| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Man Zhao, Aixian Liu, Jiaojiao Wu, Linhong Mo, Fang Lu, Guiling Wa. Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis. Medicine. vol 103. issue 4. 2024-01-26. PMID:38277520. |
in kyoto encyclopedia of genes and genomes (kegg) analysis, they were mainly enriched in nf-κb signaling pathway, fluid shear stress and atherosclerosis, p53 signaling pathway, tnf signaling pathway, and apoptosis. |
2024-01-26 |
2024-01-29 |
Not clear |
| Yan Xu, Yang Zhou, Xiling Yi, Xiaocui Ni. LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling. Cell biology international. 2024-01-24. PMID:38263609. |
moreover, the addition of p53 inhibitor partially reversed the effects of lrp8 knockdown on oc cell proliferation and apoptosis, indicating the involvement of p53 signaling in lrp8-mediated oc progression. |
2024-01-24 |
2024-01-26 |
human |
| Polina Malatesta, Konstantinos Kyriakidis, Megumi Hada, Hiroko Ikeda, Akihisa Takahashi, Premkumar B Saganti, Alexandros G Georgakilas, Ioannis Michalopoulo. Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity. Biomolecules. vol 14. issue 1. 2024-01-23. PMID:38254688. |
after irradiation with x-rays or c-ions under 1g, identified degs were found to be involved in dna damage repair, signal transduction by p53 class mediator, cell cycle arrest and apoptosis pathways. |
2024-01-23 |
2024-01-25 |
human |
| Daniel J Turnham, Hannah Smith, Richard W E Clarkso. Suppression of Bcl3 Disrupts Viability of Breast Cancer Cells through Both p53-Dependent and p53-Independent Mechanisms via Loss of NF-κB Signalling. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255248. |
bcl3 suppression significantly reduced viability and was shown to induce apoptosis in all cell lines tested, while an additional p53-dependent senescence and senescence-associated secretory phenotype was also observed in those cells with functional p53. |
2024-01-23 |
2024-01-25 |
Not clear |
| Cui Tang, Aili Wang, YanLin Zhao, WenYing Mou, Jun Jiang, Jie Kuang, Bin Sun, Erjiang Tan. Leukotriene B4 receptor knockdown affects PI3K/AKT/mTOR signaling and apoptotic responses in colorectal cancer. Biomolecules & biomedicine. 2024-01-23. PMID:38259082. |
further in-depth investigation revealed that ltb4r knockdown significantly amplified the apoptosis in crc cells and upregulated the expression of apoptosis-related proteins, such as caspase-3 and caspase-9, while diminishing p53 expression. |
2024-01-23 |
2024-01-25 |
mouse |
| Stefan Djordjevic, Raphaël Itzykson, Frédéric Hague, Delphine Lebon, Julien Legrand, Hakim Ouled-Haddou, Guillaume Jedraszak, Juliette Harbonnier, Louison Collet, Etienne Paubelle, Jean-Pierre Marolleau, Loïc Garçon, Thomas Boye. STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells. Molecular oncology. 2024-01-18. PMID:38234211. |
phenotypically, stim2 knockdown drastically inhibited cell proliferation and induced genomic stress with dna double-strand breaks, as shown by increased levels of phosphorylate histone h2axγ (p-h2axγ), followed by activation of the cellular tumor antigen p53 pathway, decreased expression of cell cycle regulators such as cyclin-dependent kinase 1 (cdk1)-cyclin b1 and m-phase inducer phosphatase 3 (cdc25c), and a decreased apoptosis threshold with a low antiapoptotic/proapoptotic protein ratio. |
2024-01-18 |
2024-01-20 |
human |
