| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anmol Choudhury, Sudakshya S Lenka, Abha Gupta, Deepa Mandal, Adrija Sinha, Utsa Saha, Shaikh Sheeran Naser, Dibyangshee Singh, Faizan Zarreen Simnani, Aishee Ghosh, Shalini Kumari, Apoorv Kirti, Tithi Parija, Raghuraj Singh Chauhan, Nagendra Kumar Kaushik, Mrutyunjay Suar, Suresh K Verm. Controlled in vivo intrinsic detrimental effect of d-Limonene channelized by influential proximal interaction through apoptosis and steatosis in embryonic zebrafish (Danio rerio). The Science of the total environment. 2024-08-04. PMID:39098420. |
computational evaluation deduced the cellular mechanism of d-limonene biotoxicity as irregularities in oxidative stress, apoptosis and steatosis due of their intrinsic interaction with metabolic proteins like zhe1a (-4.8 kcal/mol), sod1(-5.3 kcal/mol), p53, caspase3 and apoa1 leading to influential change in structural and functional integrity of the metabolic proteins. |
2024-08-04 |
2024-08-07 |
zebrafish |
| Jue Lin, Hongli Liu, Xiaoli Huang, Yongqiang Den. Toxicological effects of Honokiol on zebrafish and its underlying mechanism. Journal of biochemical and molecular toxicology. vol 38. issue 8. 2024-08-04. PMID:39097765. |
additionally, research found that honokiol could induce apoptosis in liver and gill tissues through the p53 pathway and possessed the ability to enhance antioxidation. |
2024-08-04 |
2024-08-06 |
zebrafish |
| Nana Ma, Xia Liu, Lining Zhao, Yue Liu, Xinyi Peng, Dan Ma, Lei Ma, Ryoiti Kiyama, Sijun Don. Bisphenol P induces increased oxidative stress in renal tissues of C57BL/6 mice and human renal cortical proximal tubular epithelial cells, resulting in kidney injury. The Science of the total environment. 2024-08-02. PMID:39094650. |
transcriptomic analysis revealed alterations in genes and pathways related to oxidative stress, p53 signaling, autophagy, and apoptosis. |
2024-08-02 |
2024-08-06 |
mouse |
| Lina Xing, Xuefei Guo, Xiaolei Zhang, Ying Wang, Feng He, Jinhai Re. EXPRESS: PTBP1 is a potential indicator of disease progression in acute myeloid leukaemia. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2024-07-31. PMID:39080831. |
in addition, ptbp1 expression was positively correlated with the expression of the proliferation marker ki-67 and negatively correlated with the expression of the apoptosis marker p53 in aml patients. |
2024-07-31 |
2024-08-02 |
Not clear |
| Wenshu Li, Longyuan Li, Huan Yang, Chenxi Shi, Zhe Lei, Lingchuan Guo, Yuhong Wan. Unraveling the Role of Frontiers in bioscience (Landmark edition). vol 29. issue 7. 2024-07-31. PMID:39082342. |
unraveling the role of the p53, a pivotal tumor suppressor, regulates various cellular responses, including dna repair and apoptosis. |
2024-07-31 |
2024-08-02 |
Not clear |
| Mengmeng Zhang, Liu Yang, Jun Shu, Xin Gu, Yan Ha. CDK5RAP3 Inhibition by Hypoxia Activates P38MAPK to Facilitate Angiogenesis. International heart journal. vol 65. issue 4. 2024-07-31. PMID:39085114. |
cdk5rap3 is a recognized tumor suppressor that inhibits chk1 and chk2 and activates p53, all of which are involved with mediating toxin-induced apoptosis of cancer cells. |
2024-07-31 |
2024-08-03 |
human |
| Barbara Łasut-Szyszka, Agnieszka Gdowicz-Kłosok, Małgorzata Krześniak, Magdalena Głowala-Kosińska, Agnieszka Będzińska, Marek Rusi. Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligand. Apoptosis : an international journal on programmed cell death. 2024-07-28. PMID:39068622. |
therefore, the combination of actd + nut3a activates p53 in an extraordinary way, which overcomes the resistance of cancer cells to apoptosis triggered by faslg. |
2024-07-28 |
2024-08-02 |
human |
| Ruirui Li, Ning Zhou, Cheng Zhang, Mengqi Wu, Wenping Xu, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhan. Cardiotoxicity risk induced by sanitary insecticide Dimefluthrin. Chemosphere. 2024-07-27. PMID:39067820. |
qpcr analysis implied that dim induced apoptosis via the p53/caspase pathway by up-regulating the expression levels of p53, cytochrome c (cyto-c), caspase-9, and caspase-3. |
2024-07-27 |
2024-08-02 |
human |
| Tao Liu, Lubing Gu, Anna Mui, Zhongzhi Wu, Najah Albadari, Wei Li, Muxiang Zho. An MDM2 degrader shows potent cytotoxicity to MDM2-overexpressing acute lymphoblastic leukemia cells with minimal toxicity to normal cells/tissues. Cancer letters. 2024-07-25. PMID:39053726. |
