| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Teng, Jingyao Mu, Fangyi Xu, Xiangcheng Zhang, Mukesh K Sriwastva, Qiaohong M Liu, Xiaohong Li, Chao Lei, Kumaran Sundaram, Xin Hu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Eric C Rouchka, Xiang Zhang, Jun Yan, Michael L Merchant, Huang-Ge Zhan. Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death. Cell host & microbe. 2022-06-02. PMID:35654045. |
mechanistically, iaa promotes apoptosis of microglial cells by recruiting the transcriptional regulator p53 to the s100a8 promoter region. |
2022-06-02 |
2023-08-14 |
mouse |
| Yucheng Liu, Xinyan Wang, Wucheng Zhu, Zhongheng Sui, Xiangqing Wei, Yang Zhang, Jiansong Qi, Yanhong Xing, Wuyang Wan. TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis. Cancer letters. 2022-06-01. PMID:35644286. |
damage to dna resulted from trpml1-mediated autophagy inhibition subsequently activates p53, which ultimately triggers mitochondrial mediated apoptosis by modulating pro- and anti-apoptosis proteins in these cancer cells. |
2022-06-01 |
2023-08-13 |
human |
| Hidetoshi Satoh, Shintaro Ochi, Kosuke Mizuno, Yutaka Saga, Shohei Ujita, Miyu Toyoda, Yuichi Nishiyama, Kasumi Tada, Yosuke Matsushita, Yuichi Deguchi, Keiji Suzuki, Yoshimasa Tanaka, Hiroshi Ueda, Toshiya Inaba, Yoshio Hosoi, Akinori Morita, Shin Aok. Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors. Bioorganic & medicinal chemistry. vol 67. 2022-05-31. PMID:35635928. |
it is known that p53 is an important transcription factor and plays a central role in ionizing radiation (ir)-induced dna damage responses such as cell cycle arrest, dna repair and apoptosis. |
2022-05-31 |
2023-08-13 |
Not clear |
| Hidetoshi Satoh, Shintaro Ochi, Kosuke Mizuno, Yutaka Saga, Shohei Ujita, Miyu Toyoda, Yuichi Nishiyama, Kasumi Tada, Yosuke Matsushita, Yuichi Deguchi, Keiji Suzuki, Yoshimasa Tanaka, Hiroshi Ueda, Toshiya Inaba, Yoshio Hosoi, Akinori Morita, Shin Aok. Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors. Bioorganic & medicinal chemistry. vol 67. 2022-05-31. PMID:35635928. |
the experimental results suggest that a direct relationship exists between the inhibitory effect of these stk160830 derivatives on the expression level of p53 and their radioprotective activity and that the suppression of p53 by stk160830 derivatives contribute to protecting molt-4 cells from apoptosis that is induced by exposure to radiation. |
2022-05-31 |
2023-08-13 |
Not clear |
| Hossein Allahmoradi, S Mohsen Asghari, Atieh Ahmadi, Elham Assareh, Mahboobeh Nazar. Anti-tumor and anti-metastatic activity of the FGF2 118-126 fragment dependent on the loop structure. The Biochemical journal. 2022-05-31. PMID:35638868. |
according to immunohistochemical studies, the anti-tumor properties of bgf1 were associated with suppression of tumor cell proliferation (ki-67 expression), angiogenesis (cd31 expression), and apoptosis induction (as was shown by increased p53 expression and tunel staining and decreased bcl-2 expression). |
2022-05-31 |
2023-08-13 |
Not clear |
| Pei Wang, Zhiheng Chang, Jing Meng, Xia Cui, Jianyuan Chai, Tong Dan. Overexpression of CCN1 in esophageal squamous cell carcinoma attenuates cell proliferation through amyloid precursor protein without DR6 involvement. Human cell. 2022-05-31. PMID:35639282. |
overexpression of ccn1 in escc cells induced cell cycle arrest rather than apoptosis through upregulation of app and its association with p53 without dr6 involvement. |
