| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hs. Amentoflavone induces caspase-dependent/-independent apoptosis and dysregulates cyclin-dependent kinase-mediated cell cycle in colorectal cancer in vitro and in vivo. Environmental toxicology. 2023-02-02. PMID:36727907. |
importantly, the apoptosis induction of amentoflavone is not affected by the activity of p53 in crc. |
2023-02-02 |
2023-08-14 |
Not clear |
| Zi-Jian Xu, Meng Liu, Qin-Jian Niu, Yu-Xuan Huang, Ling Zhao, Xin Gen Lei, Lv-Hui Su. Both selenium deficiency and excess impair male reproductive system via inducing oxidative stress-activated PI3K/AKT-mediated apoptosis and cell proliferation signaling in testis of mice. Free radical biology & medicine. 2023-02-02. PMID:36731804. |
moreover, western blotting analysis revealed that sed and see dysregulated pi3k-akt-mediated apoptosis and cell proliferation signaling, including upregulating (p < 0.05) caspase 3, cleaved-caspase 3, bcl-2 and (or) p53 and downregulating (p < 0.05) pi3k, p-akt, p-mtor, 4e-bp1, p-4e-bp1 and (or) p-p70s6k in the testis of mice compared with sea. |
2023-02-02 |
2023-08-14 |
mouse |
| Jingshan Tong, Xiao Tan, Suisui Hao, Kaylee Ermine, Xinyan Lu, Zhaojin Liu, Anupma Jha, Jian Yu, Lin Zhan. Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction. Oncogene. 2023-01-31. PMID:36721000. |
our recent study revealed that selective cdk4/6 inhibitors sensitize colorectal cancer (crc) cells to therapy-induced apoptosis by inducing death receptor 5 (dr5) via the p53 family member p73. |
2023-01-31 |
2023-08-14 |
Not clear |
| Nangwon Yee, Hyeonjin Kim, Eungyung Kim, Yong Ho Cha, Lei Ma, Na Eun Cho, Dongwook Kim, Chae Yeon Kim, Sung-Hyun Kim, Zaeyoung Ryoo, Junkoo Yi, Myoung Ok Ki. Effects of Sangju Honey on Oral Squamous Carcinoma Cells. Journal of cancer prevention. vol 27. issue 4. 2023-01-30. PMID:36713940. |
moreover, sangju honey stimulated apoptosis by increasing the expression of p21, p53, cleaved caspase 3, and caspase 9. |
2023-01-30 |
2023-08-14 |
human |
| Cai-Wen Fan, Mei-Shan Li, Xi-Xi Song, Li Luo, Jing-Chen Jiang, Jia-Zi Luo, Heng-Shan Wan. Discovery of novel 2-oximino-2-indolylacetamide derivatives as potent anticancer agents capable of inducing cell autophagy and ferroptosis. Bioorganic & medicinal chemistry. vol 80. 2023-01-29. PMID:36709571. |
additionally, 4d significantly induced cell apoptosis, caused mitochondrial dysfunction, promoted bax, cleaved-parp and p53 expression and inhibited bcl-2 expression in 5-8f cells. |
2023-01-29 |
2023-08-14 |
mouse |
| Zhao Zhang, Yuze Yang, Lijiao Yan, Xuerui Wan, Kangyongjie Sun, Huitian Gou, Jucai Ding, Jie Peng, Guo Liu, Chuan Wan. Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study. PloS one. vol 18. issue 1. 2023-01-27. PMID:36706149. |
the kyoto encyclopedia of genes and genomes (kegg) analysis indicated the following pathways were linked to matrine-induced toxicity and apoptosis, including cytokine-cytokine receptor interaction pathway, viral protein interaction with cytokine and cytokine receptor, p53 and ppar pathway. |
2023-01-27 |
2023-08-14 |
cattle |
| Saksham Garg, Japneet Singh, Smita Rastogi Verm. Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics. Journal of molecular modeling. vol 29. issue 2. 2023-01-26. PMID:36700982. |
