| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuanping Lu, Weiqin Zhou, Caiping Ma. Fluorescent, pH, and UCST Responsive Polymer Nanomaterials for Treatment of Recurrent Miscarriage. Journal of fluorescence. 2024-09-13. PMID:39269549. |
the results showed that the system loaded with low molecular weight heparin increased mdm2 and decreased p53 expression in a dose-dependent manner, thereby inhibiting trophoblast cell apoptosis. |
2024-09-13 |
2024-09-16 |
Not clear |
| S Cirrik, G Hacioglu, E Kabartan, B Tezcan Yavuz, C Sirin Tomru. Can Alpha-Pinene Prevent Methotrexate-Induced Cardiac and Hepatic Damage? Physiological research. vol 73. issue 4. 2024-09-12. PMID:39264082. |
key words: mda, gsh, caspase-3, p53, oxidative stress, apoptosis. |
2024-09-12 |
2024-09-14 |
rat |
| Yuting Ma, Haifeng Wang, Xiao Hu, Hong Zou, Tongyi Xu, Zhigao Wang, Xingrong Ju, Rong H. Inhibitory Effects of Royal Jelly and Its Functional Components on the Proliferation of MKN-28 Gastric Cancer Cells. Journal of agricultural and food chemistry. 2024-09-12. PMID:39262347. |
rj and its functional components stagnated the cell cycle in the g0/g1 phase, accompanied by the accumulation of reactive oxygen species, decreased mitochondrial membrane potential, and increased expression levels of p53 and p21 proteins, caspase-3 activation, and apoptosis. |
2024-09-12 |
2024-09-14 |
Not clear |
| Min Guo, Yu-Dan Ye, Jian-Piao Cai, Hai-Tong Xu, Wei Wei, Jia-Yu Sun, Chen-Yang Wang, Chang-Bing Wang, Ying-Hua Li, Bing Zh. PEG-SeNPs as therapeutic agents inhibiting apoptosis and inflammation of cells infected with H1N1 influenza A virus. Scientific reports. vol 14. issue 1. 2024-09-12. PMID:39266597. |
furthermore, the downregulation of p-atm, p-atr and p53 protein, along with the upregualation of akt protein indicated that peg-senps could inhibit h1n1-induced cell apoptosis through reactive oxygen species (ros)-mediated related signaling pathways. |
2024-09-12 |
2024-09-15 |
human |
| Ziyang Yu, Yirong Teng, Hongbo Yang, Yudi Wang, Xichen Li, Lei Feng, Wenbo Xu, Yinglu Hao, Yanping L. Inhibiting H2AX Can Ameliorate Myocardial Ischemia/Reperfusion Injury by Regulating P53/JNK Signaling Pathway. Cardiology research and practice. vol 2024. 2024-09-11. PMID:39257436. |
in vitro experiments demonstrated that inhibiting h2ax could attenuate mitochondrial damage and apoptosis in myocardial cells by modulating the p53 and jnk signaling pathways. |
2024-09-11 |
2024-09-13 |
mouse |
| Andreas Gollner, Dorothea Rudolph, Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Peter Jung, Harald Weinstabl, Jürgen Ramharter, Rolf Grempler, Jens Quant, Jörg Rinnenthal, Alejandro Pérez Pitarch, Bojana Golubovic, Daniel Gerlach, Gerd Bader, Kristiane Wetzel, Sebastian Otto, Christian Mandl, Guido Boehmelt, Darryl B McConnell, Norbert Kraut, Patrizia Sin. Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules. Molecular cancer therapeutics. 2024-09-11. PMID:39259562. |
compounds that bind to the mdm2 protein and disrupt its interaction with p53 restore p53 tumor suppressor activity, thereby promoting cell cycle arrest and apoptosis. |
2024-09-11 |
2024-09-13 |
mouse |
| Andreas Gollner, Dorothea Rudolph, Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Peter Jung, Harald Weinstabl, Jürgen Ramharter, Rolf Grempler, Jens Quant, Jörg Rinnenthal, Alejandro Pérez Pitarch, Bojana Golubovic, Daniel Gerlach, Gerd Bader, Kristiane Wetzel, Sebastian Otto, Christian Mandl, Guido Boehmelt, Darryl B McConnell, Norbert Kraut, Patrizia Sin. Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules. Molecular cancer therapeutics. 2024-09-11. PMID:39259562. |
