| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze-Yang Qiu, Kai-Na Shi, Hui-Hua Li, Bo Zhan. CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade. Toxicology and applied pharmacology. 2024-09-29. PMID:39343043. |
mechanistically, cbr-470-1 upregulated nrf2 expression, which increased the expression levels of antioxidant enzymes (nqo1, sod1, prdx1, and gclc) and antiferroptotic proteins (slc7a11 and gpx4) and downregulated the protein expression of p53 and nlrp3, leading to the inhibition of ros production and inflammation and subsequent cardiomyocyte death (apoptosis, ferroptosis and pyroptosis). |
2024-09-29 |
2024-10-02 |
mouse |
| Ze-Yang Qiu, Kai-Na Shi, Hui-Hua Li, Bo Zhan. CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade. Toxicology and applied pharmacology. 2024-09-29. PMID:39343043. |
in summary, cbr-470-1 prevented i/r-mediated cardiac injury possibly through inhibiting cardiomyocyte apoptosis, ferroptosis and pyroptosis via nrf2-mediated inhibition of p53 and nlrp3 and activation of the slc7a11/gpx4 pathway. |
2024-09-29 |
2024-10-02 |
mouse |
| Pan Zhai, Xiao-Hu Ouyang, Meng-Ling Yang, Lan Lin, Jun-Yi Li, Yi-Ming Li, Xiang Cheng, Rui Zhu, De-Sheng H. Luteolin protects against myocardial ischemia/reperfusion injury by reducing oxidative stress and apoptosis through the p53 pathway. Journal of integrative medicine. 2024-09-29. PMID:39343710. |
luteolin protects against myocardial ischemia/reperfusion injury by reducing oxidative stress and apoptosis through the p53 pathway. |
2024-09-29 |
2024-10-02 |
Not clear |
| Wenke Guo, Yaoqiang Ren, Xinguang Qi. FBXO2 promotes the progression of papillary thyroid carcinoma through the p53 pathway. Scientific reports. vol 14. issue 1. 2024-09-29. PMID:39343799. |
fbxo2 knockdown inhibited ptc cell proliferation and promoted apoptosis by targeting p53 for ubiquitination and degradation. |
2024-09-29 |
2024-10-02 |
mouse |
| Yani Zou, Helin Xu, Xiu Wu, Xuesong Liu, Jianfu Zha. Enhancing Radiotherapy Sensitivity in Prostate Cancer with Lentinan-Functionalized Selenium Nanoparticles: Mechanistic Insights and Therapeutic Potential. Pharmaceutics. vol 16. issue 9. 2024-09-28. PMID:39339266. |
in vivo studies confirmed that the combination treatment inhibited pca growth by synergistically activating the p53 pathway to induce cell apoptosis. |
2024-09-28 |
2024-10-01 |
Not clear |
| Qiao-Hong Xiao, Hao Xiang, Ya-Nan Tian, Jiao-Long Huang, Ming-Qun Li, Pu-Qing Wang, Kai Lian, Peng-Xia Yu, Meng-Yao Xu, Ruo-Nan Zhang, Yan Zhang, Jie Huang, Wei-Cheng Zhang, Peng Dua. Polystyrene microplastics alleviate the developmental toxicity of silver nanoparticles in embryo-larval zebrafish (Danio rerio) at the transcriptomic level. The Science of the total environment. 2024-09-28. PMID:39341243. |
these phenomena revealed that the cell cycle, oxidative stress, apoptosis, lipid metabolism, ferroptosis and p53 signalling pathway were obviously affected by single agnps exposure at 96 hpf (hours post fertilization). |
2024-09-28 |
2024-10-01 |
zebrafish |
| Ioana Vornic, Alexandru Nesiu, Ana Maria Ardelean, Oana Cristina Todut, Victoria Cristina Pasare, Cristina Onel, Ionuț Daniel Raducan, Cristian George Fura. Antioxidant Defenses, Oxidative Stress Responses, and Apoptosis Modulation in Spontaneous Abortion: An Immunohistochemistry Analysis of First-Trimester Chorionic Villi. Life (Basel, Switzerland). vol 14. issue 9. 2024-09-28. PMID:39337859. |
