| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ömer Güllülü, Stephanie Hehlgans, Claus Rödel, Emmanouil Fokas, Franz Röde. Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer-A Promising Signaling Network for Therapeutic Interventions. Cancers. vol 13. issue 4. 2021-03-03. PMID:33557398. |
tumor suppressor protein p53 and inhibitor of apoptosis proteins in colorectal cancer-a promising signaling network for therapeutic interventions. |
2021-03-03 |
2023-08-13 |
Not clear |
| Juan Liu, Cen Zhang, Jianming Wang, Wenwei Hu, Zhaohui Fen. The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway. International journal of molecular sciences. vol 21. issue 21. 2021-03-02. PMID:33182266. |
while it has been widely accepted that the role of p53 in regulation of cell cycle arrest, senescence and apoptosis contributes greatly to the function of p53 in tumor suppression, emerging evidence has implicated that p53 also exerts its tumor suppressive function through regulation of many other cellular processes, such as metabolism, anti-oxidant defense and ferroptosis. |
2021-03-02 |
2023-08-13 |
Not clear |
| Yu Wang, Hongjing Zhao, Yachen Liu, Jingyan Li, Xiaopan Nie, Puyi Huang, Mingwei Xin. Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene. Environmental pollution (Barking, Essex : 1987). vol 274. 2021-03-02. PMID:33540255. |
in the same treatment, lyc reduced inflammation and apoptosis by a detectable change in pro-inflammatory factors (tumor necrosis factor-alpha (tnf-β), interleukin (il)-1β, il-6 and il-8), anti-inflammatory factors (transforming growth factor-beta (tgf-β) and il-10) and pro-apoptosis related genes (p53, p53 upregulated modulator of apoptosis (puma), bax/bcl-2 ratio, caspase-3/9). |
2021-03-02 |
2023-08-13 |
cat |
| Jeong Hoon Pan, Hyunjin Kim, Jingsi Tang, Kaleigh E Beane, Jeen-Woo Park, Seongbae Kong, Byungwhi C Kong, Young Jun Kim, Eui-Cheol Shin, Jun Ho Kim, Jiangchao Zhao, Jin Hyup Lee, Jae Kyeom Ki. Acute alcohol consumption-induced let-7a inhibition exacerbates hepatic apoptosis by regulating Rb1 in mice. Alcohol (Fayetteville, N.Y.). vol 85. 2021-03-01. PMID:31734308. |
taken together, the current study provides mechanistic evidence that alcohol consumption-induced let-7a suppression results in the upregulation of rb1, thereby promoting hepatic apoptosis through induction of pro-apoptotic proteins (e.g., p73), and by, at least in part, preventing mdm2-mediated p53 degradation. |
2021-03-01 |
2023-08-13 |
mouse |
| Zhihui Huang, Xiaofei Liu, Aijun Ma, Xin-An Wang, Xiaoli Guo, Tingting Zhao, Jinsheng Zhang, Shuangshuang Yang, Rongjing X. Molecular cloning, characterization and expression analysis of p53 from turbot Scophthalmus maximus and its response to thermal stress. Journal of thermal biology. vol 90. 2021-03-01. PMID:32479378. |
once activated by diverse cell stresses, p53 reversibly activates downstream target genes to regulate cell cycle and apoptosis. |
2021-03-01 |
2023-08-13 |
Not clear |
| Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Min-Hee Kang, Jin-Hoi Ki. Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer. International journal of molecular sciences. vol 21. issue 18. 2021-02-26. PMID:32947930. |
endoplasmic reticulum-mediated stress and apoptosis were confirmed by upregulation of protein kinase rna-like endoplasmic reticulum kinase (perk), inositol-requiring enzyme 1 (ire1), activating transcription factor 6 (atf6), activating transcription factor 4 (atf4), p53, bax, and caspase-3 and down regulation of b-cell lymphoma 2 (bcl-2). |
2021-02-26 |
2023-08-13 |
human |
| Camille Jacques, Robel Tesfaye, Melanie Lavaud, Steven Georges, Marc Baud'huin, François Lamoureux, Benjamin Or. Implication of the p53-Related miR-34c, -125b, and -203 in the Osteoblastic Differentiation and the Malignant Transformation of Bone Sarcomas. Cells. vol 9. issue 4. 2021-02-25. PMID:32230926. |
in response to various cell signals, the tumor-suppressor protein p53 activates a huge range of genes, whose mirnas promote genomic-integrity maintenance, cell-cycle arrest, cell senescence, and apoptosis. |
2021-02-25 |
2023-08-13 |
Not clear |
| Seung Bae Rho, Seung-Hoon Lee, Hyun-Jung Byun, Boh-Ram Kim, Chang Hoon Le. IRF-1 Inhibits Angiogenic Activity of HPV16 E6 Oncoprotein in Cervical Cancer. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33076322. |
over-expression of hpv16 e6 elevated cell growth by attenuating irf-1-induced apoptosis and repressing p21 and p53 expression, but activating cyclin d1 and nuclear factor kappa b (nf-κb) expression. |
2021-02-25 |
2023-08-13 |
human |
| Adrian Trujillo-Uscanga, Ana Lorena Gutiérrez-Escolan. Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication. Virology. vol 550. 2021-02-24. PMID:32890980. |
p53 is implicated in several cellular pathways such as induction of cell-cycle arrest, differentiation, senescence, and apoptosis. |
2021-02-24 |
2023-08-13 |
Not clear |
| Adrian Trujillo-Uscanga, Ana Lorena Gutiérrez-Escolan. Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication. Virology. vol 550. 2021-02-24. PMID:32890980. |
