| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chin-Hu Lai, Parthasarathi Barik, Dennis Jine-Yuan Hsieh, Cecilia Husan Day, Tsung-Jung Ho, Ray-Jade Chen, Wei-Wen Kuo, V Vijaya Padma, Marthandam Asokan Shibu, Chih-Yang Huan. Inhibition of cell death-inducing p53 target 1 through miR-210-3p overexpression attenuates reactive oxygen species and apoptosis in rat adipose-derived stem cells challenged with Angiotensin II. Biochemical and biophysical research communications. vol 532. issue 3. 2021-03-16. PMID:32888650. |
according to the results obtained, ang ii affects the normal cell cycle and triggers apoptosis in radscs with a corresponding increase in the expression of cell death-inducing p53 target 1 (cdip1) protein. |
2021-03-16 |
2023-08-13 |
rat |
| Hong Wang, Xueping Wan, Paul F Pilch, Leif W Ellisen, Susan K Fried, Libin Li. An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming. eLife. vol 9. 2021-03-16. PMID:33320092. |
here we show p53 protein expression can be up-regulated in adipocytes by nutrient starvation without activating cell senescence, apoptosis, or a death-related p53 canonical pathway. |
2021-03-16 |
2023-08-13 |
mouse |
| Ibrahim H Polat, Míriam Tarrado-Castellarnau, Rohit Bharat, Jordi Perarnau, Adrian Benito, Roldán Cortés, Philippe Sabatier, Marta Cascant. Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism. Biology. vol 10. issue 2. 2021-03-16. PMID:33498665. |
moreover, inhibition of 6pgd via chemical inhibitor s3 resulted in an induction of senescence, which, together with the cell cycle arrest and apoptosis induction, might be orchestrated by p53 activation. |
2021-03-16 |
2023-08-13 |
Not clear |
| Noha A Rezk, Mohamad Bakry Lashin, Norhan A Sabba. MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis. Non-coding RNA research. vol 6. issue 1. 2021-03-16. PMID:33718673. |
the role of the sirutin 1 (sirt1) and microrna-34 a (mir-34a) in endometriosis and the extent to which the mir-34a/sirt1/p53 signaling pathway is involved in its pathogenesis is unclear, so we aimed to investigate the expression of mirna 34-a, sirt1, forkhead boxo (foxo-1), p53 and other apoptotic markers in endometrial tissue of women with endometriosis in order to better understand their role and the mechanisms of their actions in the pathogenesis of such disease and if it is related to apoptosis or not. |
2021-03-16 |
2023-08-13 |
Not clear |
| Yujia Xu, Kun Zeng, Xiaoge Wang, Jieyu Zhang, Biyin Cao, Zubin Zhang, Chunhua Qiao, Xiaofeng Xu, Qi Wang, Yuanying Zeng, Xinliang Ma. Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway. Bioscience trends. vol 14. issue 2. 2021-03-15. PMID:32173687. |
further studies showed that these agents such as 4061 and 4065b displayed potent activity to induce mm cell apoptosis by upregulating pro-apoptotic p53 and bax while downregulating pro-survival bcl-2. |
2021-03-15 |
2023-08-13 |
Not clear |
| Xiufen Zheng, Junying Zhang, Tian Fang, Xiaoxiao Wang, Siwei Wang, Zhifei Ma, Youtao Xu, Chencheng Han, Mengting Sun, Lin Xu, Jie Wang, Rong Yi. The long non-coding RNA PIK3CD-AS2 promotes lung adenocarcinoma progression via YBX1-mediated suppression of p53 pathway. Oncogenesis. vol 9. issue 3. 2021-03-12. PMID:32165621. |
in vitro studies showed that pik3cd-as2 increased cell growth and slowed apoptosis in p53 |
2021-03-12 |
2023-08-13 |
Not clear |
| Meryem Akpolat, Zehra Safi Oz, Kanat Gulle, Ayse C Hamamcioglu, Bekir H Bakkal, Mete Kecec. X irradiation induced colonic mucosal injury and the detection of apoptosis through PARP-1/p53 regulatory pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-03-11. PMID:32361637. |
in this regard, colonic mucosal injury caused by whole-body x-irradiation induced apoptosis through parp-1, caspase 3 and p53 regulatory pathway were evaluated in experimental rat models. |
2021-03-11 |
2023-08-13 |
rat |
| Pradip Kumar Jaiswara, Vishal Kumar Gupta, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Chandramani Pathak, Santosh Kumar, Ajay Kuma. Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism. Environmental toxicology. vol 36. issue 4. 2021-03-11. PMID:33274819. |
nimbolide-induced apoptosis in t lymphoma cells by altering the level of reactive oxygen species, p53, bcl2, bax, and cytochrome c, with subsequent cleavage of caspase 3. |
2021-03-11 |
2023-08-13 |
Not clear |
| Ying Zhang, Xiangyang Cao, Peifeng Li, Yanan Fan, Leilei Zhang, Wuyin Li, Youwen Li. PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy-induced osteoporosis mouse model. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:32017075. |
besides, we found that pi3k activation significantly decreased psmc6-induced osteoblast apoptosis and promoted cell proliferation through regulating the protein levels of p53, cyclind1, and cleaved caspase-3/9. |
2021-03-10 |
2023-08-13 |
