| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George R Flentke, Thomas E Wilkie, Josh Baulch, Yanping Huang, Susan M Smit. Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PloS one. vol 19. issue 6. 2024-06-28. PMID:38941348. |
this was followed by reduced proliferation, stabilization of nuclear p53, and apoptosis that was prevented by overexpression of mdm2 or dominant-negative p53. |
2024-06-28 |
2024-07-01 |
zebrafish |
| Ana Neves, Tânia Albuquerque, Rúben Faria, Cecília R A Santos, Eric Vivès, Prisca Boisguérin, Diana Carneiro, Daniel F Bruno, Maria D Pavlaki, Susana Loureiro, Ângela Sousa, Diana Cost. Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells. Pharmaceutics. vol 16. issue 6. 2024-06-27. PMID:38931902. |
the combined action of the anticancer drug with p53 supplementation in cancer cells enhances cytotoxicity, which was correlated to apoptosis activation through quantification of caspase-3 activity. |
2024-06-27 |
2024-06-29 |
zebrafish |
| Ana Neves, Tânia Albuquerque, Rúben Faria, Cecília R A Santos, Eric Vivès, Prisca Boisguérin, Diana Carneiro, Daniel F Bruno, Maria D Pavlaki, Susana Loureiro, Ângela Sousa, Diana Cost. Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells. Pharmaceutics. vol 16. issue 6. 2024-06-27. PMID:38931902. |
our findings demonstrated the great potential of peptide tmz/p53 co-delivery complexes for cellular transfection, p53 expression, and apoptosis induction, holding promising therapeutic value toward glioblastoma. |
2024-06-27 |
2024-06-29 |
zebrafish |
| Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma, Jinying Xu, Yingying Fan, Yuewen Chen, Yu Che. Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis. Cell death & disease. vol 15. issue 6. 2024-06-27. PMID:38937439. |
in turn, coronin 2b-mediated nucleolar stress leads to p53 stabilization and activation, eventually resulting in neuronal apoptosis. |
2024-06-27 |
2024-06-30 |
Not clear |
| Amna Fayyaz, Mahnoor Basit, Andleeb Farooq, Tooba Khan, Umama Ayub, Somia Khan, Muhammad Armaghan, Mati-Ur-Rahman, Muhammad Ammad, Dietrich Büsselberg, Khushbukhat Khan, Solomon Habtemariam, Javad Sharifi-Ra. Therapeutic potential of ethoxy mansonone G: A comprehensive exploration of its anticancer actions in breast cancer, colorectal cancer, and non-small cell lung carcinoma. Cell biology international. 2024-06-26. PMID:38924324. |
through the stimulation of the tumor protein (p53) and extracellular signal-regulated kinase (erk) signaling cascades, it also causes apoptosis. |
2024-06-26 |
2024-06-29 |
Not clear |
| Ya Chen, Congcong Zhu, Zongguang Tai, Tianyan Lian, Quangang Zhu, Zhongjian Che. Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop. Molecular biotechnology. 2024-06-24. PMID:38914920. |
regulating the expression of apoptotic proteins bax, bcl-2, and p53 promote apoptosis. |
2024-06-24 |
2024-06-27 |
mouse |
| Or Michaeli, Ishai Luz, Maayan Vatarescu, Tal Manko, Noam Weizman, Yevgeniya Korotinsky, Alexandra Tsitrina, Alex Braiman, Lior Arazi, Tomer Cook. APR-246 as a radiosensitization strategy for mutant p53 cancers treated with alpha-particles-based radiotherapy. Cell death & disease. vol 15. issue 6. 2024-06-18. PMID:38890278. |
it was previously reported that cells carrying wild-type (wt) p53 exhibit accelerated senescence and significant rates of apoptosis in response to rt, whereas cells harboring mutant p53 (mutp53) do not. |
2024-06-18 |
2024-06-21 |
human |
| Mozhgan Soltani, Amin Farhadi, Sarah Rajabi, Masoud Homayouni-Tabrizi, Fatimah Sameer Hussein, Navid Mohammadia. Folic acid-modified nanocrystalline cellulose for enhanced delivery and anti-cancer effects of crocin. Scientific reports. vol 14. issue 1. 2024-06-17. PMID:38886450. |
fluorescent staining, flow cytometry, and molecular analysis confirmed that ncf-cr-nps induced apoptosis in ht-29 cells by increasing p53 and caspase 8 expression. |
2024-06-17 |
2024-06-21 |
Not clear |
| Pan Shen, Mei Xue, Zhishuo Hu, Liang Han, Xuan Den. Direct targeting of S100A9 with Icariin counteracted acetaminophen‑induced hepatotoxicity. International immunopharmacology. vol 136. 2024-06-16. PMID:38810310. |
in vitro, icariin pretreatment significantly inhibited hepatocellular damage and apoptosis by reducing the bax/bcl-2 ratio as well as the expression of cleaved-caspase 3 and cleaved-parp depended on the p53 pathway. |
2024-06-16 |
2024-06-18 |
mouse |
| Xinyu Wu, Jiawei Chen, Kaixin Ping, Yan Xia, Mengxin Li, Yannan Xiang, Huimao Feng, Jingquan Don. Silybin mitigated liver and brain damage after difenoconazole exposure: Crosstalk between oxidative stress, inflammation, ferroptosis and apoptosis. Pesticide biochemistry and physiology. vol 202. 2024-06-16. PMID:38879300. |
