| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hudie Wei, Haolan Wang, Genxin Wang, Lingzhi Qu, Longying Jiang, Shuyan Dai, Xiaojuan Chen, Ye Zhang, Zhuchu Chen, Youjun Li, Ming Guo, Yongheng Che. Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nature communications. vol 14. issue 1. 2023-07-18. PMID:37463921. |
overall, our study provides a structural basis for the interaction between p53 and bcl-2, and suggests a molecular mechanism by which p53 regulates transcription-independent apoptosis by antagonizing the interaction of bcl-2 with pro-apoptotic bcl-2 family members. |
2023-07-18 |
2023-08-14 |
Not clear |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
further, acridine orange staining exhibited more apoptosis in treated groups with increased p53, caspase-3, caspase-9 and decreased bcl-2 gene expression. |
2023-07-16 |
2023-08-14 |
human |
| Hyun-Min Kim, Xiaoyu Zheng, Ethan Le. Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446210. |
while p53 has been extensively studied in cancer research, specifically in relation to fundamental cellular processes, including gene transcription, apoptosis, and cell cycle progression, its association with histone modifiers has received limited attention. |
2023-07-14 |
2023-08-14 |
Not clear |
| Noha A T Abbas, Shaimaa S El-Sayed, Samaa Salah Abd El-Fatah, Walaa M Sarhan, Eman M A Abdelghany, Omnia Sarhan, Shireen S Mahmou. Mechanistic aspects of ameliorative effects of Eicosapentanoic acid ethyl ester on methotrexate-evoked testiculopathy in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-14. PMID:37450014. |
methotrexate-induced testicular apoptosis (caspase-3 and p53) was suppressed upon epa-e treatment. |
2023-07-14 |
2023-08-14 |
rat |
| Muhammad Ajmal Shah, Syed Muhammad Abuzar, Kainat Ilyas, Irtaza Qadees, Momna Bilal, Rimsha Yousaf, Roaa Muhammad Tahir Kassim, Azhar Rasul, Uzma Saleem, Maria Silvana Alves, Haroon Khan, Renald Blundel, Philippe Jeande. Ginsenosides in cancer: Targeting cell cycle arrest and apoptosis. Chemico-biological interactions. 2023-07-14. PMID:37451663. |
can prevent and treat cancer by targeting different pathways and molecules by induction of autophagy, neutralizing ros, induction of cancerous cell death by controlling the p53 pathway, modulation of mirnas by decreasing smad2 expression, regulating bcl-2 expression by normalizing the nf-kb pathway, inhibition of inflammatory pathways by decreasing the production of cytokines like il-8, causing cell cycle arrest by restricting cyclin e1 and cdc2, and induction of apoptosis during malignancy by decreasing β-catenin levels etc. |
2023-07-14 |
2023-08-14 |
Not clear |
| Zhenhao Chen, Jian Song, Lin Xie, Guangyu Xu, Chaojun Zheng, Xinlei Xia, Feizhou Lu, Xiaosheng Ma, Fei Zou, Jianyuan Jiang, Hongli Wan. N6-methyladenosine hypomethylation of circGPATCH2L regulates DNA damage and apoptosis through TRIM28 in intervertebral disc degeneration. Cell death and differentiation. 2023-07-12. PMID:37438603. |
mechanistically, as a protein decoy for tripartite motif containing 28 (trim28) within aa 402-452 region, circgpatch2l abrogates the phosphorylation of trim28 and inhibits p53 degradation, which contributes to dna damage accumulation and cellular apoptosis and leads to ivdd progression. |
2023-07-12 |
2023-08-14 |
Not clear |
| Majid Ghorbani, Mohammad Soukhtanloo, Amir Salek Farrokhi, Seyed Mahdi Hassanian, Fatemeh Ghorbani, Amir Reza Afshari, Mohsen Taherian, Mohammad Hadi Sadeghia. Auraptene-induced cytotoxic effects in acute myeloid leukemia cell lines. Medical oncology (Northwood, London, England). vol 40. issue 8. 2023-07-11. PMID:37432498. |
auraptene induces cell cycle arrest the early and late phases of apoptosis by upregulation of bax and p53 proteins. |
2023-07-11 |
2023-08-14 |
Not clear |
