| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Tian, Chengli Liu, Jianming Liao, Guijun Wang, Wenrui Han, Xiaoxing Xiong, Zhibiao Chen, Lijuan Gu, Mingchang L. ATF2/BAP1 Axis Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage via P53 Pathway. Stroke. 2024-07-05. PMID:38965653. |
atf2/bap1 axis mediates neuronal apoptosis after subarachnoid hemorrhage via p53 pathway. |
2024-07-05 |
2024-07-11 |
Not clear |
| Mehmet Kadir Erdogan, Ramazan Gundogdu, Yusuf Toy, Ibrahim Halil Gecibesler, Yakup Yapar, Lutfi Behcet, Gokhan Zengi. Comparison of Anticancer, Antioxidant, Enzyme Inhibitory Effects and Phytochemical Contents between Edible Lettuce (Lactuca sativa) and A New Wild Species (Lactuca anatolica). Chemistry & biodiversity. 2024-07-03. PMID:38958194. |
it was revealed that la and ls treatment at 50 µg/ml concentrations in a549 cells completely suppressed the colony forming capacity, and treatment with ic50 doses inhibited cell migration, and triggered apoptosis by regulating caspase-3, cparp, p53 and p21. |
2024-07-03 |
2024-07-06 |
Not clear |
| Ignacio Ruz-Caracuel, Tamara Caniego-Casas, Teresa Alonso-Gordoa, Irene Carretero-Barrio, Carmen Ariño-Palao, Almudena Santón, Marta Rosas, Héctor Pian, Javier Molina-Cerrillo, Patricia Luengo, José Palacio. Transcriptomic Differences in Medullary Thyroid Carcinoma According to Grade. Endocrine pathology. 2024-07-03. PMID:38958823. |
major pathways differentially expressed between high-grade and low-grade mtcs were dna damage repair, p53 signaling, cell cycle, apoptosis, and myc signaling. |
2024-07-03 |
2024-07-06 |
Not clear |
| Qian Zhang, Shuting Li, Jing Fang, Yue Hao, Junge Lu, Lu Zhang, Minmin Zhang, Li Zhang, Yihe Wang, Yu Zhang, Hongying Du, Yuan Gao, Zuosen Yang, Wei Sun, Lingjun Yan, Guowei Pa. The combined effects of polystyrene of different sizes and cadmium in mouse kidney tissues. Ecotoxicology and environmental safety. vol 281. 2024-06-29. PMID:38944012. |
an increase in the bax/bcl2 ratio and overexpression of p53 and caspase-3 revealed that renal cell apoptosis might be induced via the mitochondrial pathway. |
2024-06-29 |
2024-07-02 |
mouse |
| Yue Ni, Hongce Chen, Qiuqiang Zhan, Zhengfei Zhuan. Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis. Cellular signalling. 2024-06-29. PMID:38944257. |
taken together, pml promotes apoptosis and ferroptosis, in which the mediation of p53 and the nuclear export of pml play important roles. |
2024-06-29 |
2024-07-02 |
Not clear |
| George R Flentke, Thomas E Wilkie, Josh Baulch, Yanping Huang, Susan M Smit. Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PloS one. vol 19. issue 6. 2024-06-28. PMID:38941348. |
this was followed by reduced proliferation, stabilization of nuclear p53, and apoptosis that was prevented by overexpression of mdm2 or dominant-negative p53. |
2024-06-28 |
2024-07-01 |
zebrafish |
| Ana Neves, Tânia Albuquerque, Rúben Faria, Cecília R A Santos, Eric Vivès, Prisca Boisguérin, Diana Carneiro, Daniel F Bruno, Maria D Pavlaki, Susana Loureiro, Ângela Sousa, Diana Cost. Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells. Pharmaceutics. vol 16. issue 6. 2024-06-27. PMID:38931902. |
the combined action of the anticancer drug with p53 supplementation in cancer cells enhances cytotoxicity, which was correlated to apoptosis activation through quantification of caspase-3 activity. |
2024-06-27 |
2024-06-29 |
zebrafish |
| Ana Neves, Tânia Albuquerque, Rúben Faria, Cecília R A Santos, Eric Vivès, Prisca Boisguérin, Diana Carneiro, Daniel F Bruno, Maria D Pavlaki, Susana Loureiro, Ângela Sousa, Diana Cost. Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells. Pharmaceutics. vol 16. issue 6. 2024-06-27. PMID:38931902. |
our findings demonstrated the great potential of peptide tmz/p53 co-delivery complexes for cellular transfection, p53 expression, and apoptosis induction, holding promising therapeutic value toward glioblastoma. |
2024-06-27 |
2024-06-29 |
zebrafish |
| Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma, Jinying Xu, Yingying Fan, Yuewen Chen, Yu Che. Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis. Cell death & disease. vol 15. issue 6. 2024-06-27. PMID:38937439. |
in turn, coronin 2b-mediated nucleolar stress leads to p53 stabilization and activation, eventually resulting in neuronal apoptosis. |
2024-06-27 |
2024-06-30 |
Not clear |
| Amna Fayyaz, Mahnoor Basit, Andleeb Farooq, Tooba Khan, Umama Ayub, Somia Khan, Muhammad Armaghan, Mati-Ur-Rahman, Muhammad Ammad, Dietrich Büsselberg, Khushbukhat Khan, Solomon Habtemariam, Javad Sharifi-Ra. Therapeutic potential of ethoxy mansonone G: A comprehensive exploration of its anticancer actions in breast cancer, colorectal cancer, and non-small cell lung carcinoma. Cell biology international. 2024-06-26. PMID:38924324. |
through the stimulation of the tumor protein (p53) and extracellular signal-regulated kinase (erk) signaling cascades, it also causes apoptosis. |
