| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong-Kyu Lee, Hyeon Ho Heo, Nackhyoung Kim, Ui-Hyun Park, Hyesook Youn, Eun-Yi Moon, Eun-Joo Kim, Soo-Jong U. Tumor antigen PRAME is a potential therapeutic target of p53 activation in melanoma cells. BMB reports. 2024-06-05. PMID:38835116. |
the tumor suppressor p53 is a transcriptional regulator that mediates cell cycle arrest and apoptosis in response to stress signals. |
2024-06-05 |
2024-06-07 |
human |
| Hyeon Jin Kim, Mi Suk Jeong, Se Bok Jan. Identification and structure of AIMP2-DX2 for therapeutic perspectives. BMB reports. 2024-06-05. PMID:38835119. |
in response to dna damage, a component of aimp2 separates from the multi-trna synthetase complex, binds to p53, and prevents its degradation by mdm2, inducing apoptosis. |
2024-06-05 |
2024-06-07 |
Not clear |
| Qiuyue Jin, Xiaohui Zhou, Xiaomin Niu, Canqi Ping, Xiaozhou Dong, Danyu Duan, Rongrong Wang, Yi Chen, Fei Pan, Fan Yang, Xihua Yang, Guoshun Zhang, Ruili Wang, Shuqiu Zhang, Guolian Re. Co-delivery of doxorubicin-dihydroartemisinin prodrug/TEPP-46 nano-liposomes for improving antitumor and decreasing cardiotoxicity in B16-F10 tumor-bearing mice. Colloids and surfaces. B, Biointerfaces. vol 241. 2024-06-04. PMID:38833960. |
the presence of tepp-46 increased the content of p53 protein, which further induced tumor cell apoptosis. |
2024-06-04 |
2024-06-07 |
mouse |
| Micheline Kirsch-Volders, Miroslav Mišík, Jacques de Gerlach. Tetraploidy as a metastable state towards malignant cell transformation within a systemic approach of cancer development. Mutation research. Genetic toxicology and environmental mutagenesis. vol 896. 2024-05-31. PMID:38821671. |
the available data shows that stress-induced tetraploidisation/polyploidisation leads to p53 stabilisation, cell cycle arrest, followed by cellular senescence or apoptosis, suppressing the proliferation of tetraploid cells. |
2024-05-31 |
2024-06-02 |
Not clear |
| Feng-Ling Zhou, Bin Yuan, Yi-Xian Ye, Shu-Ye Deng, Jing Ma, Hong Liu, Yuan-Zheng Ma, Yan-Fei We. [Effects of plumbagin on proliferation and apoptosis of human hepatocellular carcinoma cells based on CKB/p53 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 9. 2024-05-30. PMID:38812135. |
in conclusion, plumbagin significantly inhibited the proliferative ability of huh-7 cells, and the mechanism may be related to the inhibition of ckb expression, activation of the p53 signaling pathway, and regulation of the expression of mitochondrial-associated apoptotic proteins, ultimately inducing cell apoptosis. |
2024-05-30 |
2024-06-08 |
mouse |
| Zihuan Wang, Xu Zhang, Yuchen Luo, Yijiang Song, Cheng Xiang, Yilin He, Kejin Wang, Yingnan Yu, Zhen Wang, Wenxuan Peng, Yi Ding, Side Liu, Changjie W. Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis). Cell death & disease. vol 15. issue 5. 2024-05-29. PMID:38811536. |
therapeutic targeting of arid1a-deficient cancer cells with rita (reactivating p53 and inducing tumor apoptosis). |
2024-05-29 |
2024-06-02 |
Not clear |
| Zihuan Wang, Xu Zhang, Yuchen Luo, Yijiang Song, Cheng Xiang, Yilin He, Kejin Wang, Yingnan Yu, Zhen Wang, Wenxuan Peng, Yi Ding, Side Liu, Changjie W. Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis). Cell death & disease. vol 15. issue 5. 2024-05-29. PMID:38811536. |
in this study, we observed that arid1a-deficient colorectal cancer (crc) cells showed synthetic lethal effects with a p53 activator, rita (reactivating p53 and inducing tumor apoptosis). |
