| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatemeh Hosseini, Masoumeh Mirzaei Chegeni, Ali Bidaki, Mohammad Zaer, Hossein Abolhassani, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Arezoo Ashrafnia Menarbazari, Alaa Moeinzadeh, Ahmad Reza Farmani, Mohammad Tavakkoli Yarak. 3D-printing-assisted synthesis of paclitaxel-loaded niosomes functionalized by cross-linked gelatin/alginate composite: Large-scale synthesis and in-vitro anti-cancer evaluation. International journal of biological macromolecules. 2023-05-08. PMID:37156313. |
the anticancer effect of the designed nanocarrier could be attributed to gene expression regulation, where a significant increase in the expression and activity of genes promoting apoptosis (casp-3, casp-8, and casp-9) and inhibiting metastasis (bax, and p53) and a remarkable decrease in metastasis-enhancing genes (bcl2, mmp-2, and mmp-9) were observed. |
2023-05-08 |
2023-08-14 |
Not clear |
| Juan Gao, Jifei Liu, Yonghong Li, Junxi Liu, He Wang, Miao Chai, Ying Dong, Zhenchang Zhang, Gang Su, Manxia Wan. Targeting p53 for neuroinflammation: New therapeutic strategies in ischemic stroke. Journal of neuroscience research. 2023-05-08. PMID:37156641. |
the tumor suppressor protein p53 has long been regarded as a key substance in the regulation of the cell cycle and apoptosis in the past. |
2023-05-08 |
2023-08-14 |
Not clear |
| Na-Rae Joo, Sang-Ah Park, Jung-Hwan Park, Sang-Muk O. TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53. Biochemical and biophysical research communications. vol 664. 2023-05-06. PMID:37148702. |
in addition, sirt1 inhibition augmented acetylation of p53 or expression of puma and noxa in response to tnf-α, leading to cov434 cell apoptosis. |
2023-05-06 |
2023-08-14 |
human |
| Bianca M Lupan, Rachel A Solecki, Camila Manso Musso, Fernando C Alsina, Debra L Silve. The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis. Development (Cambridge, England). 2023-05-04. PMID:37139782. |
using eif4a3;p53 compound mice, we show that apoptosis is most impactful for early neurogenesis, while additional p53-independent mechanisms contribute to later stages. |
2023-05-04 |
2023-08-14 |
mouse |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Vanessa Queirós, Ulisses M Azeiteiro, Marta Casado Belloso, Juan Luis Santos, Esteban Alonso, Amadeu M V M Soares, Rosa Freitas, Benjamin Piña, Carlos Barat. Effects of ifosfamide and cisplatin exposure combined with a climate change scenario on the transcriptome responses of the mussel Mytilus galloprovincialis. The Science of the total environment. 2023-05-04. PMID:37142022. |
both drugs upregulated genes related to dna damage and apoptosis (p53, caspase 8 and gadd45), especially at warmer conditions. |
2023-05-04 |
2023-08-14 |
Not clear |
| Ignacio Rodriguez-Pastrana, Eleni Birli, Amanda S Coutt. p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY. Cell death and differentiation. 2023-05-04. PMID:37142657. |
the tumour suppressor p53 is a nuclear transcription factor with key roles during dna damage to enable a variety of cellular responses including cell cycle arrest, apoptosis and dna repair. |
2023-05-04 |
2023-08-14 |
human |
| Huiling Hu, Xinhua Liu, Danyao Nie, Min Fang, Jing Zhang, Guoming Zhan. Insights into CD154-mediated pathways in ocular hypertensive glaucoma: The role of Müller cells and P2X7 in retinal neuroprotection and therapeutic potential. Cell biology international. 2023-05-03. PMID:37132435. |
p21, p53, and p2x7 expression were examined, and cellular senescence and apoptosis were detected by β-gal and tunel staining, retinal pathology was examined by h&e staining, and cd154 and β-gal expression were detected by elisa. |
2023-05-03 |
2023-08-14 |
mouse |
| Domnica Carpov, Rareş Buigă, Viorica Magdalena Nag. DNA damage response and potential biomarkers of radiosensitivity in head and neck cancers: clinical implications. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128786. |
the purpose of this review was to elucidate the mechanisms involved in avoiding radiation-induced apoptosis of head and neck cancers mediated by modulating the repair of dna damage via p53, epidermal growth factor receptor (egfr) and p16. |
2023-05-02 |
2023-08-14 |
Not clear |
| Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I Katz, Gwen A Lomberk, Raul A Urrutia, Jonathan P Kat. KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress. Cell death & disease. vol 14. issue 5. 2023-05-02. PMID:37130837. |
in response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. |
2023-05-02 |
2023-08-14 |
