| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Kito, Tania J González-Robles, Sharon Kaisari, Juhee Pae, Sheena Faye Garcia, Juliana Ortiz-Pacheco, Beatrix Ueberheide, Ruth Lehmann, Antonio Marzio, Gergely Rona, Michele Pagan. GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer. bioRxiv : the preprint server for biology. 2025-04-01. PMID:40166203. |
this event protects p53 from degradation, resulting in cell cycle arrest or apoptosis in daughter cells. |
2025-04-01 |
2025-04-03 |
Not clear |
| Shuai Zhao, Jingwen Luo, Pingping Xu, Jingwei Zeng, Guangbo Yan, Fang Yu, Liwei Qin, Cheng Zhang, Peng Li, Mengxing Cai, Wuxiang Mao, Chin-Yu Chen, Wanping Chen, Rui Han, Fei Wang, Yang Wang, Lixin M. Designed peptide binders and nanobodies as PROTAC starting points for targeted degradation of PCNA and BCL6. International journal of biological macromolecules. 2025-03-31. PMID:40164264. |
significantly, our results demonstrate the utility of bioprotacs in degrading pcna and bcl6, thereby activating p53 and promoting apoptosis. |
2025-03-31 |
2025-04-03 |
Not clear |
| Tianying Du, Wanjun Wang, Rui Zhan. Royal jelly and doxorubicin suppressed tumor cells in the xenograft model of lung cancer via the STAT3/FOXM1/ATG7 signaling pathways in athymic nude mice: a biochemical, immunohistochemically and molecular approach. Toxicology research. vol 14. issue 2. 2025-03-31. PMID:40161259. |
additionally, rj promoted mitochondrial apoptosis through increased p53 expression and reduced angiogenesis by suppressing vegf. |
2025-03-31 |
2025-04-03 |
mouse |
| Zhijie Li, Hui Ren, Shuaishuai Tan, Bing Su, Yuchen Wang, Wenwen Ren, Boyang Zhang, Can Song, Rulong Du, Yuchun Gu, Lida Wu, Hongyu L. CircITGA7 overexpression suppresses HCC progression via miR-330/BCL11B axis regulation. Cancer cell international. vol 25. issue 1. 2025-03-29. PMID:40155933. |
further research found that circitga7 can inhibit mir-330 to release bcl11b expression, thereby promoting p53 expression, blocking the cell cycle and promoting apoptosis in hcc cells. |
2025-03-29 |
2025-04-01 |
Not clear |
| Mohamed S Abdel-Maksoud, Renad Abdullah Altai, Sarah Saad A Albalawi, Maram N Alrashidi, Nader E Abo-Dya, Nehal Elsherbiny, Yasser M Ragab, Aeshah A Awaji, Mohamed El-Sherbiny, Hassabelrasoul Elfadil Ha, Mohammad M Abd-Alhasee. Diacerein's Antiproliferative Effects Alone and with 5-Fluorouracil in an Ehrlich Solid Tumour Model: Molecular Docking, Molecular Dynamics Simulation Studies, and Experimental Verification. European journal of pharmacology. 2025-03-29. PMID:40157706. |
furthermore, diacerein and 5-fu combination significantly suppressed oxidative stress, inhibited akt phosphorylation, decreased downstream inflammation (nf-κb, tnf-α, il-1β), and increased apoptosis by modulating bax, bcl2, p53, and caspase-3 levels in tumor tissues. |
2025-03-29 |
2025-04-02 |
mouse |
| Zuxiong Zhang, Ruxia Hu, Jie Liu, Xiaohan Yang, Youban Xiao, Xi Xu, Xinxin Liu, Wen Zeng, Shuyong Zhang, Liefeng Wan. Antitumor activity of gilteritinib, an inhibitor of AXL, in human solid tumors. Cell death discovery. vol 11. issue 1. 2025-03-29. PMID:40157901. |
mechanistically, rna-seq analysis revealed that gilteritinib significantly downregulated multiple cancer-related pathways, including those related to apoptosis, the cell cycle, the mtor pathway, the ampk pathway, the p53 pathway, the foxo pathway, the hippo pathway, and the wnt pathway. |
2025-03-29 |
2025-04-02 |
human |