2024-05-29 |
2024-06-02 |
Not clear |
| Zihuan Wang, Xu Zhang, Yuchen Luo, Yijiang Song, Cheng Xiang, Yilin He, Kejin Wang, Yingnan Yu, Zhen Wang, Wenxuan Peng, Yi Ding, Side Liu, Changjie W. Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis). Cell death & disease. vol 15. issue 5. 2024-05-29. PMID:38811536. |
arid1a loss exhibits an opposing effect on p53 targets, leading to decreased p21 expression and increased levels of proapoptotic genes, puma and noxa, which is further potentiated by rita treatment, ultimately inducing cell apoptosis. |
2024-05-29 |
2024-06-02 |
Not clear |
| b' Mohammad Mijanur Rahman, Huixin Wu, Trygve O Tollefsbo. A novel combinatorial approach using\xa0sulforaphane- and withaferin A-rich extracts for prevention of estrogen receptor-negative breast cancer through epigenetic and gut microbial mechanisms. Scientific reports. vol 14. issue 1. 2024-05-27. PMID:38802425.' |
at the molecular level, the bsp and ash combination upregulated tumor suppressors (p53, p57) along with apoptosis associated proteins (bax, puma) and bax:bcl-2 ratio. |
2024-05-27 |
2024-05-31 |
mouse |
| Adrian I Abdo, Zlatko Kopeck. Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer. Current issues in molecular biology. vol 46. issue 5. 2024-05-26. PMID:38785562. |
at higher cp exposures, inactivation, apoptosis, and autophagy of malignant cells can occur via the degradation of the pi3k/akt and mitogen-activated protein kinase (mapk)-dependent and -independent activation of the master tumour suppressor p53, leading to caspase-mediated cell death. |
2024-05-26 |
2024-05-27 |
Not clear |
| Jannatul Ferdoush, Rizwaan Abdul Kadir, Matthew Ogle, Ayan Sah. Regulation of eukaryotic transcription initiation in response to cellular stress. Gene. vol 924. 2024-05-26. PMID:38795856. |
several transcription factors such as p53, c/ebp homologous protein (chop), activating transcription factor 6 (atf6α), e2f, transforming growth factor (tgf)-β, adenomatous polyposis coli (apc), smad, and myc have been implicated in regulation of transcription of target genes involved in cell cycle progression, apoptosis, and dna damage repair pathways. |
2024-05-26 |
2024-05-31 |
human |
| Kirti S Prabhu, Serah Jessy, Shilpa Kuttikrishnan, Farina Mujeeb, Zahwa Mariyam, Ummu Habeeba, Nuha Ahmad, Ajaz A Bhat, Shahab Uddi. Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies. Pharmaceuticals (Basel, Switzerland). vol 17. issue 5. 2024-05-25. PMID:38794148. |
ps modulates several key cellular processes, including apoptosis, autophagy, cell migration and invasion, angiogenesis, and resistance to chemotherapy, targeting crucial signaling pathways such as those involving nf-κb, p53, and stat3, among others. |
2024-05-25 |
2024-05-27 |
human |
| Lyudmila Boyanova, José Medeiros, Daniel Yordanov, Raina Gergova, Rumyana Markovsk. Turmeric and curcumin as adjuncts in controlling Helicobacter pylori-associated diseases: A narrative review. Letters in applied microbiology. 2024-05-25. PMID:38794899. |
curcumin also displayed numerous anticancer activities such as apoptosis induction, anti-inflammatory and anti-angiogenic effects, caspase-3 upregulation, bax protein enhancement, p53 gene activation, and chemosensitization. |
2024-05-25 |
2024-05-27 |
Not clear |
