| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiyang Sun, Lingling Zhang, Zhuoqing Fang, Dingyu Liu, Min Shao, Yujie Liu, Bing Liao, Ying Ji. PRPF8 controls alternative splicing of PIRH2 to modulate the p53 pathway and survival of human ESCs. Journal of cellular physiology. 2023-06-26. PMID:37357506. |
strikingly, silencing of p53 rescues prpf8 kd-induced apoptosis, indicating that prpf8 kd triggers hesc apoptosis through activating the p53 pathway. |
2023-06-26 |
2023-08-14 |
human |
| Masumeh Sanaei, Fraidoon Kavoos. Effect of Zebularine on Apoptotic Pathways in Hepatocellular Carcinoma Cell Lines. International journal of preventive medicine. vol 14. 2023-06-23. PMID:37351028. |
this study was assigned to assess the effect of zebularine on intrinsic and extrinsic pathways, dnat 1, 3a, and 3b, p21, and p53, viability, and apoptosis in hepatocellular carcinoma (hcc) cell lines. |
2023-06-23 |
2023-08-14 |
human |
| Roba Abukwaik, Elias Vera-Siguenza, Daniel A Tennant, Fabian Spil. Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy. Journal of theoretical biology. 2023-06-22. PMID:37348784. |
two critical factors play a role in chemoresistance: the p53 tumour suppressor gene and the x-linked inhibitor of apoptosis (xiap). |
2023-06-22 |
2023-08-14 |
Not clear |
| Roba Abukwaik, Elias Vera-Siguenza, Daniel A Tennant, Fabian Spil. Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy. Journal of theoretical biology. 2023-06-22. PMID:37348784. |
this study introduces a mathematical model characterising the apoptosis pathway activation by p53 before and after mitochondrial outer membrane permeabilisation upon treatment with the chemotherapy doxorubicin (dox). |
2023-06-22 |
2023-08-14 |
Not clear |
| Roba Abukwaik, Elias Vera-Siguenza, Daniel A Tennant, Fabian Spil. Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy. Journal of theoretical biology. 2023-06-22. PMID:37348784. |
consequently, the model predicts that failure to activate apoptosis in some cancer cells expressing wild-type p53 might be due to heterogeneity between cells in upregulating the xiap protein, rather than due to the p53 protein concentration. |
2023-06-22 |
2023-08-14 |
Not clear |
| Haili Li, Ze Zhang, Huixin Li, Xinyu Pan, Yue Wan. New Insights into the Roles of p53 in Central Nervous System Diseases. The international journal of neuropsychopharmacology. 2023-06-20. PMID:37338366. |
in addition to its role in tumors, p53 has a widespread expression in the brain and participates in most cell processes, such as dendrite formation, oxidative stress, apoptosis, autophagy, dna repair and cell cycle arrest. |
2023-06-20 |
2023-08-14 |
Not clear |
| Shuai Wang, Jie Bai, Yilin Che, Weikun Qu, Jing L. Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1. Frontiers in pharmacology. vol 14. 2023-06-16. PMID:37324479. |
fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through usp22/sirt 1. |
2023-06-16 |
2023-08-14 |
Not clear |
| Aiqing Ma, Xianhua Da. The mechanism accounting for DNA damage strength modulation of p53 dynamical properties. Journal of bioinformatics and computational biology. 2023-06-16. PMID:37325863. |
in addition, the pulse interval is negatively correlated with apoptosis; the greater the damage strength, the smaller the pulse interval, the faster the p53 accumulation rate, and the cells are more susceptible to apoptosis. |
2023-06-16 |
2023-08-14 |
Not clear |
| Haixia Ji, Ou Qiao, Yi Zhang, Wenzhe Wang, Xiaoyin Han, Xinyu Zhang, Changxiao Liu, Wenyuan Ga. Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells. Phytotherapy research : PTR. 2023-06-16. PMID:37326338. |
herein, we illustrate that the tumor repressor p53 mediate magnolol (mag) triggers colon cancer cell apoptosis. |
2023-06-16 |
2023-08-14 |
Not clear |
| A Frega, C Gentili, S Proietti, E Lepore, V Unfer, A Fus. Epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid significantly increase apoptosis and p53 expression in HeLa cells. European review for medical and pharmacological sciences. vol 27. issue 11. 2023-06-15. PMID:37318498. |
epigallocatechin gallate, folic acid, vitamin b12, and hyaluronic acid significantly increase apoptosis and p53 expression in hela cells. |
2023-06-15 |
2023-08-14 |
human |
| Weiwei Lv, Haotian Gu, Defu He, Zhiquan Liu, Chunxia Yao, Weiwei Huang, Quan Yuan, Wenzong Zho. Polystyrene nanospheres-induced hepatotoxicity in swamp eel (Monopterus albus): From biochemical, pathological and transcriptomic perspectives. The Science of the total environment. 2023-06-15. PMID:37321506. |
moreover, signaling cascades keap1-nrf2, p53 and ppar were either substantially initiated or dysregulated to orchestrate ps-nps hepatotoxicity featuring oxidative damage, hepatocyte apoptosis and lipid steatosis. |
2023-06-15 |
2023-08-14 |
Not clear |
