| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Syed Saad Hussain, Shaheen Faizi, Kinza Rafi, Shabana U Simje. Novel Mannich base 3FB3FA8H induces apoptosis by upregulating P53 pathway in neuroblastoma cells. Molecular and cellular biochemistry. vol 471. issue 1-2. 2021-02-02. PMID:32472321. |
novel mannich base 3fb3fa8h induces apoptosis by upregulating p53 pathway in neuroblastoma cells. |
2021-02-02 |
2023-08-13 |
Not clear |
| Syed Saad Hussain, Shaheen Faizi, Kinza Rafi, Shabana U Simje. Novel Mannich base 3FB3FA8H induces apoptosis by upregulating P53 pathway in neuroblastoma cells. Molecular and cellular biochemistry. vol 471. issue 1-2. 2021-02-02. PMID:32472321. |
dysregulation of p53 gene is one of the key factors contributing to the etiology of neuroblastoma which causes cells to evade apoptosis. |
2021-02-02 |
2023-08-13 |
Not clear |
| Syed Saad Hussain, Shaheen Faizi, Kinza Rafi, Shabana U Simje. Novel Mannich base 3FB3FA8H induces apoptosis by upregulating P53 pathway in neuroblastoma cells. Molecular and cellular biochemistry. vol 471. issue 1-2. 2021-02-02. PMID:32472321. |
3fb3fa8h has shown modulation of p53 pathway leading to apoptosis of neuroblastoma cells. |
2021-02-02 |
2023-08-13 |
Not clear |
| Kapil Saxena, Marina Konoplev. An expert overview of emerging therapies for acute myeloid leukemia: novel small molecules targeting apoptosis, p53, transcriptional regulation and metabolism. Expert opinion on investigational drugs. vol 29. issue 9. 2021-02-02. PMID:32746655. |
an expert overview of emerging therapies for acute myeloid leukemia: novel small molecules targeting apoptosis, p53, transcriptional regulation and metabolism. |
2021-02-02 |
2023-08-13 |
Not clear |
| Vincenza Simona Delvecchio, Ilenia Sana, Maria Elena Mantione, Maria Giovanna Vilia, Pamela Ranghetti, Alessandra Rovida, Piera Angelillo, Lydia Scarfò, Paolo Ghia, Marta Muzi. Interleukin-1 receptor-associated kinase 4 inhibitor interrupts toll-like receptor signalling and sensitizes chronic lymphocytic leukaemia cells to apoptosis. British journal of haematology. vol 189. issue 3. 2021-02-01. PMID:32057093. |
to note, irak4 inhibitor induced p53 and triggered apoptosis. |
2021-02-01 |
2023-08-13 |
Not clear |
| Yoshihisa Tokumaru, Eriko Katsuta, Masanori Oshi, Judith C Sporn, Li Yan, Lan Le, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takab. High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer. International journal of molecular sciences. vol 21. issue 9. 2021-02-01. PMID:32357442. |
mir-34a is a well-known tumor suppressive microrna which exerts its anti-cancer functions by playing a role in p53, apoptosis induction, and epithelial-mesenchymal transition (emt) suppression. |
2021-02-01 |
2023-08-13 |
Not clear |
| Yoshihisa Tokumaru, Eriko Katsuta, Masanori Oshi, Judith C Sporn, Li Yan, Lan Le, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takab. High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer. International journal of molecular sciences. vol 21. issue 9. 2021-02-01. PMID:32357442. |
high mir-34a tumors enriched the p53 pathway and apoptosis gene sets. |
2021-02-01 |
2023-08-13 |
Not clear |
| Yoshihisa Tokumaru, Eriko Katsuta, Masanori Oshi, Judith C Sporn, Li Yan, Lan Le, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takab. High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer. International journal of molecular sciences. vol 21. issue 9. 2021-02-01. PMID:32357442. |
in conclusion, the clinical relevance of mir-34a high expressing tumors was associated with suppressed cell proliferation, enhanced p53 pathway and apoptosis, but enhanced emt and these findings did not reflect better survival outcomes in large bc patient cohorts. |
2021-02-01 |
2023-08-13 |
Not clear |
| Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V Davuluri, Lois Resnick-Silverman, James J Manfredi, Erik W Debler, Steven B McMaho. Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nature communications. vol 12. issue 1. 2021-02-01. PMID:33473123. |
the tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate decisions (e.g., cell cycle arrest, apoptosis). |
2021-02-01 |
2023-08-13 |
Not clear |
| Boris Klimovich, Thorsten Stiewe, Oleg Timofee. Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell cycle (Georgetown, Tex.). vol 19. issue 1. 2021-01-29. PMID:31749402. |
inactivation of mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. |
2021-01-29 |
2023-08-13 |
Not clear |
| Lisa C Hüsemann, Alina Reese, Claudia Radine, Roland P Piekorz, Wilfried Budach, Dennis Sohn, Reiner U Jänick. The microtubule targeting agents eribulin and paclitaxel activate similar signaling pathways and induce cell death predominantly in a caspase-independent manner. Cell cycle (Georgetown, Tex.). vol 19. issue 4. 2021-01-29. PMID:31959066. |
on the molecular level, several key proteins involved in apoptosis such as p53, plk1, caspase-2, and bim as well as the two mapks erk and jnk were activated by both compounds to a similar extent. |
2021-01-29 |
2023-08-13 |
Not clear |
