| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jogendra S Pawar, Saad Mustafa, Ilora Ghos. Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells. Saudi journal of biological sciences. vol 29. issue 5. 2022-07-18. PMID:35844432. |
this suggests that chrysin and capsaicin trigger an increase in mitochondrial ros, and p53 interaction leading to premature senescence and apoptosis in concentration dependent manner and have therapeutic potential for cancer treatment. |
2022-07-18 |
2023-08-14 |
human |
| Yiming Shao, Jiao He, Xinan Zhang, Panpan Xie, Hongkai Lian, Meng Zhan. Mechanism of Astragali Radix for the treatment of osteoarthritis: A study based on network pharmacology and molecular docking. Medicine. vol 101. issue 28. 2022-07-15. PMID:35839041. |
the kyoto encyclopedia of genes and genomes pathway analysis revealed that huangqi might exert antiosteoarthritis effect mainly through the pi3k-akt signaling pathway, apoptosis, the mitogen-activated protein kinases signaling pathway, and the p53 signaling pathway. |
2022-07-15 |
2023-08-14 |
Not clear |
| Anders Brahm. Quantifying Cellular Repair, Misrepair and Apoptosis Induced by Boron Ions, Gamma Rays and PRIMA-1 Using the RHR Formulation. Radiation research. 2022-07-14. PMID:35834822. |
the low-dose apoptosis is due to the fact that the full activation of the checkpoint kinases atm and chk2 requires >8 and >18 dsbs per cell to phosphorylate p53 at serine 15 and 20. |
2022-07-14 |
2023-08-14 |
mouse |
| Anders Brahm. Quantifying Cellular Repair, Misrepair and Apoptosis Induced by Boron Ions, Gamma Rays and PRIMA-1 Using the RHR Formulation. Radiation research. 2022-07-14. PMID:35834822. |
finally, the formulation was used to estimate the increase in dna repair and apoptotic response in combination with the mutant p53 reactivating compound prima-1 and γ rays, indicating a 10-2 times increase in apoptosis with 5 μm of the compound reaching apoptosis levels not far from peak apoptosis boron ions in a tp53 mutant cell line. |
2022-07-14 |
2023-08-14 |
mouse |
| Yanying Liang, Xiuyuan Zhang, Wenwen Geng, Yun Wang, Yue Ding, Qin Song, Yanzhi Yuan, Chunling Zhao, Zhaoju Tian, Jian Wang, Chunyan Tia. 19q13.12 KRAB zinc-finger protein ZNF383 represses p53 signaling pathway by interacting with p53. Cellular signalling. 2022-07-14. PMID:35835334. |
here, we revealed that znf383, another member of the kzfps mapped at 19q13.12, could inhibit p53-mediated apoptosis and the activation of ifn-β pathway by decreasing the h3k36me2 level at p53's binding sites and the attenuating the binding of p53 to its target genes. |
2022-07-14 |
2023-08-14 |
human |
| Abdul-Quddus Kehinde Oyedele, Temitope Isaac Adelusi, Abdeen Tunde Ogunlana, Mojeed Ashiru Ayoola, Rofiat Oluwabusola Adeyemi, Musa Oladayo Babalola, James Babatunde Ayorinde, Josiah Ayoola Isong, Toheeb Olakunle Ajasa, Ibrahim Damilare Boyenl. Promising disruptors of p53-MDM2 dimerization from some medicinal plant phytochemicals: a molecular modeling study. Journal of biomolecular structure & dynamics. 2022-07-13. PMID:35822492. |
p53, which functions as a tumor suppressor, is critical in preventing tumor development by regulating the cell cycle and inducing apoptosis in damaged cells. |
2022-07-13 |
2023-08-14 |
Not clear |
| Oleg Semenov, Alexandra Daks, Olga Fedorova, Oleg Shuvalov, Nickolai A Barle. Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition. Frontiers in molecular biosciences. vol 9. 2022-07-11. PMID:35813818. |
on the molecular level, the suppression of these effects is exerted by p53 via regulation of its target genes, whose products are involved in cell cycle, apoptosis, autophagy, dna repair, and interactions with immune cells. |
2022-07-11 |
2023-08-14 |
Not clear |
| Muzi Zhang, Yuwen Fan, Haibo Jiang, Jian Shao, Ming L. Establishment of hyperammonemia mode in yellow catfish and the mitigation of exogenous L-ornithine-L-aspartate. Developmental and comparative immunology. 2022-07-08. PMID:35803415. |
the results showed that ammonia poisoning could induce serum ammonia content elevated, liver damage (serum aminotransferase activity elevated and liver malondialdehyde accumulation), and up-regulation of cytokine (il 1, il 8 and tnfɑ), apoptosis (p53, bax, cytochrome c, caspase 3 and caspase 9) and autophagy (dynein, beclin 1, akt and pten) genes transcription, but lola could mitigate the adverse effect of ammonia poisoning. |
2022-07-08 |
2023-08-14 |
Not clear |
| Ambuja Navalkar, Ajoy Paul, Arunima Sakunthala, Satyaprakash Pandey, Amit Kumar Dey, Sandhini Saha, Sarthak Sahoo, Mohit K Jolly, Tushar K Maiti, Samir K Maj. Oncogenic gain of function due to p53 amyloids by aberrant alteration of cell cycle and proliferation. Journal of cell science. 2022-07-07. PMID:35796018. |
global gene expression profiling of cells suggests that p53 amyloid formation dysregulates the genes associated with cell cycle, proliferation, apoptosis, senescence along with major signaling pathways. |
2022-07-07 |
2023-08-14 |
Not clear |
| Ambuja Navalkar, Ajoy Paul, Arunima Sakunthala, Satyaprakash Pandey, Amit Kumar Dey, Sandhini Saha, Sarthak Sahoo, Mohit K Jolly, Tushar K Maiti, Samir K Maj. Oncogenic gain of function due to p53 amyloids by aberrant alteration of cell cycle and proliferation. Journal of cell science. 2022-07-07. PMID:35796018. |
our data indicate that specifically targeting the key molecules in pathways affected by p53 amyloid formation such as cyclin-dependent kinase-1, leads to loss of oncogenic phenotype and induces apoptosis of cells. |
2022-07-07 |
2023-08-14 |
Not clear |
| Mo Chen, Suyong Choi, Tianmu Wen, Changliang Chen, Narendra Thapa, Jeong Hyo Lee, Vincent L Cryns, Richard A Anderso. A p53-phosphoinositide signalosome regulates nuclear AKT activation. Nature cell biology. 2022-07-07. PMID:35798843. |
the tumour suppressor p53 and pi3k-akt pathways have fundamental roles in the regulation of cell growth and apoptosis, and are frequently mutated in cancer. |
2022-07-07 |
2023-08-14 |
Not clear |
| Yutao Guan, Qianlong Wu, Miaomiao Li, Danyang Chen, Jingyao Su, Liandong Zuo, Bing Zhu, Yinghua L. Epigallocatechin-3-gallate induced HepG2 cells apoptosis through ROS-Mediated AKT /JNK and p53 signaling pathway.. Current cancer drug targets. 2022-07-06. PMID:35792125. |
epigallocatechin-3-gallate induced hepg2 cells apoptosis through ros-mediated akt /jnk and p53 signaling pathway.. hepatocarcinoma is the third leading cause of cancer-related deaths around the world. |
2022-07-06 |
2023-08-14 |
Not clear |
| Yutao Guan, Qianlong Wu, Miaomiao Li, Danyang Chen, Jingyao Su, Liandong Zuo, Bing Zhu, Yinghua L. Epigallocatechin-3-gallate induced HepG2 cells apoptosis through ROS-Mediated AKT /JNK and p53 signaling pathway.. Current cancer drug targets. 2022-07-06. PMID:35792125. |
furthermore, egcg enhanced cytotoxic effects on hepg2 cells and triggered intracellular reactive oxygen species; the signaling pathways of akt, jnk, and p53 were activated to advance cell apoptosis. |
2022-07-06 |
2023-08-14 |
Not clear |
| Yasuzumi Matsui, Yohei Mineharu, Yuki Noguchi, Etsuko Yamamoto Hattori, Hirohito Kubota, Masahiro Hirata, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikub. Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation. Biochemical and biophysical research communications. vol 620. 2022-07-06. PMID:35792512. |
apoptosis array analysis showed that chb-m' treatment induced phosphorylation of p53 serine 15 residues. |
2022-07-06 |
2023-08-14 |
Not clear |
| Monikaben Padariya, Mia-Lyn Jooste, Ted Hupp, Robin Fåhraeus, Borek Vojtesek, Fritz Vollrath, Umesh Kalathiya, Konstantinos Karakosti. The Elephant evolved p53 isoforms that escape mdm2-mediated repression and cancer. Molecular biology and evolution. 2022-07-06. PMID:35792674. |
the p53 tumour suppressor is a transcription factor with roles in cell development, apoptosis, oncogenesis, ageing and homeostasis in response to stresses and infections. |
2022-07-06 |
2023-08-14 |
Not clear |
| Y X Wei, D D Zhang, Y Y Gao, C H Hang, J X Sh. Inhibition of the myeloid differentiation primary response protein 88 reducres neuron injury in the early stages of subarachnoid hemorrhage in an in vitro experimental model. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 73. issue 1. 2022-07-06. PMID:35793767. |
in each group, apoptosis of neuronal cells along with changes in the expression of proteins including myd88, p-jnk, p-erk, p-p38, nfκb, bcl-2, and p53 were measured. |
2022-07-06 |
2023-08-14 |
Not clear |
| Shanshan Zeng, Meifeng Li, Xining Cheng, Shina Lu, Zhiqing Feng, Zeyin Jiang, Zhichao Sun, Xiaowen Xu, Huiling Mao, Chengyu H. Grass carp (Ctenopharyngodon idella) DYRK2 modulates cell apoptosis through phosphorylating p53. Fish & shellfish immunology. 2022-07-05. PMID:35781054. |
grass carp (ctenopharyngodon idella) dyrk2 modulates cell apoptosis through phosphorylating p53. |
2022-07-05 |
2023-08-14 |
Not clear |
| Shanshan Zeng, Meifeng Li, Xining Cheng, Shina Lu, Zhiqing Feng, Zeyin Jiang, Zhichao Sun, Xiaowen Xu, Huiling Mao, Chengyu H. Grass carp (Ctenopharyngodon idella) DYRK2 modulates cell apoptosis through phosphorylating p53. Fish & shellfish immunology. 2022-07-05. PMID:35781054. |
in mammals, dyrk2 increases p53 phosphorylation level by interacting with it and then promotes cell apoptosis. |
2022-07-05 |
2023-08-14 |
Not clear |
| Shanshan Zeng, Meifeng Li, Xining Cheng, Shina Lu, Zhiqing Feng, Zeyin Jiang, Zhichao Sun, Xiaowen Xu, Huiling Mao, Chengyu H. Grass carp (Ctenopharyngodon idella) DYRK2 modulates cell apoptosis through phosphorylating p53. Fish & shellfish immunology. 2022-07-05. PMID:35781054. |
to study the molecular mechanism by which cidyrk2 promoting cell apoptosis, subcellular localization and immunoprecipitation experiments were used to study the relationship between grass carp dyrk2 and the pro-apoptotic protein p53. |
2022-07-05 |
2023-08-14 |
Not clear |
| Shanshan Zeng, Meifeng Li, Xining Cheng, Shina Lu, Zhiqing Feng, Zeyin Jiang, Zhichao Sun, Xiaowen Xu, Huiling Mao, Chengyu H. Grass carp (Ctenopharyngodon idella) DYRK2 modulates cell apoptosis through phosphorylating p53. Fish & shellfish immunology. 2022-07-05. PMID:35781054. |
in a word, our results showed that grass carp dyrk2 induces cell apoptosis by increasing the phosphorylation level of p53. |
2022-07-05 |
2023-08-14 |
Not clear |