| Li Li, Yan Liu, Yawei Zheng, Jian Zhu, Dan Wu, Xiaohui Yan, Changyin Li, Minghua Wu, Wenlei L. Exploring the mechanisms under Zuogui Pill's treatment of ischemic stroke through network pharmacology and Frontiers in pharmacology. vol 14. 2023-07-10. PMID:37426810. |
based on pathway enrichment studies, zuogui pill may exert neuroprotection through mapk signaling, pi3k-akt signaling and apoptosis, as well as enhance neurite outgrowth and axonal regeneration effect via mtor signaling, p53 signaling and wnt signaling pathways. |
2023-07-10 |
2023-08-14 |
Not clear |
| Papia Basuthakur, Arpita Roy, Chitta Ranjan Patra, Sumana Chakravart. Therapeutic potentials of terbium hydroxide nanorods for amelioration of hypoxia-reperfusion injury in cardiomyocytes. Biomaterials advances. vol 153. 2023-07-10. PMID:37429046. |
concurrently, thnr also exhibit apoptosis inhibitory effects mainly by suppression of pro-apoptotic proteins like cytochrome c, caspase 3, bax and p53 with simultaneous restoration of anti-apoptotic protein, bcl-2 and survivin. |
2023-07-10 |
2023-08-14 |
rat |
| Romina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Ali Salaritabar, Mohammad Amin Javid. P53 status, and G2/M cell cycle arrest, are determining factors in cell-death induction mediated by ELF-EMF in glioblastoma. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407632. |
the size of u87 cells increased significantly after elf-emf exposure (overexpressing p53 in u251 cells increased the apoptosis induction by elf-emf). |
2023-07-05 |
2023-08-14 |
Not clear |
| Romina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Ali Salaritabar, Mohammad Amin Javid. P53 status, and G2/M cell cycle arrest, are determining factors in cell-death induction mediated by ELF-EMF in glioblastoma. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407632. |
increasing expression of p53, p21 and decreasing ccnb1, induction of cell g2/m cycle arrest, and consequently increase in the cell size can be suggested as one of the main mechanisms of apoptosis induction by elf-emf; furthermore, our results demonstrate the possible footprint of p53 in the apoptosis induction by elf-emf, as u87 carry the wild type of p53 and u251 has the mutated form of this gene. |
2023-07-05 |
2023-08-14 |
Not clear |
| Nicole Heinzl, Elisabeth Maritschnegg, Katarzyna Koziel, Christine Schilhart-Wallisch, Georg Heinze, Wei-Lei Yang, Robert C Bast, Jalid Sehouli, Elena I Braicu, Ignace Vergote, Toon Van Gorp, Sven Mahner, Valentina Paspalj, Christoph Grimm, Eva Obermayr, Eva Schuster, Barbara Holzer, Frederic Rousseau, Joost Schymkowitz, Nicole Concin, Robert Zeillinge. Amyloid-like p53 as prognostic biomarker in serous ovarian cancer-a study of the OVCAD consortium. Oncogene. 2023-07-04. PMID:37402882. |
interestingly, p53 aggregation was significantly associated with elevated levels of p53 autoantibodies and increased apoptosis, suggesting that high levels of p53 aggregates may trigger an immune response and/or exert a cytotoxic effect. |
2023-07-04 |
2023-08-14 |
Not clear |
| Yongting Zhang, Liang Hong, Xuehui Li, Yuyu Li, Xujun Zhang, Jingjing Jiang, Fan Shi, Hongyan Dia. M1 macrophage-derived exosomes promote autoimmune liver injury by transferring long noncoding RNA H19 to hepatocytes. MedComm. vol 4. issue 4. 2023-07-03. PMID:37398637. |
mechanistically, h19 upregulated the transcription of hypoxia-inducible factor-1 alpha (hif-1α), which accumulated in the cytoplasm and mediated hepatocyte apoptosis by upregulating p53. |
2023-07-03 |
2023-08-14 |
Not clear |
| Jing Zhou, Huiying Bian, Nan W. Protein inhibitor of activated STAT3 (PIAS3) attenuates psoriasis and associated inflammation. The Journal of dermatology. 2023-07-01. PMID:37392066. |
