| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingwen Tan, Mingjun Sun, Jinyao Yin, Qian Zhou, Ruihuan Zhao, Qian Chen, Huiwen Sun, Chenglan Jiang, Shuting Li, Yuefeng H. Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65. Chemico-biological interactions. 2022-10-08. PMID:36208777. |
hsa_circ_0005050 interacts with ilf3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65. |
2022-10-08 |
2023-08-14 |
human |
| Rajani Rai, Vishal Chandra, Amy L Kennedy, Rosemary E Zuna, Doris Mangiaracina Benbroo. Distinct mechanism of cervical cancer cell death caused by the investigational new drug SHetA2. Frontiers in oncology. vol 12. 2022-10-07. PMID:36203464. |
the investigational new drug sheta2 targets these vulnerabilities in ovarian and endometrial cancer cells by disrupting complexes of the mortalin hsp with its client proteins (mitochondrial support proteins, metabolic enzymes, p53) leading to mitochondrial leakage of cytochrome c and apoptosis-inducing factor (aif), and caspase-dependent apoptosis. |
2022-10-07 |
2023-08-14 |
Not clear |
| Chengpeng Yu, Dean Rao, Tiantian Wang, Jia Song, Lei Zhang, Wenjie Huan. Emerging roles of TRIM27 in cancer and other human diseases. Frontiers in cell and developmental biology. vol 10. 2022-10-06. PMID:36200036. |
its ubiquitination targets include pten, iκbα and p53, which allows it to regulate many signaling pathways to exert its functions under both physiological and pathological conditions, such as cell proliferation, differentiation and apoptosis. |
2022-10-06 |
2023-08-14 |
human |
| Caogeng Zhang, Juping Ni, Wei Fan, Ju Ho. Nutlin-3 Promotes TRAIL-Induced Liver Cancer Cells Apoptosis by Activating p53 to Inhibit bcl-2 and Surviving Expression. Annals of clinical and laboratory science. vol 52. issue 4. 2022-10-05. PMID:36197780. |
nutlin-3 promotes trail-induced liver cancer cells apoptosis by activating p53 to inhibit bcl-2 and surviving expression. |
2022-10-05 |
2023-08-14 |
human |
| Etsuro It. [Bone marrow failure and TP53 activating mutations]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 63. issue 9. 2022-10-05. PMID:36198537. |
the p53 tumor suppressor protein is a transcription factor activated in response to various cellular stresses and induces genes involved in apoptosis, cell cycle arrest, and dna repair. |
2022-10-05 |
2023-08-14 |
Not clear |
| Gajendran Nithya, Rajasekaran Santhanasabapathy, Manickam Kalappan Vanitha, Pandi Anandakumar, Dhanapalan Sakthisekara. Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene-induced experimental lung cancer. Journal of biochemical and molecular toxicology. 2022-10-04. PMID:36193556. |
furthermore, tq administration in b(a)p-induced animals downregulated phosphatidylinositol 3-kinase/protein kinase b signaling pathway and induced apoptosis as evidenced by a decrease in cytochrome c, proapoptotic bax, caspase-3, and p53 with a parallel increase in antiapoptotic bcl-2. |
2022-10-04 |
2023-08-14 |
mouse |
| Uttom Kumar, Marcos Castellanos-Uribe, Sean T May, Ernesto Yagü. Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer. Gene. 2022-10-04. PMID:36195266. |
both cal51 and caldox stress signatures share 12 common genes (trim22, fas, spata18, sulf2, cdkn1a, gdf15, myo6, cxcl5, crot, eppk1, zmat3 and cd44), with roles in the above-mentioned pathways, indicating that these cells have similar functional responses to doxorubicin relaying on the p53 control of apoptosis. |
2022-10-04 |
2023-08-14 |
Not clear |
