| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Akar, Rahime Özlem Öztopuz, Başak Büyük, Mehmet Akif Ovali, Damla Aykora, Ümit Ali Malço. Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage. Molecular neurobiology. 2023-03-18. PMID:36933146. |
in this study, we aimed to investigate the potential therapeutic effects of pic on ob injury following sah at molecular mechanism based on sirt1, inflammatory (tnf-α, il1-β, nf-κb, il-6, tlr4), and apoptosis (p53, bax, bcl-2, caspase-3)-related gene expression markers and histopathology level; 27 male wistar albino rats were used in a pre-chiasmatic subarachnoid hemorrhage model. |
2023-03-18 |
2023-08-14 |
rat |
| Heba K Nabih, Ahmed R Hamed, Shaymaa M M Yahy. Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition. Scientific reports. vol 13. issue 1. 2023-03-17. PMID:36928762. |
this action is initiated through cell cycle arrest at g0/g1 phase via increasing the expression of p53, but independently on apoptosis. |
2023-03-17 |
2023-08-14 |
human |
| Beihui Xu, Qi Li, Jianjun Zhang, Fuxiang Che. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells. Molecular oncology. 2023-03-17. PMID:36931700. |
lim domain-containing protein ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells. |
2023-03-17 |
2023-08-14 |
Not clear |
| Beihui Xu, Qi Li, Jianjun Zhang, Fuxiang Che. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells. Molecular oncology. 2023-03-17. PMID:36931700. |
in conclusion, as a novel p53 negative regulator, ajuba inhibits the apoptosis of crc cells induced by chemotherapeutic drugs and it may be a new therapeutic target for crc treatment. |
2023-03-17 |
2023-08-14 |
Not clear |
| Charlie Marvalim, Arpita Datta, Soo Chin Le. Role of p53 in breast cancer progression: An insight into p53 targeted therapy. Theranostics. vol 13. issue 4. 2023-03-16. PMID:36923534. |
in the presence of genotoxic stress, p53 is activated to facilitate dna repair, cell cycle arrest, and apoptosis. |
2023-03-16 |
2023-08-14 |
Not clear |
| Cuiting Lv, Aihua Lan, Xiao Fan, Caiguo Huang, Gong Yan. Asperolide A induces apoptosis and cell cycle arrest of human hepatoma cells with p53-Y220C mutant through p38 mediating phosphorylation of p53 (S33). Heliyon. vol 9. issue 3. 2023-03-16. PMID:36923828. |
asperolide a induces apoptosis and cell cycle arrest of human hepatoma cells with p53-y220c mutant through p38 mediating phosphorylation of p53 (s33). |
2023-03-16 |
2023-08-14 |
human |
| Cuiting Lv, Aihua Lan, Xiao Fan, Caiguo Huang, Gong Yan. Asperolide A induces apoptosis and cell cycle arrest of human hepatoma cells with p53-Y220C mutant through p38 mediating phosphorylation of p53 (S33). Heliyon. vol 9. issue 3. 2023-03-16. PMID:36923828. |
however, phosphorylation of p53 at s33 by p38 activation could be a principal factor in the aa-induced apoptosis and g2/m cell cycle arrest of huh-7 cells. |
2023-03-16 |
2023-08-14 |
human |
| Enrico Escobar, Fernán Gómez-Valenzuela, Cristian Peñafiel, Eduardo Chimenos-Küstner, Ricardo Pérez-Tomá. Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts. Journal of clinical and experimental dentistry. vol 15. issue 2. 2023-03-13. PMID:36911151. |
bcl-2-associated protein x (bax) and the tumour suppressor protein p53 collectively promote p53-mediated apoptosis. |
2023-03-13 |
2023-08-14 |
Not clear |
| Y G El-Baz, A Moustafa, M A Ali, G E El-Desoky, S M Wabaidur, M M Faisa. An Analysis of the Toxicity, Antioxidant, and Anti-Cancer Activity of Cinnamon Silver Nanoparticles in Comparison with Extracts and Fractions of Cinnamomum Cassia at Normal and Cancer Cell Levels. Nanomaterials (Basel, Switzerland). vol 13. issue 5. 2023-03-11. PMID:36903823. |
the anti-cancer activity depended on apoptosis marker protein levels (caspase3, p53, bax, and pcl2) in normal and cancerous cells. |
2023-03-11 |
2023-08-14 |
cat |
| Siyang Liu, Tianyao Liu, Jiaxuan Jiang, Hongqian Guo, Rong Yan. p53 mutation and deletion contribute to tumor immune evasion. Frontiers in genetics. vol 14. 2023-03-09. PMID:36891151. |
upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. |
2023-03-09 |
2023-08-14 |
human |
| Kun Jia, Haibin Xiong, Wei Yuan, Lirong Huang, Jiaxin Xu, Chen Lu, Ying Hu, Kaijie Huang, Qiang Luo, Jinze Ma, Huiqiang L. Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway. Fish & shellfish immunology. 2023-03-09. PMID:36893927. |
using small-molecule antagonists and p53 morpholino revealed that the nf-κb/p53 pathway was responsible for the apoptosis of hscs upon dfd exposure. |
2023-03-09 |
2023-08-14 |
zebrafish |
| Sulieman Ibraheem Shelash Al-Hawary, Saade Abdalkareem Jasim, Mustafa M Kadhim, Sarah Jaafar Saadoon, Irfan Ahmad, Rosario Mireya Romero Parra, Suzan Hasan Hammoodi, Roua Abulkassim, Noora M Hameed, Waleed K Alkhafaje, Yasser Fakri Mustafa, Mohammad Javed Ansar. Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations. Phytotherapy research : PTR. 2023-03-08. PMID:36883769. |
