| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahesh Manjunath Gouda, Rex Devasahayam Arokia Balaya, Prashant Kumar Modi, Safwen Kadri, Jaikanth Chanderasekaran, Akarsha Balnadupete, Yashodhar Prabhakar Bhandar. Impact of Curcumin on the IL-17A-Mediated p53-Fibrinolytic System: Mouse Proteomics and Integrated Human Fibrosis scRNAseq Insights. Inflammation. 2024-10-18. PMID:39424752. |
furthermore, the enrichment of pathways and differential expression of proteins underscored the significance of il-17a in governing downstream regulatory pathways such as inflammation, nf-kappab signaling, mitogen-activated protein kinases (mapk), p53, oxidative phosphorylation, jak-stat, and apoptosis. |
2024-10-18 |
2024-10-21 |
mouse |
| Omar L Nelson, Rebecca Rosales, Jane Turbov, Larry G Thaete, Gayathriy Balamayooran, J Mark Cline, J Wesley Pike, Gustavo C Rodrigue. Vitamin D Significantly Inhibits Carcinogenesis in the Mogp-TAg Mouse Model of Fallopian Tube Ovarian Cancer. Nutrients. vol 16. issue 19. 2024-10-16. PMID:39408285. |
after 7 weeks, cholecalciferol significantly reduced p53 signatures, serous tubal epithelial carcinoma, ft cancer, and plasma ca125 while increasing apoptosis in the fte. |
2024-10-16 |
2024-10-18 |
mouse |
| Hong Guo, Yuanwei Dong, Danqing Luo, Meng Gong, Jianfeng Sun, Zhipeng Wu, Zhixiang Liu, Lei Zhong, Song Ji. MRPL41, as a target for acupuncture, promotes neuron apoptosis in models of ischemic stroke via activating p53 pathway. Neurochemistry international. 2024-10-15. PMID:39406282. |
mrpl41, as a target for acupuncture, promotes neuron apoptosis in models of ischemic stroke via activating p53 pathway. |
2024-10-15 |
2024-10-18 |
Not clear |
| Hong Guo, Yuanwei Dong, Danqing Luo, Meng Gong, Jianfeng Sun, Zhipeng Wu, Zhixiang Liu, Lei Zhong, Song Ji. MRPL41, as a target for acupuncture, promotes neuron apoptosis in models of ischemic stroke via activating p53 pathway. Neurochemistry international. 2024-10-15. PMID:39406282. |
our data uncover that acu targets mrpl41, following with inhibiting neuron apoptosis via p53 pathway, thereby ameliorating ischemic stroke. |
2024-10-15 |
2024-10-18 |
Not clear |
| Ali Soleimanzadeh, Niki Karvani, Farshid Davoodi, Rahim Molaie, Abbas Rais. Efficacy of silver-doped Carbon dots in Chemical Castration: a rat model study. Scientific reports. vol 14. issue 1. 2024-10-15. PMID:39406851. |
histological and genes expression analysis also revealed apoptosis and testicular damage in the agcds groups, indicated by significant increases in p53, bax, and caspase-3 levels, and significant reductions in akt, pi3k, and bcl-2. |
2024-10-15 |
2024-10-18 |
rat |
| Tianjun Xing, Zhu Wang, Xiaojie Hao, Jingjun Mu, Bin Wan. Copper Nanoparticles Green-Formulated by Curcuma longa Extract Induce Apoptosis via P53 and STAT3 Signaling Pathways in Bladder Carcinoma Cell. Biological trace element research. 2024-10-13. PMID:39397139. |
copper nanoparticles green-formulated by curcuma longa extract induce apoptosis via p53 and stat3 signaling pathways in bladder carcinoma cell. |
2024-10-13 |
2024-10-16 |
Not clear |
| Tianjun Xing, Zhu Wang, Xiaojie Hao, Jingjun Mu, Bin Wan. Copper Nanoparticles Green-Formulated by Curcuma longa Extract Induce Apoptosis via P53 and STAT3 Signaling Pathways in Bladder Carcinoma Cell. Biological trace element research. 2024-10-13. PMID:39397139. |