| Eleonora Piscitelli, Edoardo Abeni, Cristiana Balbino, Elena Angeli, Cinzia Cocola, Paride Pelucchi, Mira Palizban, Alberto Diaspro, Martin Götte, Ileana Zucchi, Rolland A Reinbol. Glycosylation Regulation by TMEM230 in Aging and Autoimmunity. International journal of molecular sciences. vol 26. issue 6. 2025-03-27. PMID:40141059. |
genes and biological and molecular pathways associated with hallmarks of aging were in mitochondria-dependent oxidative phosphorylation and reactive oxygen species synthesis, er-dependent stress and unfolded protein response, dna repair (uv response and p53 signaling pathways), and senescence, glycolysis and apoptosis regulation through pi3k-akt-mtor signaling have been shown to play important roles in aging or neurodegeneration (such as parkinson's and alzheimer's disease). |
2025-03-27 |
2025-03-30 |
Not clear |
| Pooja Narain Adtani, Sura Ali Ahmed Fuoad Al-Bayati, Walid Shaaban Elsaye. Sulforaphane from Brassica Oleracea Induces Apoptosis in Oral Squamous Carcinoma Cells via p53 Activation and Mitochondrial Membrane Potential Dysfunction. Pharmaceuticals (Basel, Switzerland). vol 18. issue 3. 2025-03-27. PMID:40143169. |
sulforaphane from brassica oleracea induces apoptosis in oral squamous carcinoma cells via p53 activation and mitochondrial membrane potential dysfunction. |
2025-03-27 |
2025-03-30 |
Not clear |
| Caiqi Xu, Yaoyao Wu, Sui Yang, Xuechun Zhao, Hao Zhang, Yunwen Yan, Jiemin Zhao, Wei Wei, Qian Meng, Yujuan Wang, Rui Zhan. Inhibition of DJ-1 induces TFAM secretion from cancer cells to suppress tumor growth via promoting M1 macrophage polarization. Cellular signalling. 2025-03-27. PMID:40147549. |
dj-1 knockdown promotes p53 translocation to the mitochondria and stimulates the intrinsic mitochondrial apoptosis pathway, resulting in tfam release. |
2025-03-27 |
2025-03-30 |
human |
| S Madesh, Raghul Murugan, Avra Sau, S Jubie, Akey Krishna Swaroop, Rajakrishnan Rajagopal, Kathiravan Muthu Kumaradoss, Jesu Arockiara. Nano-Encapsulated Coumarin Derivative, CS-QM2 Inhibits Neoplasm Growth: Experimented in Zebrafish Model. Journal of biochemical and molecular toxicology. vol 39. issue 4. 2025-03-27. PMID:40143626. |
gene expression analysis showed upregulation of apoptosis and tumor suppressor genes (cas3, p53) and downregulation of inflammatory genes (cox-2, nf-kb). |
2025-03-27 |
2025-03-30 |
cat |
| Jing Sun, Jiaxuan Huai, Wenhui Zhang, Tianyu Zhao, Run Shi, Xuanbin Wang, Minglun Li, Xuehua Jiao, Xiqiao Zho. Therapeutic strategies for adrenocortical carcinoma: integrating genomic insights, molecular targeting, and immunotherapy. Frontiers in immunology. vol 16. 2025-03-27. PMID:40145087. |
this review discusses the complex molecular pathogenesis of acc, focusing on critical pathways implicated in the tumorigenesis and providing potential targets for therapy: the wnt/β-catenin signaling pathway, the igf2/igf1r axis, and the apoptosis pathway regulated by p53. |
2025-03-27 |
2025-03-30 |
Not clear |
| Xiaoli Zhang, Chun Ran, Qingzhi Song, Guoqing L. Extracorporeal shock waves effectively suppress colorectal cancer proliferation and growth. Scientific reports. vol 15. issue 1. 2025-03-22. PMID:40119128. |
the in vitro study showed that esv mechanistically suppressed cell proliferation and induced apoptosis and ferroptosis by activating the p53 signaling pathway. |
2025-03-22 |
2025-03-25 |
mouse |
| Zehua Wang, Xinming Su, Zhiqing Zhan, Hangxuan Wang, Shuhan Zhou, Jiasheng Mao, Hening Xu, Shiwei Dua. miR-660: A novel regulator in human cancer pathogenesis and therapeutic implications. Gene. 2025-03-22. PMID:40120868. |
mir- 660 targets 19 genes involved in 6 pathways such as pi3k/akt/mtor, stat3, wnt/β- catenin, p53, nf‑κb, and ras, influencing cell cycle, proliferation, apoptosis, and invasion/migration. |