2024-06-26 |
2024-06-29 |
Not clear |
| Ya Chen, Congcong Zhu, Zongguang Tai, Tianyan Lian, Quangang Zhu, Zhongjian Che. Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop. Molecular biotechnology. 2024-06-24. PMID:38914920. |
regulating the expression of apoptotic proteins bax, bcl-2, and p53 promote apoptosis. |
2024-06-24 |
2024-06-27 |
mouse |
| Or Michaeli, Ishai Luz, Maayan Vatarescu, Tal Manko, Noam Weizman, Yevgeniya Korotinsky, Alexandra Tsitrina, Alex Braiman, Lior Arazi, Tomer Cook. APR-246 as a radiosensitization strategy for mutant p53 cancers treated with alpha-particles-based radiotherapy. Cell death & disease. vol 15. issue 6. 2024-06-18. PMID:38890278. |
it was previously reported that cells carrying wild-type (wt) p53 exhibit accelerated senescence and significant rates of apoptosis in response to rt, whereas cells harboring mutant p53 (mutp53) do not. |
2024-06-18 |
2024-06-21 |
human |
| Mozhgan Soltani, Amin Farhadi, Sarah Rajabi, Masoud Homayouni-Tabrizi, Fatimah Sameer Hussein, Navid Mohammadia. Folic acid-modified nanocrystalline cellulose for enhanced delivery and anti-cancer effects of crocin. Scientific reports. vol 14. issue 1. 2024-06-17. PMID:38886450. |
fluorescent staining, flow cytometry, and molecular analysis confirmed that ncf-cr-nps induced apoptosis in ht-29 cells by increasing p53 and caspase 8 expression. |
2024-06-17 |
2024-06-21 |
Not clear |
| Pan Shen, Mei Xue, Zhishuo Hu, Liang Han, Xuan Den. Direct targeting of S100A9 with Icariin counteracted acetaminophen‑induced hepatotoxicity. International immunopharmacology. vol 136. 2024-06-16. PMID:38810310. |
in vitro, icariin pretreatment significantly inhibited hepatocellular damage and apoptosis by reducing the bax/bcl-2 ratio as well as the expression of cleaved-caspase 3 and cleaved-parp depended on the p53 pathway. |
2024-06-16 |
2024-06-18 |
mouse |
| Xinyu Wu, Jiawei Chen, Kaixin Ping, Yan Xia, Mengxin Li, Yannan Xiang, Huimao Feng, Jingquan Don. Silybin mitigated liver and brain damage after difenoconazole exposure: Crosstalk between oxidative stress, inflammation, ferroptosis and apoptosis. Pesticide biochemistry and physiology. vol 202. 2024-06-16. PMID:38879300. |
in this study, we analyzed the interactions between genes and proteins associated with oxidative stress, inflammation, ferroptosis and apoptosis using the string database and ranked the nodes in the network using the cytoscape plugin cytohubba, and found that p53, caspase3, tnf-α, il-6 and bcl-2 were the key hub genes. |
2024-06-16 |
2024-06-18 |
cat |
| Ying Li, Li Wan, Hexin Li, Xiaokun Tang, Siyuan Xu, Gaoyuan Sun, Wei Huang, Min Tan. Small molecule NMD and MDM2 inhibitors synergistically trigger apoptosis in HeLa cells. Molecules and cells. 2024-06-13. PMID:38871298. |
in this study, we evaluated the impacts of nmd inhibitor, mdm2 inhibitor, and their combination on cell apoptosis, cell cycle, and p53 target genes in hpv-18-positive hela cells. |
2024-06-13 |
2024-06-16 |
Not clear |
| Ying Li, Li Wan, Hexin Li, Xiaokun Tang, Siyuan Xu, Gaoyuan Sun, Wei Huang, Min Tan. Small molecule NMD and MDM2 inhibitors synergistically trigger apoptosis in HeLa cells. Molecules and cells. 2024-06-13. PMID:38871298. |
our findings revealed that xr-2failed to activate p53 or induce apoptosis in hela cells, whereas smg1i repressed cell proliferation at high concentrations. |
2024-06-13 |
2024-06-16 |
Not clear |
| Yafei Duan, Yukai Yang, Hua Li, Zhe Zhang, Xiaoying Chen, Meng Xiao, Yuxiu Na. The toxic effects of tetracycline exposure on the physiological homeostasis of the gut-liver axis in grouper. Environmental research. 2024-06-12. PMID:38866314. |
further, intestinal health was also affected, including the damaged intestinal mucosa, the decreased mrna expression levels of tight junction proteins (zo-1, occludin, and claudin-3), along with the increased gene expression levels of inflammation (il-1β, il-8, tnf-α) and apoptosis (casp-3 and p53). |
2024-06-12 |
2024-06-15 |
Not clear |
| Aswathi R K, Suresh Arumugam, Natrajan Muninathan, Kuppusamy Baskar, Deepthi S, Dinesh Roy . P53 Gene as a Promising Biomarker and Potential Target for the Early Diagnosis of Reproductive Cancers. Cureus. vol 16. issue 5. 2024-06-12. PMID:38864057. |
p53 is a key tumor suppressor that recognizes the carcinogenic biological pathways and eradicates them by apoptosis. |
2024-06-12 |
2024-06-14 |
Not clear |
| Oleg A Kuchur, Sofya S Pogodaeva, Anna V Shcherbakova, Segrey A Tsymba. Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53. Bioscience reports. vol 44. issue 6. 2024-06-11. PMID:38813981. |
the p53 protein plays an important role in regulating processes such as apoptosis, repair, and cell division, and the loss of its functionality often accompanies various types of tumors and contributes to the development of chemoresistance. |
2024-06-11 |
2024-06-14 |
Not clear |