it can regulate multiple signaling pathways, such as pi3k/akt, wnt/β-catenin, jak/stat, p53, mapks, and nf-ĸb, which are involved in cancer cell proliferation, metastasis, apoptosis, angiogenesis, and autophagy. |
2023-03-08 |
2023-08-14 |
Not clear |
| Tian Jiang, Ye Song Liang, Yue Gu, Fu Cheng Yao, Yi Fan Liu, Kai Xi Zhang, Fei Biao Song, Jun Long Sun, Jian Lu. Different reoxygenation rates induce different metabolic, apoptotic and immune responses in Golden Pompano (Trachinotus blochii) after hypoxic stress. Fish & shellfish immunology. 2023-03-05. PMID:36871632. |
in the aspect of apoptosis, differentially expressed genes (degs) in the rrg were enriched in the p53 signaling pathway, which promoted cell apoptosis, while degs in the grg seem to activate cell apoptosis at early stage of reoxygenation but was restrained latterly. |
2023-03-05 |
2023-08-14 |
Not clear |
| Jia-Luo Cai, Yi-Lin Zhu, Xiao-Ping Li, Xin-Hua Xia, Gui-Ming Deng, Qiao-Zhen Tong, Gang-Qiang Yi, Bo Chen. [Mechanism of Huangjing Qianshi Decoction in treatment of prediabetic mice based on transcriptome sequencing]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 4. 2023-03-05. PMID:36872274. |
therefore, huangjing qianshi decoction can improve the state of prediabetes, and the mechanism may be related to cell cycle and apoptosis, pi3k/akt pathway, p53 pathway, and other biological pathways regulated by il-6, nr3c2, and vegfa. |
2023-03-05 |
2023-08-14 |
mouse |
| Rachel H Mansky, Erin A Greguske, Dahyun Yu, Nicole Zarate, Taylor A Intihar, Wei Tsai, Taylor G Brown, Mackenzie N Thayer, Kompal Kumar, Rocio Gomez-Pasto. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Cell reports. vol 42. issue 3. 2023-03-03. PMID:36867535. |
p53 and hsf1 are two major transcription factors involved in cell proliferation and apoptosis, whose dysregulation contributes to cancer and neurodegeneration. |
2023-03-03 |
2023-08-14 |
mouse |
| Chunyan Hu, Elena Priceputu, Marc Cool, Pavel Chrobak, Nathalie Bouchard, Clara Forestier, Clifford A Lowell, Serge Bénichou, Zaher Hanna, Virginie Royal, Paul Jolicoeu. NEF-INDUCED HIV-ASSOCIATED NEPHROPATHY THROUGH HCK/LYN. The American journal of pathology. 2023-03-03. PMID:36868467. |
studies of gene-deficient tg mice revealed that the presence of b and t cells and that of several genes was dispensable for the development of hivan: those involved in apoptosis (p53, trail, tnf-α, tnf-r2, bax), in immune cell recruitment (mip-1α, mcp-1, ccr-2, ccr-5 and cx3cr-1), in no formation (enos, inos) or in cell signaling (fyn, lck, hck/fgr). |
2023-03-03 |
2023-08-14 |
mouse |
| Fei Xu, Jingtao Zhang, Lingyun Ji, Wenqiang Cui, Jie Cui, Zhao Tang, Ning Sun, Guangming Zhang, Minghao Guo, Baojun Liu, Jingcheng Don. Inhibition of Non-small Cell Lung Cancer by Ferroptosis and Apoptosis Induction through P53 and GSK-3β/Nrf2 Signal Pathways using Qingrehuoxue Formula. Journal of Cancer. vol 14. issue 3. 2023-03-02. PMID:36860928. |
inhibition of non-small cell lung cancer by ferroptosis and apoptosis induction through p53 and gsk-3β/nrf2 signal pathways using qingrehuoxue formula. |
2023-03-02 |
2023-08-14 |
mouse |
| Shuxian Zou, Chongchong Zhang, Huan Xu, Zhihui Liu, Yongliang Hu, Wei Wang, Kun Liu, Qin Wen, Lun Son. ISG20L1 acts as a co-activator of DAPK1 in the activation of p53 dependent cell death pathway. Journal of cell science. 2023-03-01. PMID:36855954. |
under chemotherapeutic agents (such as arsenite, 5-fu, vp-16) exposure, dapk1 functions as novel p53 kinase, which induces phosphorylation of p53 at ser15 and transactivates p53 target, ets-1, to synergistically repress ikkβ dependent mdm2 stability, and ultimately removes the inhibitory effect of mdm2 on gadd45α, resulting in gadd45α accumulation and cell apoptosis. |
2023-03-01 |
2023-08-14 |
Not clear |
| Haolan Wang, Ming Guo, Hudie Wei, Yongheng Che. Targeting p53 pathways: mechanisms, structures, and advances in therapy. Signal transduction and targeted therapy. vol 8. issue 1. 2023-03-01. PMID:36859359. |
the p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability, and is widely regarded as the "guardian of the genome". |
2023-03-01 |
2023-08-14 |
human |
| Li Yang, Jianyong Cheng, Dejun Xu, Zelin Zhang, Rongmao Hua, Huali Chen, Jiaxin Duan, Xiaoya Li, Qingwang L. Melatonin Ameliorates Diquat-Induced Testicular Toxicity via Reducing Oxidative Stress, Inhibiting Apoptosis, and Maintaining the Integrity of Blood-Testis Barrier in Mice. Toxics. vol 11. issue 2. 2023-02-28. PMID:36851035. |
melatonin treatment also attenuated diquat-induced spermatogonia apoptosis in vivo and in vitro by modulating the expression of apoptosis-related proteins, including p53, cleaved-caspase3, and bax/bcl2. |
2023-02-28 |
2023-08-14 |
mouse |