| Mayuri Khot, Anika Sood, Kamatham Pushpa Tryphena, Poojitha Pinjala, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatr. Dimethyl fumarate ameliorates Parkinsonian pathology by modulating autophagy and apoptosis via Nrf2-TIGAR-LAMP2/Cathepsin D axis. Brain research. 2023-06-14. PMID:37315723. |
dmf promoted autophagosome formation and inhibited apoptosis by removing the inhibitory effect of p53 on tigar. |
2023-06-14 |
2023-08-14 |
mouse |
| Aylin Balcı Özyurt, Pınar Erkekoğlu, Naciye Dilara Zeybek, Ali Aşcı, Ünzile Yaman, Ofcan Oflaz, Murat Kızılgün, Evin İşcan, Tuğçe Batur, Mehmet Öztürk, Belma Koçer-Gümüşe. Toxic effects of Aroclor 1254 on rat liver and modifying roles of selenium. International journal of environmental health research. 2023-06-13. PMID:37309736. |
histopathology, oxidant/antioxidant balance, apoptosis and cell cycle proteins (p53, p21) in liver were evaluated. |
2023-06-13 |
2023-08-14 |
human |
| Liangzi Cao, Hao Li, Xiaofang Liu, Yubang Wang, Bowen Zheng, Chengzhong Xing, Naijin Zhang, Jingwei Li. Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers. BMC cancer. vol 23. issue 1. 2023-06-08. PMID:37291499. |
nedd4 family members interacted proteins were enriched in various pathways including p53, akt, apoptosis and autophagy, which were confirmed by further western blot and flow cytometric analysis in a549 and h1299 lung cancer cells. |
2023-06-08 |
2023-08-14 |
Not clear |
| b' Kate\\xc5\\x99ina Wolfov\\xc3\\xa1, Petra Otev\\xc5\\x99elov\\xc3\\xa1, Ale\\xc5\\xa1 Holoubek, Barbora Brodsk\\xc3\\xa. Nucleolar phosphoprotein modifications as a marker of apoptosis induced by RITA treatment. Biochimica et biophysica acta. Molecular cell research. 2023-06-05. PMID:37276927.' |
reactivating p53 and inducing tumor apoptosis (rita) has been reported to increase the p53 activity and to trigger p53-dependent apoptosis in cancer cells with wild-type p53. |
2023-06-05 |
2023-08-14 |
Not clear |
| Giorgio Bogani, Bradley J Monk, Robert L Coleman, Ignace Vergote, Ana Oakin, Isabelle Ray-Coquard, Andrea Mariani, Giovanni Scambia, Francesco Raspagliesi, Bruno Bolognes. Selinexor in patients with advanced and recurrent endometrial cancer. Current problems in cancer. 2023-06-04. PMID:37271639. |
selinexor, blocking xpo1, induces nuclear localization of tumor suppressor proteins (including p53, p73, brca1, and prb), leading to the selective induction of apoptosis, and inhibition of dna damage repair proteins. |
2023-06-04 |
2023-08-14 |
Not clear |
| Kalpana Baghel, Mukesh Kumar Niranjan, Rashmi Srivastav. Withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of Coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent Caspase-3 mediated low immunoreactivity of estrogen receptor alpha. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023-06-02. PMID:37266906. |
withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent caspase-3 mediated low immunoreactivity of estrogen receptor alpha. |
2023-06-02 |
2023-08-14 |
Not clear |
| Kalpana Baghel, Mukesh Kumar Niranjan, Rashmi Srivastav. Withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of Coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent Caspase-3 mediated low immunoreactivity of estrogen receptor alpha. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023-06-02. PMID:37266906. |
neuronal apoptosis was observed in the poa and pvn of pr quail as indicated by the abundant expression of caspase-3 and p53 which reduces after the administration of ws root extract. |
2023-06-02 |
2023-08-14 |
Not clear |
| Kalpana Baghel, Mukesh Kumar Niranjan, Rashmi Srivastav. Withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of Coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent Caspase-3 mediated low immunoreactivity of estrogen receptor alpha. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023-06-02. PMID:37266906. |
further, the study concluded that change in photoperiod from 3 months exposure of 16l: 8d to 13.5l: 10.5d directly activates neuronal apoptosis via expression of caspase3 and p53 expression in the brain and increases neuronal and gonadal oxidative stress while ws root extract reverses them via enhanced estrogen and its receptor erα expression in the hypothalamic pre-optic and pvn area of japanese quail. |
2023-06-02 |
2023-08-14 |
Not clear |
| Farnaz Hemmati, Ayuba Akinpelu, Jiyeon Song, Farshad Amiri, Anya McDaniel, Collins McMurray, Alexandros Afthinos, Stelios T Andreadis, Andrew V Aitken, Vinicia C Biancardi, Sharon Gerecht, Panagiotis Mistrioti. Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-06-02. PMID:37267923. |
the results of this study show that continuous exposure to tight confinement can trigger frequent nuclear envelope rupture events, which in turn promote p53 activation and cell apoptosis. |
2023-06-02 |
2023-08-14 |
Not clear |