| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingshan Ji, Jing Han, Lisong Wang, Jiajia Liu, Yiran Dong, Kai Zhu, Lei Sh. MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy. Cell cycle (Georgetown, Tex.). vol 19. issue 21. 2021-10-22. PMID:33064974. |
mir-34a overexpression inhibited proliferation and promoted apoptosis of rvecs, which was effectively abolished by sirt1 up-regulation. |
2021-10-22 |
2023-08-13 |
rat |
| Qingshan Ji, Jing Han, Lisong Wang, Jiajia Liu, Yiran Dong, Kai Zhu, Lei Sh. MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy. Cell cycle (Georgetown, Tex.). vol 19. issue 21. 2021-10-22. PMID:33064974. |
in summary, our data demonstrate that mir-34a promotes apoptosis of rvecs by targeting sirt1 in dr rats. |
2021-10-22 |
2023-08-13 |
rat |
| Yulu Wang, Shichao Gao, Victor Zheng, Ling Chen, Min Ma, Shichen Shen, Jun Qu, Hanting Zhang, Mark E Gurney, James M O'Donnell, Ying X. A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway. Frontiers in cell and developmental biology. vol 8. 2021-10-22. PMID:33363155. |
inhibition of pde4d alters the expression of protein kinase a (pka), sirt1, akt, and bcl-2/bax which are components of signaling pathways for regulating endocrine response, stress resistance, neuronal autophagy, and apoptosis. |
2021-10-22 |
2023-08-13 |
mouse |
| Ruijuan Guan, Hongwei Yao, Ziying Li, Jing Qian, Liang Yuan, Zhou Cai, Mingjing Ding, Wei Liu, Jingyi Xu, Yuanyuan Li, Dejun Sun, Jian Wang, Wenju L. Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 183. issue 2. 2021-10-22. PMID:34515779. |
sodium tanshinone iia sulfonate attenuates cigarette smoke extract-induced mitochondrial dysfunction, oxidative stress, and apoptosis in alveolar epithelial cells by enhancing sirt1 pathway. |
2021-10-22 |
2023-08-13 |
mouse |
| Ruijuan Guan, Hongwei Yao, Ziying Li, Jing Qian, Liang Yuan, Zhou Cai, Mingjing Ding, Wei Liu, Jingyi Xu, Yuanyuan Li, Dejun Sun, Jian Wang, Wenju L. Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 183. issue 2. 2021-10-22. PMID:34515779. |
sirtuin 1 (sirt1) is able to attenuate mitochondrial dysfunction, oxidative stress, and to modulate apoptosis. |
2021-10-22 |
2023-08-13 |
mouse |
| Ruijuan Guan, Hongwei Yao, Ziying Li, Jing Qian, Liang Yuan, Zhou Cai, Mingjing Ding, Wei Liu, Jingyi Xu, Yuanyuan Li, Dejun Sun, Jian Wang, Wenju L. Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 183. issue 2. 2021-10-22. PMID:34515779. |
the protective effects of sts were associated with sirt1 upregulation, because sirt1 inhibition by ex 527 significantly attenuated or abolished the ability of sts to reverse the cse-induced mitochondrial damage, oxidative stress, and apoptosis in a549 cells. |
2021-10-22 |
2023-08-13 |
mouse |
| Ruijuan Guan, Hongwei Yao, Ziying Li, Jing Qian, Liang Yuan, Zhou Cai, Mingjing Ding, Wei Liu, Jingyi Xu, Yuanyuan Li, Dejun Sun, Jian Wang, Wenju L. Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 183. issue 2. 2021-10-22. PMID:34515779. |
in conclusion, sts ameliorates cse-induced aec apoptosis by improving mitochondrial function and reducing oxidative stress via enhancing sirt1 pathway. |
2021-10-22 |
2023-08-13 |
mouse |
| Li-Jing Yang, Yan Chen, Jing He, Sha Yi, Lu Wen, Shuai Zhao, Guo-Hui Cu. Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783411. |
this activity is associated with the accumulation of ros, which contributes to the activation of caspase-3 and the cleavage of poly (adp-ribose) polymerase (parp), accompanied with apoptosis in rpmi-8226 cells treated with ga. mammalian sirt1, as the closest homolog of the yeast sir2, was extensively involved in regulating cell processes, including cell senescence, aging and neuronal protection, as well as having anti-apoptotic properties. |
2021-10-21 |
2023-08-12 |
Not clear |
| Li-Jing Yang, Yan Chen, Jing He, Sha Yi, Lu Wen, Shuai Zhao, Guo-Hui Cu. Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783411. |
in conclusion, our study found that ga is able to induce apoptosis in rpmi-8226 cells via ros accumulation followed by caspase-3 activation, parp cleavage and sirt1 downregulation. |
2021-10-21 |
2023-08-12 |
Not clear |
| Haruko Hiraike, Osamu Wada-Hiraike, Shunsuke Nakagawa, Shigehira Saji, Daichi Maeda, Yuichiro Miyamoto, Kenbun Sone, Michihiro Tanikawa, Katsutoshi Oda, Keiichi Nakagawa, Tetsu Yano, Masashi Fukayama, Yuji Taketan. Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer. Experimental and therapeutic medicine. vol 2. issue 6. 2021-10-21. PMID:22977628. |
