| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Li, Yang Cao, Lin-Na Li, Xin Chu, Yan-Song Wang, Jia-Jun Cai, Jin Zhao, Song Ma, Gang Li, Zhong-Kai Fa. Neuroprotective Effects of Oxymatrine via Triggering Autophagy and Inhibiting Apoptosis Following Spinal Cord Injury in Rats. Molecular neurobiology. 2023-04-28. PMID:37115405. |
omt significantly enhanced autophagy activity, inhibited apoptosis in neurons, and increased sirt1 and p-ampk expression levels. |
2023-04-28 |
2023-08-14 |
rat |
| Enhao Wang, Yang Li, Hejie Li, Yingzhao Liu, Ruijie Ming, Jiahui Wei, Peiyu Du, Xiangrui Li, Shimin Zong, Hongjun Xia. METTL3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the N6-methyladenosine level of SIRT1 mRNA. Neuroscience. 2023-04-22. PMID:37087022. |
mettl3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the n6-methyladenosine level of sirt1 mrna. |
2023-04-22 |
2023-08-14 |
mouse |
| Enhao Wang, Yang Li, Hejie Li, Yingzhao Liu, Ruijie Ming, Jiahui Wei, Peiyu Du, Xiangrui Li, Shimin Zong, Hongjun Xia. METTL3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the N6-methyladenosine level of SIRT1 mRNA. Neuroscience. 2023-04-22. PMID:37087022. |
we assessed the effects of m6a methyltransferase mettl3 on sirt1 protein expression, reactive oxygen species (ros) levels, and apoptosis in an oxidative stress model of organ of corti 1 (oc1) cells. |
2023-04-22 |
2023-08-14 |
mouse |
| Enhao Wang, Yang Li, Hejie Li, Yingzhao Liu, Ruijie Ming, Jiahui Wei, Peiyu Du, Xiangrui Li, Shimin Zong, Hongjun Xia. METTL3 reduces oxidative stress-induced apoptosis in presbycusis by regulating the N6-methyladenosine level of SIRT1 mRNA. Neuroscience. 2023-04-22. PMID:37087022. |
in oc1 cells, mettl3 positively regulated sirt1 protein levels, while reversely regulated the level of ros and apoptosis. |
2023-04-22 |
2023-08-14 |
mouse |
| Huan Liu, Linjing Xu, Lizi Zhou, Wenna Han, Zhongyi Li, Chunhong Li. DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-04-14. PMID:37059380. |
the results showed that dbp caused mitochondrial damage, autophagy, apoptosis and necroptosis; transcriptomics analysis identified that mapk and pi3k were significant factors in the cytotoxic changes induced by dbp; n-acetyl-l-cysteine (nac), sirt1 activator, erk inhibitor, p38 inhibitor and erk sirna treatments counteracted the changes of sirt1/pgc-1α and nrf2 pathway-related proteins, autophagy and necroptotic apoptosis proteins induced by dbp. |
2023-04-14 |
2023-08-14 |
human |
| Sonali Karnik, Hessam Noori-Dokht, Taylor Williams, Amin Joukar, Stephen B Trippel, Uma Sankar, Diane R Wagne. Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047494. |
sirt1 enzymatic activity decreased as early as 5 min following the mechanical overload, and remained suppressed for at least 24 h. the chondrocyte injury response, including apoptosis, oxidative stress, secretion of inflammatory mediators, and alterations in cartilage matrix expression, was prevented with pharmacological activation of sirt1 in a dose-dependent manner. |
2023-04-13 |
2023-08-14 |
cattle |
| Di Ran, Dehui Zhou, Gang Liu, Yonggang Ma, Waseem Ali, Rui Yu, Qinghua Wang, Hongyan Zhao, Jiaqiao Zhu, Hui Zou, Zongping Li. Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53 Journal of agricultural and food chemistry. 2023-04-06. PMID:37023393. |
it is further revealed that sirt1 activation markedly reprograms bone metabolic and stress-response pathways that incline with osteoblast (ob) apoptosis. |
2023-04-06 |
2023-08-14 |
human |
| Chunxiao Dong, Zongyi Li, Xin Wang, Dulei Zou, Haoyun Duan, Can Zhao, Qingjun Zhou, Weiyun Sh. SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis. Experimental eye research. 2023-04-04. PMID:37015319. |
in this study, we showed that cecs exhibited cellular apoptosis, reactive oxygen species (ros) accumulation and decreased sirt1 expression. |
2023-04-04 |
2023-08-14 |
mouse |
| Alireza Karimollah, Anahid Hemmatpur, Fatemeh Safari, Mahsa Fakhrgholami, Tina Trava. Tropisetron restores normal expression of BAD, SIRT1, SIRT3, and SIRT7 in the rat pressure overload-induced cardiac hypertrophy model. Journal of biochemical and molecular toxicology. 2023-03-31. PMID:36999403. |
present findings suggest that tropisetron can suppress cardiomyocyte hypertrophy progression to heart failure by counteracting bnp, sirt1, sirt3, sirt7, and bad overexpression-mediated apoptosis in a rat model of cardiac hypertrophy. |
2023-03-31 |
2023-08-14 |
rat |
| Jian Gao, Fan Li, Ye Huang, Shihao Li, Qisi Li. Naphthofuran Derivative BF4, A New Potent SIRT1 Activator, Regulates Lipid Metabolism in 3T3-L1 Adipocytes via the SIRT1-AMPK Pathway. Medicinal chemistry (Shariqah (United Arab Emirates)). 2023-03-31. PMID:36999720. |
