| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Yang, Jianxia Chen, Yanghaoyu Chen, Yan Jiang, Baoxue Ge, Ling Hon. Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax. International immunopharmacology. vol 91. 2021-05-26. PMID:33373810. |
thus, it seems that sirt1 acts as a novel regulator of apoptosis signaling in m. tuberculosis infection via its effects on bax. |
2021-05-26 |
2023-08-13 |
mouse |
| Fei He, Qingshu Li, Bo Sheng, Haitao Yang, Wei Jian. SIRT1 Inhibits Apoptosis by Promoting Autophagic Flux in Human Nucleus Pulposus Cells in the Key Stage of Degeneration via ERK Signal Pathway. BioMed research international. vol 2021. 2021-05-26. PMID:33728342. |
sirt1 inhibits apoptosis by promoting autophagic flux in human nucleus pulposus cells in the key stage of degeneration via erk signal pathway. |
2021-05-26 |
2023-08-13 |
human |
| Fei He, Qingshu Li, Bo Sheng, Haitao Yang, Wei Jian. SIRT1 Inhibits Apoptosis by Promoting Autophagic Flux in Human Nucleus Pulposus Cells in the Key Stage of Degeneration via ERK Signal Pathway. BioMed research international. vol 2021. 2021-05-26. PMID:33728342. |
silent information regulation 2 homologue-1 (sirt1) can protect human degenerative nucleus pulposus (np) cells from apoptosis by activating autophagy. |
2021-05-26 |
2023-08-13 |
human |
| Zhen Zhang, Xin Chen, Sichen Li. Role of Sirtuin-1 in Neonatal Hypoxic-Ischemic Encephalopathy and Its Underlying Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32826847. |
in addition, enhanced cell viability and reduced cell apoptosis were observed, suggesting that sirt1 overexpression relieved ogd-induced neuronal cell injury. |
2021-05-20 |
2023-08-13 |
rat |
| Sapana Bansod, Chandraiah Godug. Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model. International immunopharmacology. vol 90. 2021-05-19. PMID:33310297. |
these results suggest that nb exerts strong anti-pancreatitis effects against cerulein-induced ap by combating inflammatory and apoptosis signaling via sirt1 activation. |
2021-05-19 |
2023-08-13 |
mouse |
| Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollah. The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular biology reports. vol 48. issue 3. 2021-05-19. PMID:33772418. |
the effect of n-acetyl cysteine on the expression of fxr (nr1h4), lxrα (nr1h3) and sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. |
2021-05-19 |
2023-08-13 |
rat |
| Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollah. The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular biology reports. vol 48. issue 3. 2021-05-19. PMID:33772418. |
the aim of this study was to consider the expression of farnesoid x receptor (fxr), liver x receptor (lxrα) and sirtuin 1 (sirt1), oxidative stress, inflammation, apoptosis, and the protective role of n-acetylcysteine (nac) in the liver of rats treated with cadmium (cd). |
2021-05-19 |
2023-08-13 |
rat |
| Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollah. The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular biology reports. vol 48. issue 3. 2021-05-19. PMID:33772418. |
our results suggested that nac protects liver tissue against cd toxicity by elevating antioxidant capacity, mitigating oxidative stress, inflammation, apoptosis and up-regulation of fxr, lxr, and sirt1 genes. |
2021-05-19 |
2023-08-13 |
rat |
| Jian Gao, Qing-Qing Chen, Ye Huang, Kai-Hang Li, Xiao-Ju Geng, Tao Wang, Qi-Si Lin, Ruo-Si Ya. Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators. Frontiers in pharmacology. vol 12. 2021-05-18. PMID:33995069. |
more importantly, compounds m1, 6b, and 6d could resist high glucose-induced apoptosis of hk-2 cells by activating sirt1 and deacetylation of p53. |
2021-05-18 |
2023-08-13 |
Not clear |
| Tayebeh Rezaei, Maryam Hejazi, Behzad Mansoori, Ali Mohammadi, Mohammad Amini, Jafar Mosafer, Sarah Rezaei, Ahad Mokhtarzadeh, Behzad Baradara. microRNA-181a mediates the chemo-sensitivity of glioblastoma to carmustine and regulates cell proliferation, migration, and apoptosis. European journal of pharmacology. vol 888. 2021-05-17. PMID:32810491. |
moreover, mir-181a was shown to increase the sub g1 cell cycle arrest and apoptosis induction by carmustine via regulating the expression of related genes including caspase-9, bcl-2, and sirt1. |
2021-05-17 |
2023-08-13 |
human |
| Jiayu Diao, Hongmou Zhao, Penghua You, Hongjun You, Haoyu Wu, Xiling Shou, Gong Chen. Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1α pathway. Biochemical and biophysical research communications. vol 546. 2021-05-17. PMID:33561745. |