brigimadlin treatment restored p53 activity and led to apoptosis induction in preclinical models of tp53 wild-type, mdm2-amplified cancer. |
2024-09-11 |
2024-09-13 |
mouse |
| Liang Shen, Shaodai Huang, Hongyan Fan, Changlin Zha. Colchicine Prevents Cardiac Rupture in Mice with Myocardial Infarction by Inhibiting P53-Dependent Apoptosis. International heart journal. 2024-09-11. PMID:39261032. |
colchicine also attenuated the activation of p53 and decreased the expression of cleaved-caspase 3 and bax, as assessed by western blotting.colchicine prevents cardiac rupture via inhibition of apoptosis, which is attributable to the downregulation of p53 activity. |
2024-09-11 |
2024-09-14 |
mouse |
| Yanping Huang, George R Flentke, Susan M Smit. Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, p70/S6K, and ribosomal biogenesis. bioRxiv : the preprint server for biology. 2024-09-10. PMID:39005448. |
the functional impact of these signals with respect to rbg, p53, and apoptosis were assessed using gain-of-function constructs and small molecule mediators. |
2024-09-10 |
2024-09-13 |
Not clear |
| Vrinda Gupta, Shareen Singh, Thakur Gurjeet Sing. Pervasive Expostulation of p53 Gene Promoting the Precipitation of Neurogenic Convulsions: A Journey in Therapeutic Advancements. European journal of pharmacology. 2024-09-09. PMID:39251181. |
research indicates that changes in p53 expression during neuronal apoptosis, neuroinflammation, and oxidative stress play a significant role in the pathogenesis of epilepsy. |
2024-09-09 |
2024-09-13 |
Not clear |
| Mohamed K Elgohary, Mahmoud S Elkotamy, Tarfah Al-Warhi, Wagdy M Eldehna, Hatem A Abdel-Azi. Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction. Bioorganic chemistry. vol 153. 2024-09-08. PMID:39244969. |
via inhibiting the interaction between mdm2 and p53, lsm-83177 can elevate the active p53 levels within cells, thereby promoting apoptosis and inhibiting tumor growth. |
2024-09-08 |
2024-09-11 |
Not clear |
| Wuyang Lv, Jia Liao, Cuicui Li, Dongyang Liu, Xiaoxiao Luo, RuXue Diao, YuChen Wang, Yingyu Ji. Aquaporin 1 is renoprotective in septic acute kidney injury by attenuating inflammation, apoptosis and fibrosis through inhibition of P53 expression. Frontiers in immunology. vol 15. 2024-09-06. PMID:39238634. |
aquaporin 1 is renoprotective in septic acute kidney injury by attenuating inflammation, apoptosis and fibrosis through inhibition of p53 expression. |
2024-09-06 |
2024-09-08 |
mouse |
| Ganesh Suraj Bose, Shruti Jindal, Kiran Gautam Landage, Aarzoo Jindal, Monali Prakash Mahale, Abhijeet P Kulkarni, Smriti Mitta. SMAR1 and p53-regulated lncRNA RP11-431M3.1 enhances HIF1A translation via miR-138 in colorectal cancer cells under oxidative stress. The FEBS journal. 2024-09-06. PMID:39240540. |
smar1 inhibits cancer cell metastasis and invasion and is also known to inhibit apoptosis during low-dose stress in coordination with p53. |
2024-09-06 |
2024-09-08 |
Not clear |
| Luis Antonio Flores-López, Sergio Enríquez-Flores, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Gabriel López-Velázquez, Rubí Viedma-Rodríguez, Alejandro Ávalos-Rodríguez, Alejandra Contreras-Ramos, Clara Ortega-Camarill. Pancreatic β‑cell apoptosis in type 2 diabetes is related to post‑translational modifications of p53 (Review). Molecular medicine reports. vol 30. issue 5. 2024-09-02. PMID:39219257. |
pancreatic β‑cell apoptosis in type 2 diabetes is related to post‑translational modifications of p53 (review). |