antioxidant supplementation, modulation of p53 activity, and the enhancement of dna repair mechanisms may represent potential approaches to mitigate os and apoptosis in the placenta. |
2024-09-28 |
2024-10-01 |
Not clear |
| Immacolata Maietta, Eleonora Viscusi, Stefano Laudati, Giuseppe Iannaci, Antonio D'Antonio, Rosa Marina Melillo, Maria Letizia Motti, Valentina De Falc. Targeting the p90RSK/MDM2/p53 Pathway Is Effective in Blocking Tumors with Oncogenic Up-Regulation of the MAPK Pathway Such as Melanoma and Lung Cancer. Cells. vol 13. issue 18. 2024-09-27. PMID:39329730. |
thus, the inhibition of p90rsk restores p53 expression, which in turn inhibits cell proliferation and promotes apoptosis. |
2024-09-27 |
2024-09-29 |
human |
| Masoud Karimi-Googheri, Zahra Madjd, Jafar Kiani, Ziba Shabani, Mohammad Kazemi Arababadi, Mazaher Gholipourmalekabad. The Effects of Severe Symptoms of SARS-CoV-2 Infections on the Anti/Proapoptotic Molecules: A 6-Month Cohort Study. Viral immunology. 2024-09-25. PMID:39321348. |
this cohort study examined the expression of p53, bcl-2, bid, bak, and bax molecules, the genes associated with induction or inhibition of apoptosis, in the sars-cov-2-infected patients with severe and mild symptoms in an iranian population. |
2024-09-25 |
2024-09-28 |
Not clear |
| Nan Xu, Xilin Jiang, Yan Liu, Muhammad Junaid, Manzoor Ahmad, Chunqing Bi, Wenjing Guo, Chen'ao Jiang, Shulin Li. Chronic environmental level exposure to Perfluorooctane Sulfonate overshadows Graphene Oxide to induce apoptosis through activation of the ROS-p53-caspase pathway in marine medaka Oryzias melastigma. Chemosphere. 2024-09-21. PMID:39306112. |
pfos individual and pfos-go combined exposures significantly impacted fish growth, upregulated expressions of six apoptosis-related genes including p53, apaf1, il1b, tnfa, bcl2l1, bax, as well as enriched cell cycle and p53 signaling pathways (transcriptomic analysis) related to apoptosis compared to control group. |
2024-09-21 |
2024-09-24 |
Not clear |
| Monique Mills, Chihiro Emori, Parveen Kumar, Zachary Boucher, Joshy George, Ewelina Bolcun-Fila. Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes. Developmental biology. 2024-09-21. PMID:39306223. |
dna damage activates multiple response pathways related to apoptosis, p53, interferon signaling, inflammation, cell adhesion, and intercellular communication. |
2024-09-21 |
2024-09-24 |
mouse |
| Kranthi Kumar Chougoni, Victoria Neely, Boxiao Ding, Eziafa Oduah, Vianna T Lam, Bin Hu, Jennifer E Koblinski, Bradford E Windle, Swati Palit Deb, Sumitra Deb, Jorge J Nieva, Senthil K Radhakrishnan, Hisashi Harada, Steven R Grossma. Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis. Cancer research communications. 2024-09-20. PMID:39302104. |
oncogenic mutant p53 sensitizes non-small cell lung cancer cells to proteasome inhibition via oxidative stress-dependent induction of mitochondrial apoptosis. |
2024-09-20 |
2024-09-22 |
human |
| Xiaobing Tian, Wafik S El-Deir. Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics. Oncotarget. vol 15. 2024-09-17. PMID:39288289. |
integrated stress response (isr) activation and apoptosis through hri kinase by pg3 and other p53 pathway-restoring cancer therapeutics. |
2024-09-17 |
2024-09-20 |
Not clear |
