| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georgia L Nolt, Alexander R Keeble, Yuan Wen, Aubrey C Strong, Nicholas T Thomas, Taylor R Valentino, Camille R Brightwell, Kevin A Murach, Sini Patrizia, Harald Weinstabl, Andreas Gollner, John J McCarthy, Christopher S Fry, Michael Franti, Antonio Filareto, Charlotte A Peterson, Cory M Dunga. Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice. GeroScience. 2023-10-23. PMID:37872294. |
p53 plays an integral role in all these processes, as upregulation of p53 causes apoptosis in senescent cells and prevents mitotic catastrophe in mpcs from old mice. |
2023-10-23 |
2023-11-08 |
mouse |
| Qian Chen, Mingjun Sun, Huirong Cheng, Jun Qi, Jingwen Tan, Yun Gu, Tianle Yu, Ming Li, Hao Xu, Yuefeng He, Weihua We. Inorganic arsenic-mediated upregulation of TUG1 promotes apoptosis in human bronchial epithelial by activating the p53 signaling pathway. Toxicology and industrial health. 2023-10-21. PMID:37864286. |
inorganic arsenic-mediated upregulation of tug1 promotes apoptosis in human bronchial epithelial by activating the p53 signaling pathway. |
2023-10-21 |
2023-11-08 |
human |
| Dipanshu Aggarwal, Devi Charan Shetty, Anshi Jain, Nikita Gulati, Saurabh Junej. Pathogenetic model of survivin-dependent molecular signalling pathways in tumorigenesis of oral cancer and precursor lesions. Journal of oral and maxillofacial pathology : JOMFP. vol 27. issue 2. 2023-10-20. PMID:37854918. |
p53 tumour suppressor gene limits unchecked cellular growth in response to dna damage, by causing g1 arrest and the activation of apoptosis. |
2023-10-20 |
2023-11-08 |
Not clear |
| Tugba Elgun, Asiye Gok Yurttas, Kamil Cinar, Sennur Ozcelik, Ahmet Gu. Effect of Aza-BODIPY-Photodynamic Therapy on The Expression of Carcinoma-Associated Genes and Cell Death Mode. Photodiagnosis and photodynamic therapy. 2023-10-20. PMID:37863378. |
our results showed that aza-bodipy-pdt induced apoptosis, probably through p53 and caspase3 in mcf-7 cells. |
2023-10-20 |
2023-11-08 |
Not clear |
| Chandrayee Ghosh, Jiangnan Hu, Electron Kebebe. Advances in translational research of the rare cancer type adrenocortical carcinoma. Nature reviews. Cancer. 2023-10-19. PMID:37857840. |
in adult primary adrenocortical carcinoma, the main somatic genetic alterations occur in genes that encode proteins involved in the wnt-β-catenin pathway, cell cycle and p53 apoptosis pathway, chromatin remodelling and telomere maintenance pathway, camp-protein kinase a (pka) pathway or dna transcription and rna translation pathways. |
2023-10-19 |
2023-11-08 |
Not clear |
| Ziqi Yu, Xue Dong, Mei Song, Aizhang Xu, Qing He, Huilin Li, Wen Ouyang, Lotfi Chouchane, Xiaojing M. Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. International journal of cancer. 2023-10-19. PMID:37855385. |
targeting ubr5 inhibits postsurgical breast cancer lung metastases by inducing cdc73 and p53 mediated apoptosis. |
2023-10-19 |
2023-11-08 |
mouse |
| Ziqi Yu, Xue Dong, Mei Song, Aizhang Xu, Qing He, Huilin Li, Wen Ouyang, Lotfi Chouchane, Xiaojing M. Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. International journal of cancer. 2023-10-19. PMID:37855385. |
transcriptome analyses revealed a prominent role of the p53 pathway in dovitinib-induced apoptosis of tumor cells differentially regulated by ubr5 and cdc73. |
2023-10-19 |
2023-11-08 |
mouse |
| Ming Wang, Zhicheng Sun, Yanggang Ou, Wei Ge, Mengqian Yuan, Bin X. Electroacupuncture Mediates Fat Metabolism and Autophagy via a Sirt3-Dependent Mechanism in Mice Fed High-Fat Diet. Advanced biology. 2023-10-16. PMID:37840428. |
at the molecular level, ea enhances the expression of thermogenesis-associated genes in brown adipose tissue and decreases p53 expression, suggesting a decrease in apoptosis. |
2023-10-16 |
2023-11-08 |
mouse |
| Jingpu Zhao, Yongfeng X. PITX1 plays essential functions in cancer. Frontiers in oncology. vol 13. 2023-10-16. PMID:37841446. |
notably, pitx1 interacts with p53 and exerts control over crucial cellular processes including cell cycle progression, apoptosis, and chemotherapy resistance. |
2023-10-16 |
2023-11-08 |
Not clear |
| Lei Xia, Wenbiao Ma, Ahmad Afrashteh, Mir Amirhossein Sajadi, Hadi Fakheri, Mohammad Valil. The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer. Biochemia medica. vol 33. issue 3. 2023-10-16. PMID:37841775. |
p53 is a tumour suppressor that activates the apoptosis pathway in aging and cancer cells in addition to stimulating the glutaminolysis and antioxidant pathways. |
2023-10-16 |
2023-11-08 |
Not clear |