the study outlines the production of new copper nanoparticles infused with curcuma longa extract to trigger apoptosis through p53 and signal transducer and activator of transcription 3 (stat3) signaling pathways in bladder carcinoma cells. |
2024-10-13 |
2024-10-16 |
Not clear |
| Yuexuan Wang, Yewen Wang, Yunxiang Jiang, Qiwei Qin, Shina We. The Essential Function of Cathepsin X of the Orange-spotted Grouper, Epinephelus coioides during SGIV Infection. Developmental and comparative immunology. 2024-10-12. PMID:39395685. |
furthermore, the overexpression of eccx also accelerated the process of sgiv-induced apoptosis, potentially by enhancing the promoter activity of p53 and ap-1. |
2024-10-12 |
2024-10-15 |
zebrafish |
| Ling-Kun Zhang, Yuan Li, Limin Zhai, Yunzhi Tang, Yuxuan Jiao, Yitong Mei, Runcai Yang, Rong You, Liang Yin, He Ni, Jian Ge, Yan-Qing Gua. Natural Phycocyanin/Paclitaxel Micelle Delivery of Therapeutic P53 to Activate Apoptosis for HER2 or ER Positive Breast Cancer Therapy. ACS biomaterials science & engineering. 2024-10-11. PMID:39390952. |
natural phycocyanin/paclitaxel micelle delivery of therapeutic p53 to activate apoptosis for her2 or er positive breast cancer therapy. |
2024-10-11 |
2024-10-13 |
Not clear |
| Doyeong Kim, Sang-Min Park, Seo-Young Lee, Jinchul Kim, Han-Byul Jung, Young Sook Kim, Sun-Ku Chun. Antisense-mediated splicing correction as a therapeutic approach for p53 K120R mutation. BMB reports. 2024-10-09. PMID:39384177. |
given that p53 exerts its tumor suppressor function by regulating target genes responsible for growth arrest or apoptosis, the p53 k120r protein enhanced by amo exhibits impaired transcriptional regulation of cdkn1a, a key growth arrest gene, while maintaining normal induction of the pro-apoptotic bbc3 gene. |
2024-10-09 |
2024-10-12 |
Not clear |
| Qing-Yong Hu, Lei Li, Yu-Huang Li, Hai-Bo Zhang, Tao Deng, Yang Liu, Feng-Tian Li, Zhi-Xiong Xiao, Yang Ca. A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth. Acta pharmacologica Sinica. 2024-10-09. PMID:39384887. |
p53, a tumor suppressor protein, has a vital role in the regulation of the cell cycle, apoptosis, and dna damage repair. |
2024-10-09 |
2024-10-12 |
mouse |
| Qing-Yong Hu, Lei Li, Yu-Huang Li, Hai-Bo Zhang, Tao Deng, Yang Liu, Feng-Tian Li, Zhi-Xiong Xiao, Yang Ca. A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth. Acta pharmacologica Sinica. 2024-10-09. PMID:39384887. |
this study used our newly designed structure-based virtual screening approach on a commercial compound library to identify a novel compound, cgma-q18, which directly binds to mdm2, leading to the activation of p53, the induction of apoptosis, and cell cycle arrest in cancer cells. |
2024-10-09 |
2024-10-12 |
mouse |
| Chunping Yao, Xiujuan Cao, Zheng Fu, Jing Tian, Wei Dong, Jin Xu, Kang An, Limin Zhai, Jinming Y. Retracted: Boschniakia rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53. Medical science monitor : international medical journal of experimental and clinical research. vol 30. 2024-10-07. PMID:39370918. |
retracted: boschniakia rossica polysaccharide triggers laryngeal carcinoma cell apoptosis by regulating expression of bcl-2, caspase-3, and p53. |
2024-10-07 |
2024-10-09 |
Not clear |
| Chunping Yao, Xiujuan Cao, Zheng Fu, Jing Tian, Wei Dong, Jin Xu, Kang An, Limin Zhai, Jinming Y. Retracted: Boschniakia rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53. Medical science monitor : international medical journal of experimental and clinical research. vol 30. 2024-10-07. PMID:39370918. |