dbc1/kiaa1967 (deleted in breast cancer 1) is a putative tumor-suppressor gene cloned from breast cancer specimens and is reported to regulate p53-dependent apoptosis through its specific inhibition of sirt1 deacetylase. |
2021-10-21 |
2023-08-12 |
Not clear |
| Tong Wang, Huixia Cui, Nan Ma, Youhong Jian. Nicotinamide-mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis. Oncology letters. vol 6. issue 2. 2021-10-21. PMID:24137378. |
nicotinamide-mediated inhibition of sirt1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Pratibha V Nerurkar, Vivek R Nerurka. Can Sir(2) regulate cancer? Cellscience. vol 4. issue 4. 2021-10-20. PMID:19750026. |
in contrast, recent studies demonstrate that targeted silencing of sirtuin 1 (sirt1) expression or activity by the deleted in breast cancer 1 (dbc1) may be beneficial by promoting p53-induced apoptosis in cancer cells, and by sensitizing cancerous cells to radiation therapy. |
2021-10-20 |
2023-08-12 |
Not clear |
| Xiaojing Deng, Hailun Zheng, Dapeng Li, Yongju Xue, Qizhi Wang, Shanjun Yan, Yu Zhu, Min Den. MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1. Experimental and therapeutic medicine. vol 15. issue 4. 2021-10-20. PMID:29581731. |
the present study aimed to identify whether microrna (mirna/mir)-34a regulates the proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1 (sirt1). |
2021-10-20 |
2023-08-13 |
human |
| Xiaojing Deng, Hailun Zheng, Dapeng Li, Yongju Xue, Qizhi Wang, Shanjun Yan, Yu Zhu, Min Den. MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1. Experimental and therapeutic medicine. vol 15. issue 4. 2021-10-20. PMID:29581731. |
therefore, the present results suggested that mirna-34a serves a pivotal role in gastric cancer as a cancer suppressor gene by targeting sirt1 to regulate the proliferation and apoptosis of gastric cancer cells. |
2021-10-20 |
2023-08-13 |
human |
| Hyesung Lee, Taek-Yeol Jung, Seong Hun Lim, Eun Ju Choi, Jinu Lee, Do Sik Mi. Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1. Experimental & molecular medicine. vol 53. issue 9. 2021-10-15. PMID:34471223. |
moreover, pld2 did not protect against apoptosis induced by sirt1 depletion under genotoxic stress. |
2021-10-15 |
2023-08-13 |
Not clear |
| Hyesung Lee, Taek-Yeol Jung, Seong Hun Lim, Eun Ju Choi, Jinu Lee, Do Sik Mi. Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1. Experimental & molecular medicine. vol 53. issue 9. 2021-10-15. PMID:34471223. |
collectively, our results suggest that pld2 is a positive regulator of sirt1 and modulates p53-mediated apoptosis via sirt1. |
2021-10-15 |
2023-08-13 |
Not clear |
| Yujuan Qi, Kai Zhang, Peijun Li, Zhenhua W. Down-regulating miR-217-5p Protects Cardiomyocytes against Ischemia/Reperfusion Injury by Restoring Mitochondrial Function via Targeting SIRT1. Inflammation. vol 44. issue 1. 2021-10-07. PMID:33064238. |
after i/r treatment, the viability of h9c2 cardiomyocyte-derived cell line and atp contents were reduced, but ldh and ros contents were increased, at the same time, cell apoptosis and the expressions of mir-217-5p, p62 and cleaved caspase-3 were increased, whereas the expressions of sirt1, lc3 (light chain 3), pink1 (pten-induced kinase 1), parkin, bcl-2, and c-iap (inhibitor of apoptosis protein) were reduced. |
2021-10-07 |
2023-08-13 |
Not clear |
| Fatemeh Darvishzadeh Mahani, Mohammad Khaksari, Alireza Raji-Amirhasan. Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1. International urology and nephrology. vol 53. issue 11. 2021-10-07. PMID:33458788. |
in the kidneys, sirt1 inhibits renal cell apoptosis, inflammation, and fibrosis. |
2021-10-07 |
2023-08-13 |
Not clear |
| Li Zhang, Bailing Luo, Yuan Ting, Shengyang He, Lihua Xie, Shenghua Su. SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD. Growth factors (Chur, Switzerland). vol 38. issue 2. 2021-10-05. PMID:32819170. |
sirt1 attenuates endoplasmic reticulum stress and apoptosis in rat models of copd. |
2021-10-05 |
2023-08-13 |
rat |
| Li Zhang, Bailing Luo, Yuan Ting, Shengyang He, Lihua Xie, Shenghua Su. SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD. Growth factors (Chur, Switzerland). vol 38. issue 2. 2021-10-05. PMID:32819170. |
the present study aimed to investigate the protective role of sirtuin 1 (sirt1) and oxygen regulated protein 150 (orp150) in a rat copd model by inducing changes in er stress and apoptosis. |
2021-10-05 |
2023-08-13 |
rat |