| Xingfu Shu, Jinxian Su, Yu Zhao, Chun Liu, Yao Chen, Xiaomei Ma, Zifan Wang, Jialin Bai, Haixia Zhang, Zhongren M. Regulation of HeLa cell proliferation and apoptosis by bovine lactoferrin. Cell biochemistry and function. 2023-10-16. PMID:37842864. |
furthermore, blf primarily induced apoptosis in hela cells by increasing the expression of the proapoptotic proteins p53, bax, and cleaved-caspase-3 and downregulating the expression of the antiapoptotic protein bcl-2. |
2023-10-16 |
2023-11-08 |
cattle |
| Youn-Joo Jung, Thillaichidambaram Muneeswaran, Jin Soo Choi, Sumin Kim, Jong Hun Han, Wan-Seob Cho, June-Woo Par. Modified toxic potential of multi-walled carbon nanotubes to zebrafish (Danio rerio) following a two-year incubation in water. Journal of hazardous materials. vol 462. 2023-10-15. PMID:37839374. |
subsequently, the mrna expression of antioxidant enzymes, including cat, gst, and sod, in a-cnt group increased by 1.5- to 1.7-fold, consistent with increased expression of genes associated with inflammation (interleukin-8) and apoptosis (p53) compared to control. |
2023-10-15 |
2023-11-08 |
cat |
| H Libalova, T Zavodna, H Margaryan, F Elzeinova, A Milcova, K Vrbova, H Barosova, T Cervena, J Topinka, P Rössne. Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds. Toxicology in vitro : an international journal published in association with BIBRA. 2023-10-14. PMID:37838151. |
dox triggered the most robust p53 signaling indicating activation of ddr, followed by cell cycle arrest in the g2/m phase, induction of apoptosis and senescence, possibly due to the severe and irreparable dna lesions. |
2023-10-14 |
2023-11-08 |
human |
| Jun Lin, Yin-Ying Lu, Hong-Yu Shi, Pei Li. Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Polysaccharides Alleviate Photoaging by Regulating Nrf2 Pathway and Autophagy. International journal of medicinal mushrooms. vol 25. issue 10. 2023-10-13. PMID:37830196. |
results showed that iop inhibited cell senescence and apoptosis by reducing the protein expressions of p16, p21, and p53. |
2023-10-13 |
2023-10-15 |
human |
| Ayaz Shahid, Steven Yeung, Rita Miwalian, Angela Mercado, Bradley T Andresen, Ying Huan. The Journal of pharmacology and experimental therapeutics. 2023-10-12. PMID:37827703. |
carvedilol also reduced nm-induced apoptosis and p53 expression. |
2023-10-12 |
2023-10-15 |
mouse |
| Xi Liu, Zhao Liu, Cong Wang, Jinhua Miao, Shan Zhou, Qian Ren, Nan Jia, Lili Zhou, Youhua Li. Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes. Cell death & disease. vol 14. issue 10. 2023-10-12. PMID:37828075. |
mechanistically, exosomal-tnfaip8 promoted p53 ubiquitination leading to its degradation, thereby inhibiting fibroblasts apoptosis and inducing their proliferation. |
2023-10-12 |
2023-10-15 |
human |
| Mohamed Zaza, Mohammed H Rashed, Hesham Elrefaey, Memy H Hassan, Osama M Abo-Salem, El-Sayed M El-Saye. PRIMA-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosis. Canadian journal of physiology and pharmacology. 2023-10-11. PMID:37818839. |
prima-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosis. |
2023-10-11 |
2023-10-15 |
human |
| b' Zhijia Wang, Samu V Himanen, Heidi M Haikala, Caroline C Friedel, Anniina Vihervaara, Matja\\xc5\\xbe Barbori\\xc4\\x8. Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. Nucleic acids research. 2023-10-09. PMID:37811895.' |
while blocking p-tefb triggers their apoptosis in a p53-dependent manner, it impedes cell proliferation irrespective of p53 by preventing induction of genes downstream of the dna damage-induced nf-κb signaling. |
2023-10-09 |
2023-10-15 |
Not clear |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the hypoxia-inducible factor-1(hif-1) signaling pathway, atp-binding cassette(abc) transporters, cytochrome p450-mediated metabolism of xenobiotics, p53 signaling pathway, and cell apoptosis were key signaling pathways of hqez in treating gastric cancer. |
2023-10-06 |
2023-10-15 |
Not clear |
| Majid S Jabir, Ahmed M Al-Shammari, Zainab O Ali, Salim Albukhaty, Ghassan M Sulaiman, Sabrean F Jawad, Sawsan S Hamzah, Asad Syed, Abdallah M Elgorban, Rajalakshmanan Eswaramoorthy, Nouf S S Zaghloul, Ali G Al-Dulimi, Mazin A A Naj. Combined oncolytic virotherapy gold nanoparticles as synergistic immunotherapy agent in breast cancer control. Scientific reports. vol 13. issue 1. 2023-10-06. PMID:37803068. |
the findings demonstrated that ndv and gnps induced apoptosis in cancer cells by activating caspase-9, the p53 protein, and other proteins related to apoptosis, which holds promise as a combination therapy for breast cancer. |
2023-10-06 |
2023-10-15 |
human |