| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Grazia Ambrosini, Christopher A Natale, Elgilda Musi, Tina Garyantes, Gary K Schwart. The GPER Agonist LNS8801 Induces Mitotic Arrest and Apoptosis in Uveal Melanoma Cells. Cancer research communications. vol 3. issue 4. 2023-04-10. PMID:37035582. |
in contrast, the clinical gper agonist, lns8801, upregulated p53 and p21, induced melanocytic differentiation markers, inhibited cell proliferation and cell migration, and induced apoptosis. |
2023-04-10 |
2023-08-14 |
Not clear |
| Sara Tutunchi, Ahmad Bereimipour, Sayyed Mohammad Hossein Ghaderia. Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression. Molecular biotechnology. 2023-04-08. PMID:37031335. |
the apoptosis, cell adhesion molecules, pi3k/akt and p53 signaling pathways were the most abundant functional categories among gene targets. |
2023-04-08 |
2023-08-14 |
Not clear |
| Xue Jiang, Jie Wang, Jin Liu, Haiyan Zhu, Jian Hu, Xingzhen Sun, Wendi Zho. Resveratrol ameliorates penconazole-induced cardiotoxicity by inhibition of oxidative stress and apoptosis in zebrafish larvae. Ecotoxicology and environmental safety. vol 256. 2023-04-05. PMID:37018857. |
in addition, pen elevated oxidative stress via reactive oxygen species (ros) accumulation and triggered cardiomyocytic apoptosis by upregulation of p53, bcl-2, bax and caspase 3. |
2023-04-05 |
2023-08-14 |
zebrafish |
| Chao Hao, Meng Cao, Hanyi Ouyang, Zhuo Chen, Gaoyun Hu, Qianbin L. Recent advances in the development of HIPK2 inhibitors as anti-renal fibrosis agents. Future medicinal chemistry. 2023-04-04. PMID:37013895. |
hipk2 is a serine/threonine kinase, located in the nucleus, that was initially found to be able to phosphorylate p53 at ser46 to promote apoptosis; it has been widely studied. |
2023-04-04 |
2023-08-14 |
Not clear |
| Mohammad Faujul Kabir, Jazmyne L Jackson, Annie D Fuller, Leonny Gathuka, Adam L Karami, Don-Gerard Conde, Alena Klochkova, Anbin Mu, Kathy Q Cai, Andres J Klein-Szanto, Amanda B Muir, Kelly A Whela. Diclofenac exhibits cytotoxic activity associated with metabolic alterations and p53 induction in ESCC cell lines and decreases ESCC tumor burden in vivo. Carcinogenesis. 2023-04-04. PMID:37014121. |
p53 was further identified as mediator of dcf-mediated toxicity in te11 as genetic depletion of p53 partially limited apoptosis in response to dcf. |
2023-04-04 |
2023-08-14 |
human |
| Dakshita Hardatt, Manju Dahiya, Sonal Vyas, Gurvinder Singh, Jyoti Jain, Sumeet Gupta, Meenakshi Dhanawa. Effect of Vitamin D on Retinoblastoma Protein in Prediabetic Individuals. Current diabetes reviews. 2023-04-03. PMID:37005543. |
in diabetic or stress conditions, p53 becomes a transcription factor, resulting in the transactivation of ckis, which leads to cell cycle arrest, cell senescence, or cell apoptosis. |
2023-04-03 |
2023-08-14 |
Not clear |
| Xiaodi Huang, Qi Y. Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility. Frontiers in endocrinology. vol 14. 2023-04-03. PMID:37008951. |
functional analysis of circrna-targeted genes revealed that apoptosis, pi3k-akt, and p53 signaling pathways were enriched in the pem-tfi comparison groups, whereas the functions of target genes involved in the jak-stat and tgf-β signaling pathways were enriched in the pem-oem comparison groups. |
2023-04-03 |
2023-08-14 |
Not clear |
| Chang Yang, Zhi-Qiang Wang, Zhao-Cong Zhang, Ge Lou, Wei-Lin Ji. CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 161. 2023-04-01. PMID:37002567. |
