| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Deng, Junqing Zou, Ye Hong, Qiang Peng, Xinxin Fu, Rui Duan, Jie Chen, Xiangliang Che. Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats. Cells. vol 11. issue 22. 2022-11-26. PMID:36429082. |
our findings suggest that tmao increases oxidative stress-induced neuroinflammation and apoptosis by inhibiting the sirt1 pathway, thereby exacerbating cognitive dysfunction and neuropathological changes in vad rats. |
2022-11-26 |
2023-08-14 |
rat |
| Jing Wang, Qing-Guo Jin, Rong-Ping Liu, Xin-Qin Wang, Ying-Hua Li, Nam-Hyung Kim, Yong-Nan X. Dihydromyricetin supplementation during in vitro culture improves porcine oocyte developmental competence by regulating oxidative stress. The Journal of reproduction and development. 2022-11-20. PMID:36403957. |
further, dhm supplementation also improved glutathione levels and mitochondrial membrane potential; reduced natural reactive oxygen species levels in blastomeres and apoptosis rate; upregulated nanog, oct4, sod1, sod2, sirt1, and bcl2 expression; and downregulated beclin1, atg12, and bax expression. |
2022-11-20 |
2023-08-14 |
Not clear |
| Jing Zhang, Jian Ping, Na Jiang, Lieming X. Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways. Journal of food biochemistry. 2022-10-31. PMID:36314441. |
resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the sirt1 and jnk signaling pathways. |
2022-10-31 |
2023-08-14 |
mouse |
| Jing Zhang, Jian Ping, Na Jiang, Lieming X. Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways. Journal of food biochemistry. 2022-10-31. PMID:36314441. |
furthermore, whether the sirtuin1 (sirt1) and c-jun n-terminal kinase (jnk) signaling pathways were associated with the resveratrol-mediated induction of autophagy and apoptosis in js1 cells was examined. |
2022-10-31 |
2023-08-14 |
mouse |
| Jing Zhang, Jian Ping, Na Jiang, Lieming X. Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways. Journal of food biochemistry. 2022-10-31. PMID:36314441. |
the sirt1 inhibitor ex527 reversed autophagy, and the jnk inhibitor sp600125 reversed both autophagy and apoptosis induced by resveratrol. |
2022-10-31 |
2023-08-14 |
mouse |
| Jing Zhang, Jian Ping, Na Jiang, Lieming X. Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways. Journal of food biochemistry. 2022-10-31. PMID:36314441. |
these findings suggest that the sirt1 and jnk signaling pathways may be involved in the resveratrol-mediated inhibition of hsc activation by regulating autophagy and apoptosis. |
2022-10-31 |
2023-08-14 |
mouse |
| Jing Zhang, Jian Ping, Na Jiang, Lieming X. Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways. Journal of food biochemistry. 2022-10-31. PMID:36314441. |
sirt1 may be responsible for inducing autophagy, while jnk affects both autophagy and apoptosis. |
2022-10-31 |
2023-08-14 |
mouse |
| Jing Zhang, Jian Ping, Na Jiang, Lieming X. Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways. Journal of food biochemistry. 2022-10-31. PMID:36314441. |
it was shown that resveratrol inhibited hsc activation by inducing autophagy and apoptosis in a dose-dependent manner, and the mechanism may be associated with the sirt1 and jnk signaling pathways. |
2022-10-31 |
2023-08-14 |
mouse |
| Gangireddy Sujeevan Reddy, Jetta Sandeep Kumar, B Thirupataiah, Harshavardhan Bhuktar, Sharda Shukla, Manojit Pa. Recent advances in transition metal-catalyzed reactions of chloroquinoxalines: Applications in bioorganic chemistry. Bioorganic chemistry. vol 129. 2022-10-24. PMID:36274386. |
several of these resultant quinoxaline derivatives have shown diverse biological activities which include apoptosis inducing activities, sirt1 inhibition, inhibition of luciferace enzyme, antibacterial and antifungal activities, cytotoxicity towards cancer cells, inhibition of pde4 (phosphodiesterase 4), potential uses against covid-19, etc. |
2022-10-24 |
2023-08-14 |
Not clear |
| Dong Yu, Xing-Yuan Zhao, Qing-Peng Meng, Da Teng, Ke Deng, Ning Li. Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI. Brain research. 2022-10-02. PMID:36183792. |
sirtuin 1 (sirt1) has a neuroprotective effect via its effect on various biological processes, such as inflammation, metabolism, apoptosis, and autophagy. |
2022-10-02 |
2023-08-14 |
mouse |
