| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hend Mohamed Anwar, Sherin Ramadan Hamad, Gad Elsayed Mohamed Salem, Rania Hassan Mohamed Soliman, Eman Maher Elba. Inflammatory Modulation of miR-155 Inhibits Doxorubicin-Induced Testicular Dysfunction via SIRT1/FOXO1 Pathway: Insight into the Role of Acacetin and Bacillus cereus Protease. Applied biochemistry and biotechnology. 2022-06-17. PMID:35715546. |
aberrant testicular mir-34c, a germ-specific mirna, and mir-155 expressions were observed, along with decreased protein expression of sirtuin1 (sirt1) dependent forkhead box 1 (foxo1) acetylation which induces apoptosis. |
2022-06-17 |
2023-08-14 |
rat |
| Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Che. 18β-Glycyrrhetinic Acid Protects against Cholestatic Liver Injury in Bile Duct-Ligated Rats. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624826. |
the concurrent or concomitant activation of sirt1, fxr, and nrf2 not only restored the homeostatic regulation of bile acid metabolism, but also alleviated oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis. |
2022-05-28 |
2023-08-13 |
rat |
| Zhijun Zeng, Cong Chen, Ying Situ, Zhibin Shen, Yanfen Chen, Zhisi Zhang, Chunping Tang, Tao Jian. Anoectochilus roxburghii flavonoids extract ameliorated the memory decline and reduced neuron apoptosis via modulating SIRT1 signaling pathway in senescent mice. Journal of ethnopharmacology. 2022-05-24. PMID:35609756. |
anoectochilus roxburghii flavonoids extract ameliorated the memory decline and reduced neuron apoptosis via modulating sirt1 signaling pathway in senescent mice. |
2022-05-24 |
2023-08-13 |
mouse |
| Soudabeh Balarastaghi, Samira Barangi, Hossein Hosseinzadeh, Mohsen Imenshahidi, Zahra Moosavi, Bibi Marjan Razavi, Gholamreza Karim. Melatonin improves arsenic-induced hypertension through the inactivation of the Sirt1/autophagy pathway in rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-22. PMID:35598369. |
the systolic blood pressure (sbp) changes, oxidative stress markers, the aorta histopathological injuries, contractile and relaxant responses, the level of apoptosis (bnip3 and caspase-3) and autophagy (sirt1, beclin-1 and lc3 ii/i ratio) proteins were determined in rats aorta. |
2022-05-22 |
2023-08-13 |
rat |
| Soudabeh Balarastaghi, Samira Barangi, Hossein Hosseinzadeh, Mohsen Imenshahidi, Zahra Moosavi, Bibi Marjan Razavi, Gholamreza Karim. Melatonin improves arsenic-induced hypertension through the inactivation of the Sirt1/autophagy pathway in rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-22. PMID:35598369. |
the levels of ho-1 and nrf-2, apoptosis markers, sirt1, and autophagy proteins also enhanced in as group. |
2022-05-22 |
2023-08-13 |
rat |
| Guozhong Chen, Xiaoyun Shan, Lin Li, Lihua Dong, Guiyuan Huang, Hongmiao Ta. circHIPK3 regulates apoptosis and mitochondrial dysfunction induced by ischemic stroke in mice by sponging miR-148b-3p via CDK5R1/SIRT1. Experimental neurology. 2022-05-16. PMID:35576990. |
mechanistically, circhipk3 functions as an endogenous sponge of mir-148b-3p to decrease its activity, resulting in upregulation of cdk5r1 and cdk5 expression, downregulation of sirt1 expression and subsequent bmec apoptosis and mitochondrial dysfunction. |
2022-05-16 |
2023-08-13 |
mouse |
| Shisheng Jiang, Chaoming Huang, Guodong Zheng, Wei Yi, Bo Wu, Junyuan Tang, Xiawen Liu, Biyun Huang, Dan Wu, Tingdong Yan, Mingxi Li, Chunpeng Wan, Yi Ca. EGCG Inhibits Proliferation and Induces Apoptosis Through Downregulation of SIRT1 in Nasopharyngeal Carcinoma Cells. Frontiers in nutrition. vol 9. 2022-05-13. PMID:35548580. |
egcg inhibits proliferation and induces apoptosis through downregulation of sirt1 in nasopharyngeal carcinoma cells. |
2022-05-13 |
2023-08-13 |
human |
| Fei Tang, Fengmei Wang, Hongmin Lv, Huiling Xiang, Yi Liu, Ping Li. Retracted Article: MicroRNA-1271 modulates hepatitis B virus replication, cell proliferation and apoptosis in hepatitis B virus-related hepatocellular carcinoma by targeting SIRT1. RSC advances. vol 9. issue 68. 2022-05-11. PMID:35541395. |
retracted article: microrna-1271 modulates hepatitis b virus replication, cell proliferation and apoptosis in hepatitis b virus-related hepatocellular carcinoma by targeting sirt1. |
2022-05-11 |
2023-08-13 |
Not clear |
| Fei Tang, Fengmei Wang, Hongmin Lv, Huiling Xiang, Yi Liu, Ping Li. Retracted Article: MicroRNA-1271 modulates hepatitis B virus replication, cell proliferation and apoptosis in hepatitis B virus-related hepatocellular carcinoma by targeting SIRT1. RSC advances. vol 9. issue 68. 2022-05-11. PMID:35541395. |
moreover, overexpression of sirt1 reversed the effects of mir-1271 overexpression on hbv replication, cell proliferation and apoptosis in hbv-related hcc cells. |
2022-05-11 |
2023-08-13 |
Not clear |
| Zhaohui Cao, Zhuan Wu, Tingting Duan, Cifei Tang, Di Huang, Xiaobo H. Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells. Acta biochimica et biophysica Sinica. vol 54. issue 3. 2022-05-10. PMID:35538036. |