curaxin cbl0137 was designed to regulate p53 and nuclear factor-κb simultaneously and exhibits antitumor activity by inhibiting tumor cell proliferation and inducing apoptosis in multiple cancers. |
2023-04-01 |
2023-08-14 |
Not clear |
| Zhe Hao, Qian Yuan, Hui Tang, Chuntao Lei, Yu Chen, Hua Su, Chun Zhan. The MAD2B-APC/C-MDM2 axis mediates acute kidney injury by modulating p53. The FEBS journal. 2023-04-01. PMID:37002708. |
mad2b conditional knockout augmented the upregulation of p53 in kidneys suffering from cisplatin-induced aki, therefore promoting the deterioration of renal function, g1 phase arrest and apoptosis of proximal tubular epithelial cells. |
2023-04-01 |
2023-08-14 |
Not clear |
| Zhe Hao, Qian Yuan, Hui Tang, Chuntao Lei, Yu Chen, Hua Su, Chun Zhan. The MAD2B-APC/C-MDM2 axis mediates acute kidney injury by modulating p53. The FEBS journal. 2023-04-01. PMID:37002708. |
the apc/c antagonist protame ameliorated cisplatin-induced aki and blocked mad2b knockdown-induced p53 upregulation and reduced cell cycle arrest and apoptosis in tubular epithelial cells by upregulating mdm2. |
2023-04-01 |
2023-08-14 |
Not clear |
| Gabriele Baniulyte, Serene A Durham, Lauren E Merchant, Morgan A Sammon. Shared gene regulatory strategies for the p53 and ATF4-dependent transcriptional networks. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993734. |
the master tumor suppressor p53 regulates multiple cell fate decisions, such as cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. |
2023-03-30 |
2023-08-14 |
Not clear |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Sing. Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia. Behavioural brain research. 2023-03-30. PMID:36997095. |
s1pl inhibition decreased the levels of p53 and promoted tigar, thereby increasing anti-inflammatory microglial phenotype and inhibiting apoptosis in the brain of diabetic mice. |
2023-03-30 |
2023-08-14 |
mouse |
| Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Christophe Hermans, Céline Merlin, Ho Wa Lau, Elly Marcq, Marlies Verschuuren, Winnok H De Vos, Filip Lardon, Evelien L J Smits, Christophe Debe. Auranofin Synergizes with the PARP Inhibitor Olaparib to Induce ROS-Mediated Cell Death in Mutant p53 Cancers. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978917. |
the aurola combination also led to the highest accumulation of ros, which resulted in ros-dependent cytotoxicity of mutant p53 nsclc cells through distinct types of cell death, including caspase-3/7-dependent apoptosis, inhibited by z-vad-fmk, and lipid peroxidation-dependent ferroptosis, inhibited by ferrostatin-1 and alpha-tocopherol. |
2023-03-29 |
2023-08-14 |
mouse |
| Gabriella D'Oraz. p53 Function and Dysfunction in Human Health and Diseases. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979441. |
the p53 protein is a sequence-specific dna-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but not limited to, cell cycle arrest, cell apoptosis, cell growth, dna repair, cell metabolism, and the immune response [...]. |
2023-03-29 |
2023-08-14 |
human |
| Fares Al-Mansour, Abdullah Alraddadi, Buwei He, Anes Saleh, Marta Poblocka, Wael Alzahrani, Shaun Cowley, Salvador Maci. Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic. Aging. vol 15. 2023-03-29. PMID:36988504. |
here, we show that cudc-907 was indeed able to selectively induce apoptosis in cells driven to senesce by p53 expression, but not when senescence happened in the absence of p53. |
2023-03-29 |