| Sami A Gabr, Wael M Elsaed, Mohamed Ahmed Eladl, Mohamed El-Sherbiny, Hasnaa Ali Ebrahim, Saad Mohamed Asseri, Yasir A M Eltahir, Nehal Elsherbiny, Mamdouh Eldesoqu. Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines. Life (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36143462. |
the protective activities of curcumin against the growth of cancer cells are mediated by modulating oxidative stress, regulating fibrosis, sirt1 activation, and inducing cellular apoptosis. |
2022-09-23 |
2023-08-14 |
cat |
| Chaoyou Fang, Houshi Xu, Ling Yuan, Zhengyang Zhu, Xiaoyu Wang, Yibo Liu, Anke Zhang, Anwen Shao, Meiqing Lo. Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future. Oxidative medicine and cellular longevity. vol 2022. 2022-09-15. PMID:36105479. |
sirt1, a member of the sirtuin family, plays a crucial role in modulating a wide range of physiological processes, including apoptosis, dna repair, inflammatory response, and oxidative stress. |
2022-09-15 |
2023-08-14 |
Not clear |
| Shilin Jiang, Chengyuan Zhang, Ye Lu, Feng Yua. Mechanical stress-caused chondrocyte dysfunction and cartilage injury can be attenuated by dioscin via activating sirtuin1/forkhead box O1. Journal of biochemical and molecular toxicology. 2022-09-15. PMID:36106352. |
dioscin inhibited apoptosis and metabolic disorders in oa-like chondrocytes via maintaining the transcriptional activity of foxo1 and enhancing sirt1 expression. |
2022-09-15 |
2023-08-14 |
mouse |
| Xi Fang, Qiang Han, Shiyong Li, Ailin Lu. Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway. Heliyon. vol 8. issue 9. 2022-09-12. PMID:36091956. |
the hippocampal tissue and serum were collected to determine the levels of sirt1, mfn2, perk, and other proteins or cytokines related to er stress, apoptosis, and neuroinflammation. |
2022-09-12 |
2023-08-14 |
rat |
| Deliang Cheng, Lijun Zhang, Xiaoju Lian. SIRT1 targeted by miR-211-5p regulated proliferation and apoptosis of Dex-treated growth plate chondrocytes via mediating SOX2. Clinical and experimental pharmacology & physiology. 2022-09-10. PMID:36086922. |
sirt1 targeted by mir-211-5p regulated proliferation and apoptosis of dex-treated growth plate chondrocytes via mediating sox2. |
2022-09-10 |
2023-08-14 |
Not clear |
| Man Di, Qianfeng Zhang, Jingjing Wang, Xifeng Xiao, Jianlei Huang, Yuan Ma, Hongya Yang, Mao L. Epigallocatechin-3-gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)-induced endometritis via silent information regulator transcript-1 (SIRT1)/nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) pathway. Journal of biochemical and molecular toxicology. 2022-09-03. PMID:36056792. |
additionally, egcg decreased oxidative stress and reduced cell apoptosis by upregulating sirt1 expression, downregulating the nlrp3 inflammasome activation. |
2022-09-03 |
2023-08-14 |
mouse |
| Hongli Gao, Lingling Yang, YiShun Sha. SIRT1 / NF-κB pathway on neuronal apoptosis in rats with ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 5. 2022-08-27. PMID:36029487. |
sirt1 / nf-κb pathway on neuronal apoptosis in rats with ischemic stroke. |
2022-08-27 |
2023-08-14 |
rat |
| Pei-Ying Pai, James K S Wong, Zhen-Yang Cui, Yi-Yuan Lin, Shin-Da Le. Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis. Journal of cardiovascular development and disease. vol 9. issue 8. 2022-08-25. PMID:36005430. |
angiotensin ii receptor blocker irbesartan enhanced sirt1 longevity signaling replaces the mitochondrial biogenetic survival pathway to attenuate hypertension-induced heart apoptosis. |
2022-08-25 |
2023-08-14 |
rat |
| Xiangqian Ren, Yi Wang, Lin Han, Zhenzhen Sun, Bin Yua. Effect of Rosuvastatin on Myocardial Apoptosis in HypertensiveRats Through SIRT1/NF-κB Signaling Pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 4. 2022-08-21. PMID:35988282. |
the study aimed to observe the effect of rosuvastatin on myocardial apoptosis in hypertensive rats through the silent information regulator 1 (sirt1)/nuclear factor-κb (nf-κb) signaling pathway. |
2022-08-21 |
2023-08-14 |
rat |
| Xiangqian Ren, Yi Wang, Lin Han, Zhenzhen Sun, Bin Yua. Effect of Rosuvastatin on Myocardial Apoptosis in HypertensiveRats Through SIRT1/NF-κB Signaling Pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 4. 2022-08-21. PMID:35988282. |
rosuvastatin can inhibit myocardial apoptosis in hypertensive rats through up-regulating sirt1 and down-regulating nf-κb. |
2022-08-21 |
2023-08-14 |
rat |