| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Wang, Yutong Sui, Ye Niu, Dan Liu, Qi Xu, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Jiahong Shi, Xiaomei Liu, Jinyu Li. PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis. Stem cell reviews and reports. 2022-08-12. PMID:35962175. |
a recent study from our lab showed that pre-b-cell leukemia transcription factor1 (pbx1) overexpression attenuates hair follicle-derived mesenchymal stem cells (hf-mscs) senescence and apoptosis by regulating ros-mediated dna damage via parp1 downregulation; thus, suggesting that parp1 downregulation is a common manifestation of the roles of both pbx1 and sirt1 in hf-mscs senescence attenuation, and implying a potential link between pbx1 and sirt1. |
2022-08-12 |
2023-08-14 |
Not clear |
| Yuan Wang, Yutong Sui, Ye Niu, Dan Liu, Qi Xu, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Jiahong Shi, Xiaomei Liu, Jinyu Li. PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis. Stem cell reviews and reports. 2022-08-12. PMID:35962175. |
to this end, hf-mscs overexpressing pbx1, overexpressing both pbx1 and parp1, downregulating sirt1, and overexpressing pbx1 as well as downregulating sirt1 were generated, and senescence, apoptosis, dna damage, and repair biomarkers were analyzed. |
2022-08-12 |
2023-08-14 |
Not clear |
| Yuan Wang, Yutong Sui, Ye Niu, Dan Liu, Qi Xu, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Jiahong Shi, Xiaomei Liu, Jinyu Li. PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis. Stem cell reviews and reports. 2022-08-12. PMID:35962175. |
our results showed that (1) pbx1 overexpression alleviated hf-mscs senescence and apoptosis accompanied by sirt1 upregulation, parp1 downregulation, and increased intracellular nad and atp levels. |
2022-08-12 |
2023-08-14 |
Not clear |
| Yuan Wang, Yutong Sui, Ye Niu, Dan Liu, Qi Xu, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Jiahong Shi, Xiaomei Liu, Jinyu Li. PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis. Stem cell reviews and reports. 2022-08-12. PMID:35962175. |
(2) sirt1 knockdown enhanced cellular senescence and apoptosis, accompanied by increased ros accumulation, dna damage aggravation, and decreased intracellular nad and atp levels. |
2022-08-12 |
2023-08-14 |
Not clear |
| Yuan Wang, Yutong Sui, Ye Niu, Dan Liu, Qi Xu, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Jiahong Shi, Xiaomei Liu, Jinyu Li. PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis. Stem cell reviews and reports. 2022-08-12. PMID:35962175. |
(3) pbx1 overexpression rescued hf-mscs senescence and apoptosis induced by sirt1 knockdown. |
2022-08-12 |
2023-08-14 |
Not clear |
| Juan Zhao, Yong Tan, Zhe Feng, Yahong Zhou, Feihong Wang, Ge Zhou, Jing Yan, Xiaowei Ni. Catalpol attenuates polycystic ovarian syndrome by regulating sirtuin 1 mediated NF-κB signaling pathway. Reproductive biology. vol 22. issue 3. 2022-07-29. PMID:35905692. |
the viability, proliferation and apoptosis of cells and the levels of sirt1 and nf-κb pathway-related proteins were measured. |
2022-07-29 |
2023-08-14 |
human |
| Juan Zhao, Yong Tan, Zhe Feng, Yahong Zhou, Feihong Wang, Ge Zhou, Jing Yan, Xiaowei Ni. Catalpol attenuates polycystic ovarian syndrome by regulating sirtuin 1 mediated NF-κB signaling pathway. Reproductive biology. vol 22. issue 3. 2022-07-29. PMID:35905692. |
silencing sirt1 increased the viability and proliferation, whilst decreased the apoptosis of cat-treated kgn cells. |
2022-07-29 |
2023-08-14 |
human |
| Ruike Wang, Mingzhi Yang, Yingying Wu, Rundong Liu, Mengchen Liu, Qiong Li, Xiao Su, Yongjuan Xin, Wenqian Huo, Qihong Deng, Yue Ba, Hui Huan. SIRT1 modifies DNA methylation linked to synaptic deficits induced by Pb in vitro and in vivo. International journal of biological macromolecules. 2022-07-15. PMID:35839949. |
in vitro results showed that after the treatment with srt1720, the expression of sirt1 was activated and thus reversed the effect on dnmts, mecp2, apoptosis and synaptic plasticity-related genes and their dna methylation levels induced by pb exposure. |
2022-07-15 |
2023-08-14 |
rat |
| Fuquan Wang, Jiamin Ma, Jingxu Wang, Ming Chen, Haifa Xia, Shanglong Yao, Dingyu Zhan. SIRT1 ameliorated septic associated-lung injury and macrophages apoptosis via inhibiting endoplasmic reticulum stress. Cellular signalling. 2022-07-10. PMID:35811055. |
sirt1 ameliorated septic associated-lung injury and macrophages apoptosis via inhibiting endoplasmic reticulum stress. |
2022-07-10 |
2023-08-14 |
Not clear |
| Yong Jung Kang, Young Hoon Kwon, Jung Yoon Jang, Jun Ho Lee, Sanggwon Lee, Yujin Park, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells. Biomolecules & therapeutics. 2022-07-10. PMID:35811306. |
