| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meifeng Li, Jihuan Hu, Jiazhan Zhou, Chuxin Wu, Dongming Li, Huiling Mao, Lingbao Kong, Chengyu Hu, Xiaowen X. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish & shellfish immunology. 2023-12-03. PMID:38043873. |
in a kat8-independent manner, cisirt1 also inhibited p53-induced apoptosis by directly deacetylating p53 and promoting the degradation of p53. |
2023-12-03 |
2023-12-10 |
Not clear |
| Fang-Fang Yu, Shui-Yuan Yu, Lei Sun, Juan Zuo, Kang-Ting Luo, Miao Wang, Xiao-Li Fu, Feng Zhang, Hui Huang, Guo-Yu Zhou, Yan-Jie Wang, Yue B. T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway. Journal of hazardous materials. vol 465. 2023-12-01. PMID:38039814. |
the increased binding of p53 and cypd mediated the excessive opening of mptp, changed mitochondrial membrane permeability, and ultimately induced mitochondrial dysfunction and apoptosis of chondrocytes. |
2023-12-01 |
2023-12-10 |
rat |
| Yidian Wang, Shouye Hu, Weisong Zhang, Binfei Zhang, Zhi Yan. Emerging role and therapeutic implications of p53 in intervertebral disc degeneration. Cell death discovery. vol 9. issue 1. 2023-12-01. PMID:38040675. |
recently, p53 was shown to play an important role in maintaining ivd microenvironment homeostasis by regulating ivd cell senescence, apoptosis, and metabolism by activating downstream target genes. |
2023-12-01 |
2023-12-10 |
Not clear |
| Sheree D Martin, Timothy Connor, Andrew Sanigorski, Kevin A McEwen, Darren C Henstridge, Brunda Nijagal, David De Souza, Dedreia L Tull, Peter J Meikle, Greg M Kowalski, Clinton R Bruce, Paul Gregorevic, Mark A Febbraio, Fiona M Collier, Ken R Walder, Sean L McGe. Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity. Cell death & disease. vol 14. issue 12. 2023-12-01. PMID:38040704. |
mechanistically, increased hdac4 and 5 decreased acetylation of p53 at k120, a modification required for transcriptional activation of apoptosis. |
2023-12-01 |
2023-12-10 |
mouse |
| Jie Wang, Hao Yin, Wei Zhu, Qingyi He, Haitang Zhang, Lu Sun, Yunxiao Qiao, Yanwei Xian. Research on the resistance of isoviolanthin to hydrogen peroxide-triggered injury of skin keratinocytes based on Transcriptome sequencing and molecular docking. Medicine. vol 102. issue 47. 2023-11-28. PMID:38013320. |
our results found isoviolanthin could probably increase skin keratinocyte viability, by resisting against apoptosis of skin keratinocytes through downregulating the level of p53 for the first time. |
2023-11-28 |
2023-11-29 |
human |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
s1pr2 inhibition increased p-akt and tigar levels and reduced the levels of p53 in the pfc and hippocampus of type 2 diabetic mice, thereby decreasing apoptosis. |
2023-11-27 |
2023-11-29 |
mouse |
| Karsten Gülow, Deniz Tümen, Claudia Kuns. The Important Role of Protein Kinases in the p53 Sestrin Signaling Pathway. Cancers. vol 15. issue 22. 2023-11-25. PMID:38001650. |
p53, a crucial tumor suppressor and transcription factor, plays a central role in the maintenance of genomic stability and the orchestration of cellular responses such as apoptosis, cell cycle arrest, and dna repair in the face of various stresses. |
2023-11-25 |
2023-11-28 |
Not clear |
| Francisco Rodríguez-Esparragón, Laura B Torres-Mata, Sara E Cazorla-Rivero, Jaime A Serna Gómez, Jesús M González Martín, Ángeles Cánovas-Molina, José A Medina-Suárez, Ayose N González-Hernández, Lidia Estupiñán-Quintana, María C Bartolomé-Durán, José C Rodríguez-Pérez, Bernardino Clavo Vara. Analysis of ANRIL Isoforms and Key Genes in Patients with Severe Coronary Artery Disease. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003316. |
the cdkn2a and the cdkn2b genes at the cdkn2a/b locus encode the cyclin-dependent kinase inhibitor protein (cdki) p16ink4a and the p53 regulatory protein p14arf, which are involved in cell cycle regulation, aging, senescence, and apoptosis. |
2023-11-25 |
2023-11-28 |
Not clear |
| Xiaoyu Wang, Yiqian Zhang, Peng Lu, Hao Zhang, Yufeng Li, Hongyan Dong, Zhongming Zhan. Corrigendum to (title of manuscript): PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation via PEDF-R. Biochemical and biophysical research communications. vol 689. 2023-11-25. PMID:37985352. |
corrigendum to (title of manuscript): pedf attenuates hypoxia-induced apoptosis and necrosis in h9c2 cells by inhibiting p53 mitochondrial translocation via pedf-r. |
2023-11-25 |
2023-11-28 |
Not clear |
| Jun Li, Miao Tang, Ruo-Xian Ke, Pei-Lin Li, Zhi-Guo Sheng, Ben-Zhan Zh. The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells. Toxicology and applied pharmacology. 2023-11-23. PMID:37995810. |
cbl0137, a promising small molecular anti-cancer drug candidate, has been found to effectively induce apoptosis via activating p53 and suppressing nuclear factor-kappa b (nf-κb). |
2023-11-23 |
2023-11-29 |
Not clear |
| Yuan-Yen Chang, Meilin Wang, Jui-Hsuan Yeh, Shang-Chun Tsou, Tzu-Chun Chen, Min-Yen Hsu, Yi-Ju Lee, Inga Wang, Hui-Wen Li. The protective effects of beta-mangostin against sodium iodate-induced retinal ROS-mediated apoptosis through MEK/ERK and p53 signaling pathways. Food & function. 2023-11-22. PMID:37990840. |
