| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Wang, Xiangfeng Yao, Nan Jiang, Juan Zhang, Guanyong Liu, Xianxu Li, Can Wang, Zhongkang Yang, Jinhua Wang, Lusheng Zhu, Jun Wan. Environmentally relevant concentrations of butyl benzyl phthalate triggered oxidative stress and apoptosis in adult zebrafish (Danio rerio) liver: Combined analysis at physiological and molecular levels. The Science of the total environment. 2022-11-12. PMID:36370777. |
moreover, bbp interfered with apoptosis by forming a stable complex with apoptosis proteins (p53 and caspase-3). |
2022-11-12 |
2023-08-14 |
zebrafish |
| Fernando Redondo, Carolina Hurtado-Marcos, Fernando Izquierdo, Carmen Cuéllar, Soledad Fenoy, Yanira Sáez, Ángela Magnet, Lorena Galindo-Regal, Natalia Uribe, Manuel López-Bañeres, Ana Isabel Jiménez, Antonio Llombart-Cussac, Carmen Del Águila, Juan Carlos Andreu-Balleste. Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients. Cancers. vol 14. issue 21. 2022-11-11. PMID:36358760. |
infection by microsporidia inhibits p53 and caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. |
2022-11-11 |
2023-08-14 |
Not clear |
| Hamad Ghaleb Daila. Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364033. |
it has been demonstrated that several therapeutic agents including antioxidants, minocycline, gapdh ligands, p53 inhibitors, jnk (c-jun n-terminal kinase) inhibitors, glycogen synthase kinase-3 inhibitor, non-steroidal anti-inflammatory drugs, d2 dopamine receptor agonists, fk506, cell cycle inhibitors, statins, drugs targeting peroxisome proliferator-activated receptors, and gene therapy have the potential to provide protection to neurons against apoptosis. |
2022-11-11 |
2023-08-14 |
Not clear |
| Maqusood Ahamed, Rashid Lateef, Mohd Javed Akhtar, Pavan Rajanahall. Dietary Antioxidant Curcumin Mitigates CuO Nanoparticle-Induced Cytotoxicity through the Oxidative Stress Pathway in Human Placental Cells. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364205. |
the apoptosis data also exhibited that cuo nps modulate the expression of several genes (p53, bax, bcl-2, casp3, and casp9), the activity of enzymes (caspase-3 and -9), and mitochondrial membrane potential loss, which was successfully reverted by co-treatment with curcumin. |
2022-11-11 |
2023-08-14 |
human |
| Dawei Cui, Zhengzheng Xu, Shengjie Qiu, Yuxin Su. Nasturtium officinale L. and metformin alleviate the estradiol -induced polycystic ovary syndrome with synergistic effects through modulation of Bax/Bcl-2/p53/caspase-3 signaling pathway and anti-inflammatory and anti-oxidative effects. Journal of food biochemistry. 2022-11-09. PMID:36351033. |
finally, by measuring the expression of apoptosis related genes (bax/bcl-2/p53/caspase-3) with the help of real-time pcr and the expression of p53 with the help of immunohistochemistry in ovarian cells. |
2022-11-09 |
2023-08-14 |
rat |
| Seref Gul, Yasemin Kubra Akyel, Zeynep Melis Gul, Safak Isin, Onur Ozcan, Tuba Korkmaz, Saba Selvi, Ibrahim Danis, Ozgecan Savlug Ipek, Fatih Aygenli, Ali Cihan Taskin, Büşra Aytül Akarlar, Nurhan Ozlu, Nuri Ozturk, Narin Ozturk, Durişehvar Özer Ünal, Mustafa Guzel, Metin Turkay, Alper Okyar, Ibrahim Halil Kavakl. Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nature communications. vol 13. issue 1. 2022-11-08. PMID:36347873. |
furthermore, m47-mediated cry1 reduction enhanced oxaliplatin-induced apoptosis in ras-transformed p53 null fibroblast cells. |
2022-11-08 |
2023-08-14 |
mouse |