our previously reported naphthofuran derivative bf4, identified as a potent silent information regulator 1 (sirt1) activator, could alleviate high glucose stimulating apoptosis and inflammation response in human renal tubular epithelial (hk-2) cells. |
2023-03-31 |
2023-08-14 |
human |
| Ziyang Huang, Qiuling Huang, Kai Xu, Lina Liang, Yamin Li, Wei Zhou, Na Ning, Jiewen Zhou, Jiajia Hu, Shanshan Liu, Lei Dan. Protective effect of ZYMT, a traditional Chinese patent medicine in a mouse model of retinitis pigmentosa. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-03-29. PMID:36989720. |
tunel, immunofluorescence and qpcr were used to evaluate cell apoptosis and expressions of sirt1, iba1, bcl-2, bax and caspase-3. |
2023-03-29 |
2023-08-14 |
mouse |
| Ali Akar, Rahime Özlem Öztopuz, Başak Büyük, Mehmet Akif Ovali, Damla Aykora, Ümit Ali Malço. Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage. Molecular neurobiology. 2023-03-18. PMID:36933146. |
in this study, we aimed to investigate the potential therapeutic effects of pic on ob injury following sah at molecular mechanism based on sirt1, inflammatory (tnf-α, il1-β, nf-κb, il-6, tlr4), and apoptosis (p53, bax, bcl-2, caspase-3)-related gene expression markers and histopathology level; 27 male wistar albino rats were used in a pre-chiasmatic subarachnoid hemorrhage model. |
2023-03-18 |
2023-08-14 |
rat |
| Yan Xi, Zhongchao Chi, Xufeng Tao, Xiaohan Zhai, Zirui Zhao, Jiaqi Ren, Shilei Yang, Deshi Don. Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1. Environmental toxicology. 2023-02-22. PMID:36811345. |
naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of sirt1. |
2023-02-22 |
2023-08-14 |
mouse |
| Yan Xi, Zhongchao Chi, Xufeng Tao, Xiaohan Zhai, Zirui Zhao, Jiaqi Ren, Shilei Yang, Deshi Don. Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1. Environmental toxicology. 2023-02-22. PMID:36811345. |
therefore, naringin is a valuable lead compound for preventing doxorubicin-induced liver damage by reducing oxidative stress, inflammation, and apoptosis via up-regulation of sirt1. |
2023-02-22 |
2023-08-14 |
mouse |
| Siqi Li, Qiong Huang, Baimei H. SIRT1 as a Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease. Lung. 2023-02-15. PMID:36790647. |
multiple studies have indicated that sirt1 plays an important role in oxidative stress, apoptosis, inflammation, autophagy, and cellular senescence, which contributes to the pathogenesis and development of copd. |
2023-02-15 |
2023-08-14 |
Not clear |
| Wenrong Li, Siyuan Dong, Qun Chen, Chen Chen, Zhaoheng Don. Corrigendum to "Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis" [Eur. J. Pharmacol. 878 (2020) 173098]. European journal of pharmacology. 2023-02-15. PMID:36792384. |
corrigendum to "selenium may suppress peripheral blood mononuclear cell apoptosis by modulating hsp70 and regulate levels of sirt1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis" [eur. |
2023-02-15 |
2023-08-14 |
Not clear |
| Min An, Yi Qiu, Caixia Wang, Penglei Ma, Yumei Din. Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain. Journal of neuropathology and experimental neurology. 2023-02-13. PMID:36779914. |
rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating jnk signaling pathway and suppressing sirt1 expression in chronic constriction injury-induced neuropathic pain. |
2023-02-13 |
2023-08-14 |
rat |
| Min An, Yi Qiu, Caixia Wang, Penglei Ma, Yumei Din. Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain. Journal of neuropathology and experimental neurology. 2023-02-13. PMID:36779914. |
in rescue experiments, srt1720, an activator of sirt1, reversed the effect of rac2 on glial activation, inflammatory response, and apoptosis. |
2023-02-13 |
2023-08-14 |
rat |
| Min An, Yi Qiu, Caixia Wang, Penglei Ma, Yumei Din. Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain. Journal of neuropathology and experimental neurology. 2023-02-13. PMID:36779914. |
these findings indicate that rac2 enhances the activation of microglia and astrocytes, inflammatory response, and apoptosis via activating the jnk signaling pathway and suppressing sirt1 expression in cci-induced np. |
2023-02-13 |
2023-08-14 |
rat |
| Hongbin Li, Xiaoxuan Niu, Huijuan Shi, Min Feng, Yuming Du, Rongqing Sun, Ning Ma, Haili Wang, Dan Wei, Min Ga. circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury. Laboratory investigation; a journal of technical methods and pathology. vol 102. issue 9. 2023-02-12. PMID:36775423. |
silencing pik3ca and/or sirt1 reversed the effect of circhectd1 overexpression on the apoptosis of lps-induced hbe and mle-12 cells. |
2023-02-12 |
2023-08-14 |
mouse |