during calicivirus infections, apoptosis is required for virus exit and spread into the host; yet, the role of p53 during infection is unknown. |
2021-02-24 |
2023-08-13 |
Not clear |
| Jing Ma, Linrong Li, Kexin Yue, Yingguang Li, Hanfang Liu, Peng George Wang, Chaojie Wang, Jiajia Wang, Wen Luo, Songqiang Xi. Bromocoumarinplatin, targeting simultaneously mitochondria and nuclei with p53 apoptosis pathway to overcome cisplatin resistance. Bioorganic chemistry. vol 99. 2021-02-23. PMID:32217375. |
bromocoumarinplatin, targeting simultaneously mitochondria and nuclei with p53 apoptosis pathway to overcome cisplatin resistance. |
2021-02-23 |
2023-08-13 |
Not clear |
| Qian Pu, Yan-Rong Lv, Ke Dong, Wen-Wen Geng, Hai-Dong Ga. Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells. BMC cancer. vol 20. issue 1. 2021-02-23. PMID:32571254. |
tumor suppressor otud3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells. |
2021-02-23 |
2023-08-13 |
Not clear |
| Chul Min Yang, Moo-Koo Kang, Woong-Jae Jung, Jung-Sik Joo, Yong-Jin Kim, Yeeun Choi, Hyoung-Pyo Ki. p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncology letters. vol 21. issue 3. 2021-02-23. PMID:33613715. |
the tumor suppressor protein p53 is a transcription factor that serves important roles in cell apoptosis by regulating the cell cycle. |
2021-02-23 |
2023-08-13 |
human |
| Chul Min Yang, Moo-Koo Kang, Woong-Jae Jung, Jung-Sik Joo, Yong-Jin Kim, Yeeun Choi, Hyoung-Pyo Ki. p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncology letters. vol 21. issue 3. 2021-02-23. PMID:33613715. |
in conclusion, expression of p53 may confer 5-fu sensitivity by regulating chromatin accessibility of distinct genes associated with cell apoptosis in a transcription-independent manner. |
2021-02-23 |
2023-08-13 |
human |
| Ijeoma A Toulassi, Usama A Al Saedi, Sai Dheeraj Gutlapalli, Sujan Poudel, Varshitha Kondapaneni, Mehwish Zeb, Ivan Cancarevi. A Paradigm Shift in the Management of Atherosclerosis: Protective Role of Sirtuins in Atherosclerosis. Cureus. vol 13. issue 1. 2021-02-23. PMID:33614337. |
the reviewed literature reported that sirtuins prevent and ameliorate atherosclerosis by halting inflammation, apoptosis, oxidative stress, and regulating low-density lipoprotein (ldl) cholesterol. sirtuin 1 (sirt1) and sirtuin 6 (sirt6) inhibit the rela component of nf-kb, thus suppressing inflammation, sirt1 inhibits p53 by deacetylation, and the latter stabilize telomeres thus preventing apoptosis and cell death. |
2021-02-23 |
2023-08-13 |
human |
| Tao Zhang, Yu-Chao Yin, Xiang Ji, Bo Zhang, Sheng Wu, Xiao-Zhe Wu, Hong Li, Ya-Dan Li, Ya-Ling Ma, Yu Wang, Hai-Tao Li, Bin Zhang, Di W. AT1R knockdown confers cardioprotection against sepsis-induced myocardial injury by inhibiting the MAPK signaling pathway in rats. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-22. PMID:31433522. |
terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling staining was applied to measure cell apoptosis, and messenger rna and protein levels of apoptosis-related proteins (fas ligand [fasl], b-cell cll/lymphoma [bcl-2], p53) were also detected. |
2021-02-22 |
2023-08-13 |
rat |
| Tao Zhang, Yu-Chao Yin, Xiang Ji, Bo Zhang, Sheng Wu, Xiao-Zhe Wu, Hong Li, Ya-Dan Li, Ya-Ling Ma, Yu Wang, Hai-Tao Li, Bin Zhang, Di W. AT1R knockdown confers cardioprotection against sepsis-induced myocardial injury by inhibiting the MAPK signaling pathway in rats. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-22. PMID:31433522. |
eventually, decreased at1r expression inhibited myocardial cell apoptosis (shown as decreased apoptosis rate and p53 and fasl expression as well as increased bcl-2 expression). |
2021-02-22 |
2023-08-13 |
rat |
| Xiaohui Xu, Xiaoyun Zhou, Zhenju Chen, Chao Gao, Luo Zhao, Yushang Cu. Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin. Aging. vol 12. issue 6. 2021-02-22. PMID:32209729. |
moreover, xist's oncogenic effects and ability to promote ddp chemoresistance were largely related to its binding to the tgf-β effector smad2, which inhibited its translocation to the nucleus and prevented the transcription of p53 and nlrp3, crucial regulators of apoptosis and pyroptosis, respectively. |
2021-02-22 |
2023-08-13 |
mouse |
| Huankai Yao, Xiuli Zhang, Nan Zhang, Jindong Li, Yan Li, Qunli We. Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway. Journal of natural medicines. vol 75. issue 1. 2021-02-22. PMID:32865667. |
further dapi staining has revealed wikstromol at 10 μm induced apoptosis of cancer cells, which was associated with the activation of caspase-3 following down-regulation of bcl-2 as well as up-regulation of bax, cleaved parp and phosphorylated p53. |
2021-02-22 |
2023-08-13 |
human |
| Izumi Horikaw. Balancing and Differentiating p53 Activities toward Longevity and No Cancer? Cancer research. vol 80. issue 23. 2021-02-22. PMID:33268555. |
in an oversimplified scenario, p53, an inducer of cellular senescence and apoptosis, may thus unfavorably contribute to aging and favorably suppress tumorigenesis. |
2021-02-22 |
2023-08-13 |
Not clear |