| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Gu, Shu Zhang, Xin He, Sufang Chen, Yan Wan. High expression of PIG11 correlates with poor prognosis in gastric cancer. Experimental and therapeutic medicine. vol 21. issue 3. 2021-02-20. PMID:33603857. |
p53-induced gene 11 (pig11) is an early transcription-related target of p53 that is involved in cell apoptosis and tumor development. |
2021-02-20 |
2023-08-13 |
Not clear |
| Hui Li, Po Hu, Zhanyu Wang, Hongzheng Wang, Xiaoxuan Yu, Xiangyuan Wang, Yingjie Qing, Mengyuan Zhu, Jingyan Xu, Zhiyu Li, Qinglong Guo, Hui Hu. Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9. Archives of toxicology. vol 94. issue 1. 2021-02-19. PMID:31760435. |
besides, results showed that nd gl-v9 increased the activity of senescence-associated β-galactosidase (sa-β-gal) following the induction of mitotic catastrophe in jurkat and hut-102 cells with intact p53, while causing apoptosis in p53-deficient hut-78 cells. |
2021-02-19 |
2023-08-13 |
Not clear |
| Débora Kristina Alves-Fernandes, Érica Aparecida de Oliveira, Araceli Aparecida Hastreiter, Fernanda Faião-Flores, Aloisio Souza Felipe-Silva, Walter Turato, Ricardo Ambrósio Fock, Silvya Stuchi Maria-Engler, Silvia Berlanga de Moraes Barro. In vivo antitumoral effect of 4-nerolidylcatechol (4-NC) in NRAS-mutant human melanoma. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 141. 2021-02-19. PMID:32334110. |
4-nerolidylcathecol (4-nc), a natural product extracted from pothomorphe umbellata, induces apoptosis in melanoma cells by ros production, dna damage and increased p53 expression, in addition to inhibiting invasion in reconstructed skin. |
2021-02-19 |
2023-08-13 |
human |
| Yuejing Jiang, Xiaoji Cong, Shangwen Jiang, Ying Dong, Lei Zhao, Yi Zang, Minjia Tan, Jia L. Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation. Genomics, proteomics & bioinformatics. 2021-02-19. PMID:33607295. |
together with these findings, we discover that ampk promotes apoptosis by phosphorylating apoptosis-stimulating of p53 protein 2 (aspp2) in irradiation (ir)-dependent way and regulates histone acetylation by phosphorylating histone deacetylase 9 (hdac9) in ir-independent way. |
2021-02-19 |
2023-08-13 |
Not clear |
| Mohamed E Abdraboh, Zaidoon Shaker Essa, Abdelrazek B Abdelrazzak, Yousra M El-Far, Yasser Elsherbini, Mustafa M El-Zayat, Doaa A Al. Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32892028. |
the combined treatment stimulated p53-dependent apoptosis which was indicated by the significant increase of early apoptosis marker (annexin v) expression, dna fragmentation, expression of p53 & bax and downregulation of bcl2 expression. |
2021-02-17 |
2023-08-13 |
Not clear |
| Zuhal Eroglu, Ceren Erdem, Gulperi Oktem, Vildan Bozok Cetintas, Zekeriya Duzgu. Effect of SIRT1 activators and inhibitors on CD44+/CD133+‑enriched non‑small cell lung cancer cells. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377734. |
in the present study, cd44+ and cd133+‑enriched a549 (non‑small cell lung cancer) cells collected using the cd44 and cd133 csc surface markers by fluorescence‑activated cell sorting method were treated with sirt1 inhibitors (tenovin‑6 and sirtinol) and sirt1 activators (resveratrol and srt1720), and their effects on apoptosis, as well as the mrna and protein expression of sirt1 and p53 were investigated. |
2021-02-16 |
2023-08-13 |
Not clear |
| Zuhal Eroglu, Ceren Erdem, Gulperi Oktem, Vildan Bozok Cetintas, Zekeriya Duzgu. Effect of SIRT1 activators and inhibitors on CD44+/CD133+‑enriched non‑small cell lung cancer cells. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377734. |
of these agents, it was found that resveratrol increased p53 expression by 4.1‑fold, decreased sirt1 expression by 0.2‑fold, and it was the most potent inducer of apoptosis. |
2021-02-16 |
2023-08-13 |
Not clear |
| Gerardo D Anaya-Eugenio, Choon Yong Tan, L Harinantenaina Rakotondraibe, Esperanza Carcache Carcache de Blanc. Tumor suppressor p53 independent apoptosis in HT-29 cells by auransterol from Penicillium aurantiacobrunneum. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-16. PMID:32407985. |
tumor suppressor p53 independent apoptosis in ht-29 cells by auransterol from penicillium aurantiacobrunneum. |
2021-02-16 |
2023-08-13 |
Not clear |
| Sirin Korulu, Aysegul Yildi. p60-katanin: a novel interacting partner for p53. Molecular biology reports. vol 47. issue 6. 2021-02-16. PMID:32462563. |
p53 functions in similar cellular processes as katanin such as cell cycle, differentiation, and apoptosis depending on its interacting partners. |