here, we report a novel small-molecule chemical compound (mx69-102) that we identified to induce mdm2 protein degradation, resulting in reactivation of p53, inhibition of xiap, and potent cell growth inhibition and apoptosis in mdm2-overexpressing acute lymphoblastic leukemia (all) in vitro and in vivo. |
2024-07-25 |
2024-07-28 |
human |
| Hsuan-Yu Huang, Chia-Hung Chen, Fang-Ju Cheng, Bo-Wei Wang, Chih-Yen Tu, Yun-Ju Chen, Yu-Hao He, Chun-Hsu Yao, Wei-Chien Huan. Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer. Journal of hazardous materials. vol 477. 2024-07-24. PMID:39047551. |
tumor protein p53 (tp53)-activated long intergenic non-coding rna-p21 (lincrna-p21) undertakes a pivotal role in regulating cell apoptosis and chemosensitivity. |
2024-07-24 |
2024-07-28 |
Not clear |
| Nan Zhao, Jun Chu, Jieying Liu, Liangkun Ma, Ning Ma, Wei Song, Tianshu Su. Prenatal exposure to Benzo[a]pyrene affects maternal-fetal outcomes via placental apoptosis. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043924. |
we additionally observed elevated p53-mediated placental apoptosis in higher bap exposure groups, with altered expression levels of p53 and bax/bcl-2. |
2024-07-23 |
2024-07-26 |
mouse |
| Mahdieh Ahmadi Kamalabadi, Hamid Ostadebrahimi, Fereshteh Koosha, Asieh Fatemidokht, Iman Menbari Oskuie, Fatemeh Amin, Amin Shiralizadeh Dezful. Gd-GQDs as nanotheranostic platform for the treatment of HPV-positive oropharyngeal cancer. Medical oncology (Northwood, London, England). vol 41. issue 8. 2024-07-22. PMID:39037549. |
in contrast, the combination group exhibited a significant increase in bax protein expression, suggesting that cells could undergo apoptosis independent of the p53 pathway. |
2024-07-22 |
2024-07-24 |
Not clear |
| Jie Dai, Renjin Chen, Jie Wang, Ping Zhou, BiQiong Wang, Jianmei Li, Yun Lu, Xianlun Pang, ShaoZhi F. Intraperitoneal administration of doxorubicin-encapsulated Brucea javanica oil nanoemulsion against malignant ascites. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024-07-21. PMID:39033885. |
bjo significantly induced apoptosis of s180 cells by upregulating the expression of p53 and caspase-3 (cleaved). |
2024-07-21 |
2024-07-24 |
mouse |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
network pharmacology analysis identified multiple potential candidate targets (including tp53, bcl-2 and bax) and enriched signaling pathways (including apoptosis and p53 signaling pathway). |
2024-07-19 |
2024-07-21 |
mouse |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
quercetin treatment significantly alleviated the pathological changes in renal tissues of ang ii-infused mice and reversed 464 differentially expressed transcripts (dets), as well as enriched several signaling pathways, including those related apoptosis and p53 pathway. |
2024-07-19 |
2024-07-21 |
mouse |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
quercetin treatment significantly attenuated hypertensive renal injury and cell apoptosis in renal tissues of ang ii-infused mice and ang ii-stimulated nrk-52e cells, and by targeting p53 may be one of the potential underlying mechanisms. |
2024-07-19 |
2024-07-21 |
mouse |
| Expression of concern: Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. Canadian journal of physiology and pharmacology. 2024-07-19. PMID:39029946. |
expression of concern: acrolein induces apoptosis through the death receptor pathway in a549 lung cells: role of p53. |
2024-07-19 |
2024-07-22 |
Not clear |
| Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Li. FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells. Experimental gerontology. 2024-07-18. PMID:39025385. |
upon activation, it binds p53 in the nucleus, preventing senescent cell apoptosis and maintaining senescent cells in situ. |
2024-07-18 |
2024-07-21 |
mouse |
| Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Li. FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells. Experimental gerontology. 2024-07-18. PMID:39025385. |
in this study, we observed that foxo4-dri, a specific foxo4- p53 binding blocker, induced apoptosis in senescent leydig cells, reduced the secretion of certain senescence-associated secretory phenotype and improved the proliferation of cocultured gc-1 spg cells. |
2024-07-18 |
2024-07-21 |
mouse |
| Marek Rusi. The p53 protein - not only the guardian of the genome. Postepy biochemii. vol 70. issue 1. 2024-07-17. PMID:39016231. |
the p53 tumor suppressor protein is best known as an activator of cell cycle arrest and apoptosis. |
2024-07-17 |
2024-07-19 |
mouse |