex on Rotenone-Induced Parkinson's Disease. ACS chemical neuroscience. 2022-04-06. PMID:35385250. |
sirt1 upregulates the expression of foxo3a and hsf-1, thus inhibiting apoptosis and maintaining the homeostasis of cellular proteins. |
2022-04-06 |
2023-08-13 |
Not clear |
| Bharathi Priya Lohanathan, Baskaran Rathinasamy, Chih-Yang Huang, Vijaya Padma Viswanadh. Neferine attenuates doxorubicin-induced fibrosis and hypertrophy in H9c2 cells. Journal of biochemical and molecular toxicology. 2022-03-29. PMID:35347819. |
pretreatment with neferine markedly activated sirt1 expression and modulated the expression levels of tgf-β1 and p53, thereby significantly reducing dox-induced fibrosis, hypertrophy, and apoptosis in h9c2 cardiomyoblasts. |
2022-03-29 |
2023-08-13 |
Not clear |
| Tung-Sheng Chen, Wei-Yu Liao, Chi-Wen Huang, Chin-Hsien Chan. Adipose-Derived Stem Cells Preincubated with Green Tea EGCG Enhance Pancreatic Tissue Regeneration in Rats with Type 1 Diabetes through ROS/Sirt1 Signaling Regulation. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328586. |
in an animal model, type 1 diabetes induced the activation of several pathological signals, including islet size reduction, extracellular fibrotic collagen deposition, oxidative stress elevation, survival pathway suppression, apoptosis signaling induction, and sirt1 antioxidant pathway downregulation. |
2022-03-25 |
2023-08-13 |
rat |
| Kirthiram K Sivakumar, Jone A Stanley, Jonathan C Behlen, Liga Wuri, Sudipta Dutta, John Wu, Joe A Arosh, Sakhila K Ban. Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates SIRT1-p53 interaction in Cr(VI)-Induced Apoptosis in the ovary. Reproductive toxicology (Elmsford, N.Y.). 2022-03-21. PMID:35307491. |
the current study determines a role for the sirt1-p53 network in apoptosis induced by cr(vi) in the ovary and establishes physical interaction between sirt1 and p53. |
2022-03-21 |
2023-08-13 |
human |
| Xiaocan Lei, Peng Huo, Yuan-Jie Xie, Yaohui Wang, Guanghai Liu, Haoyan Tu, Qingxiang Shi, Zhong-Cheng Mo, Shun Zhan. Dendrobium nobile Lindl polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats. Molecular reproduction and development. 2022-03-21. PMID:35307908. |
the pathologic changes occurred in the spermatogenic tubules along with the decreased number of spermatogenic cells, downregulated proliferating cell nuclear antigen (pcna) and sirtuin 1 (sirt1) expression and increased cell apoptosis in the testes. |
2022-03-21 |
2023-08-13 |
rat |
| Xiaocan Lei, Peng Huo, Yuan-Jie Xie, Yaohui Wang, Guanghai Liu, Haoyan Tu, Qingxiang Shi, Zhong-Cheng Mo, Shun Zhan. Dendrobium nobile Lindl polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats. Molecular reproduction and development. 2022-03-21. PMID:35307908. |
furthermore, the pathologic changes in the spermatogenic tubules improved significantly with increased number of spermatogenic cells, the upregulation of pcna and sirt1 and suppression of cell apoptosis in the testes. |
2022-03-21 |
2023-08-13 |
rat |
| Xiaocan Lei, Peng Huo, Yuan-Jie Xie, Yaohui Wang, Guanghai Liu, Haoyan Tu, Qingxiang Shi, Zhong-Cheng Mo, Shun Zhan. Dendrobium nobile Lindl polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats. Molecular reproduction and development. 2022-03-21. PMID:35307908. |
collectively, our study for the first time examined the effects of dnlp on the male reproductive system of stz-induced diabetic rats, and indicated that dnlp was protective against diabetes mellitus-induced testis injury via increasing the proliferation, inhibiting cell apoptosis and upregulating sirt1 expression in testicular spermatogenic cells. |
2022-03-21 |
2023-08-13 |
rat |
| James J DiNicolantonio, Mark F McCarty, Simon Iloki Assanga, Lidianys Lewis Lujan, James H O'Keef. Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity. Open heart. vol 9. issue 1. 2022-03-18. PMID:35301252. |
sirt1 promotes 'cell cleansing' and cell survival by boosting autophagy, mitophagy, mitochondrial biogenesis, phase 2 induction of antioxidant enzymes via nrf2, and dna repair-while inhibiting nf-kb-driven inflammation, apoptosis, and cellular senescence, and boosting endothelial expression of the protective transcription factor kruppel-like factor 2. |
2022-03-18 |
2023-08-13 |
Not clear |
| Feng Gao, Yongcheng Zhao, Bin Zhang, Chunwei Xiao, Zhanfa Sun, Yuan Gao, Xueyong Do. SESN1 attenuates the Ox‑LDL‑induced inflammation, apoptosis and endothelial‑mesenchymal transition of human umbilical vein endothelial cells by regulating AMPK/SIRT1/LOX1 signaling. Molecular medicine reports. vol 25. issue 5. 2022-03-16. PMID:35293601. |
an ampk and sirt1 inhibitor reversed the effects of sesn1 overexpression on the inflammatory response, apoptosis and endmt of huvecs exposed to ox‑ldl. |
2022-03-16 |
2023-08-13 |
human |