2024-09-02 |
2024-09-04 |
Not clear |
| Luis Antonio Flores-López, Sergio Enríquez-Flores, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Gabriel López-Velázquez, Rubí Viedma-Rodríguez, Alejandro Ávalos-Rodríguez, Alejandra Contreras-Ramos, Clara Ortega-Camarill. Pancreatic β‑cell apoptosis in type 2 diabetes is related to post‑translational modifications of p53 (Review). Molecular medicine reports. vol 30. issue 5. 2024-09-02. PMID:39219257. |
the most prominent changes are increases in reactive oxygen species, the loss of mitochondrial membrane potential and the activation of the intrinsic pathway of apoptosis due to p53. |
2024-09-02 |
2024-09-04 |
Not clear |
| Luis Antonio Flores-López, Sergio Enríquez-Flores, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Gabriel López-Velázquez, Rubí Viedma-Rodríguez, Alejandro Ávalos-Rodríguez, Alejandra Contreras-Ramos, Clara Ortega-Camarill. Pancreatic β‑cell apoptosis in type 2 diabetes is related to post‑translational modifications of p53 (Review). Molecular medicine reports. vol 30. issue 5. 2024-09-02. PMID:39219257. |
these modifications protect p53 from degradation by the proteasome and, in turn, enable it to regulate the intrinsic pathway of apoptosis through the regulation of anti‑apoptotic and pro‑apoptotic elements. |
2024-09-02 |
2024-09-04 |
Not clear |
| Abhishek Chauhan, Monika Yadav, Ritu Chauhan, Rupesh Kumar Basniwal, Vinay Mohan Pathak, Anuj Ranjan, Raj Kishor Kapardar, Rajpal Srivastav, Hardeep Singh Tuli, Seema Ramniwas, Darin Mansor Mathkor, Shafiul Haque, Arif Hussai. Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions. Oncology and therapy. 2024-09-02. PMID:39222186. |
in gastric cancer, ea regulates multiple pathways involved in cell proliferation, invasion, and apoptosis, including the p53 and pi3k-akt signaling pathways. |
2024-09-02 |
2024-09-04 |
Not clear |
| Fatemeh Ebadi Meinag, Mina Fatahi, Vahid Vahedian, Nazila Fathi Maroufi, Bashir Mosayyebi, Elham Ahmadi, Mohammad Rahmat. Modulatory effects of miRNAs in doxorubicin resistance: A mechanistic view. Functional & integrative genomics. vol 24. issue 5. 2024-09-02. PMID:39222264. |
this review aimed to present the current understanding of the mechanisms and effects of mirnas on apoptosis, p53 and pten/pi3k/akt signaling pathway related to dox resistance. |
2024-09-02 |
2024-09-04 |
Not clear |
| Bu-Ting Duan, Hao-Yu Zhang, Zi-Hao Song, Xiao-Yi Han, Kai-Ling Cui, Tong Xu, Yu Zhang, Yong-Juan Zhao, Xuan Lei, Fan Tan, Lu-Lu Guo, Hui-Lin Yang, Li Zhang, Rui Bai, Xiao-Ling Lv, Ming-Xue Zhen. EtROP38 suppresses apoptosis of host cells infected with Eimeria tenella by inhibition of the p38MAPK pathway. Veterinary parasitology. vol 331. 2024-09-01. PMID:39217762. |
the results showed that the addition of etrop38 and/or knockdown of the host cells p38 gene reduced the apoptosis rate of cecal epithelial cells (cecs), decreased the mrna expressions of p38, p53, c-myc, c-fos, and c-jun and increased the expression of p65, decreased the protein expressions of c-myc, c-fos, and c-jun, decreased the p38 protein phosphorylation level, and increased the p65 protein phosphorylation level in cecs. |
2024-09-01 |
2024-09-04 |
Not clear |
| Hina Qayoom, Manzoor A Mi. Mutant P53 modulation by cryptolepine through cell cycle arrest and apoptosis in triple negative breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 179. 2024-08-31. PMID:39216450. |
mutant p53 modulation by cryptolepine through cell cycle arrest and apoptosis in triple negative breast cancer. |
2024-08-31 |
2024-09-04 |
Not clear |