| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinying Huang, Chenglong Ma, Wenxin Huang, Mengyuan Dai, Jingjing Yang, Xiaole Xu, Yuanlv Deng, Yang Yang, Huidong Zhan. Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop. Ecotoxicology and environmental safety. vol 237. 2022-04-28. PMID:35483139. |
in normal trophoblast cells, relatively low levels of lnc-hz01 and p53 suppressed p53/caspase-3 apoptosis pathway, giving normal pregnancy. |
2022-04-28 |
2023-08-13 |
human |
| Xinying Huang, Chenglong Ma, Wenxin Huang, Mengyuan Dai, Jingjing Yang, Xiaole Xu, Yuanlv Deng, Yang Yang, Huidong Zhan. Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop. Ecotoxicology and environmental safety. vol 237. 2022-04-28. PMID:35483139. |
upon bpde exposure, bpde up-regulated the expression levels of lnc-hz01 and p53, triggered this positive feedback loop, activated the p53/caspase-3 apoptosis pathway, and then induced miscarriage. |
2022-04-28 |
2023-08-13 |
human |
| Yingying Wei, Zhihui Zhu, Hongtao Hu, Jiaqi Guan, Bo Yang, Huajun Zha. Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer. European journal of pharmacology. 2022-04-26. PMID:35469839. |
eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer. |
2022-04-26 |
2023-08-13 |
Not clear |
| Yingying Wei, Zhihui Zhu, Hongtao Hu, Jiaqi Guan, Bo Yang, Huajun Zha. Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer. European journal of pharmacology. 2022-04-26. PMID:35469839. |
the mutant p53 plays a vital role in the control of cell survival and division under various stresses, including apoptosis and ferroptosis. |
2022-04-26 |
2023-08-13 |
Not clear |
| Yingying Wei, Zhihui Zhu, Hongtao Hu, Jiaqi Guan, Bo Yang, Huajun Zha. Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer. European journal of pharmacology. 2022-04-26. PMID:35469839. |
mutant p53 signaling pathway participated in eup-induced apoptosis and ferroptosis, which were rescued when mutant p53 was silent in tnbc cells. |
2022-04-26 |
2023-08-13 |
Not clear |
| Yingying Wei, Zhihui Zhu, Hongtao Hu, Jiaqi Guan, Bo Yang, Huajun Zha. Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer. European journal of pharmacology. 2022-04-26. PMID:35469839. |
taken together, the data demonstrate that the natural compound eup is a potential tnbc therapeutic agent that induces apoptosis and ferroptosis through ubiquitination of mutant p53. |
2022-04-26 |
2023-08-13 |
Not clear |
| Mónica Paesa, Danielle Pires Nogueira, Gustavo Velderrain-Rodríguez, Irene Esparza, Nerea Jiménez-Moreno, Gracia Mendoza, Jesús Osada, Olga Martin-Belloso, María Jesús Rodríguez-Yoldi, Carmen Ancín-Azpilicuet. Valorization of Onion Waste by Obtaining Extracts Rich in Phenolic Compounds and Feasibility of Its Therapeutic Use on Colon Cancer. Antioxidants (Basel, Switzerland). vol 11. issue 4. 2022-04-23. PMID:35453418. |
regarding the antiproliferative activity, the onion extracts produced cell cycle arrest in the s phase with p53 activation, intrinsic apoptosis (mitochondrial membrane potential modification) and caspase 3 activation. |
2022-04-23 |
2023-08-13 |
Not clear |
| Marios Lampros, Nikolaos Vlachos, Spyridon Voulgaris, George A Alexio. The Role of Hsp27 in Chemotherapy Resistance. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453647. |
although numerous signaling pathways and molecular mechanisms were implicated in that chemotherapy resistance, hsp27 most commonly contributed to the upregulation of akt/mtor signaling cascade and inactivation of p53, thus inhibiting the chemotherapy-mediated induction of apoptosis. |
2022-04-23 |
2023-08-13 |
Not clear |
| Xiangyu Meng, Zhuoxuan Lu, Qingyu Lv, Yongqiang Jiang, Liming Zhang, Zhifei Wan. Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy. Acta biomaterialia. 2022-04-23. PMID:35460908. |
the liberated met blocks the glycolysis process via suppressing the activity of hk2 and impairing atp production, which activates the amp-activated protein kinase (ampk) pathway and p53 pathway and damages the warburg effect, eventually leading to cells apoptosis. |
2022-04-23 |
2023-08-13 |
Not clear |
| Xiangyu Meng, Zhuoxuan Lu, Qingyu Lv, Yongqiang Jiang, Liming Zhang, Zhifei Wan. Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy. Acta biomaterialia. 2022-04-23. PMID:35460908. |
the liberated met blocks the glycolysis process via suppressing the activity of hk2 and impairing atp production, which activates the amp-activated protein kinase (ampk) pathway and p53 pathway and damages the warburg effect, eventually leading to cells apoptosis. |
2022-04-23 |
2023-08-13 |
Not clear |
| Xuan Zheng, Jianyun Zhang, Shuangting Li, Xiaolei Gao, Yixin Zhang, Meng Wang, Liying Dong, Liangjie Sun, Na Zhao, Zeyun Ma, Chong Ding, Yixiang Wan. Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis. Translational oncology. vol 21. 2022-04-23. PMID:35460941. |
