| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cunjie Li, Yuxin Xiao, Jieling Zhou, Shifeng Liu, Ligang Zhang, Xinran Song, Xinhua Guo, Qifang Song, Jianfu Zhao, Ning Den. Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-11-28. PMID:39609269. |
moreover, the overexpression of oc2 or skp2 in the knockout hcc cell line clearly inhibited the acetylation level of p53 and reduced cell apoptosis. |
2024-11-28 |
2024-12-01 |
mouse |
| Yudi Zhang, Yi Liu, Xueyan Xing, Haibin Liu, Wuxiang Gua. Genome-Wide Analysis of p53 Targets Reveals SCN2A as a Novel Player in p53-Induced Cell Arrest in HPV-Positive Cells. Viruses. vol 16. issue 11. 2024-11-27. PMID:39599840. |
the host transcription factor p53 is a critical tumor suppressor in hpv-induced carcinogenesis, regulating target genes involved in cell cycle arrest and apoptosis. |
2024-11-27 |
2024-11-29 |
Not clear |
| Ilter Ilhan, Halil Asci, Ibrahim Aydın Candan, Mehtap Savran, Orhan Berk Imeci, Mehmet Abdulkadir Sevu. Cannabidiol mitigates methotrexate-induced hepatic injury via SIRT-1/p53 signaling and mitochondrial pathways: reduces oxidative stress and inflammation. Drug and chemical toxicology. 2024-11-27. PMID:39603835. |
it activates antioxidant defenses via sirt-1 upregulation, suppresses inflammation by reducing tnf-α, and prevents apoptosis by modulating p53, bcl-2, and bax gene expressions. |
2024-11-27 |
2024-11-30 |
rat |
| Jinming Wang, Quanwei Li, Yunfei Huo, Xiaoni Liu, Ying Shi, Bangxiang Xi. ASPP2 deficiency promotes the progression of metabolic dysfunction-associated steatohepatitis via ACSL4 upregulation. Scientific reports. vol 14. issue 1. 2024-11-26. PMID:39587161. |
as a member of the p53-binding protein family, apoptosis-stimulating protein p53 2 (aspp2) is closely related to autophagy and apoptosis. |
2024-11-26 |
2024-11-28 |
mouse |
| Zhe Bai, Hui Li, Baoping Jia. Potential Therapeutic Effect of Sinigrin on Diethylnitrosamine-Induced Liver Cancer in Mice: Exploring the Involvement of Nrf-2/HO-1, PI3K-Akt-mTOR Signaling Pathways, and Apoptosis. ACS omega. vol 9. issue 46. 2024-11-25. PMID:39583716. |
sinigrin also activated the intrinsic mitochondrial apoptosis pathway mediated by p53, downregulated antiapoptotic proteins (bcl-2), up-regulated pro-apoptosis regulatory proteins like bax and caspase-3. |
2024-11-25 |
2024-11-27 |
mouse |
| Lingjing Wei, Congyan Yu, Shan Xiao, Kang Liu, Yudian Lu, Baojiang Gan, Peng Zhu, Sheng Zhan. Effects of hypoxia on survival, apoptosis, and the transcriptome of the Chinese yellow pond turtle (Mauremys mutica). Gene. 2024-11-25. PMID:39586519. |
and the degs were enriched in the inflammation, apoptosis, sugar transport, antioxidant, fructose, and mannose metabolism, arginine and proline metabolism, glycosaminoglycan biosynthesis, p53, and mapk signaling pathways. |
2024-11-25 |
2024-11-28 |
Not clear |
| M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikov. Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women. Bulletin of experimental biology and medicine. 2024-11-25. PMID:39585595. |
the expression of markers of proliferation (ki-67), apoptosis (p53), and angiogenesis (cd31, cd34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. |
2024-11-25 |
2024-11-27 |
Not clear |
| M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikov. Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women. Bulletin of experimental biology and medicine. 2024-11-25. PMID:39585595. |
a decrease in the median expression of the proliferation marker (ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers cd31 and cd34) were observed with increasing the severity of the disease. |
2024-11-25 |
2024-11-27 |
Not clear |
| Shaonan Yang, Lu Jiang, Ling Deng, Jingjing Luo, Xiaoling Zhang, Sha Chen, Zhi Don. Chaperone-Mediated Autophagy Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting P53-Mediated Mitochondria-Associated Apoptosis. Neurochemical research. vol 50. issue 1. 2024-11-22. PMID:39576398. |
the p53 activator, nutlin-3, not only reversed the inhibitory effect of cma on apoptosis, but also significantly weakened the protective effect of cma on ogd/r and mcao/r. |
2024-11-22 |
2024-11-24 |
Not clear |
| Yuanyuan Jia, Xinyue Zhang, Yiqing Cai, Hanghui Yu, Guohua Cao, Enyong Dai, Rui Kang, Daolin Tang, Nanjun Hu, Leng Ha. OSGIN1 promotes ferroptosis resistance by directly enhancing GCLM activity. Biochemical and biophysical research communications. vol 740. 2024-11-21. PMID:39571229. |
oxidative stress induced growth inhibitor 1 (osgin1) is a tumor protein p53 (tp53)-target gene involved in the oxidative stress response and promotes apoptosis. |
2024-11-21 |
2024-11-24 |
human |
| Jinke He, Shuanghong Yin, Xiaoyu Deng, Zhongchen Ma, Huan Zhang, Yuhe Miao, Jihai Yi, Chuangfu Chen, Junbo Zhan. The effector protein BspE affects Brucella survival by regulating the inflammatory response and apoptosis. International immunopharmacology. vol 144. 2024-11-20. PMID:39566384. |