2022-05-31 |
2023-08-13 |
Not clear |
| Manabu Endo, Takashi Nishioka, Kento Numazaki, Hiroshi Hasegawa, Tetsu Takahashi, Shunji Sugawara, Hiroyuki Tad. Reactivation of p53 by RITA Induces Apoptosis in Human Oral Squamous Cell Carcinoma Cells. Anticancer research. vol 42. issue 6. 2022-05-31. PMID:35641264. |
reactivation of p53 by rita induces apoptosis in human oral squamous cell carcinoma cells. |
2022-05-31 |
2023-08-13 |
human |
| Michael Tsui, Jeremy Biro, Jonathan Chan, Weixian Min, Kerry Dobbs, Luigi D Notarangelo, Eyal Grunebau. Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons. Scientific reports. vol 12. issue 1. 2022-05-31. PMID:35641516. |
greater expression of tumor protein p53 was also observed in these neurons, and inhibition of p53 using pifithrin-α prevented the apoptosis. |
2022-05-31 |
2023-08-13 |
mouse |
| Javier Quero, Lina F Ballesteros, Pedro Ferreira-Santos, Gustavo R Velderrain-Rodriguez, Cristina M R Rocha, Ricardo N Pereira, José A Teixeira, Olga Martin-Belloso, Jesús Osada, María Jesús Rodríguez-Yold. Unveiling the Antioxidant Therapeutic Functionality of Sustainable Olive Pomace Active Ingredients. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624692. |
the oh-etoh induced potential modifications in the mitochondrial membrane and led to apoptosis by cell cycle arrest in the g1/s phases with activation of p53 and caspase 3 proteins. |
2022-05-28 |
2023-08-13 |
Not clear |
| Ki-Tae Jung, Seon-Hee O. The role of autophagy in cadmium-induced acute toxicity in glomerular mesangial cells and tracking polyubiquitination of cytoplasmic p53 as a biomarker. Experimental & molecular medicine. 2022-05-27. PMID:35624155. |
here, we show that cd-induced apoptosis is promoted by the cytoplasmic polyubiquitination of p53 (polyub-p53), which is regulated by the polyubiquitination of sqstm1/p62 (polyub-p62) and autophagy in mouse kidney mesangial cells (mes13e cells). |
2022-05-27 |
2023-08-13 |
mouse |
| Nandini Sen, Ann M Arvi. Modulation of Host Cell Signaling Pathways by Varicella-Zoster Virus. Current topics in microbiology and immunology. 2022-05-27. PMID:35624345. |
in this chapter, we discuss the regulation of pi3k/akt pathway in vzv infected cells and of other pathways including p53 which, unlike pakt and pstat3, directs cells towards apoptosis. |
2022-05-27 |
2023-08-13 |
human |
| Rituraj Chakraborty, Kaviyarasi Renu, Mohamed Ahmed Eladl, Mohamed El-Sherbiny, Dalia Mahmoud Abdelmonem Elsherbini, Arshi Khalid Mirza, Balachandar Vellingiri, Mahalaxmi Iyer, Abhijit Dey, Abilash Valsala Gopalakrishna. Mechanism of chromium-induced toxicity in lungs, liver, and kidney and their ameliorative agents. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-25. PMID:35613529. |
p53, as well as pro-and anti-apoptotic proteins, are involved in apoptosis. |
2022-05-25 |
2023-08-13 |
human |
| Qiang Luo, Wei Sun, Yi-Fan Wang, Ji Li, Da-Wei L. Association of p53 with Neurodegeneration in Parkinson's Disease. Parkinson's disease. vol 2022. 2022-05-23. PMID:35601652. |
p53 is a vital transcriptional protein implicated in regulating diverse cellular processes, including cell cycle arrest, dna repair, mitochondrial metabolism, redox homeostasis, autophagy, senescence, and apoptosis. |
2022-05-23 |
2023-08-13 |
Not clear |
| Nikolaus von Knebel Doeberitz, Daniel Paech, Dominik Sturm, Stefan Pusch, Sevin Turcan, Yogen Saunthararaja. Changing paradigms in oncology: toward non-cytotoxic treatments for advanced gliomas. International journal of cancer. 2022-05-23. PMID:35603902. |