| Sofía Mucci, Luciana Isaja, María Soledad Rodríguez-Varela, Sofía Luján Ferriol-Laffouillere, Mariela Marazita, Guillermo Agustín Videla-Richardson, Gustavo Emilio Sevlever, María Elida Scassa, Leonardo Romorin. Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism. Scientific reports. vol 12. issue 1. 2022-11-06. PMID:36335243. |
acute severe hypoxia induces apoptosis of human pluripotent stem cells by a hif-1α and p53 independent mechanism. |
2022-11-06 |
2023-08-14 |
human |
| Bratati Mukherjee, Ankit Tiwari, Ananya Palo, Niharika Pattnaik, Subrat Samantara, Manjusha Dixi. Reduced expression of FRG1 facilitates breast cancer progression via GM-CSF/MEK-ERK axis by abating FRG1 mediated transcriptional repression of GM-CSF. Cell death discovery. vol 8. issue 1. 2022-11-04. PMID:36329016. |
loss of frg1 increased gm-csf levels which activated mek/erk axis and prevented apoptosis by inhibiting p53 in an erk-dependent manner. |
2022-11-04 |
2023-08-14 |
mouse |
| Yanxia Xiong, Chengyuan Wang, Mengyi Dong, Meifeng Li, Chengyu Hu, Xiaowen X. Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress. Environmental toxicology. 2022-11-04. PMID:36331003. |
as expected, chlorphoxim exposure induces apoptosis by enhancing the expression of apoptotic genes (bax, bcl2, and p53). |
2022-11-04 |
2023-08-14 |
cat |
| Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita, Naohiko Seki, Bahityar Rahmutulla, Atsushi Kaneda, Siti Nurul Zhahara, Yingbo Gong, Motoi Nishimura, Shoichiro Kawauchi, Eiryo Kawakami, Tomoaki Tanak. MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway. Scientific reports. vol 12. issue 1. 2022-11-03. PMID:36323841. |
however, the relationship between the mevalonate pathway and mir-874-induced apoptosis or its association with the tumour suppressor p53 has not been elucidated. |
2022-11-03 |
2023-08-14 |
Not clear |
| Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita, Naohiko Seki, Bahityar Rahmutulla, Atsushi Kaneda, Siti Nurul Zhahara, Yingbo Gong, Motoi Nishimura, Shoichiro Kawauchi, Eiryo Kawakami, Tomoaki Tanak. MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway. Scientific reports. vol 12. issue 1. 2022-11-03. PMID:36323841. |
mir-874-induced apoptosis was p53 dependent, and single-cell rna sequencing analysis demonstrated that mir-874 transfection resulted in apoptosis and p53 pathway activation. |
2022-11-03 |
2023-08-14 |
Not clear |
| Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita, Naohiko Seki, Bahityar Rahmutulla, Atsushi Kaneda, Siti Nurul Zhahara, Yingbo Gong, Motoi Nishimura, Shoichiro Kawauchi, Eiryo Kawakami, Tomoaki Tanak. MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway. Scientific reports. vol 12. issue 1. 2022-11-03. PMID:36323841. |
these findings suggest that mir-874 suppresses the mevalonate pathway by targeting srebf2 and pmvk, resulting in ggpp depletion, which activates the p53 pathway and promotes cycle arrest or apoptosis. |
2022-11-03 |
2023-08-14 |
Not clear |
| Mingxiu Hao, Kunli Jia. Jatrorrhizine reduces myocardial infarction-induced apoptosis and fibrosis through inhibiting p53 and TGF-β1/Smad2/3 pathways in mice. Acta cirurgica brasileira. vol 37. issue 7. 2022-11-03. PMID:36327404. |
jatrorrhizine reduces myocardial infarction-induced apoptosis and fibrosis through inhibiting p53 and tgf-β1/smad2/3 pathways in mice. |
2022-11-03 |
2023-08-14 |
mouse |
| Xiaoli Wang, Keyu He, Yuanyuan Hu, Meng Tan. A review of pulmonary toxicity of different types of quantum dots in environmental and biological systems. Chemico-biological interactions. 2022-11-03. PMID:36328131. |