the mutations in the tp53 gene are the most frequent (50-60% of human cancer) genetic alterations in cancer cells, indicating the critical role of wild-type p53 in the regulation of cell proliferation and apoptosis upon oncogenic stress. |
2023-01-26 |
2023-08-14 |
human |
| Saksham Garg, Japneet Singh, Smita Rastogi Verm. Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics. Journal of molecular modeling. vol 29. issue 2. 2023-01-26. PMID:36700982. |
overall, the results of these mutations are single amino acid substitutions in p53 and the production of dysfunctional p53 protein in large amounts, consequently allowing the escape of apoptosis and rapid progression of tumor growth. |
2023-01-26 |
2023-08-14 |
human |
| C Povýšil, J Hojný, M Kaň. Chondrosarcoma with Target-Like Chondrocytes: Update on Molecular Profiling and Specific Morphological Features. Folia biologica. vol 68. issue 3. 2023-01-23. PMID:36689318. |
immunohistochemical examination showed strong positivity for vimentin, factor xiiia, cyclin d1, osteonectin, b-cell lymphoma 2 apoptosis regulator (bcl-2), p53 and p16. |
2023-01-23 |
2023-08-14 |
Not clear |
| Robert L Fine, Yuehua Mao, Richard Dinnen, Ramon V Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W Brandt-Rau. C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672645. |
we previously demonstrated that a synthetic monomer peptide derived from the c-terminus of p53 (aa 361-382) induced preferential apoptosis in mutant p53 malignant cells, but not normal cells. |
2023-01-21 |
2023-08-14 |
human |
| Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najaf. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. Mini reviews in medicinal chemistry. 2023-01-20. PMID:36658710. |
it seems that apigenin enhances apoptosis by inducing anticancer immunity and tumor suppressor genes, like p53 and pten, and also by inhibiting stat3 and nf-κb signaling pathways. |
2023-01-20 |
2023-08-14 |
Not clear |
| Buket Altinok Gunes, Yalda Hekmatshoar, Tulin Ozkan, Sureyya Bozkurt, O Sena Erdogan Aydos, Yahya Buyukasik, Elifcan Aladag, Asuman Sungurogl. Downregulation of Stearoyl-CoA Desaturase 1 (SCD-1) Promotes Resistance to Imatinib in Chronic Myeloid Leukemia. Mediterranean journal of hematology and infectious diseases. vol 15. issue 1. 2023-01-20. PMID:36660357. |
moreover, we analyzed the mrna expression levels of genes responsible for apoptosis, such as bcl-2, p53, and other genes (scd-1, pten). |
2023-01-20 |
2023-08-14 |
Not clear |
| Ying Yang, Yang Zhang, Jiqin Yang, Manman Zhang, Tao Tian, Yuan Jiang, Xuening Liu, Genlong Xue, Xingda Li, Xiaofang Zhang, Shangxuan Li, Xiang Huang, Zheng Li, Yang Guo, Lexin Zhao, Hairong Bao, Zhiwen Zhou, Jiahui Song, Guohui Yang, Lina Xuan, Hongli Shan, Zhiren Zhang, Yanjie Lu, Baofeng Yang, Zhenwei Pa. Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury. Circulation research. vol 132. issue 2. 2023-01-19. PMID:36656967. |
aspp1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor of p53 to promote its transcriptional activity in the nucleus. |
2023-01-19 |
2023-08-14 |
Not clear |
| Ahmed R Hamed, Shaymaa M M Yahya, Heba K Nabi. Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. Naunyn-Schmiedeberg's archives of pharmacology. 2023-01-18. PMID:36651944. |
