| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Zhu, Chuan H. Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB. Journal of natural medicines. 2022-01-30. PMID:35094239. |
crocetin alleviates the caerulein-induced apoptosis and inflammation in ar42j cells by activating sirt1 via nf-κb. |
2022-01-30 |
2023-08-13 |
Not clear |
| Lin Zhu, Chuan H. Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB. Journal of natural medicines. 2022-01-30. PMID:35094239. |
after knockdown of sirt1, cell viability, apoptosis and inflammation were measured again by corresponding kits. |
2022-01-30 |
2023-08-13 |
Not clear |
| Lin Zhu, Chuan H. Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB. Journal of natural medicines. 2022-01-30. PMID:35094239. |
on the whole, we presented the first evidence for the importance of sirt1-nf-κb axis in acute pancreatitis and proposed that crocetin alleviates the caerulein-induced apoptosis and inflammation in ar42j cells by activating sirt1 via nf-κb. |
2022-01-30 |
2023-08-13 |
Not clear |
| Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi, Huijun Dua. NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy. Journal of translational medicine. vol 20. issue 1. 2022-01-29. PMID:35090502. |
nad(p)h: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating sirt1 in diabetic nephropathy. |
2022-01-29 |
2023-08-13 |
Not clear |
| Linh Ho, Nazir Hossen, Trieu Nguyen, Au Vo, Fakhrul Ahsa. Epigenetic Mechanisms as Emerging Therapeutic Targets and Microfluidic Chips Application in Pulmonary Arterial Hypertension. Biomedicines. vol 10. issue 1. 2022-01-21. PMID:35052850. |
data analyses from experimental cell models and animal induced pah models have demonstrated that significant changes in the expression levels of multiple epigenetics modifiers such as hdms, hdacs, sirtuins (sirt1 and sirt3), and brd4 correlate strongly with proliferation, apoptosis, inflammation, and fibrosis linked to the pathological vascular remodeling during pah development. |
2022-01-21 |
2023-08-13 |
Not clear |
| Ying Xin, Yifeng Zhang, Simin Deng, Xinqun H. Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Hepatic Ischemia/Reperfusion Injury in Rats. Frontiers in pharmacology. vol 12. 2022-01-20. PMID:35046803. |
our results showed that throughout the hepatic i/r process, vns significantly reduced inflammation, oxidative stress, and apoptosis, while significantly increasing the protein levels of silent information regulator 1 (sirt1) and decreasing the levels of acetylated forkhead box o1 and ac-p53, in the skeletal muscle. |
2022-01-20 |
2023-08-13 |
rat |
| Ying Xin, Yifeng Zhang, Simin Deng, Xinqun H. Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Hepatic Ischemia/Reperfusion Injury in Rats. Frontiers in pharmacology. vol 12. 2022-01-20. PMID:35046803. |
these data suggest that vns can alleviate hepatic i/r injury-induced acute skeletal muscle injury by suppressing inflammation, oxidative stress, and apoptosis, potentially via the sirt1 pathway. |
2022-01-20 |
2023-08-13 |
rat |
| Tomohiro Kozako, Naho Kato, Takeo Ohsugi, Yu-Ichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuki Higaki, Haruna Sato, Akiyoshi Aikawa, Shin-Ichiro Hond. SRT1720 induces SIRT1-independent cell death in adult T-cell leukemia/lymphoma. The FEBS journal. 2022-01-14. PMID:35029032. |
sirt1 is a histone deacetylase involved in the cell cycle and apoptosis. |
2022-01-14 |
2023-08-13 |
mouse |
| Tomohiro Kozako, Naho Kato, Takeo Ohsugi, Yu-Ichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuki Higaki, Haruna Sato, Akiyoshi Aikawa, Shin-Ichiro Hond. SRT1720 induces SIRT1-independent cell death in adult T-cell leukemia/lymphoma. The FEBS journal. 2022-01-14. PMID:35029032. |
our study shows that while srt1720 does not target sirt1, it induces cell death in atl cells via apoptosis and autophagy, and has anti-tumor activity. |
2022-01-14 |
2023-08-13 |
mouse |
| Juan-Juan Li, Mei-Ling Liu, Jia-Ni Lv, Rui-Lin Chen, Ke Ding, Jia-Qi H. Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways. International immunopharmacology. vol 104. 2022-01-09. PMID:34999393. |
polysaccharides from platycodonis radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of mir-181a-mediated hippo and sirt1 pathways. |
2022-01-09 |
2023-08-13 |
mouse |
| Juan-Juan Li, Mei-Ling Liu, Jia-Ni Lv, Rui-Lin Chen, Ke Ding, Jia-Qi H. Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways. International immunopharmacology. vol 104. 2022-01-09. PMID:34999393. |
mechanistically, prp had the similar effects as mir-181a-5p antagomir on rsv-induced apoptosis and inflammation in hep-2 cells via upregulating bcl2, mll3 and sirt1, which could be reversed by mir-181a-5p mimic. |
