| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyung-A Byun, Hyun Jun Park, Seyeon Oh, Sosorburam Batsukh, Hye Jin Sun, Taehui Kim, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byu. High-Intensity Focused Ultrasound Decreases Subcutaneous Fat Tissue Thickness by Increasing Apoptosis and Autophagy. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830763. |
heat can induce adipocyte apoptosis and autophagy, and it is known that nuclear or mitochondrial p53 is involved in apoptosis and autophagy. |
2023-02-25 |
2023-08-14 |
Not clear |
| Kyung-A Byun, Hyun Jun Park, Seyeon Oh, Sosorburam Batsukh, Hye Jin Sun, Taehui Kim, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byu. High-Intensity Focused Ultrasound Decreases Subcutaneous Fat Tissue Thickness by Increasing Apoptosis and Autophagy. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830763. |
in conclusion, hifu led to nuclear and mitochondrial p53 expression, which led to apoptosis and autophagy, and eventually decreased sat thickness in hfd-fed animals. |
2023-02-25 |
2023-08-14 |
Not clear |
| Robert L Fine, Yuehua Mao, Dario Garcia-Carracedo, Gloria H Su, Wanglong Qiu, Uri Hochfeld, Gwen Nichols, Yong-Liang Li, Richard D Dinnen, Anthony Raffo, Paul W Brandt-Rau. Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines. vol 11. issue 2. 2023-02-25. PMID:36830797. |
gene therapy with p14/tbid induces selective and synergistic apoptosis in mutant ras and mutant p53 cancer cells in vitro and in vivo. |
2023-02-25 |
2023-08-14 |
Not clear |
| Sreerama Shetty, Steven Idel. Caveolin-1-Related Intervention for Fibrotic Lung Diseases. Cells. vol 12. issue 4. 2023-02-25. PMID:36831221. |
we found that increased caveolin-1 and tumor suppressor protein, p53 expression, and apoptosis in aecs occur prior to and then with the proliferation of flfs in fibrotic lungs. |
2023-02-25 |
2023-08-14 |
mouse |
| Sreerama Shetty, Steven Idel. Caveolin-1-Related Intervention for Fibrotic Lung Diseases. Cells. vol 12. issue 4. 2023-02-25. PMID:36831221. |
aecs with elevated p53 typically undergo apoptosis. |
2023-02-25 |
2023-08-14 |
mouse |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Ling Wu, Guodong Xu, Ni Li, Linwen Zhu, Guofeng Sha. Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-23. PMID:36814470. |
curcumin analog, ho-3867, induces both apoptosis and ferroptosis via multiple mechanisms in nsclc cells with wild-type p53. |
2023-02-23 |
2023-08-14 |
Not clear |
| Suguru Saito, Shin-Ichiro Ohno, Yuichirou Harada, Yoshihiko Kanno, Masahiko Kurod. MiR-34a induces myofibroblast differentiation from renal fibroblasts. Clinical and experimental nephrology. 2023-02-22. PMID:36808381. |
mir-34a is a transcriptional target of p53, which regulates the cell cycle and apoptosis. |
2023-02-22 |
2023-08-14 |
Not clear |
| b' Hamit Emre K\\xc4\\xb1z\\xc4\\xb1l, Cihan G\\xc3\\xbcr, Adnan Ayna, Ekrem Darendelio\\xc4\\x9flu, Sefa K\\xc3\\xbc\\xc3\\xa7\\xc3\\xbckler, Sevda Sa\\xc4\\x9. Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF-induced Testicular Toxicity. Chemistry & biodiversity. 2023-02-22. PMID:36808882.' |
naf supplementation caused apoptosis in the testes by upregulating p53, nfkb, caspase-3 , caspase-6, caspase-9, and bax and downregulating bcl-2. |
2023-02-22 |
2023-08-14 |
rat |
| Yin Yang, Chen Mei, Hong Xian, Xue Zhang, Jun Li, Zhi-Xuan Liang, Yan Zhi, Yue Ma, Hong-Jun Wan. Toosendanin-induced apoptosis in canine mammary tumor CMT-U27 cells is mediated through the mitochondrial apoptotic pathway. Veterinary and comparative oncology. 2023-02-22. PMID:36809669. |
tsn induced cell apoptosis by upregulating bax, cleaved caspase-3, cleaved caspase-9, p53, and cytochrome c (cytosolic) protein expression, and downregulating bcl-2 and cytochrome c (mitochondrial) expression. |
2023-02-22 |
2023-08-14 |
human |
| Ferdane Danişman-Kalindemirtaş, Dilşad Özerkan, İshak Afşin Kariper, Huri Bulu. The Novel 5-Fluorouracil Loaded Ruthenium-based Nanocarriers Enhanced Anticancer and Apoptotic Efficiency while Reducing Multidrug Resistance in Colorectal Cancer Cells. Journal of fluorescence. 2023-02-22. PMID:36811696. |
apoptotic cells were detected by hoechst/propidium iodide double staining, and the expression levels of bax/bcl-2 and p53 proteins, in which apoptosis occurred intrinsically, were revealed. |
2023-02-22 |
2023-08-14 |
human |
| Qiangsheng Wang, Qiqin Shi, Yingchao Chen, Gang Wang, Lijing She. Recombinant human p53 adenovirus injection combined with Bortezomib inhibits proliferation and promotes apoptosis in multiple myeloma. Leukemia research. vol 127. 2023-02-21. PMID:36801701. |