human |
| Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I Katz, Gwen A Lomberk, Raul A Urrutia, Jonathan P Kat. KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress. Cell death & disease. vol 14. issue 5. 2023-05-02. PMID:37130837. |
thus, in human squamous epithelial cells, klf5 gates the response to uv or oxidative stress to determine the p53 output of growth arrest or apoptosis. |
2023-05-02 |
2023-08-14 |
human |
| Zheng Zheng, Xiang Wang, Donglei Che. Proteasome inhibitor MG132 enhances the sensitivity of human OSCC cells to cisplatin via a ROS/DNA damage/p53 axis. Experimental and therapeutic medicine. vol 25. issue 5. 2023-05-01. PMID:37123203. |
finally, in cells co-treated with mg132 and cddp, the expression of p53 was markedly elevated and the p53-mediated apoptotic pathway was further activated compared with cells treated with mg132 or cddp alone, as shown by the enhanced cell apoptosis, bax upregulation, and bcl-2 downregulation. |
2023-05-01 |
2023-08-14 |
human |
| Xiangrong Chen, Mohamed F Abdallah, Charlotte Grootaert, Filip Van Nieuwerburgh, Andreja Rajkovi. New insights into the combined toxicity of aflatoxin B1 and fumonisin B1 in HepG2 cells using Seahorse respirometry analysis and RNA transcriptome sequencing. Environment international. vol 175. 2023-05-01. PMID:37126917. |
rna transcriptome sequencing showed that the p53 signaling pathway, a major orchestrator of mitochondrial apoptosis, was differentially expressed. |
2023-05-01 |
2023-08-14 |
Not clear |
| Patrycja Szczepańska, Magdalena Rychlicka, Sylwia Groborz, Angelika Kruszyńska, Rodrigo Ledesma-Amaro, Andrzej Rapak, Anna Gliszczyńska, Zbigniew Laza. Studies on the Anticancer and Antioxidant Activities of Resveratrol and Long-Chain Fatty Acid Esters. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108328. |
the above-mentioned resveratrol derivatives similarly increased the tumor cells' apoptosis by modifying their caspase activity of pro-apoptotic pathways (p21, p53, and bax). |
2023-04-28 |
2023-08-14 |
human |
| Barbara Łasut-Szyszka, Marek Rusi. The Wheel of p53 Helps to Drive the Immune System. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108808. |
the p53 tumor suppressor protein is best known as an inhibitor of the cell cycle and an inducer of apoptosis. |
2023-04-28 |
2023-08-14 |
Not clear |
| Yi Liu, Li-Jian Chen, Xiu-Wen Li, Jian-Zheng Yang, Jia-Li Liu, Kai-Kai Zhang, Jia-Hao Li, Qi Wang, Jing-Tao Xu, Xu Zh. Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model. Chemico-biological interactions. 2023-04-28. PMID:37116852. |
our results showed that meth exposure altered the p53 and pi3k/akt signaling pathways and modulated the apoptosis pathway in heart tissue, accompanied by elevated levels of bax/bcl-2 expression and cleaved caspase-3 proteins. |
2023-04-28 |
2023-08-14 |
mouse |
| Meixian Wang, Jiahao Wang, Ayinuer Yasen, Bingyan Fan, J Joe Hull, Xingjia She. Determination of Key Components in the Insects. vol 14. issue 4. 2023-04-27. PMID:37103177. |
a homolog of p53, a key apoptosis regulator in vertebrates, has been identified and cloned from |
2023-04-27 |
2023-08-14 |
Not clear |
| Jiaxin Zhu, Kexin Zhang, Ya Zhou, Ruyi Wang, Liangping Gong, Can Wang, Keke Zhong, Wenyuan Liu, Feng Feng, Wei Q. A Carrier-Free Nanomedicine Enables Apoptosis-Ferroptosis Synergistic Breast Cancer Therapy by Targeting Subcellular Organelles. ACS applied materials & interfaces. 2023-04-27. PMID:37104698. |
especially, aa and p induced mitochondrial apoptosis of cancer cells, while sa and p inhibited tnbc by ferroptosis and upregulating p53. |
2023-04-27 |
2023-08-14 |
Not clear |
| Lin Yang, Qiuling Zhao, Ting Chen, Wenbin Liu, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Don. An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma. Clinical and experimental medicine. 2023-04-27. PMID:37106265. |
hpk1 inhibitor treatment increased pd-1, pd-l1, bax, p53 and nk-kb expression but decreased nlrp3 expression, indicating that the hpk1 inhibitor promoted apoptosis and blocked the nlrp3 inflammasome pathway to affect anti-pd-1-mediated t-cell cytotoxicity. |
2023-04-27 |
2023-08-14 |
zebrafish |
| Safieh Ebrahimi, Farshad Mirzavi, Seyed Isaac Hashemy, Maryam Khaleghi Ghadiri, Walter Stummer, Ali Gorj. The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma. BioFactors (Oxford, England). 2023-04-24. PMID:37092793. |
moreover, aprepitant and 5-ala induced apoptosis and altered the levels of apoptotic genes (up-regulation of bax and p53 along with downregulation of bcl-2). |
2023-04-24 |
2023-08-14 |
human |