| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingyuan Wang, Qiong Huang, Min Liu, Tianjiao Zhao, Xiangping Song, Qiaohui Chen, Yongqi Yang, Yayun Nan, Zerun Liu, Yuntao Zhang, Wei Wu, Kelong A. Precisely Inhibiting Excessive Intestinal Epithelial Cell Apoptosis to Efficiently Treat Inflammatory Bowel Disease with Oral Pifithrin-α Embedded Nanomedicine (OPEN). Advanced materials (Deerfield Beach, Fla.). 2023-09-25. PMID:37747308. |
as a major hub for various stressors, p53 is a central determinant of cell fate, and its inhibition can effectively reduce excessive iec apoptosis. |
2023-09-25 |
2023-10-07 |
Not clear |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Milton Talukder, Shao-Shuai Bi, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long L. Involvement of the heat shock response (HSR) regulatory pathway in cadmium-elicited cerebral damage. Environmental science and pollution research international. 2023-09-21. PMID:37730984. |
furthermore, cd exposure increased tunel-positive neuronal apoptotic cells and up-regulated protein expression of caspase-1, caspase-8, caspase-3, and p53, leading to apoptosis. |
2023-09-21 |
2023-10-07 |
chicken |
| Milton Talukder, Shao-Shuai Bi, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long L. Involvement of the heat shock response (HSR) regulatory pathway in cadmium-elicited cerebral damage. Environmental science and pollution research international. 2023-09-21. PMID:37730984. |
moreover, cd exposure activates caspase-1, caspase-8, caspase-3, and p53 protein, thereby resulting in neuronal apoptosis in the chicken brain. |
2023-09-21 |
2023-10-07 |
chicken |
| Renfeng Xu, Siting Shen, Defan Wang, Jianqing Ye, Shiting Song, Zhengchao Wang, Zhicao Yu. The role of HIF-1α-mediated autophagy in ionizing radiation-induced testicular injury. Journal of molecular histology. 2023-09-20. PMID:37728670. |
further analysis by tunel staining and western blotting found that ir induced the apoptosis in a dose-dependent manner as indicated by increased expressions of cleaved caspase3, p53 and bax on day 15 after ir treatment. |
2023-09-20 |
2023-10-07 |
mouse |
| Yu-Qing Wu, Chen-Song Zhang, Jinye Xiong, Dong-Qi Cai, Chen-Zhe Wang, Yu Wang, Yan-Hui Liu, Yu Wang, Yiming Li, Jian Wu, Jianfeng Wu, Bin Lan, Xuefeng Wang, Siwei Chen, Xianglei Cao, Xiaoyan Wei, Hui-Hui Hu, Huiling Guo, Yaxin Yu, Abdul Ghafoor, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Mingxia Zhu, Xi Huang, Xiufeng Sun, Shu-Yong Lin, Hai-Long Piao, Jianyin Zhou, Sheng-Cai Li. Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate. Cell research. 2023-09-19. PMID:37726403. |
furthermore, we show that phgdh mutants (r135w and v261m) that are constitutively bound to 3-pga abolish p53 activation even under low glucose conditions, while the mutants (t57a and t78a) unable to bind 3-pga cause constitutive p53 activation and apoptosis in hepatocellular carcinoma (hcc) cells, even in the presence of high glucose. |
2023-09-19 |
2023-10-07 |
mouse |
| Xinyu Wang, Chao Yan, Chaoyun Wang, Xiaoyan Xu, Zhihao Liu, Wang Xin, Jianwei Gon. Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism. Brain research. 2023-09-18. PMID:37722469. |
the differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, dna damage and repair, and p38/jnk mapk and p53 signaling pathways. |
2023-09-18 |
2023-10-07 |
rat |
| Jiansheng Zhu, Mingtao Huang, Chunlan Liu, Jingyu Wang, Li Zou, Fan Yang, Renfei Zh. Curcumin protects against fenvalerate-induced neurotoxicity in zebrafish (Danio rerio) larvae through inhibition of oxidative stress. Ecotoxicology and environmental safety. vol 264. 2023-09-16. PMID:37716069. |