furthermore, the bspe-pcbp1 interaction hinders p53 signaling and inhibits macrophage apoptosis. |
2024-11-20 |
2024-11-23 |
mouse |
| Nina Rembiałkowska, Julia Kucharczyk, Eivina Radzevičiūtė-Valčiukė, Vitalij Novickij, Margherita Tonci, Ata Dündar, Julita Kulbacka, Wojciech Szlas. Enhancing lung cancer growth inhibition with calcium ions: Role of mid- and high-frequency electric field pulses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 181. 2024-11-18. PMID:39557010. |
additionally, the use of these electroporation parameters can modulate key cellular processes, such as the epithelial-mesenchymal transition and apoptosis, as indicated by changes in the expression of markers such as e-cadherin, n-cadherin, bcl-2, and p53. |
2024-11-18 |
2024-11-22 |
human |
| Alireza Ahmadi, Abedeh Rezaei, Mohammad Khalaj-Kondori, Mina Khajehdeh. A Comprehensive Bioinformatic Analysis Identifies a Tumor Suppressor Landscape of the MEG3 lncRNA in Breast Cancer. Indian journal of surgical oncology. vol 15. issue 4. 2024-11-18. PMID:39555361. |
the results suggest that meg3 may play a crucial role in fundamental pathways, including apoptosis, and interact with essential genes and proteins such as p53. |
2024-11-18 |
2024-11-22 |
human |
| Ruiying Li, Xiaochuang Xia, Wenping Chen, Hongmin Wang, Lunda Feng, Zhouyi Wan. N6-Methyladenosine Modification of PERP by RBM15 Enhances the Tumorigenesis of Lung Adenocarcinoma via p53 Signaling Pathway. Molecular biotechnology. 2024-11-18. PMID:39556280. |
the promotive effect of p53 apoptosis effector related to pmp-22 (perp) on lung adenocarcinoma (luad) has been confirmed. |
2024-11-18 |
2024-11-22 |
Not clear |
| Kang Chen, Yi-Hui Jia, Zheng He, Pei-Yu Xie, Hong Liu, Ze-Xia Gao, Huan-Ling Wan. Regulation mechanism of oxidative status, immunity and apoptosis induced by hypoxia and heat exposure via PI3K/Akt signaling pathway in Megalobrama amblycephala. Fish & shellfish immunology. 2024-11-17. PMID:39551115. |
additionally, hypoxia and heat exposure up-regulated the expression of antioxidant enzyme genes (nrf2, cu/zn-sod, mn-sod cat, ho-1, pi3k and gpx-1a), inflammatory genes (interleukin il-1β, il-8 and tnf-α), immunity effectors (igm and lyz), as well as apoptosis genes (casp3, casp8, casp9 and p53) and activated p-akt/akt, suggesting apoptosis may be linked with oxidative stress and inflammation and mediated through the pi3k/akt signaling pathway. |
2024-11-17 |
2024-11-22 |
cat |
| Yanping Huang, George R Flentke, Susan M Smit. Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis. Reproductive toxicology (Elmsford, N.Y.). vol 130. 2024-11-15. PMID:39521100. |
the functional impact of these signals with respect to rbg, p53, and apoptosis were assessed using gain-of-function constructs and small molecule mediators. |
2024-11-15 |
2024-11-17 |
Not clear |
| Deepak Sharma, Rajiniraja Muniya. Pharmacophore-guided in-silico discovery of SIRT1 inhibitors for targeted cancer therapy. Computational biology and chemistry. vol 113. 2024-11-15. PMID:39546858. |
sirt1 in association with the p53 protein can regulate crucial cell processes such as glucose metabolism, lipid metabolism, mitochondrial biogenesis, dna repair, oxidative stress, apoptosis, and inflammation through the process of deacetylation. |
2024-11-15 |
2024-11-18 |
Not clear |
| Deepak Sharma, Rajiniraja Muniya. Pharmacophore-guided in-silico discovery of SIRT1 inhibitors for targeted cancer therapy. Computational biology and chemistry. vol 113. 2024-11-15. PMID:39546858. |
to promote apoptosis and decrease cell proliferation by inhibiting sirt1 protein and ultimately raising the acetylation of p53 to regain its tumor suppressor function. |
2024-11-15 |
2024-11-18 |
Not clear |
| Wei Teng, Yuanguo Ling, Niya Long, Wu Cen, Hongzhi Zhang, Lishi Jiang, Jian Liu, Xingwang Zhou, Liangzhao Ch. Repurposing flubendazole for glioblastoma ferroptosis by affecting xCT and TFRC proteins. Journal of cellular and molecular medicine. vol 28. issue 22. 2024-11-14. PMID:39543084. |
flubendazole, an fda-approved antiparasitic drug, has been shown to target p53 and promote apoptosis in glioblastoma (gbm) cells. |
2024-11-14 |
2024-11-17 |
Not clear |
| Zongmeng Zhang, Yueying Liu, Wenbin Feng, Ping Mao, Jianqin Yang, Zhenggang Zhao, Sujin Zhou, Allan Zijian Zhao, Fanghong Li, Yunping M. Omega-3 polyunsaturated fatty acids protect against cisplatin-induced nephrotoxicity by activating the Nrf2 signaling pathway. International journal of biological macromolecules. vol 282. issue Pt 6. 2024-11-13. PMID:39528186. |
furthermore, nrf2 activation can inhibit the cisplatin-induced p53 apoptosis signal by upregulating the expression of mdm2 in renal tubular epithelial cells. |
2024-11-13 |
2024-11-17 |
mouse |