| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sedigheh Edalatian Tavakoli, Alireza Motavalizadehkakhky, Masoud Homayouni Tabrizi, Jamshid Mehrzad, Rahele Zhian. Study of the anti-cancer activity of a mesoporous silica nanoparticle surface coated with polydopamine loaded with umbelliprenin. Scientific reports. vol 14. issue 1. 2024-05-20. PMID:38769394. |
the induction of apoptosis in mcf-7 cells was indicated by the upregulation of p53, caspase 8, and caspase 9 genes, enhanced sub-g1 phase cells, and the ao/pi fluorescent staining. |
2024-05-20 |
2024-05-27 |
Not clear |
| Fernando García-Valdespino, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Olivá. Captopril's influence on Danio rerio embryonic development: Unveiling significant toxic outcomes at environmentally relevant concentrations. The Science of the total environment. vol 933. 2024-05-17. PMID:38750761. |
likewise, cap, at all concentrations, exerted significant modulatory effects on the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3), organogenesis (tbx2a, tbx2b, and irx3b), and ion exchange (slc12a1 and kcnj1) in danio rerio embryos. |
2024-05-17 |
2024-05-27 |
zebrafish |
| Bo Ram Kim, Dae Yeong Kim, Na Ly Tran, Bu Gyeom Kim, Sun Il Lee, Sang Hee Kang, Byung Yook Min, Wooyoung Hur, Sang Cheul O. Daunorubicin induces GLI1‑dependent apoptosis in colorectal cancer cell lines. International journal of oncology. vol 64. issue 6. 2024-05-17. PMID:38757343. |
daunorubicin also increased p53 levels, which contributed to both gli1 suppression and apoptosis. |
2024-05-17 |
2024-05-27 |
mouse |
| Nicolaas J Boon, Rafaela A Oliveira, Pierré-René Körner, Adva Kochavi, Sander Mertens, Yuval Malka, Rhianne Voogd, Suzanne E M van der Horst, Maarten A Huismans, Lidwien P Smabers, Jonne M Draper, Lodewyk F A Wessels, Peter Haahr, Jeanine M L Roodhart, Ton N M Schumacher, Hugo J Snippert, Reuven Agami, Thijn R Brummelkam. DNA damage induces p53-independent apoptosis through ribosome stalling. Science (New York, N.Y.). vol 384. issue 6697. 2024-05-16. PMID:38753784. |
in response to excessive dna damage, human cells can activate p53 to induce apoptosis. |
2024-05-16 |
2024-05-27 |
human |
| Nicolaas J Boon, Rafaela A Oliveira, Pierré-René Körner, Adva Kochavi, Sander Mertens, Yuval Malka, Rhianne Voogd, Suzanne E M van der Horst, Maarten A Huismans, Lidwien P Smabers, Jonne M Draper, Lodewyk F A Wessels, Peter Haahr, Jeanine M L Roodhart, Ton N M Schumacher, Hugo J Snippert, Reuven Agami, Thijn R Brummelkam. DNA damage induces p53-independent apoptosis through ribosome stalling. Science (New York, N.Y.). vol 384. issue 6697. 2024-05-16. PMID:38753784. |
cells lacking p53 can still undergo apoptosis upon dna damage, yet the responsible pathways are unknown. |
2024-05-16 |
2024-05-27 |
human |
| Věra Slaninová, Lisa Heron-Milhavet, Mathilde Robin, Laura Jeanson, Adam Aissanou, Diala Kantar, Diego Tosi, Laurent Bréhélin, Céline Gongora, Alexandre Djian. The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells. BMC cancer. vol 24. issue 1. 2024-05-14. PMID:38741073. |
our results support thus an early action of taz to sensitize cells to oxaliplatin, consistent with a model in which nuclear taz in the context of dna damage and p53 activity pushes cells towards apoptosis. |
2024-05-14 |
2024-05-27 |
Not clear |
| Yi-Ni Bao, Qiao Yang, Xin-Lei Shen, Wen-Kai Yu, Li Zhou, Qing-Ru Zhu, Qi-Yuan Shan, Zhi-Chao Wang, Gang Ca. Targeting tumor suppressor p53 for organ fibrosis therapy. Cell death & disease. vol 15. issue 5. 2024-05-14. PMID:38744865. |