the protective effects of beta-mangostin against sodium iodate-induced retinal ros-mediated apoptosis through mek/erk and p53 signaling pathways. |
2023-11-22 |
2023-11-29 |
Not clear |
| Dongshi Chen, Kaylee Ermine, Yi-Jun Wang, Xiaojun Chen, Xinyan Lu, Peng Wang, Donna Beer-Stolz, Jian Yu, Lin Zhan. PUMA/RIP3 mediates chemotherapy response via necroptosis and local immune activation in colorectal cancer. Molecular cancer therapeutics. 2023-11-22. PMID:37992761. |
we identified a novel 5-fu-induced necroptosis pathway involving p53-mediated induction of the bh3-only bcl-2 family protein, p53 upregulated modulator of apoptosis (puma), which promotes cytosolic release of mitochondrial dna and stimulates its sensor z-dna-binding protein 1 (zbp1) to activate rip3. |
2023-11-22 |
2023-11-29 |
Not clear |
| Hongyan Yu, Jingxu Zhang, Jing Liu, Ruonan Pan, Yu Wang, Xiaoting Jin, Rifat Zubair Ahmed, Yuxin Zhen. TBBPA rather than its main derivatives enhanced growth of endometrial cancer via p53 ubiquitination. Journal of environmental sciences (China). vol 137. 2023-11-18. PMID:37980057. |
the ubiquitination degradation of p53 was crucial in tbbpa induced ec proliferation, which resulted in the increase of downstream cell cycle and decrease of apoptosis. |
2023-11-18 |
2023-11-20 |
mouse |
| Huimin Li, Xiyu Tang, Zhiwei Sun, Zhongyuan Qu, Xiang Zo. Integrating bioinformatics and experimental models to investigate the mechanism of the chelidonine-induced mitotic catastrophe via the AKT/FOXO3/FOXM1 axis in breast cancer cells. Biomolecules & biomedicine. 2023-11-17. PMID:37976368. |
it was found that chelidonine treatment induced mcf-7 cell apoptosis, significantly reduced the expression of survivin and promoted the expression of p53 and caspase-9. |
2023-11-17 |
2023-11-20 |
Not clear |
| Trini A Ochoa, Amy Rossi, E Steve Woodle, David Hildeman, David Allma. The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells. Journal of immunology (Baltimore, Md. : 1950). 2023-11-15. PMID:37966267. |
in this study, using a direct in vitro approach, we show that deletion of the tumor suppressor and cell cycle regulator p53 rescues recently activated mouse b cells from btz-induced apoptosis. |
2023-11-15 |
2023-11-20 |
mouse |
| Trini A Ochoa, Amy Rossi, E Steve Woodle, David Hildeman, David Allma. The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells. Journal of immunology (Baltimore, Md. : 1950). 2023-11-15. PMID:37966267. |
furthermore, btz treatment elevated intracellular p53 levels, and p53 deletion constrained apoptosis, as recently stimulated cells first transitioned from the g1 to s phase of the cell cycle. |
2023-11-15 |
2023-11-20 |
mouse |
| Xiaoyu Zhang, Hongwei Wang, Xiuli Sun, Long Zhao, Tan Li, Xia Qi, Ting Wang, Qingjun Zhou, Weiyun Sh. Development of Thermoplastic Polyurethane Films for the Replacement of Corneal Endothelial Function of Transparency Maintenance. ACS applied bio materials. 2023-11-15. PMID:37967451. |
proteomic analysis suggested that the complement inhibition, the increase of mineral absorption, and the decrease of p53 apoptosis signaling pathway and lysine degradation might be beneficial in maintaining the corneal transparency. |
2023-11-15 |
2023-11-20 |
rabbit |
| Peilin Geng, Qingri Jin, Xiujuan Zhou, Fei Zh. Effects of environmental pollutant benzop[α]yrene on the innate immunity of Scylla paramamosain and its mechanism. Fish & shellfish immunology. 2023-11-15. PMID:37967729. |
the expression levels of p53, mcm7, caspase-3, and myosin were changed with increasing concentration of bap, which indicated that bap exposure may affect apoptosis and phagocytosis in mud crabs. |
2023-11-15 |
2023-11-20 |
cat |
| Agnieszka Szyposzynska, Aleksandra Bielawska-Pohl, Marek Murawski, Rafal Sozanski, Grzegorz Chodaczek, Aleksandra Klimcza. Mesenchymal Stem Cell Microvesicles from Adipose Tissue: Unraveling Their Impact on Primary Ovarian Cancer Cells and Their Therapeutic Opportunities. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958844. |
the results suggests that the anti-cancer effect of hatmsc2-mvs, with high probability, is contributed by the delivery of molecules that induce cell cycle arrest and apoptosis (p21, tumor suppressor p53, executor caspase 3) and proapoptotic regulators (bad, bim, fas, fasl, p27, trail-r1, trail-r2), and their presence has been confirmed by apoptotic protein antibody array. |
2023-11-14 |
2023-11-20 |
human |
| Hao Chen, Cole J Ferguson, Dylan C Mitchell, Amanda Titus, Joao A Paulo, Andrew Hwang, Tsen-Hsuan Lin, Hiroko Yano, Wei Gu, Sheng-Kwei Song, Carla M Yuede, Steven P Gygi, Azad Bonni, Albert H Ki. The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961719. |
in developmental analyses of the cerebral cortex, usp7 deletion induces neuronal apoptosis, which is rescued by loss of the tumor suppressor protein p53, an established downstream mediator of usp7 signaling. |
2023-11-14 |
2023-11-20 |
mouse |