| Yousef Faridvand, Hamid Kazemzadeh, Vahid Vahedian, Pourya Mirzajanzadeh, Hamid Reza Nejabati, Nasser Safaie, Nazila Fathi Maroufi, Masoud Pezeshkian, Mohammad Nouri, Ahmadreza Jodat. Dapagliflozin attenuates high glucose-induced endothelial cell apoptosis and inflammation through AMPK/SIRT1 activation. Clinical and experimental pharmacology & physiology. 2022-03-11. PMID:35274762. |
then, cell viability, reactive oxygen species (ros), proinflammatory cytokines (il-6 and tnf-α), apoptosis, and sirt1 expression were measured. |
2022-03-11 |
2023-08-13 |
Not clear |
| Min Lei, Guibao Ke, Yan Wang, Dan Luo, Yao H. Long non-coding RNA TUG1 sponges microRNA-9 to protect podocytes from high glucose-induced apoptosis and mitochondrial dysfunction via SIRT1 upregulation. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-28. PMID:35222713. |
long non-coding rna tug1 sponges microrna-9 to protect podocytes from high glucose-induced apoptosis and mitochondrial dysfunction via sirt1 upregulation. |
2022-02-28 |
2023-08-13 |
Not clear |
| Miaomiao Liu, Ying Zhang, Xiantong Cao, Tao Shi, Yang Ya. miR-197 Participates in Lipopolysaccharide-Induced Cardiomyocyte Injury by Modulating SIRT1. Cardiology research and practice. vol 2022. 2022-02-28. PMID:35223094. |
lps restrained viability, the expressions of b-cell lymphoma-2 (bcl-2) and sirt1, but promoted apoptosis, ldh release, and levels of interleukin-6 (il-6), interleukin-1 |
2022-02-28 |
2023-08-13 |
Not clear |
| Weiwei Wei, Xingquan Wang, Yaqing Wei, Shilin Liu, Shengyu Gao, Hao Tian, Dewang S. lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1. Molecular medicine reports. vol 25. issue 4. 2022-02-25. PMID:35211764. |
under hghf conditions, hiec‑6 and sw480 cell viability was inhibited, apoptosis was promoted, tug1 expression was downregulated, and sirt1 and ampk expression levels were upregulated. |
2022-02-25 |
2023-08-13 |
Not clear |
| Weiwei Wei, Xingquan Wang, Yaqing Wei, Shilin Liu, Shengyu Gao, Hao Tian, Dewang S. lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1. Molecular medicine reports. vol 25. issue 4. 2022-02-25. PMID:35211764. |
lncrna tug1 overexpression significantly reversed the effects of hghf on cell viability, apoptosis and sirt1, ampk, ucp2 and bcl‑2 expression levels. |
2022-02-25 |
2023-08-13 |
Not clear |
| Chuang Jiang, Maoxiang Qian, Yoshihiro Gocho, Wentao Yang, Guoqing Du, Shuhong Shen, Jun J Yang, Hui Zhan. Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemia. Blood advances. 2022-02-22. PMID:35192680. |
mechanistically, ectopic sirt1 expression activated mitochondrial activity and sensitized all to panobinostat through activating mitochondria-related apoptosis pathway. |
2022-02-22 |
2023-08-13 |
Not clear |
| Chittaranjan Sahu, Shivani Singla, Gopabandhu Jen. Studies on male gonadal toxicity of bisphenol A in diabetic rats: An example of exacerbation effect. Journal of biochemical and molecular toxicology. 2022-02-21. PMID:35187753. |
the results confirmed that bpa exacerbated the testicular toxicity by altering several biochemical parameters, increasing oxidative stress, cellular/tissue injury, dna damage, apoptosis, and 8-ohdg expression, while decreasing the levels of nrf-2, catalase, sod-1, oct4, and sirt1 expressions in the testes of dia rat. |
2022-02-21 |
2023-08-13 |
rat |
| Peng Ye, Wei Li, Xin Huang, Sheng Zhao, Wu Chen, Yuqi Xia, Weimin Yu, Ting Rao, Jinzhuo Ning, Xiangjun Zhou, Yuan Ruan, Fan Chen. BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis. Journal of cellular and molecular medicine. 2022-02-17. PMID:35174626. |
in addition, under hypoxia and reoxygenation (h/r) stimulation, bmal1 knockdown decreased the level of sirt1 and exacerbated the degree of mitochondrial damage and apoptosis. |
2022-02-17 |
2023-08-13 |
rat |
| Zhongzan Cao, Ben Ma, Chengyu Cui, Jiahui Zhao, Sidi Liu, Yunqiao Qiu, Yan Zheng, Ming Gao, Xinhong Lua. Protective effects of AdipoRon on the liver of Huoyan goose fed a high-fat diet. Poultry science. vol 101. issue 4. 2022-02-12. PMID:35150940. |
the results indicated that adiporon could alter the expression of lipid metabolism-related genes, inflammatory factors, apoptosis and autophagy genes, and adiponectin and its receptor genes in liver tissues through signaling pathways such as ampk and p38 mapk, as well as the involvement of transcription factors such as pparα, pparγ, sirt1, and foxo1, reduce the lipid content in blood and liver tissues of geese fed high-fat diets, improve liver antioxidant capacity, regulate apoptosis and autophagy of hepatocytes, and reduce liver inflammatory injury. |
2022-02-12 |
2023-08-13 |
Not clear |
| Xinzhu Liu, Dawei Li, Zhaoxing Liu, Yaoyao Song, Bohan Zhang, Yu Zang, Wen Zhang, Yuezeng Niu, Chuan'an She. Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns. Burns : journal of the International Society for Burn Injuries. 2022-02-06. PMID:35123833. |
silent information regulator of transcription 1 (sirt1) can decrease oxidative stress and apoptosis of islets in diabetes mellitus. |
2022-02-06 |
2023-08-13 |
mouse |