| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmad Najem, Mohammad Krayem, Serena Sabbah, Matilde Pesetti, Fabrice Journe, Ahmad Awada, Laurent Désaubry, Ghanem E Ghane. Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies. Cells. vol 12. issue 14. 2023-07-29. PMID:37508519. |
we designed and identified novel specific phb inhibitors that can inhibit melanoma cell growth in 3d spheroid models and a large panel of representative cell lines with different molecular subtypes, including those with intrinsic and acquired resistance to mapki, by significantly moderating both mapk (craf-erk axis) and pi3k/akt pathways, and inducing apoptosis through the mitochondrial pathway and up-regulation of p53. |
2023-07-29 |
2023-08-14 |
Not clear |
| Fabio Casciano, Enrico Zauli, Massimo Busin, Lorenzo Caruso, Saleh AlMesfer, Samar Al-Swailem, Giorgio Zauli, Angeli Christy Y. State of the Art of Pharmacological Activators of p53 in Ocular Malignancies. Cancers. vol 15. issue 14. 2023-07-29. PMID:37509256. |
the biological activity of p53 is not strictly limited to cell cycle arrest but also includes the regulation of homeostasis, dna repair, apoptosis, and senescence. |
2023-07-29 |
2023-08-14 |
human |
| Yiannis Drosos, Eumorphia G Konstantakou, Aggeliki-Stefania Bassogianni, Konstantinos-Stylianos Nikolakopoulos, Dimitra G Koumoundourou, Sophia P Markaki, Ourania E Tsitsilonis, Gerassimos E Voutsinas, Dimitrios Valakos, Ema Anastasiadou, Dimitris Thanos, Athanassios D Velentzas, Dimitrios J Stravopodi. Microtubule Dynamics Deregulation Induces Apoptosis in Human Urothelial Bladder Cancer Cells via a p53-Independent Pathway. Cancers. vol 15. issue 14. 2023-07-29. PMID:37509392. |
most importantly, we revealed that paclitaxel triggered a robust dna-damage response and apoptosis program without activating the p53 pathway. |
2023-07-29 |
2023-08-14 |
human |
| Chunsheng Lu, Yuehui Liang, Ya Cheng, Chan Peng, Yuanyuan Sun, Kangle Liu, Yingqing Li, Yixia Lou, Xiao Jiang, Aihua Zhang, Jinyi Liu, Jia Cao, Fei Ha. Microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-28. PMID:37506861. |
microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling. |
2023-07-28 |
2023-08-14 |
mouse |
| Aranka Brockmueller, Anjana Sajeev, Lenka Koklesova, Samson Mathews Samuel, Peter Kubatka, Dietrich Büsselberg, Ajaikumar B Kunnumakkara, Mehdi Shakibae. Resveratrol as sensitizer in colorectal cancer plasticity. Cancer metastasis reviews. 2023-07-28. PMID:37507626. |
chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (mdr), inhibition of the sentinel gene p53, and apoptosis. |
2023-07-28 |
2023-08-14 |
Not clear |
| Shengnan Sun, Yong Yi, Zhi-Xiong Jim Xiao, Hu Che. ER stress activates TAp73α to promote colon cancer cell apoptosis via the PERK-ATF4 pathway. Journal of Cancer. vol 14. issue 11. 2023-07-27. PMID:37497416. |
the tumor suppressor p53 induces cell growth arrest and/or apoptosis in response to stress, including endoplasmic reticulum (er) stress. |
2023-07-27 |
2023-08-14 |
human |
| Shengnan Sun, Yong Yi, Zhi-Xiong Jim Xiao, Hu Che. ER stress activates TAp73α to promote colon cancer cell apoptosis via the PERK-ATF4 pathway. Journal of Cancer. vol 14. issue 11. 2023-07-27. PMID:37497416. |
it has been documented that the p53 gene is mutated in more than 50% of human tumors and loses its tumor suppressor function, suggesting that er stress-induced apoptosis might not rely on p53. |
2023-07-27 |
2023-08-14 |
human |
| Shengnan Sun, Yong Yi, Zhi-Xiong Jim Xiao, Hu Che. ER stress activates TAp73α to promote colon cancer cell apoptosis via the PERK-ATF4 pathway. Journal of Cancer. vol 14. issue 11. 2023-07-27. PMID:37497416. |
in this study, we found that activation of er stress promotes p53 null colon cancer cell apoptosis concomitant with an increased level of the tap73α protein, a homologue of p53 |
2023-07-27 |
2023-08-14 |
human |
| So-Young Lee, Geun-Hye Hong, Ji Hyung Chung, Kun-Young Par. Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang on Colon Cancer-Induced C57BL/6 Mice. Journal of medicinal food. 2023-07-27. PMID:37498372. |
besides, wdsd regulated the protein expression of apoptosis (bcl-2-associated x protein [bax], b cell lymphoma-2 [bcl-2], b cell lymphoma-extra large [bcl-xl], and caspase 9, caspase 3), and p53, p21, and proinflammatory cytokines (interleukin [il]-6, tumor necrosis factor [tnf]- |
2023-07-27 |
2023-08-14 |
mouse |
| Laura Breda, Tyler E Papp, Michael P Triebwasser, Amir Yadegari, Megan T Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A Grupp, Stella T Chou, Houping Ni, Barbara L Mui, Ying K Tam, Drew Weissman, Stefano Rivella, Hamideh Parhi. In vivo hematopoietic stem cell modification by mRNA delivery. Science (New York, N.Y.). vol 381. issue 6656. 2023-07-27. PMID:37499029. |