the tumor suppressor p53 (p53), known for its regulatory roles in cell proliferation, apoptosis, aging, and metabolism across diverse tissues, appears to play a pivotal role in aggravating biological processes such as epithelial-mesenchymal transition (emt), cell apoptosis, and cell senescence. |
2024-05-14 |
2024-05-27 |
Not clear |
| Yumei Yao, Qian Zhang, Zhi Li, Hushan Zhan. MDM2: current research status and prospects of tumor treatment. Cancer cell international. vol 24. issue 1. 2024-05-13. PMID:38741108. |
consequently, blocked p53 activity often fails in damaged cells to undergo cell cycle arrest or apoptosis. |
2024-05-13 |
2024-05-27 |
human |
| Jinmei Cheng, Junjie Xu, Yimin Gu, Yueming Wang, Jianyu Wang, Fei Su. Melatonin ameliorates 10-hydroxycamptothecin-induced oxidative stress and apoptosis via autophagy-regulated p62/Keap1/Nrf2 pathway in mouse testicular cells. Journal of pineal research. vol 76. issue 4. 2024-05-13. PMID:38738543. |
changes in apoptosis-associated protein levels (bax, bcl-2, p53, and cleaved caspase-3) and in reactive oxygen species-associated proteins (nrf2 and keap1) and index (malondialdehyde and glutathione) suggested that melatonin treatment relieved hcpt-induced cell apoptosis and oxidative damage, respectively. |
2024-05-13 |
2024-05-27 |
mouse |
| Kirti S Prabhu, Fareed Ahmad, Shilpa Kuttikrishnan, Rari Leo, Tayyiba Akbar Ali, Mahmoud Izadi, Jericha M Mateo, Majid Alam, Aamir Ahmad, Ammira S Al-Shabeeb Akil, Ajaz A Bhat, Joerg Buddenkotte, Ehsan Pourkarimi, Martin Steinhoff, Shahab Uddi. Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans. Cell death discovery. vol 10. issue 1. 2024-05-12. PMID:38724504. |
notably, this increased apoptosis was mediated through the activity of cep-1, the worm's counterpart to mammalian p53. |
2024-05-12 |
2024-05-27 |
caenorhabditis_elegans |
| Giovanni Luca Beretta, Desirè Alampi, Cristina Corno, Nives Carenini, Elisabetta Corna, Paola Pereg. KiSS-1 Modulation by Epigenetic Agents Improves the Cisplatin Sensitivity of Lung Cancer Cells. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732265. |
a modulation of proteins involved in apoptosis (p53, bax) was found in both sensitive and resistant cells, and compared to the treatment with epigenetic agents alone, the combination of cisplatin and saha or aza increased apoptosis induction. |
2024-05-11 |
2024-05-27 |
mouse |
| Yuhan Zheng, Qingyun Wei, Xuan Han, Xiangmin Tao, Tao Cao, Tianbao Chen, Peng Cao, Qichen Zha. Homologous polydopamine ameliorates haemolysis of melittin for enhancing its anticancer efficacy. Journal of materials chemistry. B. 2024-05-10. PMID:38726737. |
after cellular uptake, mpf nps induce cell apoptosis through the pi3k/akt-mediated p53 signaling pathway. |
2024-05-10 |
2024-05-27 |
mouse |
| Yanqing Liu, Zhenyi Su, Omid Tavana, Wei G. Understanding the complexity of p53 in a new era of tumor suppression. Cancer cell. 2024-05-10. PMID:38729160. |
although early studies established p53-mediated cell-cycle arrest, apoptosis, and senescence as the classic barriers in cancer development, a growing number of new functions of p53 have been discovered and the scope of p53-mediated anti-tumor activity is largely expanded. |
2024-05-10 |
2024-05-27 |
human |
| Tarek A Seaf Elnasr, Omar M Ibrahim, Mosaed S Alhumaimess, Ibrahim Hotan Alsohaimi, Yasser A El-Ossaily, Modather F Hussein, Mohamed Abdel Rafea, Hassan M A Hassan, Sherien E Sobhy, Elsayed E Hafez, Mohamed R El-Aassa. Olive leaf extract-derived chitosan-metal nanocomposite: Green synthesis and dual antimicrobial-anticancer action. International journal of biological macromolecules. 2024-05-10. PMID:38729503. |