| Stefan Djordjevic, Raphaël Itzykson, Frédéric Hague, Delphine Lebon, Julien Legrand, Hakim Ouled-Haddou, Guillaume Jedraszak, Juliette Harbonnier, Louison Collet, Etienne Paubelle, Jean-Pierre Marolleau, Loïc Garçon, Thomas Boye. STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells. Molecular oncology. 2024-01-18. PMID:38234211. |
our study reports stim2 as a new actor regulating genomic stability and p53 response in terms of cell cycle and apoptosis of human normal and malignant monocytic cells. |
2024-01-18 |
2024-01-20 |
human |
| Berta N Vazquez, Irene Fernández-Duran, Yurdiana Hernandez, Shahriar Tarighi, Joshua K Thackray, Maria Espinosa-Alcantud, Poonam Kumari, Alessandro Ianni, Lionel Cesaire, Thomas Braun, Manel Esteller, Jay Tischfield, Alejandro Vaquero, Lourdes Serran. SIRT7 and p53 interaction in embryonic development and tumorigenesis. Frontiers in cell and developmental biology. vol 11. 2024-01-18. PMID:38234684. |
p53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, dna damage repair, and cellular apoptosis; its protein activity interrelates with the sirtuin family of proteins, major regulators of the cellular response to metabolic, oxidative, and genotoxic stress. |
2024-01-18 |
2024-01-20 |
mouse |
| Xin Zhao, Fang Yin, Yilin Huang, Luoqin Fu, Yingyu Ma, Luyi Ye, Weijiao Fan, Wenxue Gao, Yu Cai, Xiaozhou Mo. Oral administration of grape-derived nanovesicles for protection against LPS/D-GalN-induced acute liver failure. International journal of pharmaceutics. 2024-01-18. PMID:38237707. |
treatment with gdnvs significantly prevented the massive apoptosis of hepatocytes caused by lps/d-galn and down-regulated the activation and expression of the mitochondrial apoptosis-related proteins p53, caspase 9, caspase 8, caspase 3 and bax. |
2024-01-18 |
2024-01-21 |
mouse |
| Mojtaba Moradi, Mohammad Arshia Hashemian, Azita Faramarzi, Nader Goodarzi, Amir Hossein Hashemian, Hadi Cheraghi, Cyrus Jalil. Therapeutic effect of sodium alginate on bleomycin, etoposide and cisplatin (BEP)-induced reproductive toxicity by inhibiting nitro-oxidative stress, inflammation and apoptosis. Scientific reports. vol 14. issue 1. 2024-01-18. PMID:38238398. |
further, modifications to the expression of bcl2, bax, caspase3, p53, and tnf-α suggested that naal alleviated bep-induced apoptosis and inflammation. |
2024-01-18 |
2024-01-21 |
rat |
| Jie Cao, Jun Mei, Jing Xi. Combined effects of hypoxia and ammonia-N exposure on the immune response, oxidative stress, tissue injury and apoptosis of hybrid grouper (Epinephelus fuscoguttatus♀×E. lanceolatus♂). Environmental science and pollution research international. vol 31. issue 1. 2024-01-17. PMID:38032527. |
additionally, antioxidant genes (sod, cat, gsh-px, hsp70, and hsp90), apoptosis genes (p53, bax, caspase 3, caspase 8, and caspase 9), and inflammatory genes (tnf-α, il-1β, il-6, and il-8) were upregulated by hypoxia and ammonia-n exposure. |
2024-01-17 |
2024-01-19 |
cat |
| Lei Ma, Ke Huang, Haibo Zhang, Eungyung Kim, Hyeonjin Kim, Zhibin Liu, Chae Yeon Kim, Kanghyun Park, Muhammad Atif Raza, Kirim Kim, Junkoo Yi, Yonghun Sung, Zae Young Ryoo, Yong-Gun Kim, Myoung Ok Ki. Imatinib inhibits oral squamous cell carcinoma by suppressing the PI3K/AKT/mTOR signaling pathway. Journal of Cancer. vol 15. issue 3. 2024-01-12. PMID:38213733. |
furthermore, imatinib suppressed migration and colony formation while promoting oscc cell apoptosis by enhancing p53, bax, and parp expression levels and reducing bcl-2 expression. |
2024-01-12 |
2024-01-14 |
Not clear |