simultaneously, the mrna and protein expression levels of tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6), interleukin-8 (il-8), and keratin 17 (k17) were significantly decreased and that of p53 was increased, thereby inhibiting the inflammatory response and promoting apoptosis. |
2023-07-01 |
2023-08-14 |
mouse |
| Raúl Barzalobre-Geronimo, Alejandra Contreras-Ramos, Aaron I Cervantes-Cruz, Miguel Cruz, Fernando Suárez-Sánchez, Jaime Goméz-Zamudio, Guadalupe Diaz-Rosas, Alejandro Ávalos-Rodríguez, Margarita Díaz-Flores, Clara Ortega-Camarill. Pancreatic β-Cell Apoptosis in Normoglycemic Rats is Due to Mitochondrial Translocation of p53-Induced by the Consumption of Sugar-Sweetened Beverages. Cell biochemistry and biophysics. 2023-07-01. PMID:37392315. |
carbohydrate consumption promotes apoptosis and mobilization of p53 from the cytosol to rat pancreatic β-cell mitochondria before blood glucose rises. |
2023-07-01 |
2023-08-14 |
rat |
| Raúl Barzalobre-Geronimo, Alejandra Contreras-Ramos, Aaron I Cervantes-Cruz, Miguel Cruz, Fernando Suárez-Sánchez, Jaime Goméz-Zamudio, Guadalupe Diaz-Rosas, Alejandro Ávalos-Rodríguez, Margarita Díaz-Flores, Clara Ortega-Camarill. Pancreatic β-Cell Apoptosis in Normoglycemic Rats is Due to Mitochondrial Translocation of p53-Induced by the Consumption of Sugar-Sweetened Beverages. Cell biochemistry and biophysics. 2023-07-01. PMID:37392315. |
carbohydrate consumption increases p53 and its mobilization into β-cell mitochondria and coincides with the increased rate of apoptosis, which occurs before serum glucose levels rise. |
2023-07-01 |
2023-08-14 |
rat |
| Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huan. Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392658. |
western blot analysis of ss showed that it reduces inflammatory factors (tweak, inos, and cox-2), mapk (jnk, p-erk, and p-38), fibrosis-related molecules (tgf-β, smad3, fibronectin, collagen, α-sma, mmp2, and mmp9), apoptosis (p53, p21, and bax), and autophagy (beclin-1, lc3a/b-i/ii, and p62), and notably increases caspase 3, bcl-2, and antioxidant (catalase, gpx3, and sod-1) levels. |
2023-07-01 |
2023-08-14 |
mouse |
| Min Guo, Danyang Chen, Mingqi Zhao, Tiantian Xu, Yingying Zhang, Misi Xiao, Yinghua Li, Bing Zh. 5-Nitrobenzo[c][1, 2, 5]selenadiazole as therapeutic agents in the regulation of oxidative stress and inflammation induced by influenza A(H1N1)pdm09 in vitro and in vivo. Journal of medical virology. vol 95. issue 7. 2023-06-30. PMID:37386905. |
immunohistochemical assays were performed to further explore the mechanism that sed-3 inhibited h1n1-induced apoptosis via reactive oxygen species-mediated mapk, akt, and p53 signaling pathways. |
2023-06-30 |
2023-08-14 |
Not clear |
| Britta Majchrzak-Stiller, Marie Buchholz, Ilka Peters, Daniel Waschestjuk, Johanna Strotmann, Philipp Höhn, Stephan Hahn, Chris Braumann, Waldemar Uhl, Thomas Müller, Hanns Möhle. GP-2250, a novel anticancer agent, inhibits the energy metabolism, activates AMP-Kinase and impairs the NF-kB pathway in pancreatic cancer cells. Journal of cellular and molecular medicine. 2023-06-30. PMID:37390227. |
the upregulation of p53 concomitant with an excess of ros supported apoptosis. |
2023-06-30 |
2023-08-14 |
Not clear |
| Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Gautam Borthakur, Musa Yilmaz, Ghayas C Issa, Samuel I Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J Jabbour, Steven M Kornblau, Nicholas J Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M Kantarjian, Michael Andreeff, Courtney D DiNard. A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis. Blood cancer journal. vol 13. issue 1. 2023-06-29. PMID:37386016. |
in tp53 wild-type acute myeloid leukemia (aml), inhibition of mdm2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. |
2023-06-29 |
2023-08-14 |
Not clear |