furthermore, in vivo delivery of pro-apoptotic puma (p53 up-regulated modulator of apoptosis) mrna with cd117/lnp affected hsc function and permitted nongenotoxic conditioning for hsct. |
2023-07-27 |
2023-08-14 |
Not clear |
| Jie Gu, Liguo Guo, Jun Hu, Guixiang Ji, Daqiang Yi. Potential adverse outcome pathway (AOP) of emamectin benzoate mediated cardiovascular toxicity in zebrafish larvae (Danio rerio). The Science of the total environment. 2023-07-27. PMID:37499828. |
furthermore, emb exposure resulted in abnormal cardiac function and vascular development, triggering neutrophil migration and aggregation toward the pericardial and dorsal vascular regions, and finalized apoptosis in the zebrafish heart region, these phenomena were further deciperred by the transcriptome analysis that the toll-like receptor pathway, p53 pathway, and apoptotic pathway were significantly affected by emb exposure. |
2023-07-27 |
2023-08-14 |
zebrafish |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
we used immunoblotting to analyze the effect of manganese, iron alone, or their combined exposure on the activation of caspase9, p53, bax, and bcl2 apoptosis signaling pathways. |
2023-07-27 |
2023-08-14 |
Not clear |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
and we also found that the apoptosis rate increased, mitochondrial membrane potential decreased, apoptosis-related proteins caspase9, p53, bax, and bcl2 expression increased, and caspase3 activity increased. |
2023-07-27 |
2023-08-14 |
Not clear |
| Camila S Silva, Tetyana Kudlyk, Volodymyr P Tryndyak, Nathan C Twaddle, Bonnie Robinson, Qiang Gu, Frederick A Beland, Suzanne C Fitzpatrick, Jyotshna Kanung. Gene expression analyses reveal potential mechanism of inorganic arsenic-induced apoptosis in zebrafish. Journal of applied toxicology : JAT. 2023-07-27. PMID:37501093. |
our data suggest that the p53 pathway is likely responsible for sodium arsenite-induced apoptosis. |
2023-07-27 |
2023-08-14 |
human |
| Yunfei Huo, Ke Cao, Buxin Kou, Mengyin Chai, Shuangshuang Dou, Dexi Chen, Ying Shi, Xiaoni Li. TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities. Genes & diseases. vol 10. issue 5. 2023-07-26. PMID:37492707. |
during tumorigenesis or tumor development, tumor suppressor p53-binding protein 2 (tp53bp2), also known as apoptosis stimulating protein 2 of p53 (aspp2), plays a critical role in p53 dependent and independent manner. |
2023-07-26 |
2023-08-14 |
Not clear |
| Zhilin He, Jinming Lin, Dong Peng, Jieyu Zeng, Xiangmin Pan, Rui Zheng, Pan Li, Bing D. Peptide fractions from Scha inchi induced apoptosis in HepG2 cells via P53 activation and a mitochondria-mediated pathway. Journal of the science of food and agriculture. 2023-07-26. PMID:37495560. |
peptide fractions from scha inchi induced apoptosis in hepg2 cells via p53 activation and a mitochondria-mediated pathway. |
2023-07-26 |
2023-08-14 |
human |
| Nora M Aborehab, Mai A Abd-Elmawla, Abeer M ElSayed, Omar Sabry, Shahira M Ezza. Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR-181a and apoptosis genes. Bioorganic chemistry. vol 139. 2023-07-25. PMID:37490810. |
the present study has proven that the underlying mechanism of acovenoside a is partially attributed to the upregulation of mir-630 and mir-181a gene expressions which in turn targets the intrinsic apoptosis genes as p53, bax and bcl2 as well as caspase 3. |
2023-07-25 |
2023-08-14 |
Not clear |
| Shantanu Gupta, Daner A Silveira, Ronaldo F Hashimot. A Boolean model of the oncogene role of FAM111B in lung adenocarcinoma. Computational biology and chemistry. vol 106. 2023-07-24. PMID:37487252. |
as for apoptosis, down-regulation of fam111b by p53 directly regulates the bag3/bcl-2 axis, which triggers apoptotic cell death. |
2023-07-24 |
2023-08-14 |
Not clear |
| Shantanu Gupta, Daner A Silveira, Ronaldo F Hashimot. A Boolean model of the oncogene role of FAM111B in lung adenocarcinoma. Computational biology and chemistry. vol 106. 2023-07-24. PMID:37487252. |
our model indicates that the cell fate between the two cellular phenotypes, arrest, and apoptosis, at the g2/m checkpoint is non-deterministic and is controlled by p53. |
2023-07-24 |
2023-08-14 |
Not clear |
| Zekai Huang, Markus Kaller, Heiko Hermekin. CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34. Cell death and differentiation. 2023-07-24. PMID:37488217. |
concomitant deletion of mir-34a and mir-34b/c resulted in significantly reduced suppression of proliferation after p53 activation, enhanced migration, invasion and emt, as well as reduced sensitivity to chemotherapeutics, increased stress-induced autophagic flux, decreased apoptosis and upregulation of autophagy-related genes after 5-fu treatment. |
2023-07-24 |
2023-08-14 |
Not clear |