2022-01-09 |
2023-08-13 |
mouse |
| Juan-Juan Li, Mei-Ling Liu, Jia-Ni Lv, Rui-Lin Chen, Ke Ding, Jia-Qi H. Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways. International immunopharmacology. vol 104. 2022-01-09. PMID:34999393. |
therefore, it demonstrated that prp not only protected against rsv-induced lung inflammation in mice but also inhibited apoptosis of rsv-infected hep-2 cells via suppressing mir-181a-5p and transcriptionally activating hippo and sirt1 pathways. |
2022-01-09 |
2023-08-13 |
mouse |
| Yunyun Zhuo, Haoming Wang, Luetao Zou, Yiyang Wang, Yanzhu Hu, Pei Li, Qiang Zho. SIRT1 Attenuates Apoptosis of Nucleus Pulposus Cells by Targeting Interactions between LC3B and Fas under High-Magnitude Compression. Oxidative medicine and cellular longevity. vol 2021. 2022-01-06. PMID:34987698. |
sirt1 attenuates apoptosis of nucleus pulposus cells by targeting interactions between lc3b and fas under high-magnitude compression. |
2022-01-06 |
2023-08-13 |
rat |
| Yunyun Zhuo, Haoming Wang, Luetao Zou, Yiyang Wang, Yanzhu Hu, Pei Li, Qiang Zho. SIRT1 Attenuates Apoptosis of Nucleus Pulposus Cells by Targeting Interactions between LC3B and Fas under High-Magnitude Compression. Oxidative medicine and cellular longevity. vol 2021. 2022-01-06. PMID:34987698. |
in this study, we investigated the involvement of mammalian silent information regulator 2 homolog (sirt1) in npc apoptosis under high-magnitude compression. |
2022-01-06 |
2023-08-13 |
rat |
| Yunyun Zhuo, Haoming Wang, Luetao Zou, Yiyang Wang, Yanzhu Hu, Pei Li, Qiang Zho. SIRT1 Attenuates Apoptosis of Nucleus Pulposus Cells by Targeting Interactions between LC3B and Fas under High-Magnitude Compression. Oxidative medicine and cellular longevity. vol 2021. 2022-01-06. PMID:34987698. |
our results showed that high-magnitude compression aggravated cellular apoptosis and attenuated the expression levels of sirt1 and microtubule-associated protein-1 light chain-3b (lc3b) in rat npcs in a three-dimensional (3d) cell culture model and an in vivo rat tail compression model, whereas sirt1 overexpression in npcs partially reversed these indicators. |
2022-01-06 |
2023-08-13 |
rat |
| Qian Yu, Jin Zhao, Baotang Li. Bazedoxifene activates the angiotensin II-induced HUVEC hypertension model by targeting SIRT1. Experimental and therapeutic medicine. vol 23. issue 2. 2021-12-31. PMID:34970343. |
the protein expression of sirtuin 1 (sirt1), oxidative stress-related proteins and apoptosis-related proteins was detected using western blotting, and apoptosis was detected using a tunel assay. |
2021-12-31 |
2023-08-13 |
human |
| Qian Yu, Jin Zhao, Baotang Li. Bazedoxifene activates the angiotensin II-induced HUVEC hypertension model by targeting SIRT1. Experimental and therapeutic medicine. vol 23. issue 2. 2021-12-31. PMID:34970343. |
furthermore, bazedoxifene activated sirt1 to promote the proliferation and inhibit the oxidative stress and apoptosis of angii-induced huvecs. |
2021-12-31 |
2023-08-13 |
human |
| Khairy A Ibrahim, Hala A Abdelgaid, Mohammed Eleyan, Rania A Mohamed, Noha M Gami. Resveratrol alleviates cardiac apoptosis following exposure to fenitrothion by modulating the sirtuin1/c-Jun N-terminal kinases/p53 pathway through pro-oxidant and inflammatory response improvements: In vivo and in silico studies. Life sciences. 2021-12-30. PMID:34968465. |
here, we have evaluated the possible ameliorative roles of resveratrol (rsv) against fnt-induced cardiac apoptosis in male rats through the sirtuin1 (sirt1)/c-jun n-terminal kinase (c-jnk)/p53 pathway concerning pro-oxidant and inflammatory cytokines. |
2021-12-30 |
2023-08-13 |
rat |
| Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zh. l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943060. |
the cytoprotective effect of l-arg was restricted by the sirt1 inhibitor ex527, which led to an increase in ros level, apoptosis rate, and decreased cell mmp. |
2021-12-24 |
2023-08-13 |
Not clear |
| Li Shan, Haiyong Zhang, Ying Han, Ruijuan Kuan. Expression and mechanism of microRNA 195 in diabetic retinopathy. Endocrine journal. 2021-12-23. PMID:34937832. |
in addition, human retinal endothelial cells and human dermal microvascular endothelial cells were cultured in a high-glucose environment to detect the targeted relationship between mir-195 and sirt1; determine the mrna and protein expression levels of sirt1, bax, and bcl-2 after mir-195 knockdown; and assess the levels of cell proliferation and apoptosis. |
2021-12-23 |
2023-08-13 |
human |