| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Kyoung Choi, Hae Dong Kim, Eun Jung Park, Seuk Young Song, Tien Thuy Phan, Miyoung Nam, Minjung Kim, Dong-Uk Kim, Kwang-Lae Ho. 8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells. Biomolecules & therapeutics. 2023-02-14. PMID:36782271. |
8-mop treated snu1 cells showed g1-arrest by upregulating p53 and apoptosis by activating caspase-3 in a dose-dependent manner, which was confirmed by loss-of-function analysis through the knockdown of p53-sirna and inhibition of apoptosis by z-vad-fmk. |
2023-02-14 |
2023-08-14 |
human |
| Akamu J Ewunkem, Maya Deve, Scott H Harrison, Perpetua M Mugand. Diepoxybutane induces the p53-dependent transactivation of the CCL4 gene that mediates apoptosis in exposed human lymphoblasts. Journal of biochemical and molecular toxicology. 2023-02-13. PMID:36775894. |
thus, the objective of this study was to determine whether the ccl4 gene is a transcriptional target of p53 and deduce its role in deb-induced apoptosis in human lymphoblasts. |
2023-02-13 |
2023-08-14 |
human |
| Akamu J Ewunkem, Maya Deve, Scott H Harrison, Perpetua M Mugand. Diepoxybutane induces the p53-dependent transactivation of the CCL4 gene that mediates apoptosis in exposed human lymphoblasts. Journal of biochemical and molecular toxicology. 2023-02-13. PMID:36775894. |
collectively, these observations demonstrate for the first time that the ccl4 gene is upregulated by wild-type p53 at the transcriptional level, and this upregulation mediates apoptosis in deb-exposed human lymphoblasts. |
2023-02-13 |
2023-08-14 |
human |
| Hongxiang Yu, Yingying Han, Can Cui, Bei Zhang, Gang L. Loss of SV2A promotes human neural stem cell apoptosis via p53 signaling. Neuroscience letters. 2023-02-13. PMID:36780942. |
loss of sv2a promotes human neural stem cell apoptosis via p53 signaling. |
2023-02-13 |
2023-08-14 |
human |
| Hongxiang Yu, Yingying Han, Can Cui, Bei Zhang, Gang L. Loss of SV2A promotes human neural stem cell apoptosis via p53 signaling. Neuroscience letters. 2023-02-13. PMID:36780942. |
sv2a knockdown promotes apoptosis, which was associated with an upregulation of genes involved in p53 signaling as determined by transcriptome analysis. |
2023-02-13 |
2023-08-14 |
human |
| Hongxiang Yu, Yingying Han, Can Cui, Bei Zhang, Gang L. Loss of SV2A promotes human neural stem cell apoptosis via p53 signaling. Neuroscience letters. 2023-02-13. PMID:36780942. |
treatment with the small molecule p53 inhibitor pifithrin-α reversed the promotion of nsc apoptosis induced by loss of sv2a. |
2023-02-13 |
2023-08-14 |
human |
| Ping Wang, Hang-Yu Wang, Xing-Jie Gao, Hua-Xia Zhu, Xiao-Peng Zhang, Feng Liu, Wei Wan. Encoding and Decoding of p53 Dynamics in Cellular Response to Stresses. Cells. vol 12. issue 3. 2023-02-11. PMID:36766831. |
as a transcription factor, p53 exhibits rich dynamics to allow for discrimination of the type and intensity of stresses and to direct the selective activation of target genes involved in different processes including cell cycle arrest and apoptosis. |
2023-02-11 |
2023-08-14 |
Not clear |
| Farukh Arjmand, Huzaifa Yasir Khan, Sartaj Tabassu. Progress of Metal-Based Anticancer Chemotherapeutic Agents in Last Two Decades and their Comprehensive Biological (DNA/RNA Binding, Cleavage and Cytotoxicity Activity) Studies. Chemical record (New York, N.Y.). 2023-02-10. PMID:36762719. |