| Mingning Qiu, Jie Liu, Yongxia Su, Rong Guo, Baoyu Zhao, Jianjun Li. Diosmetin Induces Apoptosis by Downregulating AKT Phosphorylation via P53 Activation in Human Renal Carcinoma ACHN Cells. Protein and peptide letters. vol 27. issue 10. 2021-01-28. PMID:32223728. |
diosmetin induces apoptosis by downregulating akt phosphorylation via p53 activation in human renal carcinoma achn cells. |
2021-01-28 |
2023-08-13 |
human |
| Guoguo Jin, Zhenjiang Zhao, Tania Chakraborty, Aikyadeep Mandal, Arka Roy, Souvik Roy, Zhiping Gu. Decrypting the Molecular Mechanistic Pathways Delineating the Chemotherapeutic Potential of Ruthenium-Phloretin Complex in Colon Carcinoma Correlated with the Oxidative Status and Increased Apoptotic Events. Oxidative medicine and cellular longevity. vol 2020. 2021-01-27. PMID:32566099. |
the complex triggers intrinsic apoptosis triggered by p53 and modulates the akt/mtor pathway along with other inflammatory biomarkers. |
2021-01-27 |
2023-08-13 |
human |
| Guoguo Jin, Zhenjiang Zhao, Tania Chakraborty, Aikyadeep Mandal, Arka Roy, Souvik Roy, Zhiping Gu. Decrypting the Molecular Mechanistic Pathways Delineating the Chemotherapeutic Potential of Ruthenium-Phloretin Complex in Colon Carcinoma Correlated with the Oxidative Status and Increased Apoptotic Events. Oxidative medicine and cellular longevity. vol 2020. 2021-01-27. PMID:32566099. |
studies conducted in human cell lines revealed that the complex improved levels of p53 and caspase-3 while diminishing the activities of vegf and mtor, triggers apoptosis, and induces fragmentation of dna in the ht-29 cells. |
2021-01-27 |
2023-08-13 |
human |
| Jingjing Ma, Yunting Zhang, Huan Deng, Yinghui Liu, Xiaofei Lei, Pengzhan He, Weiguo Don. Thymoquinone inhibits the proliferation and invasion of esophageal cancer cells by disrupting the AKT/GSK-3β/Wnt signaling pathway via PTEN upregulation. Phytotherapy research : PTR. vol 34. issue 12. 2021-01-27. PMID:32901987. |
further investigation of the potential mechanism revealed that tq increased the levels of p53 and p21 but significantly reduced the expression of cyclin b1, cyclin a, and cyclin e. moreover, tq led to a decrease in bcl-2 and an increase in cleaved caspase-3, cleaved caspase-7, cleaved caspase-9, and bax, indicating that tq induced apoptosis by activating the intrinsic mitochondrial apoptosis pathway. |
2021-01-27 |
2023-08-13 |
mouse |
| Nicole Wells, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Lama Almaiman, Susan M Brasser, Mee Young Hon. Effects of low-to-moderate ethanol consumption on colonic growth and gene expression in young adult and middle-aged male rats. PloS one. vol 15. issue 12. 2021-01-27. PMID:33326448. |
overall, older rats showed decreases in apoptosis and gene expression of cdk4, cdh1, and p53 compared to younger rats, but there was no observed effect of ethanol exposure on these measures. |
2021-01-27 |
2023-08-13 |
human |
| Alexander V Sirotkin, Alexander V Makarevich, Elena Kubovicova, Marina Medvedova, Adriana Kolesarova, Abdel Halim Harrat. Relationship between body conditions and environmental contaminants in bovine ovarian cells. Theriogenology. vol 147. 2021-01-26. PMID:32120185. |
the accumulation of nuclear and cytoplasmic markers of apoptosis (p53 and bax, respectively), a proliferation marker (pcna), progesterone (p4), and insulin-like growth factor i (igf-i) was evaluated by western blot and radioimmunoassay (ria) experiments. |
2021-01-26 |
2023-08-13 |
cattle |
| Alexander V Sirotkin, Alexander V Makarevich, Elena Kubovicova, Marina Medvedova, Adriana Kolesarova, Abdel Halim Harrat. Relationship between body conditions and environmental contaminants in bovine ovarian cells. Theriogenology. vol 147. 2021-01-26. PMID:32120185. |
however, in cells from bcs3 animals, all environmental pollutants inhibited p53, toluene inhibited pcna but not bax, and xylene did not affect the expression of proliferation or apoptosis markers. |
2021-01-26 |
2023-08-13 |
cattle |
| Jiachang Tan, Xiong Qin, Bin Liu, Hao Mo, Zhenjie Wu, Zhenchao Yua. Integrative findings indicate anti-tumor biotargets and molecular mechanisms of calycosin against osteosarcoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 126. 2021-01-26. PMID:32179199. |
in human study, the os sections resulted in reduced expressions of tumor protein p53 (tp53), caspase-3 (casp3), and elevated x-linked inhibitor of apoptosis protein (xiap) expression in comparison with os-free controls. |
2021-01-26 |
2023-08-13 |
human |
| Jing Chen, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Jennifer J McCann, Michael B Kasta. DNA-Damage-Induced Alternative Splicing of p53. Cancers. vol 13. issue 2. 2021-01-26. PMID:33445417. |
in an attempt to elucidate the mechanisms behind the differential regulation and apparent functional divergence between full-length (fl) p53 and the p53β isoform (apoptosis versus senescence, respectively), we identified the differential transcriptome and protein interactome between these two proteins that may result from the unique 10-amino-acid tail in p53β protein. |
2021-01-26 |
2023-08-13 |
human |