mhy2251, a new sirt1 inhibitor, induces apoptosis via jnk/p53 pathway in hct116 human colorectal cancer cells. |
2022-07-10 |
2023-08-14 |
human |
| Yunxin Zhou, Fan Zhang, Junying Din. As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases. Immune network. vol 22. issue 3. 2022-07-08. PMID:35799705. |
among 7 types of sirtuins, silent information regulator type-1 (sirt1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. |
2022-07-08 |
2023-08-14 |
human |
| Jiayi Yan, Jue Wang, John Cijiang He, Yifei Zhon. Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1. Frontiers in endocrinology. vol 13. 2022-07-07. PMID:35795148. |
sirtuin 1 (sirt1), a nad+-dependent deacetylases, has significant renal protective effects through its regulation of fibrosis, apoptosis, and senescence, oxidative stress, inflammation and aging process. |
2022-07-07 |
2023-08-14 |
Not clear |
| Zhuo Wan. Peri-implant crevicular fluid SIRT1 levels decrease in patients with peri-implant inflammatory: A prospective observational study. Transplant immunology. 2022-07-05. PMID:35781023. |
sirtuin1 (sirt1) molecule, a nicotinamide adenine dinucleotide (nad)-dependent histone deacetylase, regulates a variety of physiological and pathological processes, including oxidative stress, metabolism, cell proliferation, cell differentiation, inflammatory, and apoptosis. |
2022-07-05 |
2023-08-14 |
Not clear |
| Wang Peipei, Wang Ping, Yin Miaomiao, Wang Shu. Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. Allergologia et immunopathologia. vol 50. issue 4. 2022-07-05. PMID:35789410. |
lps-induced hk-2 cells were pretreated with sev in the absence or presence of ex527, an inhibitor of sirtuin 1 (sirt1), after which were the detection of cell viability, lactate dehydrogenase (ldh) release, apoptosis, inflammation, and oxidative stress. |
2022-07-05 |
2023-08-14 |
human |
| Wang Peipei, Wang Ping, Yin Miaomiao, Wang Shu. Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. Allergologia et immunopathologia. vol 50. issue 4. 2022-07-05. PMID:35789410. |
in conclusion, sev effectively protected hk-2 cells against lps-induced apoptosis, inflammation, and oxidative stress, and these effects may depend on the increase of sirt1 expression, thereby inactivating nf-κb signaling. |
2022-07-05 |
2023-08-14 |
human |
| Wenli Liao, Zhiwei Rao, Lingling Wu, Yong Chen, Cairong L. Cariporide Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation and Apoptosis Partly Through Regulation of Akt/GSK-3β and Sirt1 Signaling Pathway. Frontiers in pharmacology. vol 13. 2022-06-24. PMID:35747748. |
cariporide attenuates doxorubicin-induced cardiotoxicity in rats by inhibiting oxidative stress, inflammation and apoptosis partly through regulation of akt/gsk-3β and sirt1 signaling pathway. |
2022-06-24 |
2023-08-14 |
rat |
| Jay R Dave, Sayali S Chandekar, Shubhanath Behera, Kaushik U Desai, Pradnya M Salve, Neha B Sapkal, Suhas T Mhaske, Ankush M Dewle, Parag S Pokare, Megha Page, Ajay Jog, Pankaj A Chivte, Rupesh K Srivastava, Geetanjali B Toma. Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age. Science advances. vol 8. issue 25. 2022-06-24. PMID:35749495. |
an increased expression of p53 and sirt1 with donor age was correlated to their ability of eliminating tumorigenic events through apoptosis or autophagy, respectively. |
2022-06-24 |
2023-08-14 |
mouse |
| LiGuo Song, LuYan Mu, HongLiang Wan. MicroRNA-489-3p aggravates neuronal apoptosis and oxidative stress after cerebral ischemia-reperfusion injury. Bioengineered. vol 13. issue 6. 2022-06-22. PMID:35730531. |
down-regulating mir-489-3p or up-regulating sirt1 ameliorated behavioral dysfunction, neuronal damage and apoptosis, oxidative stress and brain histopathology. |
2022-06-22 |
2023-08-14 |
mouse |
| LiGuo Song, LuYan Mu, HongLiang Wan. MicroRNA-489-3p aggravates neuronal apoptosis and oxidative stress after cerebral ischemia-reperfusion injury. Bioengineered. vol 13. issue 6. 2022-06-22. PMID:35730531. |
taken together, by targeting sirt1, elevated mir-489-3p aggravates ciri-induced neuronal apoptosis and oxidative stress. |
2022-06-22 |
2023-08-14 |
mouse |
| Yuting Chen, Hui Yang, Shaoyun Chen, Zhaohong Lu, Boxin Li, Tikeng Jiang, Mei Xuan, Ruifang Ye, Hairong Liang, Xiaoshan Liu, Qizhan Liu, Huanwen Tan. SIRT1 regulated hexokinase-2 promoting glycolysis is involved in hydroquinone-enhanced malignant progression in human lymphoblastoid TK6 cells. Ecotoxicology and environmental safety. vol 241. 2022-06-17. PMID:35714482. |
knockdown of sirt1 or inhibition of glycolysis using the glycolytic inhibitor 2-deoxy-d-glucose (2-dg) downregulated the levels of sirt1 and glycolytic enzymes and significantly enhanced hq-induced cell apoptosis, although knockdown of sirt1 or 2-dg alone had little effect on apoptosis. |
2022-06-17 |
2023-08-14 |
mouse |