in addition, fen enhanced oxidative stress via excessive reactive oxygen species and antioxidant enzyme inhibition, then triggered apoptosis by upregulation of apoptotic genes (p53, bcl-2, bax and caspase 3). |
2023-09-16 |
2023-10-07 |
human |
| Gan Rao, Baoxin Qiao, Gaolong Zhong, Tong Li, Qian Su, Shaofeng Wu, Zhaoxin Tang, Lianmei H. Arsenic and polystyrene-nano plastics co-exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice. Environmental toxicology. 2023-09-14. PMID:37705229. |
psnps and as combination also triggered testicular apoptosis, containing changes in apoptotic factors (p53, bax, bcl-2, cytc, caspase-8, caspase-9, and caspase-3). |
2023-09-14 |
2023-10-07 |
mouse |
| Khalid Alhazzani, Meshal Alsahli, Ahmed Z Alanazi, Mohammad Algahtani, Ahmad A Alenezi, Ali Alhoshani, Mohammed Alqinyah, Abdullah S Alhamed, Khaled Alhosain. Augmented antitumor effects of erlotinib and cabozantinib on A549 non-small cell lung cancer: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 10. 2023-09-14. PMID:37705877. |
furthermore, mrna expression analyses for assessing apoptosis, metastasis, and cell cycle-related genes, the results showed that combination therapy significantly inhibits levels of bcl-2, mmp-9, vegf, and tgf-β while inducing p53, p21, and bax expression. |
2023-09-14 |
2023-10-07 |
Not clear |
| Khalid Alhazzani, Meshal Alsahli, Ahmed Z Alanazi, Mohammad Algahtani, Ahmad A Alenezi, Ali Alhoshani, Mohammed Alqinyah, Abdullah S Alhamed, Khaled Alhosain. Augmented antitumor effects of erlotinib and cabozantinib on A549 non-small cell lung cancer: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 10. 2023-09-14. PMID:37705877. |
in terms of oncogenic markers, western blotting analysis showed a significant reduction of bcl-2 expression and elevation in caspase3, p53, and p21 proteins as indicators of cell death via apoptosis. |
2023-09-14 |
2023-10-07 |
Not clear |
| Yao Wang, Runyi Jiang, Ting Wang, Zhipeng Wu, Haiyi Gong, Xiaopan Cai, Jialiang Liu, Xinghai Yang, Haifeng Wei, Jian Jiao, Qi Jia, Cheng Yang, Chenglong Zhao, Jianru Xia. Identification of ARAP3 as a regulator of tumor progression, macrophage infiltration and osteoclast differentiation in a tumor microenvironment-related prognostic model of Ewing sarcoma. American journal of cancer research. vol 13. issue 8. 2023-09-11. PMID:37693165. |
in addition, bioinformatic analyses and in vitro experiments proved that the high expression of arap3 regulated es cell proliferation, migration, as well as apoptosis via the p53 signaling pathway and affected macrophage infiltration and osteoclast differentiation through regulating il1b and il11 secretion of tumor cells. |
2023-09-11 |
2023-10-07 |
Not clear |
| Fuyan Hu, Bifeng Chen, Qing Wang, Zhiyuan Yang, Man Ch. Multi-omics data analysis reveals the biological implications of alternative splicing events in lung adenocarcinoma. Journal of bioinformatics and computational biology. 2023-09-11. PMID:37694487. |
these deases were strongly linked to "cancer hallmarks", such as apoptosis, dna repair, cell cycle, cell proliferation, angiogenesis, immune response, generation of precursor metabolites and energy, p53 signaling pathway and pi3k-akt signaling pathway. |
2023-09-11 |
2023-10-07 |
Not clear |
| Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhan. Exploring the Toxic Effects of ZEA on IPEC-J2 Cells from the Inflammatory Response and Apoptosis. Animals : an open access journal from MDPI. vol 13. issue 17. 2023-09-09. PMID:37684994. |