| Keith Conrad Fernandez, Laura Feeney, Ryan M Smolkin, Wei-Feng Yen, Allysia J Matthews, John H J Petrini, Jayanta Chaudhur. The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes. eLife. vol 11. 2022-10-03. PMID:36190107. |
upon activation, these double-null mature b lymphocytes fail to proliferate and survive while exhibiting transcriptional signatures of p53 signaling, apoptosis, and type i interferon response. |
2022-10-03 |
2023-08-14 |
mouse |
| Magdalena Skonieczna, Malgorzata Adamiec-Organisciok, Dorota Hudy, Arkadiusz Dziedzic, Laura Los, Lubomir Skladany, Ivica Grgurevic, Tajana Filipec-Kanizaj, Miczyslaw Jagodzinski, Michal Kukla, Joanna Nackiewic. Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the pleiotropic response to resveratrol and berberine. Advances in medical sciences. vol 67. issue 2. 2022-10-03. PMID:36191360. |
human carcinoma cells with different p53 status exposed to a combination of bioactive substances, resveratrol and berberine, revealed different responses in cell viability via p53-dependant apoptosis pathway activation. |
2022-10-03 |
2023-08-14 |
human |
| Ying Li, Meng Wu, Lili Zhang, Li Wan, Hexin Li, Lanxin Zhang, Gaoyuan Sun, Wei Huang, Junhua Zhang, Fei Su, Min Tang, Fei Xia. Nonsense-mediated mRNA decay inhibition synergizes with MDM2 inhibition to suppress TP53 wild-type cancer cells in p53 isoform-dependent manner. Cell death discovery. vol 8. issue 1. 2022-09-30. PMID:36180435. |
the combination of these two agents achieved significant synergistic effects on tp53 wild-type cancer cell lines by transactivating p53 target genes, inducing apoptosis, cell-cycle arrest and dna damage repair. |
2022-09-30 |
2023-08-14 |
mouse |
| S K Janani, S P Dhanabal, R Sureshkumar, Sai Surya Nikitha Upadhyayul. Anti-Nucleolin Aptamer as a Boom in Rehabilitation of Breast Cancer. Current pharmaceutical design. 2022-09-29. PMID:36173049. |
in this article, we have discussed about nucleolin, anti-nucleolin aptamer, namely, as1411, and its application in exhibiting various anticancer activities including apoptosis, anti-angiogenesis, anti-metastasis, stimulation of tumor suppressor (i.e p53) and inhibition of tumor inducer. |
2022-09-29 |
2023-08-14 |
Not clear |
| Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari, Rossella Galat. Correction: CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways. Journal of experimental & clinical cancer research : CR. vol 41. issue 1. 2022-09-29. PMID:36175975. |
correction: cellfood™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pakt signaling pathways. |
2022-09-29 |
2023-08-14 |
human |
| Xiao Liang, Jun-Hao Zhang, Hao-Tian Bai, Ya-Lan Li, Shu-Hui Sun, Qian-Qian Zhang, Jing Yang, Rui Wan. [Mechanism of Linderae Radix against gastric cancer based on network pharmacology and in vitro experimental validation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 18. 2022-09-27. PMID:36164911. |
finally, in an in vitro experiment, the screened radix linderae active ingredient gemmadone is used for preliminarily verifying the core targets and pathways of the human gastric cancer cell sgc-7901, the results showed that germacrone could significantly inhibit the proliferation of gastric cancer cells and induce the apoptosis of sgc-7901 by regulating the expression of p53, bax, bcl-2 and other key proteins. |
2022-09-27 |
2023-08-14 |
human |
| Yuan Yuan, Xiaojing Zhang, Kaining Du, Xiaohui Zhu, Shanshan Chang, Yang Chen, Yidan Xu, Jiachun Sun, Xiaonuan Luo, Shiqi Deng, Ying Qin, Xianling Feng, Yanjie Wei, Xinmin Fan, Ziyang Liu, Baixin Zheng, Hassan Ashktorab, Duane Smoot, Song Li, Xiaoxun Xie, Zhe Jin, Yin Pen. Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer. Cell death & disease. vol 13. issue 9. 2022-09-27. PMID:36167685. |