| Kavita Gala, Meghna Jain, Prachi Shah, Amit Pandey, Manoj Garg, Ekta Khatta. Role of p53 transcription factor in determining the efficacy of telomerase inhibitors in cancer treatment. Life sciences. 2024-01-12. PMID:38216120. |
p53 senses dna damage and is the primary effector required for sensitizing cells towards apoptosis. |
2024-01-12 |
2024-01-15 |
Not clear |
| Qianwei Zhao, Mengdan Yu, Jinxia Li, Yaoyu Guo, Zexuan Wang, Kefei Hu, Fang Xu, Yixian Liu, Lili Li, Didi Wan, Ying Zhao, Jian Shang, Jintao Zhan. GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis. Discover. Oncology. vol 15. issue 1. 2024-01-12. PMID:38216781. |
excessive ros lead to mitochondrial apoptosis that was characterized by increased expression levels of p53, cytochrome c, bax, caspase 3 and decreased expression level of bcl-2. |
2024-01-12 |
2024-01-15 |
Not clear |
| Jingzhi Li, Ming Guo, Lin Chen, Zhuchu Chen, Ying Fu, Yongheng Che. Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma. Cell death & disease. vol 15. issue 1. 2024-01-11. PMID:38212344. |
transcriptome analysis suggested that p53 amyloid aggregation dysregulated major signaling pathways associated with the cell cycle, proliferation, apoptosis, and unfolded protein response (upr). |
2024-01-11 |
2024-01-14 |
Not clear |
| A A Kozlov, Yu O Sokolova, A L Kovalenko, E D Bazhanov. Effect of Lysine Acridone Acetate on the Level of Apoptosis and Expression of Apoptosis-Associated Proteins during Antioncogenic Therapy in Colorectal Cancer in Mice. Bulletin of experimental biology and medicine. 2024-01-09. PMID:38194065. |
in nude mouse model, the level of apoptosis (tunel) and expression of proteins cd95, p53, bcl-2, histone h3, and ki-67 (immunohistochemistry) were assessed in primary tumor biopsy specimens. |
2024-01-09 |
2024-01-10 |
mouse |
| Yongmi Huang, Zhihao Jiao, Yuqing Fu, Yue Hou, Jinxiao Sun, Feiran Hu, Shangzhe Yu, Kexin Gong, Yiru Liu, Guisen Zha. An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53. European journal of medicinal chemistry. vol 265. 2024-01-09. PMID:38194777. |
if the repair is ineffective, p53 induces cell death via apoptosis. |
2024-01-09 |
2024-01-13 |
human |
| Aranka Brockmueller, Constanze Buhrmann, Amir Reza Moravejolahkami, Mehdi Shakibae. Resveratrol and p53: How are they involved in CRC plasticity and apoptosis? Journal of advanced research. 2024-01-08. PMID:38190940. |
resveratrol and p53: how are they involved in crc plasticity and apoptosis? |
2024-01-08 |
2024-01-10 |
Not clear |
| Alessia Garufi, Riccardo Pettinari, Laura Monteonofrio, Giulia Puliani, Ilaria Virdia, Marialuisa Appetecchia, Fabio Marchetti, Mara Cirone, Silvia Soddu, Gabriella D'Oraz. NRF2 activation in BON‑1 neuroendocrine cancer cells reduces the cytotoxic effects of a novel Ruthenium(II)‑curcumin compound: A pilot study. Oncology reports. vol 51. issue 2. 2024-01-08. PMID:38186307. |
nrf2 induction associated also with increased expression of endogenous p53 which is reported to be dysfunctional in bon‑1 cells and to inhibit apoptosis. |
2024-01-08 |
2024-01-10 |
Not clear |
| Weitao Hu, Guilan Chen, Wenbin Yuan, Chen Guo, Fasheng Liu, Shouhua Zhang, Zigang Ca. Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway. Ecotoxicology and environmental safety. vol 270. 2024-01-05. PMID:38181604. |
to summarize, iprodione induces apoptosis through the upregulation of p53 mediated by oxidative stress signals, leading to liver toxicity in zebrafish. |
2024-01-05 |
2024-01-08 |
human |