it summarizes mitogen-activated protein kinases, nuclear factor κb, nuclear factor-erythroid 2-related factor 2, p53, and phosphoinositide 3-kinase/akt signaling pathways in apoptosis and autophagy. |
2022-11-03 |
2023-08-14 |
Not clear |
| Penglu Wei, Juju Shang, Hongxu Liu, Wenlong Xing, Yupei Ta. Molecular Mechanisms of Notopterygii Rhizoma Et Radix for Treating Arrhythmia Based on Network Pharmacology. Combinatorial chemistry & high throughput screening. 2022-11-02. PMID:36321231. |
there were 5 key targets for nrr in relation to treating arrhythmia, and these targets are involved in the apoptotic process, extrinsic apoptotic signaling pathway in absence of ligand, endopeptidase activity involved in apoptotic process by cytochrome c. the main pathways were p53 signaling pathway, hepatitis b and apoptosis. |
2022-11-02 |
2023-08-14 |
Not clear |
| Bridget K Marcellino, Xiaobao Yang, H Ümit Kaniskan, Claudia Brady, He Chen, Karie Chen, Xing Qiu, Cara Clementelli, Lauren Herschbein, Zhijun Li, Sebastian Elghaity-Beckley, Joann Arandela, Brianna Kelly, Ronald Hoffman, Jing Liu, Yue Xiong, Jian Jin, Alan H Shi. An MDM2 degrader for treatment of acute leukemias. Leukemia. 2022-10-30. PMID:36309559. |
in wt tp53 leukemia cell lines, ms3227 led to activation of p53 targets p21, puma, and mdm2 and resulted in cell-cycle arrest, apoptosis, and decreased viability. |
2022-10-30 |
2023-08-14 |
Not clear |
| Jun Dai, Huan Wang, Ying Liao, Lei Tan, Yingjie Sun, Cuiping Song, Weiwei Liu, Xusheng Qiu, Chan Din. RNA-seq and LC-MS/MS analysis of antiviral effects mediated by cold stress and stress hormone corticosterone in chicken DF-1 cells. Veterinary microbiology. vol 275. 2022-10-29. PMID:36308941. |
down-regulated degs were related to ribosomes, oxidative phosphorylation, apoptosis, and the p53 signaling pathway. |
2022-10-29 |
2023-08-14 |
chicken |
| Keerthana Gnanapradeepan, Alexandra Indeglia, David C Stieg, Nicole Clarke, Chunlei Shao, James F Dougherty, Nivitha Murali, Maureen E Murph. PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis. The Journal of biological chemistry. 2022-10-29. PMID:36309086. |
the tumor suppressor protein p53 suppresses cancer by regulating processes such as apoptosis, cell cycle arrest, senescence, and ferroptosis, which is an iron-mediated and lipid peroxide-induced cell death pathway. |
2022-10-29 |
2023-08-14 |
human |
| Xuehua Shao, Zhuhong Zhang, Xuhong Qian, Lanying Wang, Yunfei Zhang, Yanping Lu. Potential Biochemical Pesticide-Synthesis of Neofuranocoumarin and Inhibition the Proliferation of Toxins. vol 14. issue 10. 2022-10-28. PMID:36287946. |
finally, western blotting analysis detected that the phosphorylation level of akt and bad and the expression of the apoptosis inhibitor protein bcl-xl were inhibited, cleaved-parp and p53 were increased, and cytochrome c was released from the mitochondria into the cytoplasm. |
2022-10-28 |
2023-08-16 |
Not clear |
| Xiaoming Long, Lin Chen, Jin Yang, Taotao Dong, Qisen Cheng, Weiwei Wang, Yujian Zou, Yao Su, Wenbin Dai, Bo Chen, Xin Zho. Network-based pharmacology and in vitro validation reveal that galangin induces apoptosis in bladder cancer cells by promoting the p53 signaling pathway. Anti-cancer agents in medicinal chemistry. 2022-10-28. PMID:36305128. |
network-based pharmacology and in vitro validation reveal that galangin induces apoptosis in bladder cancer cells by promoting the p53 signaling pathway. |
2022-10-28 |
2023-08-14 |
Not clear |