| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayaz Shahid, Steven Yeung, Rita Miwalian, Angela Mercado, Bradley T Andresen, Ying Huan. The Journal of pharmacology and experimental therapeutics. 2023-10-12. PMID:37827703. |
carvedilol also reduced nm-induced apoptosis and p53 expression. |
2023-10-12 |
2023-10-15 |
mouse |
| Xi Liu, Zhao Liu, Cong Wang, Jinhua Miao, Shan Zhou, Qian Ren, Nan Jia, Lili Zhou, Youhua Li. Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes. Cell death & disease. vol 14. issue 10. 2023-10-12. PMID:37828075. |
mechanistically, exosomal-tnfaip8 promoted p53 ubiquitination leading to its degradation, thereby inhibiting fibroblasts apoptosis and inducing their proliferation. |
2023-10-12 |
2023-10-15 |
human |
| Mohamed Zaza, Mohammed H Rashed, Hesham Elrefaey, Memy H Hassan, Osama M Abo-Salem, El-Sayed M El-Saye. PRIMA-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosis. Canadian journal of physiology and pharmacology. 2023-10-11. PMID:37818839. |
prima-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosis. |
2023-10-11 |
2023-10-15 |
human |
| b' Zhijia Wang, Samu V Himanen, Heidi M Haikala, Caroline C Friedel, Anniina Vihervaara, Matja\\xc5\\xbe Barbori\\xc4\\x8. Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. Nucleic acids research. 2023-10-09. PMID:37811895.' |
while blocking p-tefb triggers their apoptosis in a p53-dependent manner, it impedes cell proliferation irrespective of p53 by preventing induction of genes downstream of the dna damage-induced nf-κb signaling. |
2023-10-09 |
2023-10-15 |
Not clear |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the hypoxia-inducible factor-1(hif-1) signaling pathway, atp-binding cassette(abc) transporters, cytochrome p450-mediated metabolism of xenobiotics, p53 signaling pathway, and cell apoptosis were key signaling pathways of hqez in treating gastric cancer. |
2023-10-06 |
2023-10-15 |
Not clear |
| Majid S Jabir, Ahmed M Al-Shammari, Zainab O Ali, Salim Albukhaty, Ghassan M Sulaiman, Sabrean F Jawad, Sawsan S Hamzah, Asad Syed, Abdallah M Elgorban, Rajalakshmanan Eswaramoorthy, Nouf S S Zaghloul, Ali G Al-Dulimi, Mazin A A Naj. Combined oncolytic virotherapy gold nanoparticles as synergistic immunotherapy agent in breast cancer control. Scientific reports. vol 13. issue 1. 2023-10-06. PMID:37803068. |
the findings demonstrated that ndv and gnps induced apoptosis in cancer cells by activating caspase-9, the p53 protein, and other proteins related to apoptosis, which holds promise as a combination therapy for breast cancer. |
2023-10-06 |
2023-10-15 |
human |
| Naeem Abdul Ghafoor, Aysegul Yildi. Targeting MDM2-p53 Axis through Drug Repurposing for Cancer Therapy: A Multidisciplinary Approach. ACS omega. vol 8. issue 38. 2023-10-02. PMID:37779953. |
mouse double minute 2 (mdm2) is a key regulator of the tumor suppressor protein p53, which plays a critical role in regulating cellular growth, apoptosis, and dna repair. |
2023-10-02 |
2023-10-07 |
mouse |
| Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sorensen, Jakub Szymczyk, Katarzyna Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewsk. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-10-02. PMID:37783936. |
intracellular fgf1 protects cells from apoptosis through direct interaction with p53. |
2023-10-02 |
2023-10-07 |
Not clear |
| Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sorensen, Jakub Szymczyk, Katarzyna Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewsk. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-10-02. PMID:37783936. |
here, we show that expression of fgf1 increases the survival of cells treated with various apoptosis inducers, but only when wild-type p53 is present. |
2023-10-02 |
2023-10-07 |
Not clear |
| Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sorensen, Jakub Szymczyk, Katarzyna Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewsk. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-10-02. PMID:37783936. |