zea also caused apoptosis in porcine small intestine cells, resulting in a significant reduction in protein and/or mrna expression of apoptosis-related pathway factors such as p53, caspase 3, caspase 9, bax, and cyt-c, which in turn caused a significant decrease in protein and/or mrna expression of inflammatory-related factors such as il-1β, il-2, cox-2, nf-κd, nlrp3, il-6, and il -18, which in turn caused a significant increase in protein and/or mrna expression levels. |
2023-09-09 |
2023-10-07 |
cat |
| Ling-Hu Cai, Xiang-Yu Chen, Wei Qian, Chuan-Chuan Liu, Li-Jia Yuan, Liang Zhang, Chao Nie, Zhen Liu, Yue Li, Tian Li, Ming-Hua Li. DDB2 and MDM2 genes are promising markers for radiation diagnosis and estimation of radiation dose independent of trauma and burns. Functional & integrative genomics. vol 23. issue 4. 2023-09-09. PMID:37688632. |
totally, 33 multi-type ray co-induced genes were obtained at first from the differentially expressed genes (degs) and key genes identified by weighted gene co-expression network analysis (wgcna), and these genes were mainly enriched in dna damage, cellular apoptosis, and p53 signaling pathway. |
2023-09-09 |
2023-10-07 |
human |
| Mathew R Schnorenberg, Katrina M Hawley, Anika T Thomas-Toth, Elyse A Watkins, Yu Tian, Jeffrey M Ting, Logan B Leak, Isadora M Kucera, Michal M Raczy, Andrew L Kung, Jeffrey A Hubbell, Matthew V Tirrell, James L LaBell. Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B-Cell Lymphoma. ACS nano. 2023-09-09. PMID:37688780. |
in this work, we elucidated an opportunity for therapeutic synergy in dlbcl by reactivating tumor protein p53 with a stapled peptide, atsp-7041, thereby priming cells for apoptosis and enhancing their sensitivity to bcl-2 family modulation with a bh3-mimetic, abt-263 (navitoclax). |
2023-09-09 |
2023-10-07 |
Not clear |
| Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medin. Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea. Chemosphere. 2023-09-09. PMID:37689151. |
herein, findings indicate that both compounds induced oxidative damage and increased the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3). |
2023-09-09 |
2023-10-07 |
zebrafish |
| Yan Wang, Jing-Miao Wang, Yuan Xiao, Xue-Bin Hu, Shu-Yu Zheng, Jia-Ling Fu, Lan Zhang, Yu-Wen Gan, Xing-Miao Liang, David Wan-Cheng L. SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells. Aging. vol 15. 2023-09-08. PMID:37683133. |
in contrast, overexpression of dbc1 enhances oxidative stress-induced apoptosis, and this process depends on p53. |
2023-09-08 |
2023-10-07 |
mouse |
| El-Habib Dakir, Consuelo Gajate, Faustino Mollined. Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-08. PMID:37683591. |
here, we found that edelfosine was the most potent alkylphospholipid analog in inducing apoptosis in three different human prostate cancer cell lines (lncap, pc3, and du145) with distinct androgen dependency, and differing in tumor suppressor phosphatase and tensin homolog (pten) and p53 status. |
2023-09-08 |
2023-10-07 |
mouse |
| Cuicui Zhuang, Jinhui Zhao, Shiyao Zhang, Muhammad Shahi. Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells. Microbial pathogenesis. 2023-09-08. PMID:37683833. |
moreover, expressions of p53 and p21 promptly improved after e. coli infection, however, pifithrin-α (specific inhibitor of p53) inhibited p53-p21 pathway, apoptosis, cell cycle arrest and pyroptosis. |
2023-09-08 |
2023-10-07 |
cattle |