additionally, qrt-pcr was used to quantify genes having a role in drug resistance phenotype (abcb1, abcc1, abcc2, abcc3, abcc4, abcc5, and abcg2); apoptosis (caspases-3, and -7, bcl2, bax, and p53); anti-oxidation (nrf2); expression of melatonin receptors (mt1, mt2, and mt3); besides, programmed death receptor pd-1 gene. |
2023-01-18 |
2023-08-14 |
human |
| Jianjian Hu, Wenxue Jiang, Jiaqi Zuo, Dujuan Shi, Xiaoqi Chen, Xiao Yang, Wenhui Zhang, Lixin Ma, Zhu Liu, Qiong Xin. Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination. Communications biology. vol 6. issue 1. 2023-01-17. PMID:36650277. |
tumor suppressor p53 prevents tumorigenesis by promoting cell cycle arrest and apoptosis through transcriptional regulation. |
2023-01-17 |
2023-08-14 |
human |
| Tsukasa Oda, Nanami Gotoh, Tetsuhiro Kasamatsu, Hiroshi Handa, Takayuki Saitoh, Nobuo Sasak. DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation. Cell proliferation. 2023-01-16. PMID:36642815. |
cellular stresses stabilize and activate the p53 signalling pathway, which regulates various cellular processes, such as apoptosis, dna repair, and senescence. |
2023-01-16 |
2023-08-14 |
human |
| Lu Zhao, Jinqiang Huang, Yongjuan Li, Shenji Wu, Yujun Kan. Comprehensive analysis of immune parameters, mRNA and miRNA profiles, and immune genes expression in the gill of rainbow trout infected with infectious hematopoietic necrosis virus (IHNV). Fish & shellfish immunology. 2023-01-16. PMID:36646338. |
the mrna and mirna analysis identified 4343 differentially expressed genes (degs) and 11 differentially expressed mirnas (dems), and numerous immune-related degs involved in the toll-like receptor signaling pathway, apoptosis, dna replication, p53 signaling, rig-i-like receptor signaling pathway, and nod-like receptor signaling pathway and expression were significantly up-regulated in t48gm group, including tlr3, tlr7, tlr8, traf3, ifih1, trim25, dhx58, ddh58, hsp90a.1, nlrc3, nlrc5, socs3, irf3, irf7, casp7, mx1, and vig2. |
2023-01-16 |
2023-08-14 |
cat |
| Jin-Guo Wang, Da-Lei Li, Rong Fan, Meng-Jun Ya. Zerumbone combined with gefitinib alleviates lung cancer cell growth through the AKT/STAT3/SLC7A11 axis. Neoplasma. 2023-01-13. PMID:36637083. |
the expression of bcl-2, bax, and p53 proteins confirmed the cell apoptosis. |
2023-01-13 |
2023-08-14 |
mouse |
| Dong Ma, Pengpeng Liu, Junjun Wen, Yang Gu, Zhangshuo Yang, Jianwei Lan, Haining Fan, Zhisu Liu, Deliang Gu. FCN3 inhibits the progression of hepatocellular carcinoma by suppressing SBDS-mediated blockade of the p53 pathway. International journal of biological sciences. vol 19. issue 2. 2023-01-12. PMID:36632465. |
overexpression of fcn3 induced apoptosis and inhibited cell proliferation via the p53 signaling pathway. |
2023-01-12 |
2023-08-14 |
human |
| Alicia Wong, Samantha Pritchard, Mackenzie Moore, Brian Akhaphong, Nandini Avula, Megan Beetch, Yoshio Fujitani, Emilyn U Alejandr. Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc Transferase deletion. The Journal of biological chemistry. 2023-01-09. PMID:36623733. |
constitutive loss of ogt in β-cells results in increased er stress and apoptosis, and in the ogt-deficient pancreas, transcriptomic data previously revealed tumor suppressor protein p53 and pancreatic and duodenal homeobox 1 (pdx1), key cell survival proteins in the developing pancreas, as upstream regulators of differentially expressed genes. |
2023-01-09 |
2023-08-14 |
mouse |