further mechanistic studies in h9c2 cardiomyocytes revealed that suppression of sirt1 by sh-sirt1 counteracted the effects of ra on high glucose-induced abnormal metabolism of glucose and lipids, oxidative stress and apoptosis (p < 0.05). |
2021-05-17 |
2023-08-13 |
mouse |
| Mengmeng Yang, Yixin Cui, Jia Song, Chen Cui, Lingshu Wang, Kai Liang, Chuan Wang, Sha Sha, Qin He, Huiqing Hu, Xinghong Guo, Nan Zang, Lei Sun, Li Che. Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. Biochemical and biophysical research communications. vol 546. 2021-05-17. PMID:33578292. |
mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating sirt1. |
2021-05-17 |
2023-08-13 |
mouse |
| Xuesong Zhang, Huawei Dong, Yong Liu, Junxia Han, Shouyi Tang, Jingna S. Tetramethylpyrazine partially relieves hypoxia-caused damage of cardiomyocytes H9c2 by downregulation of miR-449a. Journal of cellular physiology. 2021-05-16. PMID:30770559. |
the protein expression levels of sirt1 and key factors involved in cell apoptosis and phosphatidylinositol 3-kinase/protein kinase 3 (pi3k/akt) pathway were evaluated using western blot analysis. |
2021-05-16 |
2023-08-13 |
Not clear |
| Xuesong Zhang, Huawei Dong, Yong Liu, Junxia Han, Shouyi Tang, Jingna S. Tetramethylpyrazine partially relieves hypoxia-caused damage of cardiomyocytes H9c2 by downregulation of miR-449a. Journal of cellular physiology. 2021-05-16. PMID:30770559. |
in conclusion, tmp partially relieved hypoxia-caused cardiomyocytes h9c2 viability loss and apoptosis at least through downregulating mir-499a, upregulating sirt1, and then activating the pi3k/akt pathway. |
2021-05-16 |
2023-08-13 |
Not clear |
| Mingxu Qi, Li He, Xiaofeng Ma, Zili L. MiR-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia-reoxygenation through regulating SIRT1. Bioscience, biotechnology, and biochemistry. vol 84. issue 7. 2021-05-14. PMID:32290769. |
mir-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia-reoxygenation through regulating sirt1. |
2021-05-14 |
2023-08-13 |
Not clear |
| Mingxu Qi, Li He, Xiaofeng Ma, Zili L. MiR-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia-reoxygenation through regulating SIRT1. Bioscience, biotechnology, and biochemistry. vol 84. issue 7. 2021-05-14. PMID:32290769. |
on the other hand, mir-181a-5p inhibited apoptosis and elevated bcl-2 expression while decreasing the expressions of bax and caspase 3 in treated cells, but the effects of mir-181a-5p could be rescued by sirt1. |
2021-05-14 |
2023-08-13 |
Not clear |
| Mingxu Qi, Li He, Xiaofeng Ma, Zili L. MiR-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia-reoxygenation through regulating SIRT1. Bioscience, biotechnology, and biochemistry. vol 84. issue 7. 2021-05-14. PMID:32290769. |
in conclusion, mir-181a-5p involved in h/r-induced cardiomyocytes apoptosis through regulating sirt1, which might become a novel direction for related diseases. |
2021-05-14 |
2023-08-13 |
Not clear |
| Bin Chen, Li Wu, Ting Cao, Hong-Mei Zheng, Tao H. MiR-221/SIRT1/Nrf2 signal axis regulates high glucose induced apoptosis in human retinal microvascular endothelial cells. BMC ophthalmology. vol 20. issue 1. 2021-05-14. PMID:32698791. |
mir-221, sirt1 and nrf2 were associated with apoptosis and proliferation and their expression were altered in dr patients. |
2021-05-14 |
2023-08-13 |
human |
| Jing Xu, Chunyang Wang, Fanjie Meng, Pengjuan X. Long non‑coding RNA H19 inhibition ameliorates oxygen‑glucose deprivation‑induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA‑29b/SIRT1/PGC‑1α axis. Molecular medicine reports. vol 23. issue 2. 2021-05-14. PMID:33313940. |
following ogd treatment, mtt, flow cytometry, elisa, rt‑qpcr and western blotting assays were performed to assess cell proliferation, cell apoptosis, inflammatory cytokine concentrations, and lncrna h19, mir‑29b, sirt1, pgc‑1α expression levels, respectively. |
2021-05-14 |
2023-08-13 |
mouse |
| Jing Xu, Chunyang Wang, Fanjie Meng, Pengjuan X. Long non‑coding RNA H19 inhibition ameliorates oxygen‑glucose deprivation‑induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA‑29b/SIRT1/PGC‑1α axis. Molecular medicine reports. vol 23. issue 2. 2021-05-14. PMID:33313940. |
collectively, the results of the present study demonstrated that lncrna h19 knockdown ameliorated ogd‑induced cell apoptosis and increases in inflammatory cytokine concentrations by regulating mir‑29b, sirt1 and pgc‑1α expression levels, which suggested the potential role of lncrna h19 in ischemic stroke. |
2021-05-14 |
2023-08-13 |
mouse |