the results showed, briefly, an exposure to niclosamide and quinacrine led to an increased apoptosis-related protein p53, cleaved caspase-3 and cleaved parp and autophagy-related protein lc3b expression, and a decreased expression of autophagy-related protein p62, finally leading to cell apoptosis and autophage. |
2022-04-23 |
2023-08-13 |
Not clear |
| Wei Li, Kai Li, Zhong Wang, Zhenzhong F. MicroRNA-377-3p promotes cell proliferation and inhibits cell cycle arrest and cell apoptosis in hepatocellular carcinoma by affecting EGR1-mediated p53 activation. Pathology, research and practice. vol 234. 2022-04-23. PMID:35461040. |
microrna-377-3p promotes cell proliferation and inhibits cell cycle arrest and cell apoptosis in hepatocellular carcinoma by affecting egr1-mediated p53 activation. |
2022-04-23 |
2023-08-13 |
Not clear |
| Saketh S Dinavahi, Yu-Chi Chen, Kishore Punnath, Arthur Berg, Meenhard Herlyn, Momeneh Foroutan, Nicholas D Huntington, Gavin P Robertso. Targeting WEE1/AKT restores p53-dependent NK cell activation to induce immune checkpoint blockade responses in 'cold' melanoma. Cancer immunology research. 2022-04-19. PMID:35439317. |
activation of the p53 pathway can increase apoptosis of cancer cells, leading to enhanced antigen presentation, and can stimulate natural killer (nk) cells through expression of stress ligands. |
2022-04-19 |
2023-08-13 |
Not clear |
| Tiantian Qi, Ruihua Jing, Bo Ma, Conghui Hu, Chan Wen, Yongping Shao, Cheng Pe. The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts. Investigative ophthalmology & visual science. vol 63. issue 4. 2022-04-18. PMID:35435923. |
the e3 ligase rnf157 inhibits lens epithelial cell apoptosis by negatively regulating p53 in age-related cataracts. |
2022-04-18 |
2023-08-13 |
human |
| Yang Wang, Yang Che, ShanShan Wang, JinMing Wang, Xiaoni Liu, Buxin Kou, Yuanyue Guan, Dexi Chen, Ying Sh. ASPP2 reduction attenuates HBV induced chronic liver damage: A hybrid mouse model study. Biochemical and biophysical research communications. vol 610. 2022-04-18. PMID:35436632. |
p53 apoptosis stimulating protein 2 (aspp2) is confirmed to participate in cellular activities including apoptosis, proliferation, autophagy, injury and so on. |
2022-04-18 |
2023-08-13 |
mouse |
| Qinwei Chen, Suqi Deng, Manman Deng, Yuanfei Shi, Mengya Zhong, Lihong Ding, Yuelong Jiang, Yong Zhou, Bing Z Carter, Bing X. Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways. Experimental hematology & oncology. vol 11. issue 1. 2022-04-17. PMID:35429966. |
in this study, we reported that triptolide synergized with mdm2 inhibitor nutlin-3a to suppress cell proliferation and induce mitochondrial-mediated apoptosis in p53 wt aml in vitro and ex vivo. |
2022-04-17 |
2023-08-13 |
Not clear |
| Rui Feng, Xue Qin, Qi Li, Samson Olugbenga Adeniran, Fushuo Huang, Yulong Li, Qian Zhao, Peng Zhen. Progesterone regulates inflammation and receptivity of cells via the NF-κB and LIF/STAT3 pathways. Theriogenology. vol 186. 2022-04-17. PMID:35430548. |
the results showed that ammonia decreased the viability of beec, upregulated the ros level and apoptosis rate, and upregulated the expressions of bax, bcl-2, p53, cyt-c, caspase-3, caspase-8 and caspase-9. |
2022-04-17 |
2023-08-13 |
cattle |
| Matina Tsampoula, Isaak Tarampoulous, Theodora Manolakou, Elpinickie Ninou, Panagiotis K Politi. The neurodevelopmental disorders associated gene Rnf113a regulates survival and differentiation properties of neural stem cells. Stem cells (Dayton, Ohio). 2022-04-16. PMID:35429390. |
importantly, rnf113a1 deficiency triggers cell apoptosis via a combined action on essential regulators of cell survival, including p53, nupr1 and rad51. |
2022-04-16 |
2023-08-13 |
mouse |
| Hongchen Li, Mingshun Lu, Haiwei Zhang, Shengnan Wang, Fei Wang, Xueya Ma, Jiaxi Liu, Xinyu Li, Haichao Yang, Haitao Shen, Ping L. Downregulation of REST in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway. Cell death & disease. vol 13. issue 4. 2022-04-14. PMID:35418568. |
downregulation of rest in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway. |
2022-04-14 |
2023-08-13 |
mouse |
| Hongchao Zhou, Yuting Zhang, Jingjing Wang, Yuchao Yan, Yi Liu, Xiaojie Shi, Qi Zhang, Xingang X. The CREB and AP-1-Dependent Cell Communication Network Factor 1 Regulates Porcine Epidemic Diarrhea Virus-Induced Cell Apoptosis Inhibiting Virus Replication Through the p53 Pathway. Frontiers in microbiology. vol 13. 2022-04-14. PMID:35418961. |
the creb and ap-1-dependent cell communication network factor 1 regulates porcine epidemic diarrhea virus-induced cell apoptosis inhibiting virus replication through the p53 pathway. |
2022-04-14 |
2023-08-13 |
Not clear |