| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing-Bo Lu, Qiong Du, Hui-Ping Wang, Zi-Han Tang, Yuan-Ben Wang, Hai-Jian Su. Salusin-β mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway. Redox biology. vol 30. 2021-04-16. PMID:31884071. |
in vitro, silencing of salusin-β diminished, whereas overexpression of salusin-β exaggerated the increased pkc phosphorylation, oxidative stress, histone γh2ax expression, p53 activation and apoptosis in either cisplatin or lps-challenged renal tubular cells. |
2021-04-16 |
2023-08-13 |
mouse |
| Qing-Bo Lu, Qiong Du, Hui-Ping Wang, Zi-Han Tang, Yuan-Ben Wang, Hai-Jian Su. Salusin-β mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway. Redox biology. vol 30. 2021-04-16. PMID:31884071. |
more importantly, salusin-β overexpression-induced tubular cell apoptosis were abolished by using the pkc inhibitor go 6976, reactive oxygen species (ros) scavenger nac, nicotinamide adenine dinucleotide phosphate (nadph) oxidase inhibitor apocynin (apo) or p53 inhibitor pifithrin-α. |
2021-04-16 |
2023-08-13 |
mouse |
| Salomé Le Goff, Ismael Boussaid, Celia Floquet, Anna Raimbault, Isabelle Hatin, Charlotte Andrieu-Soler, Mohammad Salma, Marjorie Leduc, Emilie-Fleur Gautier, Boris Guyot, Diane d'Allard, Nathalie Montel-Lehry, Sarah Ducamp, Amandine Houvert, François Guillonneau, Stéphane Giraudier, Elisabeth Cramer-Bordé, François Morlé, Jean-Jacques Diaz, Olivier Hermine, Naomi Taylor, Sandrina Kinet, Frédérique Verdier, Rose-Ann Padua, Narla Mohandas, Pierre-Emmanuel Gleizes, Eric Soler, Patrick Mayeux, Michaela Fontena. p53 activation during ribosome biogenesis regulates normal erythroid differentiation. Blood. vol 137. issue 1. 2021-04-16. PMID:32818241. |
p53 was activated spontaneously or in response to cx-5461, concomitant to ribosome biogenesis arrest, and drove a transcriptional program in which genes involved in cell cycle-arrested, negative regulation of apoptosis, and dna damage response were upregulated. |
2021-04-16 |
2023-08-13 |
human |
| Marjan Talebi, Mohsen Talebi, Eleni Kakouri, Tahereh Farkhondeh, Ali Mohammad Pourbagher-Shahri, Petros A Tarantilis, Saeed Samarghandia. Tantalizing role of p53 molecular pathways and its coherent medications in neurodegenerative diseases. International journal of biological macromolecules. vol 172. 2021-04-15. PMID:33440210. |
a recommended conception is regarding the role of p53, as a transcription factor regulating numerous cellular pathways comprising apoptosis. |
2021-04-15 |
2023-08-13 |
Not clear |
| Alexey A Kulikov, Nadezhda A Dorofeeva, Alexandra A Naumova, Eugenia L Harbachova, Margarita V Glazova, Elena V Chernigovskay. Impaired postnatal development of the hippocampus of Krushinsky-Molodkina rats genetically prone to audiogenic seizures. Epilepsy & behavior : E&B. vol 113. 2021-04-14. PMID:33161330. |
analysis of apoptosis demonstrated significantly increased number of tunel-positive cells in the dentate gyrus (dg) of km rats at p30 that was accompanied with expression of p53, bcl-2 and cleaved caspases 3 and 9. |
2021-04-14 |
2023-08-13 |
rat |
| Xiaohan Li, Qun Zhang, Mingming Zhang, Yusong Luo, Yaping F. Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC). Histology and histopathology. vol 35. issue 7. 2021-04-13. PMID:31886514. |
moreover, ing3 may interact with p300 to upregulate the level of acetylation of p53, and promote p53-mediated cell cycle arrest, senescence and/or apoptosis. |
2021-04-13 |
2023-08-13 |
Not clear |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through dram-bax in cadmium-exposed human proximal tubular cells. |
2021-04-13 |
2023-08-13 |
human |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
the tumor suppressor p53 is involved in cadmium (cd)-induced apoptosis and autophagy. |
2021-04-13 |
2023-08-13 |
human |
| Hyun-Young Lee, Seon-Hee O. Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33321290. |
the inhibition of autophagy through pharmacological and genetic knockdown reduced p53 and inhibited cd-induced apoptosis. |
2021-04-13 |
2023-08-13 |
human |
| Giovanna Butera, Jessica Brandi, Chiara Cavallini, Aldo Scarpa, Rita T Lawlor, Maria Teresa Scupoli, Emílio Marengo, Daniela Cecconi, Marcello Manfredi, Massimo Donadell. The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells. Biomolecules. vol 10. issue 6. 2021-04-12. PMID:32526853. |