incorporated in these ligand framework are biocompatible and induce a unique multi-modal mechanism of cytotoxic action involving angiogenesis, ros-induced dna damage, apoptosis by p53 mitochondrial genes and caspases etc. |
2023-02-10 |
2023-08-14 |
Not clear |
| Adeline Clergé, Jérémie Le Goff, Emilie Brotin, Edwige Abeillard, Isabelle Vaudorne, Christophe Denoyelle, Ludovic Le Hegarat, Raphaël Delépé. In vitro genotoxicity potential investigation of 7 oxy-PAHs. Environmental and molecular mutagenesis. 2023-02-09. PMID:36757094. |
in this paper, a prospective study on seven oxy-pahs selected in terms of occurrence in the environment was conducted on mutagenicity, genotoxicity, and cytotoxicity potentials using in vitro assays including ames test on 5 strains, kinetic analysis of cytotoxicity and apoptosis, phosphorylation of histone h2ax, and p53 induction assays on human lung cell line beas-2b. |
2023-02-09 |
2023-08-14 |
human |
| Runfang Wang, Jing Zhao, Cuilian Liu, Shengxian Li, Weifang Liu, Qinying Ca. Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p. Reproductive biology. vol 23. issue 1. 2023-02-08. PMID:36753931. |
downregulation of aggf1 promoted cell proliferation, invasion and migration, inhibited apoptosis in vitro, decreased p53 and bax expression, and simultaneously increased bcl-2 expression, whereas overexpression of aggf1 had the opposite results. |
2023-02-08 |
2023-08-14 |
Not clear |
| Runfang Wang, Jing Zhao, Cuilian Liu, Shengxian Li, Weifang Liu, Qinying Ca. Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p. Reproductive biology. vol 23. issue 1. 2023-02-08. PMID:36753931. |
particularly, mir-1296-5p fostered htr8/svneo cell proliferation, invasion, repression of apoptosis and regulation of p53 signaling axis by downregulating aggf1 expression. |
2023-02-08 |
2023-08-14 |
Not clear |
| Naoyuki Iwahashi, Midori Ikezaki, Yoshihiro Komohara, Yukio Fujiwara, Tomoko Noguchi, Kaho Nishioka, Kazuko Sakai, Kazuto Nishio, Mitsuharu Ueda, Yoshito Ihara, Kenji Uchimura, Kazuhiko Ino, Kazuchika Nishitsuj. Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis. PNAS nexus. vol 1. issue 3. 2023-02-06. PMID:36741442. |
our previous study showed that cancer cell-derived p53 aggregates that cells internalized interfered with p53-dependent apoptosis in recipient cells. |
2023-02-06 |
2023-08-14 |
Not clear |
| Nilesh Rai, Priyamvada Gupta, Ashish Verma, Santosh Kumar Singh, Vibhav Gauta. Isolation and characterization of N-(2-Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis-inducing potential in breast cancer cells. BioFactors (Oxford, England). 2023-02-06. PMID:36744732. |
further validation was done using in vitro study that showed pea inhibitsthe proliferation, alters nuclear morphology and attenuates the wound closure ability of mda-mb-231 and mcf-7 cells. pea induces apoptosis via upregulating cell-cycle arrest (p21), tumor suppression (p53), pro-apoptotic (bax, caspase-8, and fadd) genes, and downregulating anti-apoptotic gene bcl-2. |
2023-02-06 |
2023-08-14 |
human |