boschniakia rossica polysaccharide triggers laryngeal carcinoma cell apoptosis by regulating expression of bcl-2, caspase-3, and p53. |
2024-10-07 |
2024-10-09 |
Not clear |
| Binod G C, Laney Jia Hoyt, Sinisa Dovat, Fan Don. Upregulation of nuclear protein Hemgn by transcriptional repressor Gfi1 through repressing PU.1 contributes to the anti-apoptotic activity of Gfi1. The Journal of biological chemistry. 2024-10-07. PMID:39374784. |
an important function of gfi1 is to protect hematopoietic cells against stress-induced apoptosis, which has been attributed to its participation in the posttranscriptional modifications of p53 protein, leading to suppression of p53 activity. |
2024-10-07 |
2024-10-10 |
Not clear |
| Tineng Yang, Xiaoyang Peng, Xi Huang, Peng Cao, Hualei Che. COL6A1 Inhibits the Malignant Development of Bladder Cancer by Regulating FBN1. Cell biochemistry and biophysics. 2024-10-04. PMID:39365515. |
moreover, the col6a1 overexpression suppressed the viability, migration, and invasion, while promoting apoptosis of blca cell lines, with increased caspase-3, bax, and p53, and decreased bcl-2. |
2024-10-04 |
2024-10-07 |
mouse |
| Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han, Eun Ha Cho. Harnessing the synergy of nanosecond high-power microwave pulses and cisplatin to increase the induction of apoptosis in cancer cells through the activation of ATR/ATM and intrinsic pathways. Free radical biology & medicine. 2024-10-03. PMID:39362289. |
additionally, upregulation of atr/atm, chk1/chk2, p53, and caspase 3/8, bax, parp, and bcl2 confirms dna damage and mitochondrial dysfunction, leading to apoptosis. |
2024-10-03 |
2024-10-07 |
Not clear |
| Arif Ul Hasan, Satoshi Serada, Sachiko Sato, Mami Obara, Sho Hirata, Yukako Nagase, Yukiko Kondo, Eiichi Tair. KDM4B Histone Demethylase Inhibition Attenuates Tumorigenicity of Malignant Melanoma Cells by Overriding the p53-Mediated Tumor Suppressor Pathway. Journal of cellular biochemistry. 2024-10-03. PMID:39358852. |
interestingly, despite the reduction of p53, these interventions augmented apoptosis and senescence-induced cell death by activating pathways downstream of p53, as evidenced by reduced levels of pro-survival bcl-2 and bcl-xl proteins and increased production of pro-apoptotic cleaved caspase-3, caspase-7, bax, and the senescence inducer cdkn1a. |
2024-10-03 |
2024-10-05 |
mouse |
| Anlin Wen, Jianjun Wang, Qiaomu Deng, Tao Ren, Jian Yang, Guilan Wen, Deyuan O. The anti-inflammatory effect of arsenic trioxide effectively mitigates the pathogenic process in local chickens with avian leukosis. Poultry science. vol 103. issue 12. 2024-10-01. PMID:39353327. |
the mrna expression levels of p53, p21 and bcl-2 in the livers of alv-j-positive chickens treated with different doses of ato were significantly downregulated, which induced the apoptosis of tumor cells and slowed the inflammatory response. |
2024-10-01 |
2024-10-05 |
Not clear |
| Shangxuan Li, Meng Yang, Yinfeng Zhao, Yinghe Zhai, Chongsong Sun, Yang Guo, Xiaofang Zhang, Lingmin Zhang, Tao Tian, Ying Yang, Yao Pei, Jialiang Li, Chenhong Li, Lina Xuan, Xingda Li, Deli Zhao, Huike Yang, Yang Zhang, Baofeng Yang, Zhiren Zhang, Zhenwei Pan, Yanjie L. Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation. Nature communications. vol 15. issue 1. 2024-09-29. PMID:39341821. |
our previous study showed that aspp1 promotes cardiomyocyte apoptosis by enhancing the nuclear trafficking of p53. |
2024-09-29 |
2024-10-01 |
mouse |