in this study, we analyzed the interactions between genes and proteins associated with oxidative stress, inflammation, ferroptosis and apoptosis using the string database and ranked the nodes in the network using the cytoscape plugin cytohubba, and found that p53, caspase3, tnf-α, il-6 and bcl-2 were the key hub genes. |
2024-06-16 |
2024-06-18 |
cat |
| Ying Li, Li Wan, Hexin Li, Xiaokun Tang, Siyuan Xu, Gaoyuan Sun, Wei Huang, Min Tan. Small molecule NMD and MDM2 inhibitors synergistically trigger apoptosis in HeLa cells. Molecules and cells. 2024-06-13. PMID:38871298. |
in this study, we evaluated the impacts of nmd inhibitor, mdm2 inhibitor, and their combination on cell apoptosis, cell cycle, and p53 target genes in hpv-18-positive hela cells. |
2024-06-13 |
2024-06-16 |
Not clear |
| Ying Li, Li Wan, Hexin Li, Xiaokun Tang, Siyuan Xu, Gaoyuan Sun, Wei Huang, Min Tan. Small molecule NMD and MDM2 inhibitors synergistically trigger apoptosis in HeLa cells. Molecules and cells. 2024-06-13. PMID:38871298. |
our findings revealed that xr-2failed to activate p53 or induce apoptosis in hela cells, whereas smg1i repressed cell proliferation at high concentrations. |
2024-06-13 |
2024-06-16 |
Not clear |
| Yafei Duan, Yukai Yang, Hua Li, Zhe Zhang, Xiaoying Chen, Meng Xiao, Yuxiu Na. The toxic effects of tetracycline exposure on the physiological homeostasis of the gut-liver axis in grouper. Environmental research. 2024-06-12. PMID:38866314. |
further, intestinal health was also affected, including the damaged intestinal mucosa, the decreased mrna expression levels of tight junction proteins (zo-1, occludin, and claudin-3), along with the increased gene expression levels of inflammation (il-1β, il-8, tnf-α) and apoptosis (casp-3 and p53). |
2024-06-12 |
2024-06-15 |
Not clear |
| Aswathi R K, Suresh Arumugam, Natrajan Muninathan, Kuppusamy Baskar, Deepthi S, Dinesh Roy . P53 Gene as a Promising Biomarker and Potential Target for the Early Diagnosis of Reproductive Cancers. Cureus. vol 16. issue 5. 2024-06-12. PMID:38864057. |
p53 is a key tumor suppressor that recognizes the carcinogenic biological pathways and eradicates them by apoptosis. |
2024-06-12 |
2024-06-14 |
Not clear |
| Oleg A Kuchur, Sofya S Pogodaeva, Anna V Shcherbakova, Segrey A Tsymba. Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53. Bioscience reports. vol 44. issue 6. 2024-06-11. PMID:38813981. |
the p53 protein plays an important role in regulating processes such as apoptosis, repair, and cell division, and the loss of its functionality often accompanies various types of tumors and contributes to the development of chemoresistance. |
2024-06-11 |
2024-06-14 |
Not clear |
| Zeling Du, Meiqi Lin, Qiaohua Li, Dan Guo, Yanna Xue, Wei Liu, Hong Shi, Taiping Chen, Jiameng Da. The totipotent 2C-like state safeguards genomic stability of mouse embryonic stem cells. Journal of cellular physiology. 2024-06-11. PMID:38860420. |
unexpectedly, p53 deficiency results in defective response to dna damage, leading to early accumulation of dna damage, micronuclei, indicative of genomic instability, cell apoptosis, and reduced self-renewal capacity of escs when devoid of 2clcs in cultures. |
2024-06-11 |
2024-06-14 |
mouse |
| Fazeleh Ranjbar-Niavol, Niloufar Rezaei, Ying Zhao, Hamed Mirzaei, Moustapha Hassan, Massoud Vosoug. P53/NANOG balance; the leading switch between poorly to well differentiated status in liver cancer cells. Frontiers in oncology. vol 14. 2024-06-08. PMID:38846985. |
enforcing a well-differentiated state on cells requires tumor suppressor p53 activation as a key player in apoptosis induction and well differentiation. |
2024-06-08 |
2024-06-10 |
Not clear |
| Xiangying Zhang, Ling Xu, Zihao Fan, Yao Gao, Yuan Tian, Yaling Cao, Dexi Chen, Feng Re. Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism. Frontiers in immunology. vol 15. 2024-06-06. PMID:38840923. |
apoptosis stimulating protein of p53-2 (aspp2) is a proapoptotic member of the p53 binding protein family. |
2024-06-06 |
2024-06-08 |
Not clear |
| Lei Chen, Fengju Duan, Fangfang Ge, Lu Tian, Yuanyuan Li, Ying Li, Qing Zhu, Qiong Zhou, Hong Li. Inhibitor of apoptosis stimulating protein of p53 protects against MPP Metabolic brain disease. 2024-06-06. PMID:38842662. |
inhibitor of apoptosis stimulating protein of p53 protects against mpp inhibitor of apoptosis stimulating protein of p53 (iaspp) is related to the pathogenesis of several neurological disorders by affecting the oxidative stress and survival of neurons. |
2024-06-06 |
2024-06-08 |
Not clear |
| Yong-Kyu Lee, Hyeon Ho Heo, Nackhyoung Kim, Ui-Hyun Park, Hyesook Youn, Eun-Yi Moon, Eun-Joo Kim, Soo-Jong U. Tumor antigen PRAME is a potential therapeutic target of p53 activation in melanoma cells. BMB reports. 2024-06-05. PMID:38835116. |
the tumor suppressor p53 is a transcriptional regulator that mediates cell cycle arrest and apoptosis in response to stress signals. |
2024-06-05 |
2024-06-07 |
human |