2025-03-22 |
2025-03-26 |
human |
| Yunfei Dong, Guixian Sheng, Wenbin Che. TPX2 knockdown mediates p53 activation to induce autophagy and apoptosis for anti-colorectal cancer effects. Journal of receptor and signal transduction research. 2025-03-21. PMID:40116489. |
tpx2 knockdown mediates p53 activation to induce autophagy and apoptosis for anti-colorectal cancer effects. |
2025-03-21 |
2025-03-24 |
mouse |
| Shifeng Wang, Yuanxu Cui, Limei Wang, Chun Feng, Yifei Sun, Bangyun Huo, Honglu Jiang, Mingyu Zhao, Yingying Tu, Qiyue Wang, Yutao Yang, Qiang Zhan. Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice. Molecular metabolism. 2025-03-21. PMID:40118146. |
functional enrichment analysis highlighted the activation of tgfβ, mapk and p53 signaling pathways in smc-like cells, all of which are known to induce cell apoptosis and fibrosis. |
2025-03-21 |
2025-03-24 |
mouse |
| Yong Rao, Xiao Chen, Kaiyu Li, Minhai Nie, Xuqian Li. Research progress on the role of decorin in the development of oral mucosal carcinogenesis. Oncology research. vol 33. issue 3. 2025-03-20. PMID:40109852. |
numerous studies have confirmed that dcn can exert inhibitory effects in various solid tumors, particularly in oral squamous cell carcinoma (oscc), by activating its downstream pathways through binding with the epidermal growth factor receptor (egfr) and mesenchymal-epithelial transition (met) receptor, or by stabilizing and enhancing the expression of the tumor suppressor gene p53 to mediate apoptosis in cancer cells that have undergone mutation. |
2025-03-20 |
2025-03-22 |
Not clear |
| Liang Li, Ying Xu, Binquan Wan. [Retracted] Liriodenine induces the apoptosis of human laryngocarcinoma cells via the upregulation of p53 expression. Oncology letters. vol 29. issue 5. 2025-03-20. PMID:40110577. |
[retracted] liriodenine induces the apoptosis of human laryngocarcinoma cells via the upregulation of p53 expression. |
2025-03-20 |
2025-03-22 |
human |
| Zhaolun He, Yaowen Cui, Tingting Chen, Jing Xu, Xin Yang, Li Song, Lin Wang, Tao Peng, Shuchen Liu, Shouguo Zhan. Discovery of a novel quinoxaline derivative modulator via a dual P53/TLR2 targeting strategy for the alleviation of radiation damage. European journal of medicinal chemistry. vol 290. 2025-03-20. PMID:40112665. |
in addition, z9 significantly reduced radiation-induced apoptosis, dna damage, p53 and bax expression of ahh-1, while z9 up-regulated the expressions of tlr2 downstream proteins myd88 and p65 of huvecs. |
2025-03-20 |
2025-03-23 |
mouse |
| Amr Ahmed El-Arabey, Samia S Alkhalil, Nouf Omar AlAfaleq, Sawsan Al-Shouli, Samah Saif Eldin M Mohamed, Samia T Al-Shouli, Mohnad Abdall. Wild-Type TP53 Predicts Poor Prognosis in Lower-Grade Glioma via TP53-CXCL14-GATA3 Axis. Journal of molecular neuroscience : MN. vol 75. issue 2. 2025-03-19. PMID:40102292. |
tumor protein p53 (tp53) regulates or promotes dna damage and repair via a variety of cell cycle, apoptosis, and genomic stability pathways. |
2025-03-19 |
2025-03-21 |
Not clear |
| Preetham Ravi, Haneesh Jasuja, Dipayan Sarkar, Benjamin Vahidi Pashaki, Hanmant K Gaikwad, Pooyan Vahidi Pashaki, Dinesh R Katti, Kalidas Shetty, Kalpana S Katt. Rhodiola crenulata induces apoptosis in bone metastatic breast cancer cells via activation of caspase-9 and downregulation of MtMP activity. Scientific reports. vol 15. issue 1. 2025-03-19. PMID:40102501. |
we observed that r. crenulata induced apoptosis in bone metastasized breast cancer cells grown on a 3d in vitro testbed by upregulating pro-apoptotic proteins, p53, and caspase-9. |
2025-03-19 |
2025-03-21 |
Not clear |