| Mélanie Bodnar-Wachtel, Anne-Laure Huber, Julie Gorry, Sabine Hacot, Delphine Burlet, Laetitia Gérossier, Baptiste Guey, Nadège Goutagny, Birke Bartosch, Elise Ballot, Julie Lecuelle, Caroline Truntzer, François Ghiringhelli, Bénédicte F Py, Yohann Couté, Annabelle Ballesta, Sylvie Lantuejoul, Janet Hall, Agnès Tissier, Virginie Petrill. Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress. Life science alliance. vol 6. issue 4. 2023-02-06. PMID:36746533. |
nlrp3 down-regulation in both broncho- and mammary human epithelial cells significantly impairs atm pathway activation, leading to lower p53 activation, and provides cells with the ability to resist apoptosis induced by acute genotoxic stress. |
2023-02-06 |
2023-08-14 |
human |
| Elliot H Akama-Garren, Paul Miller, Thomas M Carroll, Michael Tellier, Gopinath Sutendra, Ludovico Buti, Justyna Zaborowska, Robert D Goldin, Elizabeth Slee, Francis G Szele, Shona Murphy, Xin L. Regulation of immunological tolerance by the p53-inhibitor iASPP. Cell death & disease. vol 14. issue 2. 2023-02-06. PMID:36746936. |
here we identify inhibitor of apoptosis stimulating p53 protein (iaspp), a negative regulator of p53 transcriptional activity, as a regulator of immunological tolerance. |
2023-02-06 |
2023-08-14 |
mouse |
| Vanessa F Merino, Yu Yan, Alvaro A Ordonez, C Korin Bullen, Albert Lee, Harumi Saeki, Krishanu Ray, Tao Huang, Sanjay K Jain, Martin G Pompe. Nucleolin mediates SARS-CoV-2 replication and viral-induced apoptosis of host cells. Antiviral research. 2023-02-05. PMID:36740097. |
ncl mediates viral-induced apoptosis and stress response via p53. |
2023-02-05 |
2023-08-14 |
Not clear |
| Xingang Xu, Yi Liu, Jie Gao, Xiaojie Shi, Yuchao Yan, Naling Yang, Quanqiong Wang, Qi Zhan. GRAMD4 regulates PEDV-induced cell apoptosis inhibiting virus replication via the endoplasmic reticulum stress pathway. Veterinary microbiology. vol 279. 2023-02-04. PMID:36738512. |
glucosyltransferase rab-like gtpase activator and myotubularin domain containing 4 (gramd4) is a proapoptotic protein, which replaced p53 inducing mitochondrial apoptosis. |
2023-02-04 |
2023-08-14 |
Not clear |
| Xiaoran Guan, Wuquan Li, Yong Wang, Qun Zhao, Xinru Yu, Jing Jiang, Weihua Bian, Cong Xu, Yeying Sun, Chunxiang Zhan. The mechanism of rh-endostatin-induced cardiotoxicity and its protection by dihydromyricetin[in vivo/in vitro, C57BL/6 mice, AC16 and hiPSC-CMs]. Toxicology letters. 2023-02-04. PMID:36739041. |
the results revealed that rh-endostatin dose-dependently enhanced cardiomyocyte apoptosis through apaf-1 apoptotic factor and apoptosis-related proteins such as p53. |
2023-02-04 |
2023-08-14 |
mouse |
| Clare M Adams, Ramkrishna Mitra, Youcai Xiao, Peter Michener, Juan Palazzo, Allen Chao, Jitendra Gour, Joel Cassel, Joseph M Salvino, Christine M Eische. Targeted MDM2 degradation reveals a new vulnerability for p53 inactivated triple negative breast cancer. Cancer discovery. 2023-02-03. PMID:36734633. |
mdm2 loss in p53 mutant/deleted tnbc cells in 2d/3d culture and tnbc patient explants, including relapsed tumors, causes apoptosis, while sparing normal cells. |
2023-02-03 |
2023-08-14 |
mouse |
| Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M Balaramnavar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Gaurav Gupta, Madan Mohan Gupt. Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 42. issue 1. 2023-02-03. PMID:36734954. |
they can synergistically inhibit cancer cell growth through p53 apoptosis in mcf-7 breast cancer cell lines. |
2023-02-03 |
2023-08-14 |
Not clear |