further, the nanoparticles induced apoptosis in cancer cells, as evidenced by the modulation of oncogenes (p21, p53, and bcl2), suggesting their therapeutic potential. |
2024-05-10 |
2024-05-27 |
Not clear |
| Anran Zhang, Xue Zheng, Shuaiyin Chen, Guangcai Dua. In vitro study of HPV18-positive cervical cancer HeLa cells based on CRISPR/Cas13a system. Gene. vol 921. 2024-05-08. PMID:38710293. |
the e6 protein is a known oncogene in cervical cancer and plays a key role in the development and progression of cervical cancer by reducing the expression level of the tumor suppressor protein p53 and ultimately leading to enhanced cell proliferation and reduced apoptosis. |
2024-05-08 |
2024-05-27 |
human |
| Anran Zhang, Xue Zheng, Shuaiyin Chen, Guangcai Dua. In vitro study of HPV18-positive cervical cancer HeLa cells based on CRISPR/Cas13a system. Gene. vol 921. 2024-05-08. PMID:38710293. |
here we developed crispr/cas13a: crrna dual plasmid system and demonstrated that crispr/cas13a could effectively and specifically knock down human papillomavirus 18 e6 mrna, downregulate the expression level of e6 protein, and restore the expression of the tumor suppressor gene p53 protein, thereby inhibiting the growth of cervical cancer cells and increasing their apoptosis, the e6-2, e6-3, and e6-5 groups resulted in apoptosis rates of 25.4%, 22.4%, and 22.2% in hela cells. |
2024-05-08 |
2024-05-27 |
human |
| Wanhong Chen, Qingbai Liu, Bin Fu, Kai Liu, Wenchao Jian. Retraction notice to "Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization" [Life Sci. 208 (2018) 208, 232-238]. Life sciences. 2024-05-02. PMID:38697876. |
retraction notice to "overexpression of grim-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization" [life sci. |
2024-05-02 |
2024-05-05 |
Not clear |
| Rongzhen Ding, Yichao Wang, Ling Xu, Shuliu Sang, Guanjin Wu, Wenxiao Yang, Yilu Zhang, Chengyan Wang, Ao Qi, Haiping Xie, Yi Liu, Aiguo Dai, Lijing Jia. QiDongNing induces lung cancer cell apoptosis via triggering P53/DRP1-mediated mitochondrial fission. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-04-29. PMID:38682742. |
our previous findings showed that chinese herbal medicine (chm) qidongning (qdn) could upregulate the expression of p53 and trigger cell apoptosis in nsclc. |
2024-04-29 |
2024-05-02 |
Not clear |
| Rongzhen Ding, Yichao Wang, Ling Xu, Shuliu Sang, Guanjin Wu, Wenxiao Yang, Yilu Zhang, Chengyan Wang, Ao Qi, Haiping Xie, Yi Liu, Aiguo Dai, Lijing Jia. QiDongNing induces lung cancer cell apoptosis via triggering P53/DRP1-mediated mitochondrial fission. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-04-29. PMID:38682742. |
the results were further verified by rescue experiments, the p53 inhibitor pifithrin-α and the mitochondrial division inhibitor mdivi1 partially inhibited qdn-induced apoptosis and mitochondrial dysfunction, whereas overexpression of p53 rather increased the efficacy of the therapy. |
2024-04-29 |
2024-05-02 |
Not clear |
| Ruqaia Abbas, Oliver Hartmann, Dorin Theodora Asiss, Rabab Abbas, Julia Kagan, Hyoung-Tae Kim, Moshe Oren, Markus Diefenbacher, Amir Orian, Sarit Larisc. ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP. Apoptosis : an international journal on programmed cell death. 2024-04-29. PMID:38684550. |
here we report that the ubiquitin e3 ligase xiap (x-linked inhibitors of apoptosis) is a direct ligase for p53 and describe a novel approach for modulating the levels of p53 by targeting the xiap pathway. |
2024-04-29 |
2024-05-03 |
Not clear |