| Hamidreza Ebrahimiyan, Elham Madreseh, Maryam Akhtari, Elham Farhadi, Ahmadreza Jamshidi, Mahdi Mahmoud. TP53 Gene Polymorphism (Rs1042522) in Rheumatoid Arthritis and Systemic Lupus Erythematosus: An Updated Systematic Review and Meta-Analysis. Current rheumatology reviews. 2024-09-16. PMID:39279707. |
the p53 protein has important roles in apoptosis, proliferation, and prevention of dna damage. |
2024-09-16 |
2024-09-18 |
Not clear |
| Ting Yang, Lingling Qiu, Shihao Chen, Zhixiu Wang, Yong Jiang, Hao Bai, Yulin Bi, Guobin Chan. RNA-Seq Analysis of Glycolysis Regulation of Avian Leukosis Virus Subgroup J Replication. Animals : an open access journal from MDPI. vol 14. issue 17. 2024-09-14. PMID:39272286. |
functional enrichment analysis indicated that some circrnas might be involved in regulating the replication of the alv-j virus by influencing some pathways like glycolysis/gluconeogenesis, the nod-like receptor signaling pathway, mapk signaling pathway, p53 signaling pathway, toll-like receptor signaling pathway, insulin signaling pathway, and apoptosis. |
2024-09-14 |
2024-09-16 |
Not clear |
| Muhammad Aamir Wahab, Nunzio Del Gaudio, Biagio Gargiulo, Vincenzo Quagliariello, Nicola Maurea, Angela Nebbioso, Lucia Altucci, Mariarosaria Cont. Exploring the Role of CBX3 as a Potential Therapeutic Target in Lung Cancer. Cancers. vol 16. issue 17. 2024-09-14. PMID:39272883. |
cbx3 promotes lung tumorigenesis by interacting with key pathways such as pi3k/akt, ras/kras, wnt/β-catenin, mapk, notch, and p53, leading to increased proliferation, inhibition of apoptosis, and enhanced resistance to therapy. |
2024-09-14 |
2024-09-16 |
Not clear |
| Chuqi Wang, Jordan Yong Ming Tan, Nishtha Chitkara, Shruti Bhat. Cancers. vol 16. issue 17. 2024-09-14. PMID:39272927. |
mutation in p53 is the most frequent event in cancer development and a leading cause of cancer therapy resistance due to evasion of the apoptosis cascade. |
2024-09-14 |
2024-09-16 |
Not clear |
| Hyun Hee Kim, Suk-Young Lee, Dae-Hee Le. Apoptosis of Pancreatic Cancer Cells after Co-Treatment with Eugenol and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. Cancers. vol 16. issue 17. 2024-09-14. PMID:39272950. |
these results demonstrate that eugenol enhances trail-induced apoptosis by upregulating dr5 through the ros-mediated er stress-chop pathway, which enhances er stress by inducing p53 and downregulating flip expression. |
2024-09-14 |
2024-09-16 |
Not clear |
| Yangtao Jin, Ping Zhou, Sisi Huang, Congcong Shao, Dongyan Huang, Xin Su, Rongfu Yang, Juan Jiang, Jianhui W. Cucurbitacin B Inhibits the Proliferation of WPMY-1 Cells and HPRF Cells via the p53/MDM2 Axis. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273281. |
our results mirrored the regulation of tumor protein p53 (tp53), mouse double minute-2 (mdm2), cyclin d1 (ccnd1), and thrombospondin 1 (thbs1) in cu b-induced prostate cell apoptosis. |
2024-09-14 |
2024-09-16 |
mouse |
| Saparja Saha, Ribhu Ray, Santanu Pau. Depside and depsidone-rich hydroalcoholic extract, resourced from the lichen Parmelinella wallichiana (Taylor) Elix & Hale selectively restricts non-small cell lung Cancer by modulating p53, FOXO1 and PALLADIN genes. Fitoterapia. 2024-09-14. PMID:39277022. |
it was also found that the lichen-induced apoptosis was regulated by two crucial tumor suppressor genes, foxo1, and p53, along with cell cycle inhibitor p21 which ultimately resulted in robust apoptosis through the up-regulation of pro-apoptotic bax expression. |
2024-09-14 |
2024-09-18 |
Not clear |