| Fariba Nikravesh, Roohollah Mirzaee Khalilabadi, Alireza Farsinejad, Hajar Mardani Valandan. Platelet microparticles influence gene expression and modulate biological activities of chronic myeloid leukemia cells (K562). Molecular biology reports. vol 51. issue 1. 2024-05-25. PMID:38796661. |
this study aimed to investigate the influence of platelet-derived microparticles on cell proliferation, apoptosis, and the expression of key genes, including p53, p21, cyclin d1, bax, and bcl-2, within the context of a chronic myeloid leukemia cell line (k562). |
2024-05-25 |
2024-05-31 |
Not clear |
| Min Liu, Yu Zhang, Jianfeng He, Wanxi Liu, Zhexuan Li, Yiti Zhang, Ao Gu, Mingri Zhao, Mujun Liu, Xionghao Li. Fusion with ARRDC1 or CD63: A Strategy to Enhance p53 Loading into Extracellular Vesicles for Tumor Suppression. Biomolecules. vol 14. issue 5. 2024-05-24. PMID:38785998. |
sevs equipped with arp or cdp significantly enhanced the enrichment of p53 fusion proteins and mrna in p53-null h1299 cells, resulting in a marked increase in apoptosis and a reduction in cell proliferation, with arp-sevs demonstrating greater effectiveness than cdp-sevs. |
2024-05-24 |
2024-05-27 |
Not clear |
| Jung-Yeon Kim, Ah Young Yang, Kiryeong Kim, Hyun Hee Kwon, Jaechan Leem, Yun-A Ki. Pharmacological inhibition of p300 ameliorates steatosis, inflammation, and fibrosis in mice with non-alcoholic steatohepatitis. Heliyon. vol 10. issue 9. 2024-05-23. PMID:38774067. |
this protective effect was achieved through the inhibition of apoptosis by reducing p53 and bax expression and the suppression of ferroptosis by decreasing lipid peroxidation while enhancing antioxidant defenses. |
2024-05-23 |
2024-05-27 |
mouse |
| Noelle A Sterling, Seo-Hee Cho, Seonhee Ki. Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-05-23. PMID:38778437. |
entosis implicates a new role for p53 in microcephaly pathogenesis, beyond apoptosis. |
2024-05-23 |
2024-05-27 |
mouse |
| Zhongbiao Wu, Zhongyan Zhu, Liyuan F. Integrating GEO, network pharmacology, and in vitro assays to explore the pharmacological mechanism of Bruceae Fructus against laryngeal cancer. Naunyn-Schmiedeberg's archives of pharmacology. vol 397. issue 6. 2024-05-22. PMID:38032489. |
platinum drug resistance, the pi3k-akt signaling pathway, the p53 signaling pathway, apoptosis, the hif-1 signaling pathway, and 147 additional pathways have been added to kegg. |
2024-05-22 |
2024-05-27 |
Not clear |
| Shokooh Mohtadi, Maryam Salehcheh, Mohammad Reza Tabandeh, Layasadat Khorsandi, Mohammad Javad Khodaya. Ketotifen counteracts cisplatin-induced acute kidney injury in mice via targeting NF-κB/NLRP3/Caspase-1 and Bax/Bcl2/Caspase-3 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776675. |
moreover, ket treatment reversed the changes in the protein expression of markers related to apoptosis (bax, bcl2, caspase-3, and p53). |
2024-05-22 |
2024-05-27 |
mouse |
| Taijin Lan, Songhua He, Xuefei Luo, Zhenyu Pi, Weihui Lai, Chunhui Jiang, Jun Gan, Suyun Wei, Zhanshuai Wu, Chenxia Yun, Jing Leng, Changlong L. Disruption of NADPH homeostasis by total flavonoids from Adinandra nitida Merr. ex Li leaves triggers ROS-dependent p53 activation leading to apoptosis in non-small cell lung cancer cells. Journal of ethnopharmacology. vol 332. 2024-05-21. PMID:38762212. |
ex li leaves triggers ros-dependent p53 activation leading to apoptosis in non-small cell lung cancer cells. |
2024-05-21 |
2024-05-27 |
Not clear |