in sum, curcumin inhibits the perk-chop pathway of er stress mediated by sirt1 and thus ameliorates ho-induced min6 cell apoptosis, suggesting that curcumin and sirt1 may provide a potential therapeutic approach for t1dm. |
2022-05-10 |
2023-08-13 |
mouse |
| Tian Su, Zhen Wang, Zhengyi Zhang, Zhanwu Hou, Xiao Han, Fei Yang, Huadong Li. Resveratrol regulates Hsp60 in HEK 293T cells during activation of SIRT1 revealed by nascent protein labeling strategy. Food & nutrition research. vol 66. 2022-05-06. PMID:35517847. |
resveratrol, a well-known natural compound and nutrient, activates the deacetylation ability of sirt1, demonstrating p53-dependent apoptosis functions in many diseases. |
2022-05-06 |
2023-08-13 |
Not clear |
| Longxing Miao, Yijun Yang, Zhongwen Li, Zengjun Fang, Yongqing Zhang, Chun-Chao Ha. Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects. Journal of ginseng research. vol 46. issue 2. 2022-05-05. PMID:35509822. |
the underlying mechanism is involved in an inhibition of oxidative stress, ros generation, inflammation and apoptosis via regulation of various cellular signaling pathways and molecules, including akt/shp, mapk, egfr/sox2, tgf-β1/smad, sirt1, gpr120/ampk/ho-1 and nf-κb. |
2022-05-05 |
2023-08-13 |
Not clear |
| Xiao Zhu, Yihan Liu, Jia Cui, Jianyi Lv, Changlong Li, Jing Lu, Xueyun Huo, Jingtao Dou, Zhigang Bai, Zhenwen Chen, Xiaoyan D. LncRNA LYPLAL1-DT screening from type 2 diabetes with macrovascular complication contributes protective effects on human umbilical vein endothelial cells via regulating the miR-204-5p/SIRT1 axis. Cell death discovery. vol 8. issue 1. 2022-05-04. PMID:35508613. |
mechanistically, lyplal1-dt acts as competing endogenous rna (cerna) by downregulating mir-204-5p, therefore enhancing sirt1 and protecting ec autophagy function; thus, alleviating apoptosis. |
2022-05-04 |
2023-08-13 |
human |
| Xiangrong Chen, Guan Wei, Ding Li, Youwu Fan, Yile Zeng, Zhengting Qian, Zhen Jia, Yong Tang, Yan Shi, Heming Wu, Xiang L. Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats. Brain research bulletin. 2022-04-29. PMID:35487384. |
our previous study demonstrated that sirt1 alleviates neuroinflammation-induced apoptosis after tbi, and activation of the pgc-1α/nrf2 pathway extenuates tbi-induced neuronal apoptosis. |
2022-04-29 |
2023-08-13 |
rat |
| Zhaohui Liu, Chunlei Li, Yan Li, Lili Yu, Min Q. Propofol Reduces Renal Ischemia Reperfusion-mediated Necroptosis by Up-regulation of SIRT1 in Rats. Inflammation. 2022-04-23. PMID:35460396. |
in conclusion, these results propose that pro attenuates ri/r-induced inflammation, oxidative stress, apoptosis, and necroptosis by up-regulation of sirt1 in rats. |
2022-04-23 |
2023-08-13 |
rat |
| Jie Wang A, Yufeng Tang, Jingjing Zhang, Jie Wang B, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian G. Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2. Redox biology. vol 52. 2022-04-22. PMID:35452917. |
further studies indicated that sirt1 exerted these beneficial effects by markedly attenuating dox-induced oxidative damage and apoptosis in a sesn2-dependent manner. |
2022-04-22 |
2023-08-13 |
mouse |
| Hongbin Li, Xiaoxuan Niu, Huijuan Shi, Min Feng, Yuming Du, Rongqing Sun, Ning Ma, Haili Wang, Dan Wei, Min Ga. circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury. Laboratory investigation; a journal of technical methods and pathology. 2022-04-20. PMID:35440759. |
silencing pik3ca and/or sirt1 reversed the effect of circhectd1 overexpression on the apoptosis of lps-induced hbe and mle-12 cells. |
2022-04-20 |
2023-08-13 |
mouse |
| Laura Fishe. Retraction: MicroRNA-1271 modulates hepatitis B virus replication, cell proliferation and apoptosis in hepatitis B virus-related hepatocellular carcinoma by targeting SIRT1. RSC advances. vol 11. issue 10. 2022-04-15. PMID:35427030. |
retraction: microrna-1271 modulates hepatitis b virus replication, cell proliferation and apoptosis in hepatitis b virus-related hepatocellular carcinoma by targeting sirt1. |
2022-04-15 |
2023-08-13 |
Not clear |
| Kai-Xuan Wang, Chen Yan, Xu Yang, Pei-Yan Zhu, Wen-Wen Cui, Cong Ye, Kan Hu, Ting Lan, Lin-Yan Huang, Wan Wang, Ping Ma, Su-Hua Qi, Bing Gu, Lan Lu. Enhanced autophagy promotes radiosensitivity by mediating Sirt1 downregulation in RM-1 prostate cancer cells. Biochemical and biophysical research communications. vol 609. 2022-04-14. PMID:35421633. |
notably, overexpression of sirt1 by plasmid significantly alleviated radiation-induced apoptosis, but silenced sirt1 by sirna further induced apoptosis, indicating the radioprotective effect of sirt1 on rm-1 cells. |
2022-04-14 |
2023-08-13 |
Not clear |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
moreover, overexpression of sirt1 in the hippocampal tissues of rats with ch and improved rat behavior, while reducing the ch-induced nerve cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |