| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajalakshmi Ramachandran, Ramya Parthasarathy, Sangeetha Dhayala. Silver nanoparticles synthesized by Euphorbia hirta exhibited antibacterial activity and induced apoptosis through downregulation of PI3Kγ mediated PI3K/Akt/mTOR/p70S6K in human lung adenocarcinoma A549 cells. Environmental toxicology. 2022-09-08. PMID:36073799. |
the obtained results demonstrated that the eh-agnps induce reactive oxygen species-mediated apoptosis by expressing p53, bax, and inhibiting pi3k/akt/mtor/p70s6k signaling pathway. |
2022-09-08 |
2023-08-14 |
human |
| Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuan. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell death & disease. vol 13. issue 9. 2022-09-06. PMID:36068197. |
administration of mm102, a selective mll1/wdr5 complex inhibitor, improved renal function and attenuated tubular injury and apoptosis, while repressing mll1, wdr5, and h3k4me3, dephosphorylating p53 and preserving e-cadherin. |
2022-09-06 |
2023-08-14 |
mouse |
| Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuan. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell death & disease. vol 13. issue 9. 2022-09-06. PMID:36068197. |
in cultured mouse renal proximal tubular cells (rptcs) exposed to cisplatin, treatment with mm102 or transfection with sirnas for either mll1 or wdr5 also inhibited apoptosis and p53 phosphorylation while preserving e-cadherin expression; p53 inhibition with pifithrin-α lowered cisplatin-induced apoptosis without affecting expression of mll1, wdr5, and h3k4me3. |
2022-09-06 |
2023-08-14 |
mouse |
| Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuan. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell death & disease. vol 13. issue 9. 2022-09-06. PMID:36068197. |
these findings suggest that mll1/wdr5 activates p53, which, in turn, represses e-cadherin, leading to apoptosis during cisplatin-induced aki. |
2022-09-06 |
2023-08-14 |
mouse |
| Lu Zhang, Bill Poland, Michelle Green, Shekman Wong, J Greg Slatte. A Population Pharmacokinetic-Pharmacodynamic Model of Navtemadlin, its Major Active Metabolite (M1) and Serum Macrophage Inhibitory Cykokine-1 (MIC-1). Xenobiotica; the fate of foreign compounds in biological systems. 2022-09-02. PMID:36052821. |
navtemadlin is a potent, selective, orally available inhibitor of murine double minute 2 that restores p53 activity to induce apoptosis in |
2022-09-02 |
2023-08-14 |
Not clear |
| Binbin Cui, Xiying Hou, Mengjun Liu, Qing Li, Chao Yu, Shenglei Zhang, Yi Wang, Jun Wang, Shougang Zhuang, Feng Li. Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice. Frontiers in pharmacology. vol 13. 2022-09-01. PMID:36046818. |
moreover, az505 inhibited cisplatin-induced phosphorylation of p53, a key driver of kidney cell apoptosis and reduced expression of p21, a cell cycle inhibitor. |
2022-09-01 |
2023-08-14 |
mouse |
| Luyin Wu, Mohammed Zeeshan, Yao Dang, Li-Ya Liang, Yan-Chen Gong, Qing-Qing Li, Ya-Wen Tan, Yuan-Yuan Fan, Li-Zi Lin, Yang Zhou, Ru-Qing Liu, Li-Wen Hu, Bo-Yi Yang, Xiao-Wen Zeng, Yunjiang Yu, Guang-Hui Don. Environmentally relevant concentrations of F-53B induce eye development disorders-mediated locomotor behavior in zebrafish larvae. Chemosphere. 2022-09-01. PMID:36049635. |
acridine orange (ao) staining revealed a dose-dependent increase in early apoptosis, accompanied by upregulation of p53, casp-9 and casp-3 genes. |
2022-09-01 |
2023-08-14 |
zebrafish |
| Deokbae Park, Jung-Hee Lee, Sang-Pil Yoo. Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 26. issue 5. 2022-08-30. PMID:36039738. |
when compared with wild-type snu-c5 cells, 5-fluorouracil-resistant snu-c5 cells showed reduced autophagy, increased ferroptosis and ferroptosis-augmented apoptosis, and less activation of caspase-8 and p53. |
2022-08-30 |
2023-08-14 |
Not clear |
| Tingting Zhou, Suli He, Xin Ye, Zhaolan Wei, Jian Wan, Hongmao Zhang, Shumao Din. Exposure to dibutyl phthalate adsorbed to multi-walled carbon nanotubes causes neurotoxicity in mice by inducing the release of BDNF. The Science of the total environment. 2022-08-30. PMID:36041608. |
rt-pcr results revealed that the expression levels of p53, caspase3, and bax genes related to apoptosis were up-regulated. |
2022-08-30 |
2023-08-14 |
mouse |
| Lu Cao, Hong Fang, Dong Yan, Xiao Man Wu, Jie Zhang, Ming Xian Chan. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. vol 5. issue 1. 2022-08-30. PMID:36042265. |
cd44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. |
2022-08-30 |
2023-08-14 |
zebrafish |
| Lu Cao, Hong Fang, Dong Yan, Xiao Man Wu, Jie Zhang, Ming Xian Chan. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. vol 5. issue 1. 2022-08-30. PMID:36042265. |