2023-08-14 |
Not clear |
| Faliang Xing, Yi Qin, Jin Xu, Wei Wang, Bo Zhan. Stress granules dynamics and promising functions in pancreatic cancer. Biochimica et biophysica acta. Reviews on cancer. 2023-03-29. PMID:36990249. |
in this review, we talk about the dynamics of sgs and their positive effects on pancreatic cancer such as sgs promote pdac viability and repress apoptosis, meanwhile emphasizing the connection between sgs in pancreatic cancer and signature mutations such kras, p53, and smad4 as well as the functions of sgs in antitumor drug resistance. |
2023-03-29 |
2023-08-14 |
Not clear |
| Xu-Dong Jiang, Yu Liu, Jian-Fei Wu, San-Ni Gong, Yao Ma, Xiang-Dong Z. Regulation of proliferation, apoptosis, hormone secretion and gene expression by acetyl-L-carnitine in yak (Bos grunniens) granulosa cells. Theriogenology. vol 203. 2023-03-27. PMID:36972666. |
rt‒qpcr results verified that gcs treated with 1 mm alc for 48 h significantly increased the expression of genes related to anti-apoptosis and the cell cycle (bcl-2, pcna, ccnd1 and ccnb1), antioxidants (cat, sod2 and gpx1), and e2 and p4 secretion (star, cyp19a1 and hsd3b1) (p < 0.05), but it significantly decreased the expression of apoptosis genes (bax and p53) (p < 0.05). |
2023-03-27 |
2023-08-14 |
cat |
| Yudong Jia, Fenglin Wang, Yuntao Gao, Hongyu Qin, Changtao Gua. Hypoxia stress induces hepatic antioxidant activity and apoptosis, but stimulates immune response and immune-related gene expression in black rockfish Sebastes schlegelii. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-03-25. PMID:36965427. |
in this study, hepatic anti-oxidant enzymes (superoxide dismutase [sod], catalase [cat], glutathione peroxidase [gsh-px]), aminotransferase (ast) and alanine aminotransferase (alt) activities, lipid peroxidation (lpo), malondialdehyde (mda) and glutathione (gsh) content, immunological parameters and the expression of apoptosis (bax, bcl2, p53, caspase3, xiap) and immune-related genes (c3, il-1β, ccl25, saa, hap, isg15) of black rockfish were determined during hypoxia and reoxygenation to illustrate the underlying defense response mechanisms. |
2023-03-25 |
2023-08-14 |
human |
| Zinaida Vasilyvna Chumak, Volodymyr Victorovich Artyomenko, Mykola Vitaliiovich Shapoval, Liudmyla Volodymyrivna Mnih, Ganna Volodymyrivna Kozhukhar, Serhii Vasilyovich Derisho. Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women. Journal of medicine and life. vol 16. issue 2. 2023-03-20. PMID:36937462. |
this study aimed to investigate the potential role of hypoxia (as indicated by hif-1α) and apoptosis markers (p53 and bcl-2) in the development of hyperplastic processes of the endometrium (hpe). |
2023-03-20 |
2023-08-14 |
Not clear |
| b' Jakub V\\xc3\\xa1vra, Artur Sergunin, Petr Pompach, Dariya Savchenko, Jakub Hran\\xc3\\xad\\xc4\\x8dek, Ivana \\xc5\\xa0loufov\\xc3\\xa1, Toru Shimizu, Mark\\xc3\\xa9ta Mart\\xc3\\xadnkov\\xc3\\xa. Characterization of the interaction between the tumour suppressor p53 and heme and its role in the protein conformational dynamics studied by various spectroscopic techniques and hydrogen/deuterium exchange coupled with mass spectrometry. Journal of inorganic biochemistry. vol 243. 2023-03-19. PMID:36934467.' |
the tumour suppressor p53 regulates the expression of a myriad of proteins that are important for numerous cellular processes, including apoptosis, cell cycle arrest, dna repair, metabolism, and even autophagy and ferroptosis. |
2023-03-19 |
2023-08-14 |
Not clear |