we report the functional effect of the hot-spot p53 mutant isoforms r175h and r273h on cancer cell secretome, showing their influence on proliferation, chemoresistance, apoptosis, and autophagy, as well as cell migration and epithelial-mesenchymal transition. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qi Yu, Weikun Xiao, Songping Sun, Alireza Sohrabi, Jesse Liang, Stephanie K Seidlit. Extracellular Matrix Proteins Confer Cell Adhesion-Mediated Drug Resistance Through Integrin α Frontiers in cell and developmental biology. vol 9. 2021-04-11. PMID:33834020. |
apoptosis, mediated by p53, was analyzed by western blotting and immunocytofluorescence. |
2021-04-11 |
2023-08-13 |
Not clear |
| Huixia Zhang, Mengda Liu, Hui Zhang, Shengliang Cao, Yue Li, Shengnan Jiang, Yinuo Song, Sidang Li. Detection of p53 mutation and serum monitoring alert caused by Marek's disease virus in poultry. BMC veterinary research. vol 16. issue 1. 2021-04-09. PMID:32831091. |
the wild type p53, a tumor suppressor gene, plays a key role in blocking cell cycle, promoting apoptosis, and maintaining the stability of the genome. |
2021-04-09 |
2023-08-13 |
chicken |
| Xiaoxiong Xiao, Lei Jiang, Huoli Hu, Yunhe Huang, Lun Yang, Yang Jiao, Guangxia We. Silencing of UAP1L1 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma. Molecular carcinogenesis. vol 60. issue 3. 2021-04-09. PMID:33434300. |
moreover, the apoptosis of escc cells was induced by knockdown of uap1l1 via regulating a variety of apoptosis-related proteins, such as upregulation of bax, cd40, cd40l, fas, fasl, igfbp-6, p21, p27, p53, and smac. |
2021-04-09 |
2023-08-13 |
Not clear |
| Dian Liu, Ayse Ertay, Charlotte Hill, Yilu Zhou, Juanjuan Li, Yanmei Zou, Hong Qiu, Xianglin Yuan, Rob M Ewing, Xin Lu, Hua Xiong, Yihua Wan. ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer. Cell death & disease. vol 11. issue 4. 2021-04-08. PMID:32269211. |
the apoptosis-stimulating protein of p53 (aspp) family of proteins can regulate apoptosis by interacting with the p53 family and have been identified to play an important role in cancer progression. |
2021-04-08 |
2023-08-13 |
Not clear |
| Akshara Pande, Mahesh Manchanda, Hans Raj Bhat, Partha Sarathi Bairy, Navin Kumar, Prashant Gahtor. Molecular insights into a mechanism of resveratrol action using hybrid computational docking/CoMFA and machine learning approach. Journal of biomolecular structure & dynamics. 2021-04-08. PMID:33829956. |
although earlier wet-lab experiments rendering its multiple biological targets, for example, epidermal growth factors, pro-apoptotic protein p53, sirtuins, and first apoptosis signal (fas) receptor, mouse double minute 2 (mdm2) ubiquitin-protein ligase, estrogen receptor, quinone reductase, etc. |
2021-04-08 |
2023-08-13 |
mouse |
| Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Che. Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke. International journal of environmental health research. 2021-04-07. PMID:33825597. |
oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke. |
2021-04-07 |
2023-08-13 |
mouse |
| Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Che. Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke. International journal of environmental health research. 2021-04-07. PMID:33825597. |
however, pifithrin-α (p53 inhibitor) and n-acetylcysteine (nac) could reduce cell apoptosis, lung structural damage and oxidative stress, accelerate the expression of bcl-2, while suppressing the expression of bax, total caspase-3 and cleaved caspase-3. |
2021-04-07 |
2023-08-13 |
mouse |
| Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Che. Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke. International journal of environmental health research. 2021-04-07. PMID:33825597. |
in conclusions, oxidative stress linking the p53 is involved in cell apoptosis in cs-treated emphysema mice. |
2021-04-07 |
2023-08-13 |
mouse |
| Junhao Wang, Zhaohui Lou, Haiyang Xi, Zhi Li, Lepeng Li, Zhenzhen Li, Kai Zhang, Tetsuya Asakaw. Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model. Open life sciences. vol 16. issue 1. 2021-04-06. PMID:33817313. |
dorsal root ganglia cells were assessed morphologically with hematoxylin and eosin staining and for apoptosis with p53 immunohistochemical staining. |
2021-04-06 |
2023-08-13 |
rat |
| Yu Fan, Yu Wang, Shaozhi Fu, Duan Liu, Sheng Li. Methylation-regulated ZNF545 inhibits growth of the p53-mutant KYSE150 cell line by inducing p21 and Bax. Experimental and therapeutic medicine. vol 18. issue 3. 2021-04-05. PMID:31410110. |
ectopic expression of znf545 activated p53 transcription and upregulated the protein expression levels of pivotal effectors p21 and bax, which are associated with cell proliferation and apoptosis, respectively, in p53-mutant kyse150 cells; while suppressing colony formation and inducing apoptosis. |
2021-04-05 |
2023-08-13 |
Not clear |