glial-lineage malignancies (gliomas) recurrently mutate and/or delete the master regulators of apoptosis p53 and/or p16/cdkn2a, undermining apoptosis-intending (cytotoxic) treatments. |
2022-05-23 |
2023-08-13 |
Not clear |
| Zihan Rao, Jiaomei Shen, Juan Wang, Zhongwei Zhang, Jianming Zhou, Jiahua Zhu, Jiali Chen, Wenjuan Chen, Huai Wan. The role of PICT1 in RPL11/Mdm2/p53 pathway-regulated inhibition of cell growth induced by topoisomerase IIα inhibitor against cervical cancer cell line. Biochemical pharmacology. 2022-05-23. PMID:35605655. |
also, d-3f increases the expression of p53 to induce cervical cancer hela cell apoptosis by enhancing its stability, due to the translocation of rpl11 to interact with mdm2 and then consequently causing the blockage of the mdm2-p53 feedback loop. |
2022-05-23 |
2023-08-13 |
Not clear |
| Jiangnan Yi, Jianzhao Liao, Tian Bai, Bole Wang, Chamba Yangzom, Zulfiqar Ahmed, Khalid Mehmood, Rao Zahid Abbas, Ying Li, Zhaoxin Tang, Hui Zhan. Battery wastewater induces nephrotoxicity via disordering the mitochondrial dynamics. Chemosphere. 2022-05-23. PMID:35605732. |
moreover, the battery wastewater exposure significantly up-regulated the autophagy (pink, parkin, mtor, atg5, lc3-b, p62) and apoptosis (bax, cytc, apaf1, p53, caspase3, caspase8) related mrna and proteins levels in kidneys. |
2022-05-23 |
2023-08-13 |
mouse |
| Songwang Xie, Zhen Hong, Yan Li, Junyong Wang, Jian Wang, Shaoquan Li, Yongchang Li. RNF216 Alleviates Radiation-Induced Apoptosis and DNA Damage Through Regulating Ubiquitination-Mediated Degradation of p53 in Glioblastoma. Molecular neurobiology. 2022-05-20. PMID:35594003. |
rnf216 alleviates radiation-induced apoptosis and dna damage through regulating ubiquitination-mediated degradation of p53 in glioblastoma. |
2022-05-20 |
2023-08-13 |
mouse |
| Songwang Xie, Zhen Hong, Yan Li, Junyong Wang, Jian Wang, Shaoquan Li, Yongchang Li. RNF216 Alleviates Radiation-Induced Apoptosis and DNA Damage Through Regulating Ubiquitination-Mediated Degradation of p53 in Glioblastoma. Molecular neurobiology. 2022-05-20. PMID:35594003. |
in conclusion, rnf216 effectively attenuated radiation-induced apoptosis and dna damage in gbm via inducing ubiquitination-mediated degradation of p53. |
2022-05-20 |
2023-08-13 |
mouse |
| Wenlong Huang, Jiefeng Xiao, Xiaoling Shi, Shukai Zheng, Haiyi Li, Caixia Liu, Kusheng W. Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental toxicology and pharmacology. 2022-05-20. PMID:35595013. |
meanwhile, behavioral changes were accompanied by increased apoptosis and malondialdehyde (mda) content, decreased superoxide dismutase (sod) activity and dopamine (da) content, and perturbed the expression of genes associated with the synthesis (th), reuptake (dat) and metabolism (mao) of da, with dopamine receptors (drs), and with the apoptosis pathway (p53, bax, bcl2, caspase-3, caspase-8, caspase-9). |
2022-05-20 |
2023-08-13 |
zebrafish |
| Jingming Ren, Rong Huang, Yanjie Li, Ruiyang Chen, Hongqi Tian, Chenlu Li. Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice. Scientific reports. vol 12. issue 1. 2022-05-19. PMID:35589816. |
furthermore, hl-003 downregulated the expression of p-p53, bax, caspase 3, and caspase 9, and upregulated the expression of bcl-2, suggesting that it could inhibit the activation of p53 to reduce cell apoptosis. |
2022-05-19 |
2023-08-13 |
mouse |