recombinant human p53 adenovirus injection combined with bortezomib inhibits proliferation and promotes apoptosis in multiple myeloma. |
2023-02-21 |
2023-08-14 |
human |
| Yuying Cui, Yu Wen, Chao Lv, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wan. [Corrigendum] Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway. Molecular medicine reports. vol 27. issue 3. 2023-02-17. PMID:36799157. |
[corrigendum] decreased rna‑binding protein igf2bp2 downregulates nt5dc2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large b‑cell lymphoma cells by regulating the p53 signaling pathway. |
2023-02-17 |
2023-08-14 |
Not clear |
| Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek A Singh, Rachana Garg, Amit Mandoli, Dinesh Kuma. Discovery of fluorinated 2‑Styryl 4(3H)-quinazolinone as potential therapeutic hit for oral cancer. Bioorganic & medicinal chemistry. vol 81. 2023-02-16. PMID:36796126. |
subsequent rna-seq analysis revealed that the compound induces the activation of molecular pathways involved in apoptosis (such as tnf signalling through nf-κb, p53 pathways) and cell differentiation and suppresses the pathways of cellular growth and development (such as kras signaling) in cal-27 cancer cells. |
2023-02-16 |
2023-08-14 |
Not clear |
| Aidan J Preston, Aaron Rogers, Miranda Sharp, Gareth Mitchell, Cristhian Toruno, Brayden B Barney, Lauren N Donovan, Journey Bly, Ryan Kennington, Emily Payne, Anthony Iovino, Gabriela Furukawa, Rosann Robinson, Bahar Shamloo, Matthew Buccilli, Rachel Anders, Sarah Eckstein, Elizabeth A Fedak, Tanner Wright, Carlo C Maley, Wendy K Kiso, Dennis Schmitt, David Malkin, Joshua D Schiffman, Lisa M Abeggle. Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria. Cell death discovery. vol 9. issue 1. 2023-02-16. PMID:36797268. |
our data show, for the first time, that expression of this truncated elephant p53 retrogene protein induces apoptosis in human cancer cells. |
2023-02-16 |
2023-08-14 |
human |
| Saeb Aliwaini, Said El Kurdi, Walaa Jy Saf. Anti-cancer activity of phytochemicals extracted from Urtica pilulifera on Hela cells. Pakistan journal of pharmaceutical sciences. vol 35. issue 6. 2023-02-15. PMID:36789820. |
fraction 4 treatment induced cell cycle arrest and intrinsic apoptosis in hela cells as evident by the increasing levels of p21, p53, parp cleavage and active caspase 9. |
2023-02-15 |
2023-08-14 |
Not clear |
| Jin-Fang Chen, Shi-Wei Wu, Zi-Man Shi, Bing H. Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action. Chinese medicine. vol 18. issue 1. 2023-02-14. PMID:36782251. |
it could affect crc cell proliferation, apoptosis, cell cycle, migration, invasion, autophagy, epithelial-mesenchymal transition, angiogenesis, and chemoresistance by regulating multiple signaling pathways, such as pi3k/akt, nf-κb, mapk, wnt/β-catenin, epidermal growth factor receptors, p53, tgf-β, mtor, hedgehog, and immunomodulatory signaling pathways. |
2023-02-14 |
2023-08-14 |
Not clear |
| Eun Kyoung Choi, Hae Dong Kim, Eun Jung Park, Seuk Young Song, Tien Thuy Phan, Miyoung Nam, Minjung Kim, Dong-Uk Kim, Kwang-Lae Ho. 8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells. Biomolecules & therapeutics. 2023-02-14. PMID:36782271. |
8-methoxypsoralen induces apoptosis by upregulating p53 and inhibits metastasis by downregulating mmp-2 and mmp-9 in human gastric cancer cells. |
2023-02-14 |
2023-08-14 |
human |
| Eun Kyoung Choi, Hae Dong Kim, Eun Jung Park, Seuk Young Song, Tien Thuy Phan, Miyoung Nam, Minjung Kim, Dong-Uk Kim, Kwang-Lae Ho. 8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells. Biomolecules & therapeutics. 2023-02-14. PMID:36782271. |
8-mop treated snu1 cells showed g1-arrest by upregulating p53 and apoptosis by activating caspase-3 in a dose-dependent manner, which was confirmed by loss-of-function analysis through the knockdown of p53-sirna and inhibition of apoptosis by z-vad-fmk. |
2023-02-14 |
2023-08-14 |
human |
| Akamu J Ewunkem, Maya Deve, Scott H Harrison, Perpetua M Mugand. Diepoxybutane induces the p53-dependent transactivation of the CCL4 gene that mediates apoptosis in exposed human lymphoblasts. Journal of biochemical and molecular toxicology. 2023-02-13. PMID:36775894. |
thus, the objective of this study was to determine whether the ccl4 gene is a transcriptional target of p53 and deduce its role in deb-induced apoptosis in human lymphoblasts. |
2023-02-13 |
2023-08-14 |
human |