we therefore postulate that intracellular fgf1 protects cells from apoptosis by directly interacting with p53. |
2023-10-02 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
licochalcone a induces g2/m phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: in-vitro and in-vivo study. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
combining multiple databases and network pharmacology, we found that the mechanism of lca inhibiting ec may be closely related to p53 signaling pathway, cell cycle regulation and apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
lca significantly up-regulated p53 protein and gene expression, thereby inducing apoptosis and cycle arrest. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
lca administration inhibited tumor growth by activating p53 signaling pathways and apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
in conclusion, lca is an excellent candidate for ec treatment by regulating p53 pathway to induce g2/m phase arrest and apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Yasuhiro Takano, Satomi Yogosawa, Yuta Imaizumi, Hiroshi Kamioka, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshid. DYRK2 promotes chemosensitivity via p53-mediated apoptosis after DNA damage in colorectal cancer. Cancer science. 2023-09-30. PMID:37776195. |
conversely, the combination of adenovirus-mediated overexpression of dyrk2 with 5-fluorouracil or oxaliplatin enhanced apoptosis and chemosensitivity through p53-ser46 phosphorylation in p53 wild-type colorectal cancer cells. |
2023-09-30 |
2023-10-07 |
mouse |
| Hao Wang, Wei Yu, Yibo Wang, Ruihao Wu, Yifei Dai, Ye Deng, Shijun Wang, Jinxiang Yuan, Rubin Ta. p53 contributes to cardiovascular diseases via mitochondria dysfunction: A new paradigm. Free radical biology & medicine. 2023-09-30. PMID:37776918. |
in this comprehensive review, we delve into the mechanisms how p53 influences mitochondrial dysfunction, including energy metabolism, mitochondrial oxidative stress, mitochondria-induced apoptosis, mitochondrial autophagy, and mitochondrial dynamics, in various cvds. |
2023-09-30 |
2023-10-07 |
Not clear |
| Anasuya Pal, Laura Gonzalez-Malerva, Seron Eaton, Chenxi Xu, Yining Zhang, Dustin Grief, Lydia Sakala, Lilian Nwekwo, Jia Zeng, Grant Christensen, Chitrak Gupta, Ellen Streitwieser, Abhishek Singharoy, Jin G Park, Joshua LaBae. Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants. NPJ breast cancer. vol 9. issue 1. 2023-09-29. PMID:37773066. |
to test whether neomorphic functions of specific tp53 missense mutations contribute to phenotypic heterogeneity, we characterized phenotypes of non-transformed mcf10a-derived cell lines expressing the ten most common missense mutant p53 proteins and observed a wide spectrum of phenotypic changes in cell survival, resistance to apoptosis and anoikis, cell migration, invasion and 3d mammosphere architecture. |
2023-09-29 |
2023-10-07 |
Not clear |
| Ravel Ray, Stuti Goel, Hind Al Khashali, Ban Darweesh, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Soluble E-Cadherin Signaling in Non-Small-Cell Lung Cancer Cells by Nicotine, BDNF, and β-Adrenergic Receptor Ligands. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760996. |
in investigating the function of se-cad, we found that immunodepletion of se-cad from the media of a549 cells untreated or treated with bdnf, nicotine, or epinephrine reduced activation of egfr and igf-1r, decreased pi3k and erk1/2 activities, increased p53 activation, decreased cell viability, and increased apoptosis, while no effects were found using h1299 cells under all conditions tested. |
2023-09-28 |
2023-10-07 |
Not clear |
| Kyuho Jeong, Jihyun Je, Theodomir Dusabimana, Hwajin Kim, Sang Won Par. Early Growth Response 1 Contributes to Renal IR Injury by Inducing Proximal Tubular Cell Apoptosis. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762598. |
interestingly, egr-1 overexpression enhanced p53 levels and tubular apoptosis, while the knockdown of egr-1 reduced p53 levels and tubular apoptosis after h |
2023-09-28 |
2023-10-07 |
mouse |