mouse |
| Qingbin Wu, Xiaochen Yuan, Bingwei Li, Ruiqin Han, Honggang Zhang, Ruijuan Xi. Salvianolic Acid Alleviated Blood-Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway. Drug design, development and therapy. vol 14. 2021-03-10. PMID:32368011. |
salvianolic acid alleviated blood-brain barrier permeability in spontaneously hypertensive rats by inhibiting apoptosis in pericytes via p53 and the ras/raf/mek/erk pathway. |
2021-03-10 |
2023-08-13 |
rat |
| Parmeshwar Bajirao Katare, Hina Lateef Nizami, Bugga Paramesha, Amit K Dinda, Sanjay K Banerje. Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation. Scientific reports. vol 10. issue 1. 2021-03-10. PMID:33159115. |
activation of toll like receptor 4 (tlr4) promotes cardiomyocyte apoptosis through sirt2 dependent p53 deacetylation. |
2021-03-10 |
2023-08-13 |
rat |
| Parmeshwar Bajirao Katare, Hina Lateef Nizami, Bugga Paramesha, Amit K Dinda, Sanjay K Banerje. Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation. Scientific reports. vol 10. issue 1. 2021-03-10. PMID:33159115. |
similar to in vivo study, nuclear translocation of p53, mitochondrial dysfunction and cellular apoptosis were observed in h9c2 cells treated with lps. |
2021-03-10 |
2023-08-13 |
rat |
| Parmeshwar Bajirao Katare, Hina Lateef Nizami, Bugga Paramesha, Amit K Dinda, Sanjay K Banerje. Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation. Scientific reports. vol 10. issue 1. 2021-03-10. PMID:33159115. |
p53 and caspase 7/caspase 9 were found to play an important role in tlr4-mediated apoptosis. |
2021-03-10 |
2023-08-13 |
rat |
| Mengwu Pan, Christine Blattne. Regulation of p53 by E3s. Cancers. vol 13. issue 4. 2021-03-10. PMID:33670160. |
today we know that p53 plays a role in different biological processes such as proliferation, invasion, pluripotency, metabolism, cell cycle control, ros (reactive oxygen species) production, apoptosis, inflammation and autophagy. |
2021-03-10 |
2023-08-13 |
Not clear |
| Kai-Kai Zhang, Hui Wang, Dong Qu, Li-Jian Chen, Li-Bin Wang, Jia-Hao Li, Jia-Li Liu, Ling-Ling Xu, Jamie Still Yoshida, Jing-Tao Xu, Xiao-Li Xie, Dong-Ri L. Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats. Frontiers in pharmacology. vol 12. 2021-03-10. PMID:33679421. |
luteolin alleviates methamphetamine-induced hepatotoxicity by suppressing the p53 pathway-mediated apoptosis, autophagy, and inflammation in rats. |
2021-03-10 |
2023-08-13 |
rat |
| Sumino Yanas. Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans. Methods in molecular biology (Clifton, N.J.). vol 2138. 2021-03-08. PMID:32219749. |
in the nematode caenorhabditis elegans, the mammalian tumor suppressor p53 ortholog cep-1 (c. elegans p53-like protein) is associated not only with the stress response, germline apoptosis, and meiotic chromosome segregation but also with longevity through the modification of energy metabolism during aging. |
2021-03-08 |
2023-08-13 |
human |
| Qian Hao, Yajie Chen, Xiang Zho. The Janus Face of p53-Targeting Ubiquitin Ligases. Cells. vol 9. issue 7. 2021-03-08. PMID:32660118. |
the tumor suppressor p53 prevents tumorigenesis and cancer progression by maintaining genomic stability and inducing cell growth arrest and apoptosis. |
2021-03-08 |
2023-08-13 |
Not clear |
| Dong-Bo Chen, Xing-Wang Xie, Yang-Jing Zhao, Xue-Yan Wang, Wei-Jia Liao, Pu Chen, Kang-Jian Deng, Ran Fei, Wan-Ying Qin, Jiang-Hua Wang, Xu Wu, Qi-Xiang Shao, Lai Wei, Hong-Song Che. RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A. Scientific reports. vol 10. issue 1. 2021-03-08. PMID:32883983. |
mechanistically, the rfx5-kdm4a pathway promoted the progression of the cell cycle from g0/g1 to s phase and was protective against cell apoptosis through regulation of p53 and its downstream genes in hcc. |
2021-03-08 |
2023-08-13 |
Not clear |
| Jiahui Yuan, Gongye Zhang, Xiaomei Li, Qiujuan Ma, Weipeng Cheng, Weiwei Wang, Bing Zhang, Tianhui Hu, Gang Son. Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33255748. |
specifically, knocking down usp39 resulted in cell cycle arrest at g2/m and subsequent apoptosis through the activation of the p53 pathway, including upregulation of p21, cleaved-cas3, cleaved-cas9 and downregulation of cdc2 and cycinb1. |
2021-03-05 |
2023-08-13 |
mouse |
| Shaoxin Cai, Jinsi Wang, Wei Zeng, Xuefei Cheng, Lihang Liu, Weihua L. Lysine-specific histone demethylase 1B (LSD2/KDM1B) represses p53 expression to promote proliferation and inhibit apoptosis in colorectal cancer through LSD2-mediated H3K4me2 demethylation. Aging. vol 12. issue 14. 2021-03-04. PMID:32726297. |
lysine-specific histone demethylase 1b (lsd2/kdm1b) represses p53 expression to promote proliferation and inhibit apoptosis in colorectal cancer through lsd2-mediated h3k4me2 demethylation. |
2021-03-04 |
2023-08-13 |
Not clear |