2021-02-16 |
2023-08-13 |
Not clear |
| Anqun Chen, Ye Feng, Han Lai, Wenjun Ju, Zhengzhe Li, Yu Li, Andrew Wang, Quan Hong, Fang Zhong, Chengguo Wei, Jia Fu, Tianjun Guan, Bichen Liu, Matthias Kretzler, Kyung Lee, John Cijiang H. Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression. The Journal of clinical investigation. vol 130. issue 10. 2021-02-16. PMID:32634130. |
mechanistically, the soluble rarres1 was endocytosed and interacted with and inhibited rio kinase 1 (riok1), resulting in p53 activation and podocyte apoptosis. |
2021-02-16 |
2023-08-13 |
mouse |
| Sang Ah Yi, Go Woon Kim, Jung Yoo, Jeung-Whan Han, So Hee Kwo. HP1γ Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3. International journal of molecular sciences. vol 21. issue 17. 2021-02-16. PMID:32825184. |
leptomycin b, which inhibits the nuclear export of hp1γ, increased cisplatin-dependent apoptosis induction by promoting the activation of p53 signaling. |
2021-02-16 |
2023-08-13 |
Not clear |
| Sang Ah Yi, Go Woon Kim, Jung Yoo, Jeung-Whan Han, So Hee Kwo. HP1γ Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3. International journal of molecular sciences. vol 21. issue 17. 2021-02-16. PMID:32825184. |
doxorubicin sensitized the cisplatin-resistant cervical cancer cells, enhancing their p53 levels and rate of apoptosis when administered together with cisplatin. |
2021-02-16 |
2023-08-13 |
Not clear |
| Linlin Zhang, Tiantian Ma, Qibing Tao, Wushuang Tan, Huatao Chen, Wei Liu, Pengfei Lin, Dong Zhou, Aihua Wang, Yaping Jin, Keqiong Tan. Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cells. Journal of animal science. vol 98. issue 10. 2021-02-15. PMID:32954430. |
microrna-34b overexpression also leads to increased cell apoptosis, with proapoptotic genes p53 and bax upregulated, while antiapoptotic gene bcl2 decreased. |
2021-02-15 |
2023-08-13 |
cattle |
| Huai Mei Chen, Jia Wang, Ying Feng Zhang, Yan Hong Ga. Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9. Oncology letters. vol 14. issue 4. 2021-02-12. PMID:29085442. |
human trna methyltransferase 9-like (htrm9l) catalyzes trna wobble base modifications, which regulate ovarian cancer growth and apoptosis via the retinoblastoma protein (prb) and p53 signaling pathways. |
2021-02-12 |
2023-08-13 |
human |
| Huai Mei Chen, Jia Wang, Ying Feng Zhang, Yan Hong Ga. Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9. Oncology letters. vol 14. issue 4. 2021-02-12. PMID:29085442. |
in the present study, htrm9l was shown to prevent tumor growth and promote apoptosis by regulating lin9, which is associated with the prb and p53 signaling pathways. |
2021-02-12 |
2023-08-13 |
human |
| Yao Sh. MEG3 regulates apoptosis of adipose‑derived stem cells. Molecular medicine reports. vol 21. issue 6. 2021-02-12. PMID:32323784. |
the present study aimed to evaluate the hypothesis that meg3 serves an important role in adsc apoptosis by regulating the expression of p53, and to explore the regulatory mechanisms of p53 in adsc apoptosis. |
2021-02-12 |
2023-08-13 |
Not clear |
| Huan-Lan Bai, Chun-Min Kang, Zhen-Qing Sun, Xue-Heng Li, Xiao-Yan Dai, Rui-Ying Huang, Jing-Jing Zhao, Yan-Rou Bei, Xian-Zhang Huang, Zhi-Feng Lu, Shao-Guo Wu, Jing-Bo Lu, Bao-Hong Ping, Qian Wang, Yan-Wei H. TTDA inhibited apoptosis by regulating the p53-Bax/Bcl2 axis in glioma. Experimental neurology. vol 331. 2021-02-11. PMID:32540359. |
ttda interacted with the p53 gene at the -1959 bp and -1530 bp region and regulated its transcription, leading to inhibition of the p53-bax/bcl2 mitochondrial apoptosis pathway in glioma cells. |
2021-02-11 |
2023-08-13 |
human |
| Amjad Ali, Sabihur Rahman Farooqui, Jagdish Rai, Jyotsna Singh, Vivek Kumar, Ritu Mishra, Akhil C Banerje. HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-11. PMID:32819562. |
human immunodeficiency virus-1 (hiv-1) nef promotes p53 protein degradation to protect hiv-1 infected cells from p53 induced apoptosis. |
2021-02-11 |
2023-08-13 |
human |
| Amjad Ali, Sabihur Rahman Farooqui, Jagdish Rai, Jyotsna Singh, Vivek Kumar, Ritu Mishra, Akhil C Banerje. HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-11. PMID:32819562. |
further, nef inhibits apoptosis of p53 null h1299 cells after exogenous expression of p53 protein. |
2021-02-11 |
2023-08-13 |
human |
| Amjad Ali, Sabihur Rahman Farooqui, Jagdish Rai, Jyotsna Singh, Vivek Kumar, Ritu Mishra, Akhil C Banerje. HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-11. PMID:32819562. |
the p53 dependent apoptosis of h1299 cells was further reduced after the expression of nef with e6ap. |
2021-02-11 |
2023-08-13 |
human |