zebrafish cd44a deficiency inhibits cell growth and proliferation, impairs cell growth and death pathways, and regulates the expression levels of many genes involved in p53 signaling, apoptosis and autophagy. |
2022-08-30 |
2023-08-14 |
zebrafish |
| A S Chukanova, M S Gulieva, E I Chukanova, S J Bagmanya. [A panel of serum biomarkers, including damage, apoptosis and neurotrophic markers, for the assessment of prognosis of the course of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 8. Vyp. 2. 2022-08-29. PMID:36036143. |
identification of the relationship between clinical and neuroimaging data and the content of serum biomarkers (damage marker - neuron-specific enolase (nse), apoptosis - p53 protein and neuroplasticity - brain-derived neurotrophic factor (bdnf)) in acute, early and late recovery periods of ischemic stroke. |
2022-08-29 |
2023-08-14 |
Not clear |
| Li Ma, Min Huang, Xiaohua Liao, Xiyu Cai, Qiang W. NR2F2 Regulates Cell Proliferation and Immunomodulation in Whartons' Jelly Stem Cells. Genes. vol 13. issue 8. 2022-08-26. PMID:36011369. |
in addition, we observed increased p53, decreased bcl-2, and increased cell apoptosis in liver cancer cell line hepg2 if co-cultured with nr2f2-depleted wj-mscs. |
2022-08-26 |
2023-08-14 |
human |
| Ying-Chyi Song, Cheng-Chieh Kuo, Chuan-Teng Liu, Tsai-Chen Wu, Yi-Ting Kuo, Hung-Rong Ye. Combined Effects of Tanshinone IIA and an Autophagy Inhibitor on the Apoptosis of Leukemia Cells via p53, Apoptosis-Related Proteins and Oxidative Stress Pathways. Integrative cancer therapies. vol 21. 2022-08-23. PMID:35996358. |
combined effects of tanshinone iia and an autophagy inhibitor on the apoptosis of leukemia cells via p53, apoptosis-related proteins and oxidative stress pathways. |
2022-08-23 |
2023-08-14 |
Not clear |
| Suming Pan, Xiangguo Zhang, Yugan Guo, Yin L. DPCPX induces Bim-dependent apoptosis in nasopharyngeal carcinoma cells. Cell biology international. 2022-08-22. PMID:35989488. |
dpcpx induced bim-dependent apoptosis in npc cells irrespective of p53 status via the foxo3a pathway following pi3k/akt inhibition. |
2022-08-22 |
2023-08-14 |
Not clear |
| Rati Lama, Chao Xu, Samuel L Galster, Javier Querol-García, Scott Portwood, Cory K Mavis, Federico M Ruiz, Diana Martin, Jin Wu, Marianna C Giorgi, Jill Bargonetti, Eunice S Wang, Francisco J Hernandez-Ilizaliturri, Gerald B Koudelka, Sherry R Chemler, Inés G Muñoz, Xinjiang Wan. Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status. Frontiers in oncology. vol 12. 2022-08-22. PMID:35992795. |
small molecule mmri62 targets mdm4 for degradation and induces leukemic cell apoptosis regardless of p53 status. |
2022-08-22 |
2023-08-14 |
Not clear |
| Lei Wang, Xiaojun Tan, Lu Chen, Sisi Xu, Weiping Huang, Nan Chen, Yizhou Wu, Chunyan Wang, Daqiang Zhou, Mangmang L. Sall4 guides p53-mediated enhancer interference upon DNA damage in mouse embryonic stem cells. Stem cells (Dayton, Ohio). 2022-08-17. PMID:35977539. |
herein, we demonstrate that sall4 negatively regulates dna damage induced apoptosis (dia) of mescs through mediating p53 recruitment to enhancers of esc-associated genes repressed by p53 from promoters of p53-activated genes. |
2022-08-17 |
2023-08-14 |
mouse |
| Michelle C Barton, Guillermina Lozan. p53 Activation Paradoxically Causes Liver Cancer. Cancer research. vol 82. issue 16. 2022-08-16. PMID:35971677. |
activation of p53 regulates a transcriptional program that can cause cell cycle arrest, senescence, apoptosis, and ferroptosis, which are potent tumor suppressive mechanisms. |
2022-08-16 |
2023-08-14 |
Not clear |
| Hongjing Cai, Pengchao Tian, Jie Ju, Tao Wang, Xinzhe Chen, Kai Wang, Fei Wang, Xue Yu, Shaocong Wang, Yin Wang, Chan Shan, Peifeng L. Long noncoding RNA NONMMUT015745 inhibits doxorubicin-mediated cardiomyocyte apoptosis by regulating Rab2A-p53 axis. Cell death discovery. vol 8. issue 1. 2022-08-16. PMID:35974003. |
taken together, our results suggested that lnc5745 protects against dox-induced cardiomyocyte apoptosis through suppressing rab2a expression, modifying p53 phosphorylation, thereby regulating p53-related apoptotic signalling pathway. |
2022-08-16 |
2023-08-14 |
human |
| Jingyi Chen, Fangxin Zhao, Hongxin Yang, Jianxun Wen, Ying Tang, Fang Wan, Xuan Zhang, Jianqiang W. Gentian violet induces apoptosis and ferroptosis via modulating p53 and MDM2 in hepatocellular carcinoma. American journal of cancer research. vol 12. issue 7. 2022-08-15. PMID:35968343. |
gentian violet induces apoptosis and ferroptosis via modulating p53 and mdm2 in hepatocellular carcinoma. |
2022-08-15 |
2023-08-14 |
Not clear |