circ_cea promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer. |
2022-09-27 |
2023-08-14 |
Not clear |
| Yuan Yuan, Xiaojing Zhang, Kaining Du, Xiaohui Zhu, Shanshan Chang, Yang Chen, Yidan Xu, Jiachun Sun, Xiaonuan Luo, Shiqi Deng, Ying Qin, Xianling Feng, Yanjie Wei, Xinmin Fan, Ziyang Liu, Baixin Zheng, Hassan Ashktorab, Duane Smoot, Song Li, Xiaoxun Xie, Zhe Jin, Yin Pen. Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer. Cell death & disease. vol 13. issue 9. 2022-09-27. PMID:36167685. |
as a result, circ_cea promotes cdk1-mediated p53 phosphorylation at ser315, then decreases p53 nuclear retention and suppresses its activity, leading to the downregulation of p53 target genes associated with apoptosis. |
2022-09-27 |
2023-08-14 |
Not clear |
| Yuan Yuan, Xiaojing Zhang, Kaining Du, Xiaohui Zhu, Shanshan Chang, Yang Chen, Yidan Xu, Jiachun Sun, Xiaonuan Luo, Shiqi Deng, Ying Qin, Xianling Feng, Yanjie Wei, Xinmin Fan, Ziyang Liu, Baixin Zheng, Hassan Ashktorab, Duane Smoot, Song Li, Xiaoxun Xie, Zhe Jin, Yin Pen. Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer. Cell death & disease. vol 13. issue 9. 2022-09-27. PMID:36167685. |
these findings suggest that circ_cea protects gc cells from stress-induced apoptosis, via acting as a protein scaffold and interacting with p53 and cdk1 proteins. |
2022-09-27 |
2023-08-14 |
Not clear |
| Md Mominur Rahman, Md Taslim Sarker, Mst Afroza Alam Tumpa, Md Yamin, Tamanna Islam, Moon Nyeo Park, Md Rezaul Islam, Abdur Rauf, Rohit Sharma, Simona Cavalu, Bonglee Ki. Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products. Frontiers in pharmacology. vol 13. 2022-09-26. PMID:36160435. |
these natural chemicals are known to affect numerous important cellular signaling pathways, such as nf-b, mapk, wnt, notch, akt, p53, ar, er, and many others, to cause cell death signals and induce apoptosis in pre-cancerous or cancer cells without harming normal cells. |
2022-09-26 |
2023-08-14 |
human |
| Shunhan Yao, Meiling Deng, Xiaojing Du, Rongzhi Huang, Qingfeng Che. A Novel Hypoxia Related Marker in Blood Link to Aid Diagnosis and Therapy in Osteoarthritis. Genes. vol 13. issue 9. 2022-09-23. PMID:36140669. |
these differences result from multiple pathways, such as the p53 signaling pathway, cell senescence, the nf-kappa b signaling pathway, ubiquitin-mediated proteolysis, and apoptosis. |
2022-09-23 |
2023-08-14 |
Not clear |
| Julia Holzerland, Lucie Fénéant, Allison Groset. Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication. Viruses. vol 14. issue 9. 2022-09-23. PMID:36146824. |
we have found that, while tcrv and junv differ in their ability to induce apoptosis in infected cells, due to active inhibition of caspase activation by the junv nucleoprotein, both viruses trigger similar upstream pro-apoptotic signaling events, including the activation/phosphorylation of p53. |
2022-09-23 |
2023-08-14 |
Not clear |
| Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Set. The role of p53 in the alternation of vascular functions. Frontiers in pharmacology. vol 13. 2022-09-23. PMID:36147350. |
tumor suppressor gene p53, also a transcription factor, act as a gatekeeper to regulate a number of genes to maintain normal cell function including but not limited to cell proliferation, cell apoptosis. |
2022-09-23 |
2023-08-14 |
Not clear |